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Erschienen in: Current Addiction Reports 2/2014

01.06.2014 | Stimulants, Cannabis, and Club Drugs (AJ Budney, R Vandrey and D Lee, Section Editors)

Considering Cannabis: The Effects of Regular Cannabis Use on Neurocognition in Adolescents and Young Adults

verfasst von: Krista M. Lisdahl, Natasha E. Wright, Christopher Medina-Kirchner, Kristin E. Maple, Skyler Shollenbarger

Erschienen in: Current Addiction Reports | Ausgabe 2/2014

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Abstract

Thirty-six percent of high-school seniors have used cannabis in the past year, and an alarming 6.5 % smoked cannabis daily, up from 2.4 % in 1993. Adolescents and emerging adults are undergoing significant neurodevelopment and animal studies suggest they may be particularly vulnerable to negative drug effects. In this review, we will provide a detailed overview of studies outlining the effects of regular (at least weekly) cannabis use on neurocognition, including studies outlining cognitive, structural, and functional findings. We will also explore the public health impact of this research.
Literatur
1.
Zurück zum Zitat Johnston LD, O'Malley PM, Bachman JG, Schulenberg JE. Monitoring the Future national results on adolescent drug use: overview of key findings, 2012. Ann Arbor: Institute for Social Research, The University of Michigan; 2013. 83pp. Johnston LD, O'Malley PM, Bachman JG, Schulenberg JE. Monitoring the Future national results on adolescent drug use: overview of key findings, 2012. Ann Arbor: Institute for Social Research, The University of Michigan; 2013. 83pp.
2.
Zurück zum Zitat Degenhardt L, Chiu WT, Sampson N, Kessler RC, Anthony JC, Angermeyer M, et al. Toward a global view of alcohol, tobacco, cannabis, and cocaine use: findings from the WHO World Mental Health Surveys. PLoS Med. 2008;5(7):e141. Degenhardt L, Chiu WT, Sampson N, Kessler RC, Anthony JC, Angermeyer M, et al. Toward a global view of alcohol, tobacco, cannabis, and cocaine use: findings from the WHO World Mental Health Surveys. PLoS Med. 2008;5(7):e141.
3.
Zurück zum Zitat Giedd JN, Vaituzis AC, Hamburger SD, Lange N, Rajapakse JC, Kaysen D, et al. Quantitative MRI of the temporal lobe, amygdala, and hippocampus in normal human development: ages 4-18 years. J Comp Neurol. 1996;366:223–30.PubMedCrossRef Giedd JN, Vaituzis AC, Hamburger SD, Lange N, Rajapakse JC, Kaysen D, et al. Quantitative MRI of the temporal lobe, amygdala, and hippocampus in normal human development: ages 4-18 years. J Comp Neurol. 1996;366:223–30.PubMedCrossRef
4.
Zurück zum Zitat Gogtay N, Giedd JN, Lusk L, Hayashi KM, Greenstein D, Vaituzis AC, et al. Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci U S A. 2004;101(21):8174–9.PubMedCentralPubMedCrossRef Gogtay N, Giedd JN, Lusk L, Hayashi KM, Greenstein D, Vaituzis AC, et al. Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci U S A. 2004;101(21):8174–9.PubMedCentralPubMedCrossRef
5.
Zurück zum Zitat Lenroot RK, Giedd JN. Brain development in children and adolescents: insights from anatomical magnetic resonance imaging. NeurosciBiobehav Rev. 2006;30:718–29. Lenroot RK, Giedd JN. Brain development in children and adolescents: insights from anatomical magnetic resonance imaging. NeurosciBiobehav Rev. 2006;30:718–29.
6.
Zurück zum Zitat Sowell ER, Thompson P, Leonard CM, Welcome SE, Kan E, Toga AW. Longitudinal mapping of cortical thickness and brain growth in normal children. J Neurosci. 2004;24(38):8223–31.PubMedCrossRef Sowell ER, Thompson P, Leonard CM, Welcome SE, Kan E, Toga AW. Longitudinal mapping of cortical thickness and brain growth in normal children. J Neurosci. 2004;24(38):8223–31.PubMedCrossRef
7.
Zurück zum Zitat Giedd JN, Blumenthal J, Jeffries NO, Castellanos FX, Liu H, Zijdenbos A, et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci. 1999;2:861–3.PubMedCrossRef Giedd JN, Blumenthal J, Jeffries NO, Castellanos FX, Liu H, Zijdenbos A, et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci. 1999;2:861–3.PubMedCrossRef
8.
Zurück zum Zitat Jernigan T, Gamst A. Changes in volume with age: consistency and interpretation of observed effects. Neurobiol Aging. 2005;26(9):1271–4.PubMedCrossRef Jernigan T, Gamst A. Changes in volume with age: consistency and interpretation of observed effects. Neurobiol Aging. 2005;26(9):1271–4.PubMedCrossRef
9.
Zurück zum Zitat Spear LP. The behavioral neuroscience of adolescence. Neurosci Biobehav Rev. 2010;24:417–63.CrossRef Spear LP. The behavioral neuroscience of adolescence. Neurosci Biobehav Rev. 2010;24:417–63.CrossRef
10.•
Zurück zum Zitat Lisdahl KM, Gilbart ER, Wright NE, Shollenbarger S. Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function. Front Psychiatry. 2013;4(53):1–19. Earlier review article by current author outlining effects of both alcohol and cannabis on the adolescent brain with particular focus on early age of onset. Lisdahl KM, Gilbart ER, Wright NE, Shollenbarger S. Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function. Front Psychiatry. 2013;4(53):1–19. Earlier review article by current author outlining effects of both alcohol and cannabis on the adolescent brain with particular focus on early age of onset.
11.•
Zurück zum Zitat Tapert SF, Granholm E, Leedy NG, Brown SA. Substance use and withdrawal: neuropsychological functioning over 8 years in youth. J Int Neuropsychol Soc. 2002;8(7):873–83. Longitudinal study examining the specific impact of cannabis use on cognition over an 8-year period.PubMedCrossRef Tapert SF, Granholm E, Leedy NG, Brown SA. Substance use and withdrawal: neuropsychological functioning over 8 years in youth. J Int Neuropsychol Soc. 2002;8(7):873–83. Longitudinal study examining the specific impact of cannabis use on cognition over an 8-year period.PubMedCrossRef
12.•
Zurück zum Zitat Tait RJ, Mackinnon A, Christensen H. Cannabis use and cognitive function: 8-year trajectory in a young adult cohort. Addiction. 2011;106(12):2195–203. Longitudinal study examining the specific impact of cannabis use on cognition over an 8-year period.PubMedCrossRef Tait RJ, Mackinnon A, Christensen H. Cannabis use and cognitive function: 8-year trajectory in a young adult cohort. Addiction. 2011;106(12):2195–203. Longitudinal study examining the specific impact of cannabis use on cognition over an 8-year period.PubMedCrossRef
13.••
Zurück zum Zitat Meier MH, Caspi A, Ambler A, Harrington H, Houts R, Keefe RS, et al. Persistent cannabis users show neuropsychological decline from childhood to midlife. Proc Natl Acad Sci U S A. 2012;109(40):2657–64. Largest prospective, longitudinal study examining impact of cananbis use on IQ and cognition.CrossRef Meier MH, Caspi A, Ambler A, Harrington H, Houts R, Keefe RS, et al. Persistent cannabis users show neuropsychological decline from childhood to midlife. Proc Natl Acad Sci U S A. 2012;109(40):2657–64. Largest prospective, longitudinal study examining impact of cananbis use on IQ and cognition.CrossRef
14.
Zurück zum Zitat Takagi M, Lubman DI, Cotton S, Fornito A, Baliz Y, Tucker A, et al. Executive control among adolescent inhalant and cannabis users. Drug Alcohol Rev. 2011;30:620–37.CrossRef Takagi M, Lubman DI, Cotton S, Fornito A, Baliz Y, Tucker A, et al. Executive control among adolescent inhalant and cannabis users. Drug Alcohol Rev. 2011;30:620–37.CrossRef
15.••
Zurück zum Zitat Fried PA, Watkinson B, Gray R. Neurocognitive consequences of marihuana-a comparison with pre-drug performance. Neurotoxicol Teratol. 2005;27(2):231–9. An important longitudinal study examining the impact of cannabis on cognition over time.PubMedCrossRef Fried PA, Watkinson B, Gray R. Neurocognitive consequences of marihuana-a comparison with pre-drug performance. Neurotoxicol Teratol. 2005;27(2):231–9. An important longitudinal study examining the impact of cannabis on cognition over time.PubMedCrossRef
16.•
Zurück zum Zitat Gruber SA, Dahlgren MK, Sagar KA, Gönenc A, Killgore WD. Age of onset of marijuana use impacts inhibitory processing. Neurosci Lett. 2012;511(2):89–94. A well designed study examining the impact of early onset cannabis use on neurocognitive functioning, focused on inhibitory control.PubMedCentralPubMedCrossRef Gruber SA, Dahlgren MK, Sagar KA, Gönenc A, Killgore WD. Age of onset of marijuana use impacts inhibitory processing. Neurosci Lett. 2012;511(2):89–94. A well designed study examining the impact of early onset cannabis use on neurocognitive functioning, focused on inhibitory control.PubMedCentralPubMedCrossRef
17.
Zurück zum Zitat Gruber SA, Sagar KA, Dahlgren MK, Racine M, Lukas SE. Age of onset of marijuana use and executive function. Psychol Addict Behav. 2012;26(3):486–506. Gruber SA, Sagar KA, Dahlgren MK, Racine M, Lukas SE. Age of onset of marijuana use and executive function. Psychol Addict Behav. 2012;26(3):486–506.
18.•
Zurück zum Zitat Lisdahl KM, Price JS. Increased marijuana use and gender predict poorer cognitive functioning in healthy emerging adults. J Int Neuropsychol Soc. 2012;18(4):678–88. Well designed study fully replicating neuropsychological findings from Medina et al., 2007 in different sample.PubMedCentralPubMedCrossRef Lisdahl KM, Price JS. Increased marijuana use and gender predict poorer cognitive functioning in healthy emerging adults. J Int Neuropsychol Soc. 2012;18(4):678–88. Well designed study fully replicating neuropsychological findings from Medina et al., 2007 in different sample.PubMedCentralPubMedCrossRef
19.••
Zurück zum Zitat Medina KL, Hanson K, Schweinsburg AD, Cohen-Zion M, Nagel BJ, Tapert SF. Neuropsychological functioning in adolescent marijuana users: Subtle deficits detectable after 30 days of abstinence. J Intern Neuropsychol Soc. 2007;13(5):807–20. One of the only studies to assess neuropsychological functioning following a closely monitored month of abstinence in adolescents with medium to heavy cannabis exposure.CrossRef Medina KL, Hanson K, Schweinsburg AD, Cohen-Zion M, Nagel BJ, Tapert SF. Neuropsychological functioning in adolescent marijuana users: Subtle deficits detectable after 30 days of abstinence. J Intern Neuropsychol Soc. 2007;13(5):807–20. One of the only studies to assess neuropsychological functioning following a closely monitored month of abstinence in adolescents with medium to heavy cannabis exposure.CrossRef
20.••
Zurück zum Zitat Hanson KL, Winward JL, Schweinsburg AD, Medina KL, Brown SA, Tapert SF. Longitudinal study of cognition among adolescent marijuana users over three weeks of abstinence. Addict Behav. 2010;35(11):970–6. A well designed study examining cognitive functioning over a 3-week period of closely monitored abstinence.PubMedCentralPubMedCrossRef Hanson KL, Winward JL, Schweinsburg AD, Medina KL, Brown SA, Tapert SF. Longitudinal study of cognition among adolescent marijuana users over three weeks of abstinence. Addict Behav. 2010;35(11):970–6. A well designed study examining cognitive functioning over a 3-week period of closely monitored abstinence.PubMedCentralPubMedCrossRef
21.
Zurück zum Zitat Harvey MA, Sellman JD, Porter RJ, Frampton CM. The relationship between non-acute adolescent marijuana use and cognition. Drug Alcohol Rev. 2007;26(3):309–19.PubMedCrossRef Harvey MA, Sellman JD, Porter RJ, Frampton CM. The relationship between non-acute adolescent marijuana use and cognition. Drug Alcohol Rev. 2007;26(3):309–19.PubMedCrossRef
22.
Zurück zum Zitat Mathias CW, Blumenthal TD, Dawes MA, Liguori A, Richard DM, Bray B, et al. Failure to sustain prepulse inhibition in adolescent marijuana users. Drug Alcohol Depend. 2011;116(1–3):110–6.PubMedCentralPubMedCrossRef Mathias CW, Blumenthal TD, Dawes MA, Liguori A, Richard DM, Bray B, et al. Failure to sustain prepulse inhibition in adolescent marijuana users. Drug Alcohol Depend. 2011;116(1–3):110–6.PubMedCentralPubMedCrossRef
23.
Zurück zum Zitat McHale S, Hunt N. Executive function deficits in short-term abstinent cannabis users. Hum Psychopharmacol. 2008;23(5):409–15.PubMedCrossRef McHale S, Hunt N. Executive function deficits in short-term abstinent cannabis users. Hum Psychopharmacol. 2008;23(5):409–15.PubMedCrossRef
24.
Zurück zum Zitat Schwartz RH, Gruenewald PJ, Klitzner M, Fedio P. Short-term memory impairment in cannabis-dependent adolescents. Am J Dis Child. 1989;143(10):1214–9.PubMed Schwartz RH, Gruenewald PJ, Klitzner M, Fedio P. Short-term memory impairment in cannabis-dependent adolescents. Am J Dis Child. 1989;143(10):1214–9.PubMed
25.
Zurück zum Zitat Solowij N, Jones KA, Rozman ME, Davis SM, Ciarrochi J, Heaven PC, et al. Verbal learning and memory in adolescent cannabis users, alcohol users and non-users. Psychopharmacol (Berl). 2011;216(1):131–44.CrossRef Solowij N, Jones KA, Rozman ME, Davis SM, Ciarrochi J, Heaven PC, et al. Verbal learning and memory in adolescent cannabis users, alcohol users and non-users. Psychopharmacol (Berl). 2011;216(1):131–44.CrossRef
26.
Zurück zum Zitat Thoma RJ, Monnig MA, Lysne PA, Ruhl DA, Pommy JA, Bogenschutz M, et al. Adolescent substance abuse: the effects of alcohol and marijuana on neuropsychological performance. Alcohol Clin Exp Res. 2011;35(1):39–46. Thoma RJ, Monnig MA, Lysne PA, Ruhl DA, Pommy JA, Bogenschutz M, et al. Adolescent substance abuse: the effects of alcohol and marijuana on neuropsychological performance. Alcohol Clin Exp Res. 2011;35(1):39–46.
27.
Zurück zum Zitat Hanson KL, Medina KL, Nagel BJ, Spadoni AD, Gorlick A, Tapert SF. Hippocampal volumes in adolescents with and without a family history of alcoholism. Am J Drug Alcohol Abuse. 2010;36:161–7.PubMedCentralPubMedCrossRef Hanson KL, Medina KL, Nagel BJ, Spadoni AD, Gorlick A, Tapert SF. Hippocampal volumes in adolescents with and without a family history of alcoholism. Am J Drug Alcohol Abuse. 2010;36:161–7.PubMedCentralPubMedCrossRef
28.•
Zurück zum Zitat Gonzalez R, Schuster RM, Mermelstein RJ, Vassileva J, Martin EM, Diviak KR. Performance of young adult cannabis users on neurocognitive measures of impulsive behavior and their relationship to symptoms of cannabis use disorders. J Clin Exp Neuropsychol. 2012;34(9):962–76. A novel study linking cognitive functioning to cannabis use disorder symptoms in youth.PubMedCentralPubMedCrossRef Gonzalez R, Schuster RM, Mermelstein RJ, Vassileva J, Martin EM, Diviak KR. Performance of young adult cannabis users on neurocognitive measures of impulsive behavior and their relationship to symptoms of cannabis use disorders. J Clin Exp Neuropsychol. 2012;34(9):962–76. A novel study linking cognitive functioning to cannabis use disorder symptoms in youth.PubMedCentralPubMedCrossRef
29.
Zurück zum Zitat Grant JE, Chamberlain SR, Schreiber L, Odlaug BL. Neuropsychological deficits associated with cannabis use in young adults. Drug Alcohol Depend. 2012;121(1–2):159–62.PubMedCentralPubMedCrossRef Grant JE, Chamberlain SR, Schreiber L, Odlaug BL. Neuropsychological deficits associated with cannabis use in young adults. Drug Alcohol Depend. 2012;121(1–2):159–62.PubMedCentralPubMedCrossRef
30.
Zurück zum Zitat Schuster RM, Crane NA, Mermelstein R, Gonzalez R. The influence of inhibitory control and episodic memory on the risky sexual behavior of young adult cannabis users. J Int Neuropsychol Soc. 2012;18(5):827–33.PubMedCentralPubMedCrossRef Schuster RM, Crane NA, Mermelstein R, Gonzalez R. The influence of inhibitory control and episodic memory on the risky sexual behavior of young adult cannabis users. J Int Neuropsychol Soc. 2012;18(5):827–33.PubMedCentralPubMedCrossRef
31.
Zurück zum Zitat Solowij N, Jones KA, Rozman ME, Davis SM, Ciarrochi J, Heaven PC, et al. Reflection impulsivity in adolescent cannabis users: a comparison with alcohol-using and non-substance-using adolescents. Psychopharmacology (Berl). 2012;219(2):575–86.CrossRef Solowij N, Jones KA, Rozman ME, Davis SM, Ciarrochi J, Heaven PC, et al. Reflection impulsivity in adolescent cannabis users: a comparison with alcohol-using and non-substance-using adolescents. Psychopharmacology (Berl). 2012;219(2):575–86.CrossRef
32.
Zurück zum Zitat Medina KL, Schweinsburg AD, Cohen-Zion M, Nagel BJ, Tapert SF. Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal asymmetry. NeurotoxicolTeratol. 2007;29:141–52. Medina KL, Schweinsburg AD, Cohen-Zion M, Nagel BJ, Tapert SF. Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal asymmetry. NeurotoxicolTeratol. 2007;29:141–52.
33.
Zurück zum Zitat Medina KL, McQueeny T, Nagel BJ, Hanson KL, Yang T, Tapert SF. Prefrontal morphometry in abstinent adolescent marijuana users: Subtle gender effects. Addict Biol. 2009;14(4):457–68.PubMedCentralPubMedCrossRef Medina KL, McQueeny T, Nagel BJ, Hanson KL, Yang T, Tapert SF. Prefrontal morphometry in abstinent adolescent marijuana users: Subtle gender effects. Addict Biol. 2009;14(4):457–68.PubMedCentralPubMedCrossRef
34.
Zurück zum Zitat Medina KL, Nagel BJ, Tapert SF. Cerebellar vermis abnormality in adolescent marijuana users. Psychiatr Res Neuroimage. 2010;182(2):152–9.CrossRef Medina KL, Nagel BJ, Tapert SF. Cerebellar vermis abnormality in adolescent marijuana users. Psychiatr Res Neuroimage. 2010;182(2):152–9.CrossRef
35.
Zurück zum Zitat McQueeny TM, Padula C, Price J, Medina KL, Logan P, Tapert SF. Gender effects on amygdala morphometry in adolescent marijuana users. Behav Brain Res. 2011;224(1):128–34.PubMedCentralPubMedCrossRef McQueeny TM, Padula C, Price J, Medina KL, Logan P, Tapert SF. Gender effects on amygdala morphometry in adolescent marijuana users. Behav Brain Res. 2011;224(1):128–34.PubMedCentralPubMedCrossRef
36.
Zurück zum Zitat Churchwell JC, Carey PD, Ferrett HL, Stein DJ, Yurgelun-Todd DA. Abnormal striatal circuitry and intensified novelty seeking among adolescents that abuse methamphetamine and cannabis. Dev Neurosci. 2012;34(4):310–7.PubMedCentralPubMedCrossRef Churchwell JC, Carey PD, Ferrett HL, Stein DJ, Yurgelun-Todd DA. Abnormal striatal circuitry and intensified novelty seeking among adolescents that abuse methamphetamine and cannabis. Dev Neurosci. 2012;34(4):310–7.PubMedCentralPubMedCrossRef
37.
Zurück zum Zitat Churchwell JC, Lopez-Larson M, Yurgelun-Todd DA. Altered frontal cortical volume and decision making in adolescent cannabis users. Front Psychol. 2010;1:225.PubMedCentralPubMedCrossRef Churchwell JC, Lopez-Larson M, Yurgelun-Todd DA. Altered frontal cortical volume and decision making in adolescent cannabis users. Front Psychol. 2010;1:225.PubMedCentralPubMedCrossRef
38.
Zurück zum Zitat Ashtari M, Avants B, Cyckowski L, Cervellione KL, Roofeh D, Cook P, et al. Medial temporal structures and memory functions in adolescents with heavy cannabis use. J Psychiatr Res. 2011;45(8):1055–66.PubMedCentralPubMedCrossRef Ashtari M, Avants B, Cyckowski L, Cervellione KL, Roofeh D, Cook P, et al. Medial temporal structures and memory functions in adolescents with heavy cannabis use. J Psychiatr Res. 2011;45(8):1055–66.PubMedCentralPubMedCrossRef
39.•
Zurück zum Zitat Cousijn J, Wiers RW, Ridderinkhof KR, van den Brink W, Veltman DJ, Goudriaan AE. Grey matter alterations associated with cannabis use: Results of a VBM study in heavy cannabis users and healthy controls. NeuroImage. 2012;59:3845–51. A well designed study examining impact of heavy cannabis use on cortical and subcortical brain structure in chronic cannabis users.PubMedCrossRef Cousijn J, Wiers RW, Ridderinkhof KR, van den Brink W, Veltman DJ, Goudriaan AE. Grey matter alterations associated with cannabis use: Results of a VBM study in heavy cannabis users and healthy controls. NeuroImage. 2012;59:3845–51. A well designed study examining impact of heavy cannabis use on cortical and subcortical brain structure in chronic cannabis users.PubMedCrossRef
40.
Zurück zum Zitat Schacht JP, Hutchison KE, Filbey FM. Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users. Neuropsychopharmacology. 2012;37(11):2368–76. Schacht JP, Hutchison KE, Filbey FM. Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users. Neuropsychopharmacology. 2012;37(11):2368–76.
41.•
Zurück zum Zitat Lopez-Larson MP, Bogorodzki P, Rogowska J, McGlade E, King JB, Terry J, et al. Altered prefrontal and insular cortical thickness in adolescent marijuana users. Behav Brain Res. 2011;220(1):164–72. In combination with Lopez-Larson (2012), a very thorough evaluation of how cannabis impacts brain structure in youth.PubMedCentralPubMedCrossRef Lopez-Larson MP, Bogorodzki P, Rogowska J, McGlade E, King JB, Terry J, et al. Altered prefrontal and insular cortical thickness in adolescent marijuana users. Behav Brain Res. 2011;220(1):164–72. In combination with Lopez-Larson (2012), a very thorough evaluation of how cannabis impacts brain structure in youth.PubMedCentralPubMedCrossRef
42.
Zurück zum Zitat Van Essen DC, Drury HA. Structural and functional analyses of human cerebral cortex using a surface-based atlas. J Neurosci. 1997;17(18):7079–102. Van Essen DC, Drury HA. Structural and functional analyses of human cerebral cortex using a surface-based atlas. J Neurosci. 1997;17(18):7079–102.
43.•
Zurück zum Zitat Mata I, Perez-Iglesias R, Roiz-Santiañez R, Tordesillas-Gutierrez D, Pazos A, Gutierrez A. et. al. (2010). Gyrification brain abnormalities associated with adolescence and early-adulthood cannabis use. Brain Res. 1317297-304. doi:10.1016/j.brainres.2009.12.069. Novel study examining gyrification, reflecting cortical gray matter complexity, in cannabis users. Mata I, Perez-Iglesias R, Roiz-Santiañez R, Tordesillas-Gutierrez D, Pazos A, Gutierrez A. et. al. (2010). Gyrification brain abnormalities associated with adolescence and early-adulthood cannabis use. Brain Res. 1317297-304. doi:10.1016/j.brainres.2009.12.069. Novel study examining gyrification, reflecting cortical gray matter complexity, in cannabis users.
44.
Zurück zum Zitat Moldrich G, Wenger T. Localization of the CB(1) cannabinoid receptor in the rat brain. An immunohistochemical study. Peptides. 2000;21:1735–42.PubMedCrossRef Moldrich G, Wenger T. Localization of the CB(1) cannabinoid receptor in the rat brain. An immunohistochemical study. Peptides. 2000;21:1735–42.PubMedCrossRef
45.
Zurück zum Zitat Medina KL, Nagel BJ, McQueeny T, Park A, Tapert SF. Depressive symptoms in adolescents: associations with white matter volume and marijuana use. J Child Psychol Psychiatr. 2007;48(6):592–600.CrossRef Medina KL, Nagel BJ, McQueeny T, Park A, Tapert SF. Depressive symptoms in adolescents: associations with white matter volume and marijuana use. J Child Psychol Psychiatr. 2007;48(6):592–600.CrossRef
46.
Zurück zum Zitat Arnone D, Barrick TR, Chengappa S, Mackay CE, Clark CA, Abou-Saleh MT. Corpus callosum damage in heavy marijuana use: preliminary evidence from diffusion tensor tractography and tract-based spatial statistics. NeuroImage. 2008;41(3):1067–74.PubMedCrossRef Arnone D, Barrick TR, Chengappa S, Mackay CE, Clark CA, Abou-Saleh MT. Corpus callosum damage in heavy marijuana use: preliminary evidence from diffusion tensor tractography and tract-based spatial statistics. NeuroImage. 2008;41(3):1067–74.PubMedCrossRef
47.
Zurück zum Zitat Ashtari M, Cervellione K, Cottone J, Ardekani BA, Sevy S, Kumra S. Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use. J Psychiatr Res. 2009;43(3):189–204.PubMedCentralPubMedCrossRef Ashtari M, Cervellione K, Cottone J, Ardekani BA, Sevy S, Kumra S. Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use. J Psychiatr Res. 2009;43(3):189–204.PubMedCentralPubMedCrossRef
48.
Zurück zum Zitat Bava S, Frank LR, McQueeny T, Schweinsburg BC, Schweinsburg AD, Tapert SF. Altered white matter microstructure in adolescent substance users. Psychiatr Res. 2009;173(3):228–37.CrossRef Bava S, Frank LR, McQueeny T, Schweinsburg BC, Schweinsburg AD, Tapert SF. Altered white matter microstructure in adolescent substance users. Psychiatr Res. 2009;173(3):228–37.CrossRef
49.••
Zurück zum Zitat Bava S, Jacobus J, Thayer RE, Tapert SF. Longitudinal changes in white matter integrity among adolescent substance users. Alcohol Clin Exp Res. 2013;37(1):181–9. Unique longitudinal study examining impact of cannabis and alcohol use over 18-month follow-up.CrossRef Bava S, Jacobus J, Thayer RE, Tapert SF. Longitudinal changes in white matter integrity among adolescent substance users. Alcohol Clin Exp Res. 2013;37(1):181–9. Unique longitudinal study examining impact of cannabis and alcohol use over 18-month follow-up.CrossRef
50.
Zurück zum Zitat DeLisi LE, Bertisch HC, Szulc KU, Majcher M, Brown K, Bappal A, et al. A preliminary DTI study showing no brain structural change associated with adolescent cannabis use. Harm Reduct J. 2006;3:17.PubMedCentralPubMedCrossRef DeLisi LE, Bertisch HC, Szulc KU, Majcher M, Brown K, Bappal A, et al. A preliminary DTI study showing no brain structural change associated with adolescent cannabis use. Harm Reduct J. 2006;3:17.PubMedCentralPubMedCrossRef
51.•
Zurück zum Zitat Gruber SA, Dahlgren MK, Sagar KA, Gonenc A, Lukas SE. Worth the wait: effects of age of onset of marijuana use on white matter and impulsivity. Psychopharmacology. 2013. doi:10.1007/s00213-013-3326-z. Combined with Gruber et al. (2012), a well designed study that measures the impact of early onset cannabis use on white matter integrity and cognitive inhibition.PubMedCentralPubMed Gruber SA, Dahlgren MK, Sagar KA, Gonenc A, Lukas SE. Worth the wait: effects of age of onset of marijuana use on white matter and impulsivity. Psychopharmacology. 2013. doi:10.​1007/​s00213-013-3326-z. Combined with Gruber et al. (2012), a well designed study that measures the impact of early onset cannabis use on white matter integrity and cognitive inhibition.PubMedCentralPubMed
52.
Zurück zum Zitat Gruber SA, Silveri MM, Dahlgren MK, Yurgelun-Todd D. Why so impulsive? White matter alterations are associated with impulsivity in chronic marijuana smokers. Exp Clin Psychopharmacol. 2011;19(3):231–42.PubMedCentralPubMedCrossRef Gruber SA, Silveri MM, Dahlgren MK, Yurgelun-Todd D. Why so impulsive? White matter alterations are associated with impulsivity in chronic marijuana smokers. Exp Clin Psychopharmacol. 2011;19(3):231–42.PubMedCentralPubMedCrossRef
53.
Zurück zum Zitat Clark DB, Chung T, Thatcher DL, Pajtek S, Long EC. Psychological dysregulation, white matter disorganization and substance use disorders in adolescences. Addiction. 2012;7(1):206–14.CrossRef Clark DB, Chung T, Thatcher DL, Pajtek S, Long EC. Psychological dysregulation, white matter disorganization and substance use disorders in adolescences. Addiction. 2012;7(1):206–14.CrossRef
54.
Zurück zum Zitat Jacobus J, Goldenberg D, Wierenga CE, Tolentino NJ, Liu TT, Tapert SF. Altered cerebral blood flow and neurocognitive correlates in adolescent cannabis users. Psychopharmacology (Berl). 2012;222(4):675–84.CrossRef Jacobus J, Goldenberg D, Wierenga CE, Tolentino NJ, Liu TT, Tapert SF. Altered cerebral blood flow and neurocognitive correlates in adolescent cannabis users. Psychopharmacology (Berl). 2012;222(4):675–84.CrossRef
55.•
Zurück zum Zitat Prescot AP, Locatelli AE, Renshaw PF, Yurgelun-Todd DA. Neurochemical alterations in adolescent chronic marijuana smokers: a proton MRS study. Neuroimage. 2011;57(1)):69–75. A rare study examining the impact of adolescent cannabis use on neuronal health utilizing MRS.PubMedCentralPubMedCrossRef Prescot AP, Locatelli AE, Renshaw PF, Yurgelun-Todd DA. Neurochemical alterations in adolescent chronic marijuana smokers: a proton MRS study. Neuroimage. 2011;57(1)):69–75. A rare study examining the impact of adolescent cannabis use on neuronal health utilizing MRS.PubMedCentralPubMedCrossRef
56.
Zurück zum Zitat Silveri MM, Jensen JE, Rosso IM, Sneider JT, Yurgelun-Todd DA. Preliminary evidence for white matter metabolite differences in marijuana-dependent young men using 2D J-resolved magnetic resonance spectroscopic imaging at 4 Tesla. PsychiatrRes. 2011;191(3):201–11. Silveri MM, Jensen JE, Rosso IM, Sneider JT, Yurgelun-Todd DA. Preliminary evidence for white matter metabolite differences in marijuana-dependent young men using 2D J-resolved magnetic resonance spectroscopic imaging at 4 Tesla. PsychiatrRes. 2011;191(3):201–11.
57.•
Zurück zum Zitat Lopez-Larson MP, Rogowska J, Bogorodzki P, Bueler CE, McGlade EC, Yurgelun-Todd DA. Cortico-cerebellar abnormalities in adolescents with heavy marijuana use. Psychiatr Res. 2012;202(3):224–32. One of the most detailed evaluations of brain structural abnormalities in young cannabis users to date.CrossRef Lopez-Larson MP, Rogowska J, Bogorodzki P, Bueler CE, McGlade EC, Yurgelun-Todd DA. Cortico-cerebellar abnormalities in adolescents with heavy marijuana use. Psychiatr Res. 2012;202(3):224–32. One of the most detailed evaluations of brain structural abnormalities in young cannabis users to date.CrossRef
58.
Zurück zum Zitat Abdullaev Y, Posner MI, Nunnally R, Dishion TJ. Functional MRI evidence for inefficient attentional control in adolescent chronic cannabis abuse. Behav Brain Res. 2010;215(1):45–57.PubMedCrossRef Abdullaev Y, Posner MI, Nunnally R, Dishion TJ. Functional MRI evidence for inefficient attentional control in adolescent chronic cannabis abuse. Behav Brain Res. 2010;215(1):45–57.PubMedCrossRef
59.
Zurück zum Zitat Schweinsburg AD, Nagel BJ, Schweinsburg BC, Park A, Theilmann RJ, Tapert SF. Abstinent adolescent marijuana users show altered fMRI response during spatial working memory. Psychia Res. 2008;163(1):40–51.CrossRef Schweinsburg AD, Nagel BJ, Schweinsburg BC, Park A, Theilmann RJ, Tapert SF. Abstinent adolescent marijuana users show altered fMRI response during spatial working memory. Psychia Res. 2008;163(1):40–51.CrossRef
60.•
Zurück zum Zitat Schweinsburg AD, Schweinsburg BC, Medina KL, McQueeny T, Brown SA, Tapert SF. The influence of recency of use on fMRI response during spatial working memory in adolescent marijuana users. J Psychol Drugs. 2010;42(3):401–12. One of a few studies to address effects of abstinence on brain function in cannabis using adolescents.CrossRef Schweinsburg AD, Schweinsburg BC, Medina KL, McQueeny T, Brown SA, Tapert SF. The influence of recency of use on fMRI response during spatial working memory in adolescent marijuana users. J Psychol Drugs. 2010;42(3):401–12. One of a few studies to address effects of abstinence on brain function in cannabis using adolescents.CrossRef
61.
Zurück zum Zitat Smith AM, Longo CA, Fried PA, Hogan MJ, Cameron I. Effects of marijuana on visuospatial working memory: an fMRI study in young adults. Psychopharmacol (Berl). 2010;210(3):429–38.CrossRef Smith AM, Longo CA, Fried PA, Hogan MJ, Cameron I. Effects of marijuana on visuospatial working memory: an fMRI study in young adults. Psychopharmacol (Berl). 2010;210(3):429–38.CrossRef
62.
Zurück zum Zitat Jacobsen LK, Pugh KR, Constable RT, Westerveld M, Mencl WE. Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent marijuana users. Biol Psychiatr. 2007;61(1):31–40.CrossRef Jacobsen LK, Pugh KR, Constable RT, Westerveld M, Mencl WE. Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent marijuana users. Biol Psychiatr. 2007;61(1):31–40.CrossRef
63.•
Zurück zum Zitat Jager G, Block RI, Luijten M, Ramsey NF. Cannabis use and memory brain function in adolescent boys: A cross-sectional multicenter functional magnetic resonance imaging study. J Am Acad Child Adolesc Psychiatry. 2010;49(6):561–72. A well designed multi-site study examining brain function in young male cannabis users.PubMedCentralPubMed Jager G, Block RI, Luijten M, Ramsey NF. Cannabis use and memory brain function in adolescent boys: A cross-sectional multicenter functional magnetic resonance imaging study. J Am Acad Child Adolesc Psychiatry. 2010;49(6):561–72. A well designed multi-site study examining brain function in young male cannabis users.PubMedCentralPubMed
64.
Zurück zum Zitat Becker B, Wagner D, Gouzoulis-Mayfrank E, Spuentrup E, Daumann J. The impact of early-onset cannabis use on functional brain correlates of working memory. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(6):837–45.PubMedCrossRef Becker B, Wagner D, Gouzoulis-Mayfrank E, Spuentrup E, Daumann J. The impact of early-onset cannabis use on functional brain correlates of working memory. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(6):837–45.PubMedCrossRef
65.
Zurück zum Zitat Becker B, Wagner D, Gouzoulis-Mayfrank E, Spuentrup E, Daumann J. Altered parahippocampal functioning in cannabis users is related to the frequency of use. Psychopharmacology. 2010;209(4):361–74.PubMedCrossRef Becker B, Wagner D, Gouzoulis-Mayfrank E, Spuentrup E, Daumann J. Altered parahippocampal functioning in cannabis users is related to the frequency of use. Psychopharmacology. 2010;209(4):361–74.PubMedCrossRef
66.
Zurück zum Zitat Tapert SF, Schweinsburg AD, Drummond SP, Paulus MP, Brown SA, Yang TT, et al. Functional MRI of inhibitory processing in abstinent adolescent marijuana users. Psychopharmacology (Berlin). 2007;194:173–83.CrossRef Tapert SF, Schweinsburg AD, Drummond SP, Paulus MP, Brown SA, Yang TT, et al. Functional MRI of inhibitory processing in abstinent adolescent marijuana users. Psychopharmacology (Berlin). 2007;194:173–83.CrossRef
67.
Zurück zum Zitat Vaidya JG, Block RI, O'Leary DS, Ponto LB, Ghoneim MM, Bechara A. Effects of chronic marijuana use on brain activity during monetary decision-making. Neuropsychopharmacology. 2012;37(3):618–29.PubMedCentralPubMedCrossRef Vaidya JG, Block RI, O'Leary DS, Ponto LB, Ghoneim MM, Bechara A. Effects of chronic marijuana use on brain activity during monetary decision-making. Neuropsychopharmacology. 2012;37(3):618–29.PubMedCentralPubMedCrossRef
68.
Zurück zum Zitat Migliorini R, Stewart JL, May AC, Taper SF, Paulus MP. What do you feel? Adolescent drug and alcohol users show altered brain response to pleasant interoceptive stimuli. DrugAlcohol Depend. 2013;133:661–8.CrossRef Migliorini R, Stewart JL, May AC, Taper SF, Paulus MP. What do you feel? Adolescent drug and alcohol users show altered brain response to pleasant interoceptive stimuli. DrugAlcohol Depend. 2013;133:661–8.CrossRef
69.•
Zurück zum Zitat Behan B, Connolly CG, Datwani MC, Ivanovic J, Morioka R, Stone A, et al. Response inhibition and elevated parietal-cerebellar correlations in chronic adolescent cannabis users. Neuropharmacology. 2013;2908(13):241–4. One of the first studies to utilize functional connectivity analysis in adolescent cannabis users. Behan B, Connolly CG, Datwani MC, Ivanovic J, Morioka R, Stone A, et al. Response inhibition and elevated parietal-cerebellar correlations in chronic adolescent cannabis users. Neuropharmacology. 2013;2908(13):241–4. One of the first studies to utilize functional connectivity analysis in adolescent cannabis users.
70.•
Zurück zum Zitat Orr C, Morioka R, Behan B, Datwani S, Doucet M, Ivanovic J, et al. Altered resting-state connectivity in adolescent cannabis users. Am J Drug Alcohol Abuse. 2013;39(6):372–81. A novel study examining resting state functional connectivity in young cannabis users.PubMedCrossRef Orr C, Morioka R, Behan B, Datwani S, Doucet M, Ivanovic J, et al. Altered resting-state connectivity in adolescent cannabis users. Am J Drug Alcohol Abuse. 2013;39(6):372–81. A novel study examining resting state functional connectivity in young cannabis users.PubMedCrossRef
71.•
Zurück zum Zitat Houck JM, Bryan AD, Feldstein Ewing SW. Functional connectivity and cannabis use in high-risk adolescents. Am J Drug Alcohol Abuse. 2013;39(6):414–23. A novel study examining functional brain connectivity in young cannabis users.PubMedCrossRef Houck JM, Bryan AD, Feldstein Ewing SW. Functional connectivity and cannabis use in high-risk adolescents. Am J Drug Alcohol Abuse. 2013;39(6):414–23. A novel study examining functional brain connectivity in young cannabis users.PubMedCrossRef
72.•
Zurück zum Zitat Harding IH, Solowij N, Harrison BJ, Takagi M, Lorenzetti V, Lubman DI, et al. Functional connectivity in brain networks underlying cognitive control in chronic cannabis users. Neuropsychopharmacology. 2012;37(8):1923–33. A novel study examining functional brain connectivity in young cannabis users.PubMedCentralPubMedCrossRef Harding IH, Solowij N, Harrison BJ, Takagi M, Lorenzetti V, Lubman DI, et al. Functional connectivity in brain networks underlying cognitive control in chronic cannabis users. Neuropsychopharmacology. 2012;37(8):1923–33. A novel study examining functional brain connectivity in young cannabis users.PubMedCentralPubMedCrossRef
73.•
Zurück zum Zitat López-Moreno JA, Echeverry-Alzate V, Bühler KM. The genetic basis of the endocannabinoid system and drug addiction in humans. J Psychopharmacol. 2012;26(1):133–43. The most up-to-date review on genetics, the endocannabinoid system and addiction in humans.PubMedCrossRef López-Moreno JA, Echeverry-Alzate V, Bühler KM. The genetic basis of the endocannabinoid system and drug addiction in humans. J Psychopharmacol. 2012;26(1):133–43. The most up-to-date review on genetics, the endocannabinoid system and addiction in humans.PubMedCrossRef
74.
Zurück zum Zitat Filbey FM, Schacht JP, Myers US, Chavez RS, Hutchison KE. Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues. Neuropsychopharmacology. 2010;35(4):967–75. Filbey FM, Schacht JP, Myers US, Chavez RS, Hutchison KE. Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues. Neuropsychopharmacology. 2010;35(4):967–75.
75.
Zurück zum Zitat Bidwell LL, Metrik J, McGeary J, Palmer RC, Francazio SS, Knopik VS. Impulsivity, Variation in the Cannabinoid Receptor (CNR1) and Fatty Acid Amide Hydrolase (FAAH) Genes, and Marijuana-Related Problems. J Stud Alcohol Drugs. 2013;74(6):867–78.PubMed Bidwell LL, Metrik J, McGeary J, Palmer RC, Francazio SS, Knopik VS. Impulsivity, Variation in the Cannabinoid Receptor (CNR1) and Fatty Acid Amide Hydrolase (FAAH) Genes, and Marijuana-Related Problems. J Stud Alcohol Drugs. 2013;74(6):867–78.PubMed
76.
Zurück zum Zitat Haughey HM, Marshall E, Schacht JP, Louis A, Hutchison KE. Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 ( CNR1) and fatty acid amide hydrolase ( FAAH) genes. Addiction. 2008;103(10):1678–86.PubMedCentralPubMedCrossRef Haughey HM, Marshall E, Schacht JP, Louis A, Hutchison KE. Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 ( CNR1) and fatty acid amide hydrolase ( FAAH) genes. Addiction. 2008;103(10):1678–86.PubMedCentralPubMedCrossRef
77.
Zurück zum Zitat Schacht JP, Selling RE, Hutchison KE. Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. Psychopharmacology Berl. 2009;203(3):511–7.PubMedCentralPubMedCrossRef Schacht JP, Selling RE, Hutchison KE. Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. Psychopharmacology Berl. 2009;203(3):511–7.PubMedCentralPubMedCrossRef
78.
Zurück zum Zitat Rubino T, Zamberletti E, Parolaro D. Adolescent exposure to cannabis as a risk factor for psychiatric disorders. J Psychopharmacol. 2012;26(1):177–88.PubMedCrossRef Rubino T, Zamberletti E, Parolaro D. Adolescent exposure to cannabis as a risk factor for psychiatric disorders. J Psychopharmacol. 2012;26(1):177–88.PubMedCrossRef
79.
Zurück zum Zitat Rubino T, Realini N, Braida D, Guidi S, Capurro V, Viganò D, et al. Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood. Hippocampus. 2009;19(8):763–72.PubMedCrossRef Rubino T, Realini N, Braida D, Guidi S, Capurro V, Viganò D, et al. Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood. Hippocampus. 2009;19(8):763–72.PubMedCrossRef
80.
Zurück zum Zitat Cha YM, White AM, Kuhn CM, Wilson WA, Swartzwelder HS. Differential effects of delta(9)-THC on learning in adolescent and adult rats. Pharmacol Biochem Behav. 2006;83(3):448–55.PubMedCrossRef Cha YM, White AM, Kuhn CM, Wilson WA, Swartzwelder HS. Differential effects of delta(9)-THC on learning in adolescent and adult rats. Pharmacol Biochem Behav. 2006;83(3):448–55.PubMedCrossRef
81.
Zurück zum Zitat Rubino T, Parolaro D. Long lasting consequences of cannabis exposure in adolescence. Mol Cell Endocrinol. 2008;286(1-2 Suppl 1):S108–13.PubMedCrossRef Rubino T, Parolaro D. Long lasting consequences of cannabis exposure in adolescence. Mol Cell Endocrinol. 2008;286(1-2 Suppl 1):S108–13.PubMedCrossRef
82.
Zurück zum Zitat Rubino T, Vigano D, Realini N, Guidali C, Braida D, Capurro V, et al. Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates. Neuropsychopharmacology. 2008;33:2760–71.PubMedCrossRef Rubino T, Vigano D, Realini N, Guidali C, Braida D, Capurro V, et al. Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates. Neuropsychopharmacology. 2008;33:2760–71.PubMedCrossRef
83.
Zurück zum Zitat Schneider M, Koch M. Chronic pubertal but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory and performance in a progressive ratio task in adult rats. Neuropsychopharmacology. 2003;28:1760–90.PubMedCrossRef Schneider M, Koch M. Chronic pubertal but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory and performance in a progressive ratio task in adult rats. Neuropsychopharmacology. 2003;28:1760–90.PubMedCrossRef
84.••
Zurück zum Zitat Pope Jr H, Gruber A, Hudson J, Cohane G, Huestis M, Yurgelun-Todd D. Early-onset cannabis use and cognitive deficits: what is the nature of the association? Drug Alcohol Depend. 2003;69(3):303. One of the first papers to address the issue of early cannabis age of onset on neurocognition.PubMedCrossRef Pope Jr H, Gruber A, Hudson J, Cohane G, Huestis M, Yurgelun-Todd D. Early-onset cannabis use and cognitive deficits: what is the nature of the association? Drug Alcohol Depend. 2003;69(3):303. One of the first papers to address the issue of early cannabis age of onset on neurocognition.PubMedCrossRef
85.
Zurück zum Zitat Ehrenreich H, Rinn T, Kunert HJ, Moeller MR, Poser W, Schilling L, et al. Specific attentional dysfunction in adults following early start of marijuana use. Psychopharmacology. 1999;142(3):295–301.PubMedCrossRef Ehrenreich H, Rinn T, Kunert HJ, Moeller MR, Poser W, Schilling L, et al. Specific attentional dysfunction in adults following early start of marijuana use. Psychopharmacology. 1999;142(3):295–301.PubMedCrossRef
86.
Zurück zum Zitat Huestegge L, Radach R, Kunert HJ, Heller D. Visual search in long-term cannabis users with early age of onset. Prog Brain Res. 2002;140:377–94.PubMedCrossRef Huestegge L, Radach R, Kunert HJ, Heller D. Visual search in long-term cannabis users with early age of onset. Prog Brain Res. 2002;140:377–94.PubMedCrossRef
87.•
Zurück zum Zitat Fontes MA, Bolla KI, Cunha PJ, Almeida PP, Jungerman F, Laranjeira RR, et al. Cannabis use before age 15 and subsequent executive functioning. Br J Psychiatr. 2011;198(6):442–7. A well designed study closely evaluating the impact of early onset cannabis use on executive functioning.CrossRef Fontes MA, Bolla KI, Cunha PJ, Almeida PP, Jungerman F, Laranjeira RR, et al. Cannabis use before age 15 and subsequent executive functioning. Br J Psychiatr. 2011;198(6):442–7. A well designed study closely evaluating the impact of early onset cannabis use on executive functioning.CrossRef
88.•
Zurück zum Zitat Tamm L, Epstein JN, Lisdahl KM, Molina B, Tapert S, Hinshaw SP, et al. Impact of ADHD and cannabis use on executive functioning in young adults. Drug Alcohol Depend. 2013;133(2):607–14. One of the only studies to specifically examine combined effects of ADHD and cannabis use on cognitive functioning in emerging adults. This is an important area of research as the effects of cannabis on the brain can mimic symptoms of ADHD (e.g., poor cognitive inhibition, reduced new learning, poorer sustained attention) and individuals with ADHD have an earlier age of cannabis use onset.PubMedCrossRef Tamm L, Epstein JN, Lisdahl KM, Molina B, Tapert S, Hinshaw SP, et al. Impact of ADHD and cannabis use on executive functioning in young adults. Drug Alcohol Depend. 2013;133(2):607–14. One of the only studies to specifically examine combined effects of ADHD and cannabis use on cognitive functioning in emerging adults. This is an important area of research as the effects of cannabis on the brain can mimic symptoms of ADHD (e.g., poor cognitive inhibition, reduced new learning, poorer sustained attention) and individuals with ADHD have an earlier age of cannabis use onset.PubMedCrossRef
89.
Zurück zum Zitat Wilson W, Mathew R, Turkington T, Hawk T, Coleman RE, Provenzale J. Brain morphological changes and early marijuana use: a magnetic resonance and positron emission tomography study. J Addict Dis. 2000;19(1):1–22.PubMedCrossRef Wilson W, Mathew R, Turkington T, Hawk T, Coleman RE, Provenzale J. Brain morphological changes and early marijuana use: a magnetic resonance and positron emission tomography study. J Addict Dis. 2000;19(1):1–22.PubMedCrossRef
90.•
Zurück zum Zitat Demirakca T, Sartorius A, Ende G, Meyer N, Welzel H, Skopp G, et al. Diminished gray matter in the hippocampus of cannabis users: Possible protective effects of cannabidiol. Drug Alcohol Depend. 2011;114(2/3):242–5. One of the first studies in human users to examine impact of THC versus CBD effects on the brain.PubMed Demirakca T, Sartorius A, Ende G, Meyer N, Welzel H, Skopp G, et al. Diminished gray matter in the hippocampus of cannabis users: Possible protective effects of cannabidiol. Drug Alcohol Depend. 2011;114(2/3):242–5. One of the first studies in human users to examine impact of THC versus CBD effects on the brain.PubMed
91.•
Zurück zum Zitat Cousijn J, Goudriaan AE, Ridderinkhof KR, wan den Brink W, Veltman DJ, Wiers RW. Approach-bias predicts development of cannabis problem severity in heavy cannabis users: Results from a prospective FMRI study. PLoS One. 2012;7(9):42394. A novel study examining how brain function relates to cannabis problems in young users.CrossRef Cousijn J, Goudriaan AE, Ridderinkhof KR, wan den Brink W, Veltman DJ, Wiers RW. Approach-bias predicts development of cannabis problem severity in heavy cannabis users: Results from a prospective FMRI study. PLoS One. 2012;7(9):42394. A novel study examining how brain function relates to cannabis problems in young users.CrossRef
92.•
Zurück zum Zitat De Bellis MD, Wang L, Bergman SR, Yaxley RH, Hooper SR, Huetel SA. Neural mechanisms of risky decision-making and reward response in adolescent onset cannabis use disorder. Drug Alcohol Depend. 2013;133:134–45. An important study examining decision-making brain response in young cannabis users.PubMedCrossRef De Bellis MD, Wang L, Bergman SR, Yaxley RH, Hooper SR, Huetel SA. Neural mechanisms of risky decision-making and reward response in adolescent onset cannabis use disorder. Drug Alcohol Depend. 2013;133:134–45. An important study examining decision-making brain response in young cannabis users.PubMedCrossRef
93.••
Zurück zum Zitat Feldstein Ewing SW, McEachern AD, Yezhuvath U, Bryan AD, Hutchison KE, Filbey FM. Integrating brain and behavior: evaluating adolescents’ response to a cannabis intervention. Psychol Addict Behav. 2013;27(2):510–25. A novel study utilizing fMRI to evaluate effects of behavioral intervention on brain function in adolescent cannabis users.PubMedCrossRef Feldstein Ewing SW, McEachern AD, Yezhuvath U, Bryan AD, Hutchison KE, Filbey FM. Integrating brain and behavior: evaluating adolescents’ response to a cannabis intervention. Psychol Addict Behav. 2013;27(2):510–25. A novel study utilizing fMRI to evaluate effects of behavioral intervention on brain function in adolescent cannabis users.PubMedCrossRef
94.
Zurück zum Zitat Urban NB, Slifstein M, Thompson JL, Xu X, Girgis RR, Raheja S, et al. Dopamine release in chronic cannabis users: a [11c]raclopride positron emission tomography study. Biol Psychiatry. 2012;71(8):677–83.PubMedCentralPubMedCrossRef Urban NB, Slifstein M, Thompson JL, Xu X, Girgis RR, Raheja S, et al. Dopamine release in chronic cannabis users: a [11c]raclopride positron emission tomography study. Biol Psychiatry. 2012;71(8):677–83.PubMedCentralPubMedCrossRef
95.
Zurück zum Zitat Hirvonen J, Goodwin R, Li C, Terry G, Zoghbi S, Morse C, et al. Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Mol Psychiatry. 2012;17(6):642–9.PubMedCentralPubMedCrossRef Hirvonen J, Goodwin R, Li C, Terry G, Zoghbi S, Morse C, et al. Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Mol Psychiatry. 2012;17(6):642–9.PubMedCentralPubMedCrossRef
96.
Zurück zum Zitat National Institute on Drug Abuse. NIDA DrugFacts: marijuana. Washington: National Institute on Drug Abuse, U.S. Department of Health and Human Services; 2012. National Institute on Drug Abuse. NIDA DrugFacts: marijuana. Washington: National Institute on Drug Abuse, U.S. Department of Health and Human Services; 2012.
97.
Zurück zum Zitat Substance Abuse and Mental Health Services Administration, Center for Behavioral Health Statistics and Quality. (August 13, 2013). The TEDS Report: Marijuana Admissions Aged 18 to 30: Early vs. Adult Initiation. Rockville, MD. Substance Abuse and Mental Health Services Administration, Center for Behavioral Health Statistics and Quality. (August 13, 2013). The TEDS Report: Marijuana Admissions Aged 18 to 30: Early vs. Adult Initiation. Rockville, MD.
98.
99.
Zurück zum Zitat Niesink RM, van Laar MW, Cannizzaro C, Janiri L. Does cannabidiol protect against adverse psychological effects of THC? Front In Psychiatry. 2013;4:130.CrossRef Niesink RM, van Laar MW, Cannizzaro C, Janiri L. Does cannabidiol protect against adverse psychological effects of THC? Front In Psychiatry. 2013;4:130.CrossRef
100.
Zurück zum Zitat Fusar-Poli P (2009). S39-01 Distinct effects of D9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. Euro Psychia. 24. Fusar-Poli P (2009). S39-01 Distinct effects of D9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing. Euro Psychia. 24.
101.
Zurück zum Zitat Winton-Brown TT, Allen P, Bhattacharyya S, Borgwardt SJ, Fusar-Poli P, Crippa JA, et al. Modulation of auditory and visual processing by delta-9-tetrahydrocannabinol and cannabidiol: an FMRI study. Neuropsychopharmacology. 2011;36(7):1340–8.PubMedCentralPubMedCrossRef Winton-Brown TT, Allen P, Bhattacharyya S, Borgwardt SJ, Fusar-Poli P, Crippa JA, et al. Modulation of auditory and visual processing by delta-9-tetrahydrocannabinol and cannabidiol: an FMRI study. Neuropsychopharmacology. 2011;36(7):1340–8.PubMedCentralPubMedCrossRef
102.
Zurück zum Zitat Bhattacharyya S, Morrison PD, Fusar-Poli P, Martin-Santos R, Borgwardt S, Winton-Brown T, et al. Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology. 2010;35(3):764–74. Bhattacharyya S, Morrison PD, Fusar-Poli P, Martin-Santos R, Borgwardt S, Winton-Brown T, et al. Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology. 2010;35(3):764–74.
103.
Zurück zum Zitat Englund A, Morrison P, Nottage J, Hague D, Kane F, Bonaccorso S, et al. Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment. J Psychopharmacol. 2013;27(1):19–27.PubMedCrossRef Englund A, Morrison P, Nottage J, Hague D, Kane F, Bonaccorso S, et al. Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment. J Psychopharmacol. 2013;27(1):19–27.PubMedCrossRef
104.
Zurück zum Zitat Morgan CJ, Schafer G, Freeman TP, Curran HV. Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study: naturalistic study [corrected]. Br J Psychiatry. 2010;197(4):285–90. Morgan CJ, Schafer G, Freeman TP, Curran HV. Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study: naturalistic study [corrected]. Br J Psychiatry. 2010;197(4):285–90.
105.
Zurück zum Zitat Morgan CJ, Gardener C, Schafer G, Swan S, Demarchi C, Freeman TP, et al. Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being. Psychol Med. 2012;42(2):391–400.PubMedCrossRef Morgan CJ, Gardener C, Schafer G, Swan S, Demarchi C, Freeman TP, et al. Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being. Psychol Med. 2012;42(2):391–400.PubMedCrossRef
106.
Zurück zum Zitat Hill SY, Kostelnik B, Holmes B, Goradia D, McDermott M, Diwadkar V, et al. fMRI BOLD response to the eyes task in offspring from multiplex alcohol dependence families. Alcoholism Clin Exp Res. 2007;31(12):2028–35.CrossRef Hill SY, Kostelnik B, Holmes B, Goradia D, McDermott M, Diwadkar V, et al. fMRI BOLD response to the eyes task in offspring from multiplex alcohol dependence families. Alcoholism Clin Exp Res. 2007;31(12):2028–35.CrossRef
107.
Zurück zum Zitat Nigg JT, Glass JM, Wong MM, Poon E, Jester JM, Fitzgerald HE, et al. Neuropsychological executive functioning in children at elevated risk for alcoholism: findings in early adolescence. J Abnorm Psychol. 2004;113(2):302–14. Nigg JT, Glass JM, Wong MM, Poon E, Jester JM, Fitzgerald HE, et al. Neuropsychological executive functioning in children at elevated risk for alcoholism: findings in early adolescence. J Abnorm Psychol. 2004;113(2):302–14.
108.
Zurück zum Zitat Ridenour TA, Tarter RE, Reynolds M, Mezzich A, Kirisci L, Vanyukov M. Neurobehavior disinhibition, parental substance use disorder, neighborhood quality and development of cannabis use disorder in boys. Drug Alcohol Depend. 2009;102(1–3):71–7.PubMedCentralPubMedCrossRef Ridenour TA, Tarter RE, Reynolds M, Mezzich A, Kirisci L, Vanyukov M. Neurobehavior disinhibition, parental substance use disorder, neighborhood quality and development of cannabis use disorder in boys. Drug Alcohol Depend. 2009;102(1–3):71–7.PubMedCentralPubMedCrossRef
109.
Zurück zum Zitat Schweinsburg AD, Paulus MP, Barlett VC, Killeen LA, Caldwell LC, Pulido C, et al. An FMRI study of response inhibition in youths with a family history of alcoholism. Ann New York Acad Sci. 2004;1021:391–4.CrossRef Schweinsburg AD, Paulus MP, Barlett VC, Killeen LA, Caldwell LC, Pulido C, et al. An FMRI study of response inhibition in youths with a family history of alcoholism. Ann New York Acad Sci. 2004;1021:391–4.CrossRef
110.
Zurück zum Zitat Spadoni AD, Norman AL, Schweinsburg AD, Tapert SF. Effects of family history of alcohol use disorders on spatial working memory BOLD response in adolescents. Alcohol Clin Exp Res. 2008;32(7):1135–45.PubMedCentralPubMedCrossRef Spadoni AD, Norman AL, Schweinsburg AD, Tapert SF. Effects of family history of alcohol use disorders on spatial working memory BOLD response in adolescents. Alcohol Clin Exp Res. 2008;32(7):1135–45.PubMedCentralPubMedCrossRef
111.
Zurück zum Zitat Tapert SF, Brown SA. Substance dependence, family history of alcohol dependence, and neuropsychological functioning in adolescence. Addiction. 2000;95:1043–53.PubMedCrossRef Tapert SF, Brown SA. Substance dependence, family history of alcohol dependence, and neuropsychological functioning in adolescence. Addiction. 2000;95:1043–53.PubMedCrossRef
112.•
Zurück zum Zitat Cheetham A, Allen NB, Whittle S, Simmons JG, Yücel M, Lubman DI. Orbitofrontal volumes in early adolescence predict initiation of cannabis use: a 4-year longitudinal and prospective study. Biol Psychiatry. 2012;71(8):684–92. A well designed prospective longitudinal study examining neurocognitive predictors of cannabis initiation.PubMedCrossRef Cheetham A, Allen NB, Whittle S, Simmons JG, Yücel M, Lubman DI. Orbitofrontal volumes in early adolescence predict initiation of cannabis use: a 4-year longitudinal and prospective study. Biol Psychiatry. 2012;71(8):684–92. A well designed prospective longitudinal study examining neurocognitive predictors of cannabis initiation.PubMedCrossRef
113.
Zurück zum Zitat Raphael D. Adolescence as a gateway to adult health outcomes. Maturitas. 2013;75(2):137–41.PubMedCrossRef Raphael D. Adolescence as a gateway to adult health outcomes. Maturitas. 2013;75(2):137–41.PubMedCrossRef
114.
Zurück zum Zitat Caulkins JP, Kilmer B, MacCoun RJ, Pacula RL, Reuter P. Design considerations for legalizing cannabis: lessons inspired by analysis of California's Proposition 19. Addiction. 2012;107(5):865–71.PubMedCrossRef Caulkins JP, Kilmer B, MacCoun RJ, Pacula RL, Reuter P. Design considerations for legalizing cannabis: lessons inspired by analysis of California's Proposition 19. Addiction. 2012;107(5):865–71.PubMedCrossRef
Metadaten
Titel
Considering Cannabis: The Effects of Regular Cannabis Use on Neurocognition in Adolescents and Young Adults
verfasst von
Krista M. Lisdahl
Natasha E. Wright
Christopher Medina-Kirchner
Kristin E. Maple
Skyler Shollenbarger
Publikationsdatum
01.06.2014
Verlag
Springer International Publishing
Erschienen in
Current Addiction Reports / Ausgabe 2/2014
Elektronische ISSN: 2196-2952
DOI
https://doi.org/10.1007/s40429-014-0019-6

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