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High Blood Pressure & Cardiovascular Prevention

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01.03.2017 | Original Article

Clinical Benefits of Unilateral Adrenalectomy in Patients with Subclinical Hypercortisolism Due to Adrenal Incidentaloma: Results from a Single Center

verfasst von: Luigi Petramala, Giuseppe Cavallaro, Matteo Galassi, Cristiano Marinelli, Gianfranco Tonnarini, Antonio Concistrè, Umberto Costi, Maurizio Bufi, Piernatale Lucia, Giuseppe De Vincentis, Gino Iannucci, Giorgio De Toma, Claudio Letizia

Erschienen in: High Blood Pressure & Cardiovascular Prevention | Ausgabe 1/2017

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Abstract

Introduction

This study was designed to evaluate the results of unilateral laparoscopic adrenalectomy in patients with subclinical hypercortisolism (SH) due to adrenal incidentaloma (AI) concerning the main cardiometabolic disorders.

Methods

We have studied between January 2000 to December 2015, 645 patients with AI (283 males and 362 females; mean age 61.9 ± 10 years) and we found 70 patients with SH (27 males and 43 females; mean age 61.9 ± 8.4 years). Twenty-six (37%) SH patients (6 males and 20 females; mean age 58.7 ± 7.1 years) underwent unilateral laparoscopic adrenalectomy, whereas 44 SH patients (21 males and 23 females; mean age 63.9 ± 9.9 years) performed a conservative treatment. All SH patients were evaluated at diagnosis and after follow-up (mean 12 months; range 9–15 months).

Results

In only SH patients undergoing unilateral adrenalectomy we found a statistical significant reduction of the arterial hypertension and metabolic syndrome (p < 0.05, respectively). In particular we observed a reduction of 24-h systolic blood pressure and “non-dipper” pattern (p < 0.05, respectively) evaluated with ambulatory blood pressure monitoring (ABPM).

Conclusions

Our study confirm the high prevalence of SH in AI, and the unilateral laparoscopic adrenalectomy seemed to have a beneficial effect on some cardiometabolic disorders.

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Titel: Clinical Benefits of Unilateral Adrenalectomy in Patients with Subclinical Hypercortisolism Due to Adrenal Incidentaloma: Results from a Single Center
verfasst von: Luigi Petramala
Giuseppe Cavallaro
Matteo Galassi
Cristiano Marinelli
Gianfranco Tonnarini
Antonio Concistrè
Umberto Costi
Maurizio Bufi
Piernatale Lucia
Giuseppe De Vincentis
Gino Iannucci
Giorgio De Toma
Claudio Letizia
Publikationsdatum: 01.03.2017
Verlag: Springer International Publishing
Erschienen in: High Blood Pressure & Cardiovascular Prevention / Ausgabe 1/2017
Print ISSN: 1120-9879
Elektronische ISSN: 1179-1985
DOI: https://doi.org/10.1007/s40292-017-0182-7

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Clinical Benefits of Unilateral Adrenalectomy in Patients with Subclinical Hypercortisolism Due to Adrenal Incidentaloma: Results from a Single Center