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01.04.2020 | Review

Septic-Associated Encephalopathy: a Comprehensive Review

verfasst von: Aurélien Mazeraud, Cássia Righy, Eleonore Bouchereau, Sarah Benghanem, Fernando Augusto Bozza, Tarek Sharshar

Erschienen in: Neurotherapeutics | Ausgabe 2/2020

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Abstract

Septic-associated encephalopathy (SAE) is a key manifestation of sepsis, ranging from delirium to coma and occurring in up to 70% of patients admitted to the ICU. SAE is associated with higher ICU and hospital mortality, and also with poorer long-term outcomes, including cognitive and functional outcomes. The pathophysiology of SAE is complex, and it may involve neurotransmitter dysfunction, inflammatory and ischemic lesions to the brain, microglial activation, and blood–brain barrier dysfunction. Delirium (which is included in the SAE spectrum) is mostly diagnosed with validated scales in the ICU population. There is no established treatment for SAE; benzodiazepines should generally be avoided in this setting. Nonpharmacological prevention and management is key for treating SAE; it includes avoiding oversedation (mainly with benzodiazepines), early mobilization, and sleep promotion.

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Titel: Septic-Associated Encephalopathy: a Comprehensive Review
verfasst von: Aurélien Mazeraud
Cássia Righy
Eleonore Bouchereau
Sarah Benghanem
Fernando Augusto Bozza
Tarek Sharshar
Publikationsdatum: 01.04.2020
Verlag: Springer International Publishing
Erschienen in: Neurotherapeutics / Ausgabe 2/2020
Print ISSN: 1933-7213
Elektronische ISSN: 1878-7479
DOI: https://doi.org/10.1007/s13311-020-00862-1

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HMGB1 Is a Therapeutic Target and Biomarker in Diazepam-Refractory Status Epilepticus with Wide Time Window

Therapeutic Development of Apolipoprotein E Mimetics for Acute Brain Injury: Augmenting Endogenous Responses to Reduce Secondary Injury