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Translational Stroke Research
Erschienen in: Translational Stroke Research 6/2020

26.06.2020 | Review Article

Mitochondrial Transfer as a Therapeutic Strategy Against Ischemic Stroke

verfasst von: Wei Chen, Jingjing Huang, Yueqiang Hu, Seyed Esmaeil Khoshnam, Alireza Sarkaki

Erschienen in: Translational Stroke Research | Ausgabe 6/2020

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Abstract

Stroke is a debilitating disease that remains the second leading cause of death and disability worldwide. Despite accumulating knowledge of the disease pathology, treatments for stroke are limited, and clinical translation of the neuroprotective agents has not been a complete success. Accumulating evidence links mitochondrial dysfunction to brain impairments after stroke. Recent studies have implicated the important roles of healthy mitochondria in neuroprotection and neural recovery following ischemic stroke. New and convincing studies have shown that mitochondrial transfer to the damaged cells can help revive cells energetic in the recipient cells. Hence, mitochondrial transplantation has shown to replace impaired or dysfunctional mitochondria with exogenous healthy mitochondria after ischemic stroke. We highlight the potential of mitochondrial transfer by stem cells as a therapeutic strategy for the treatment of ischemic stroke. This review captures the recent advances in the mitochondrial transfer as a novel and promising treatment for ischemic stroke.
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Metadaten
Titel
Mitochondrial Transfer as a Therapeutic Strategy Against Ischemic Stroke
verfasst von
Wei Chen
Jingjing Huang
Yueqiang Hu
Seyed Esmaeil Khoshnam
Alireza Sarkaki
Publikationsdatum
26.06.2020
Verlag
Springer US
Erschienen in
Translational Stroke Research / Ausgabe 6/2020
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-020-00828-7

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