Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Clinical Neuroradiology
Erschienen in: Clinical Neuroradiology 3/2017

04.01.2016 | Original Article

Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain during Normal Aging

verfasst von: S. K. Das, MD, J. L. Wang, MD, L. Bing, MD, A. Bhetuwal, MD, H. F. Yang, PhD

Erschienen in: Clinical Neuroradiology | Ausgabe 3/2017

Einloggen, um Zugang zu erhalten

Abstract

Objective

To provide estimates of the diffusional kurtosis in different anatomical regions of a healthy brain and to assess age dependency of diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) derived parametric values in these regions.

Materials and Methods

Eighty healthy volunteers underwent DKI of the brain with 3.0 T magnetic resonance imaging. The DKI was obtained by using three b values of 0, 1000, 2000 s/mm2, and with 50 diffusion directions. The regions of interest-based measurements were calculated to obtain several DKI estimates of 21 different locations of brain, and then, the age dependency for DKI- and DTI-derived parameters in these regions were assessed by using linear and nonlinear regressions.

Results

The mean kurtosis varied from 0.73 ± 0.01 (head of caudate nucleus) to 1.07 ± 0.08 (splenium of corpus callosum (CC)). The radial kurtosis varied from 0.84 ± 0.06 (head of caudate nucleus) to 1.05 ± 0.07 (splenium of CC), and axial kurtosis from 0.41 ± 0.02 (genu of CC) to 0.78 ± 0.02 (pallidum). DTI-derived parametric values also varied across the region. Age dependence was found for DKI-derived parameters in almost all measured regions except for corona radiata and centrum semiovale. On the contrary, DTI failed to show age dependency in many regions including gray matter structure.

Conclusion

In conclusion, the knowledge of range of diffusion kurtosis parameters in each anatomical region in different age group is important before its clinical application to diagnose the pathology.
Literatur
1.
Jensen JH, Helpern JA, Ramani A, Lu H, Kaczynski K. Diffusional kurtosis imaging: the quantification of non-Gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med. 2005;53:1432–40.CrossRefPubMed
2.
Wang JJ, Lin WY, Lu CS, Weng YH, Ng SH, Wang CH, Liu HL, Hsieh RH, Wan YL, Wai YY. Parkinson disease: diagnostic utility of diffusion kurtosis imaging. Radiology. 2011;261:210–7.CrossRefPubMed
3.
Lätt J, Nilsson M, Wirestam R, Ståhlberg F, Karlsson N, Johansson M, Sundgren PC, van Westen D. Regional values of diffusional kurtosis estimates in the healthy brain. J Magn Reson Imaging. 2013;37:610–8.CrossRefPubMed
4.
Lebel C, Beaulieu C. Longitudinal development of human brain wiring continues from childhood into adulthood. J Neurosci. 2011;31:10937–47.CrossRefPubMed
5.
Lebel C, Walker L, Leemans A, Phillips L, Beaulieu C. Microstructural maturation of the human brain from childhood to adulthood. Neuroimage. 2008;40:1044–55.CrossRefPubMed
6.
Falangola MF, Jensen JH, Babb JS, Hu C, Castellanos FX, Di Martino A, Ferris SH, Helpern JA. Age-related non-Gaussian diffusion patterns in the prefrontal brain. J Magn Reson Imaging. 2008;28:1345–50.CrossRefPubMedPubMedCentral
7.
Dekaban AS. Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights. Ann Neurol. 1978;4:345–56.CrossRef
8.
Benes FM, Turtle M, Khan Y, Farol P. Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, and adulthood. Arch Gen Psychiatry. 1994;51:477–84.CrossRefPubMed
9.
Yakovlev PI, Lecours AR. The myelogenetic cycles of regional maturation of the brain. In: Minkowski A, editor. Regional development of the brain early in life. Boston: Blackwell Science; 1967. pp. 3–70.
10.
Huttenlocher PR. Synaptic density in human frontal cortex—developmental changes and effects of aging. Brain Res. 1979;163:195–205.CrossRefPubMed
11.
Huttenlocher PR, de Courten C. The development of synapses in striate cortex of man. Hum Neurobiol. 1978;6:1–9.
12.
Tofts PS. Quantitative MRI of the brain: measuring changes caused by disease. England: Wiley; 2003. pp. 1–621.CrossRef
13.
Jernigan TL, Fennema-Notestine C. White matter mapping is needed. Neurobiol Aging. 2004;25:37–9.CrossRefPubMed
14.
Binder JR, Swanson SJ, Hammeke TA, Morris GL, Mueller WM, Fischer M, Benbadis S, Frost JA, Rao SM, Haughton VM. Determination of language dominance using functional MRI: a comparison with the Wada test. Neurology. 1996;46:978–84.CrossRefPubMed
15.
Yang AW, Jensen JH, Hu CC, Tabesh A, Falangola MF, Helpern JA. Effect of CSF suppression for diffusional kurtosis imaging. J Magn Reson Imaging. 2013;37:365–71.CrossRefPubMed
16.
Helpern JA, Adisetiyo V, Falangola MF, Hu C, Di Martino A, Williams K, Castellanos FX, Jensen JH. Preliminary evidence of altered gray and white matter microstructural development in the frontal lobe of adolescents with attention-deficit hyperactivity disorder: a diffusional kurtosis imaging study. J Magn Reson Imaging. 2011;33:17–23.CrossRefPubMedPubMedCentral
17.
Lu H, Jensen JH, Hu C, Falangola MF, Ramani A, Ferris S, Helpern JA. Alterations in cerebral microstructural integrity in normal aging and in Alzheimer’s Disease: a multi-contrast diffusion MRI study. Proceedings of the 14th Annual Meeting of ISMRM, Seattle, Washington, 2006 (abstract 723).
18.
Qian W, Zhang Z, Wu EX, Cheung MM, Chan Q, Khong P-L, Kim M. Characterization of neural tissues in humans using Diffusion Kurtosis Imaging. Proceedings of the 19th Annual Meeting of ISMRM. Montreal, Canada, 2011 (abstract 3948).
19.
Lu H, Jensen JH, Ramani A, Helpern JA. Three-dimensional characterization of non-Gaussian water diffusion in humans using diffusion kurtosis imaging. NMR Biomed. 2006;19:236–47.CrossRefPubMed
20.
Lebel C, Gee M, Camicioli R, Wieler M, Martin W, Beaulieu C. Diffusion tensor imaging of white matter tract evolution over the lifespan. Neuroimage. 2012;60:340–52.CrossRefPubMed
21.
Hasan KM, Kamali A, Abid H, Kramer LA, Fletcher JM, Ewing-Cobbs L. Quantification of the spatiotemporal microstructural organization of the human brain association, projection and commissural pathways across the lifespan using diffusion tensor tractography. Brain Struct Funct. 2010;214:361–73.CrossRefPubMedPubMedCentral
22.
Kochunov P, Williamson DE, Lancaster J, Fox P, Cornell J, Blangero J, Glahn DC. Fractional anisotropy of water diffusion in cerebral white matter across the lifespan. Neurobiol Aging. 2010;33:9–20.CrossRefPubMedPubMedCentral
23.
Westlye LT, Walhovd KB, Dale AM, Bjørnerud A, Due-Tønnessen P, Engvig A, Grydeland H, Tamnes CK, Ostby Y, Fjell AM. Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry. Cereb Cortex. 2010;20:2055–68.CrossRefPubMed
24.
Catani M, Allin MP, Husain M, Pugliese L, Mesulam MM, Murray RM, Jones DK. Symmetries in human brain language pathways correlate with verbal recall. Proc Natl Acad Sci USA. 2007;104:17163–8.CrossRefPubMedPubMedCentral
25.
Jung RE, Haier RJ. The parieto-frontal integration theory (P-FIT) of intelligence: converging neuroimaging evidence. J Behav Brain Sci. 2007;30:135–54.CrossRef
26.
Zhang J, Evans A, Hermoye L, Lee SK, Wakana S, Zhang W, Donohue P, Miller MI, Huang H, Wang X, van Zijl PC, Mori S. Evidence of slow maturation of the superior longitudinal fasciculus in early childhood by diffusion tensor imaging. Neuroimage. 2007;38:239–47.CrossRefPubMedPubMedCentral
27.
Dubois J, Hertz-Pannier L, Dehaene-Lambertz G, Cointepas Y, Le Bihan D. Assessment of the early organization and maturation of infants’ cerebral white matter fiber bundles: a feasibility study using quantitative diffusion tensor imaging and tractography. Neuroimage. 2006;30:1121–32.CrossRefPubMed
28.
Dubois J, Dehaene-Lambertz G, Perrin M, Mangin JF, Cointepas Y, Duchesnay E, Le Bihan D, Hertz-Pannier L. Asynchrony of the early maturation of white matter bundles in healthy infants: quantitative landmarks revealed noninvasively by diffusion tensor imaging. Hum Brain Mapp. 2008;29:14–27.CrossRefPubMed
29.
Hermoye L, Saint-Martin C, Cosnard G, Lee SK, Kim J, Nassogne MC, Menten R, Clapuyt P, Donohue PK, Hua K, Wakana S, Jiang H, van Zijl PC, Mori S. Pediatric diffusion tensor imaging: normal database and observation of the white matter maturation in early childhood. Neuroimage. 2006;29:493–504.CrossRefPubMed
30.
Catani M, Jones DK, Donato R, Ffytche DH. Occipito-temporal connections in the human brain. Brain. 2003;126:2093–107.CrossRefPubMed
31.
Aboitiz F, Montiel J. One hundred million years of interhemispheric communication: the history of the corpus callosum. Braz J Med Biol Res. 2003;36:409–20.CrossRefPubMed
32.
Caverzasi E, Papinutto N, Amirbekian B, Berger MS, Henry RG. Q-Ball of inferior fronto-occipital fasciculus and beyond. PLoS One. 2014;9:e100274.CrossRefPubMedPubMedCentral
33.
Hasan KM, Sankar A, Halphen C, Kramer LA, Brandt ME, Juranek J, Cirino PT, Fletcher JM, Papanicolaou AC, Ewing-Cobbs L. Development and organization of the human brain tissue compartments across the lifespan using diffusion tensor imaging. Neuroreport. 2007;18:1735–9.CrossRefPubMed
34.
Hasan KM, Halphen C, Boska MD, Narayana PA. Diffusion tensor metrics, T2 relaxation, and volumetry of the naturally aging human caudate nuclei in healthy young and middle-aged adults: possible implications for the neurobiology of human brain aging and disease. Magn Reson Med. 2008;59:7–13.CrossRefPubMed
35.
Camara E, Bodammer N, Rodriguez-Fornells A, Tempelmann C. Age-related water diffusion changes in human brain: a voxel based approach. Neuroimage. 2007;34:1588–99.CrossRefPubMed
36.
Lee CY, Tabesh A, Nesland T, Jensen JH, Helpern JA, Spampinato MV, Bonilha L. Human brain asymmetry in microstructural connectivity demonstrated by diffusional kurtosis imaging. Brain Res. 2014;1588:73–80.CrossRefPubMedPubMedCentral
37.
Saenger VM, Barrios FA, Martínez-Gudiño ML, Alcauter S. Hemispheric asymmetries of functional connectivity and grey matter volume in the default mode network. Neuropsychologia. 2012;50:1308–15.CrossRefPubMed
38.
Goldberg E, Roediger D, Kucukboyaci NE, Carlson C, Devinsky O, Kuzniecky R, Halgren E, Thesen T. Hemispheric asymmetries of cortical volume in the human brain. Cortex. 2013;49:200–10.CrossRefPubMed
39.
Knecht S, Dräger B, Deppe M, Bobe L, Lohmann H, Flöel A, Ringelstein EB, Henningsen H. Handedness and hemispheric language dominance in healthy humans. Brain. 2000;123:2512–8.CrossRefPubMed
40.
Bernard JA, Taylor SF, Seidler RD. Handedness, dexterity, and motor cortical representations. J Neurophysiol. 2011;105:88–99.CrossRefPubMed
41.
Metadaten
Titel
Regional Values of Diffusional Kurtosis Estimates in the Healthy Brain during Normal Aging
verfasst von
S. K. Das, MD
J. L. Wang, MD
L. Bing, MD
A. Bhetuwal, MD
H. F. Yang, PhD
Publikationsdatum
04.01.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Neuroradiology / Ausgabe 3/2017
Print ISSN: 1869-1439
Elektronische ISSN: 1869-1447
DOI
https://doi.org/10.1007/s00062-015-0490-z

Weitere Artikel der Ausgabe 3/2017

Clinical Neuroradiology 3/2017 Zur Ausgabe

Correspondence

One Stop Management in Acute Stroke: First Mothership Patient Transported Directly to the Angiography Suite

Original Article

The Derivo Embolization Device, a Second-Generation Flow Diverter for the Treatment of Intracranial Aneurysms, Evaluated in an Elastase-Induced Aneurysm Model

Original Article

Differentiation of Hemangioblastoma from Metastatic Brain Tumor using Dynamic Contrast-enhanced MR Imaging

Original Article

Clinical Application of Fiber Visualization with LIC Maps Using Multidirectional Anisotropic Glyph Samples (A-Glyph LIC)

Original Article

The Hijdra scale has significant prognostic value for the functional outcome of Fisher grade 3 patients with subarachnoid hemorrhage

Clinical Case

Was dehnt sich da in den IV. Ventrikel aus?

Neu im Fachgebiet Radiologie

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

S3-Leitlinie zu Pankreaskrebs aktualisiert

23.04.2024 Pankreaskarzinom Nachrichten

Die Empfehlungen zur Therapie des Pankreaskarzinoms wurden um zwei Off-Label-Anwendungen erweitert. Und auch im Bereich der Früherkennung gibt es Aktualisierungen.

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

18.04.2024 Pädiatrische Notfallmedizin Nachrichten

Im Choosing-Wisely-Programm, das für die deutsche Initiative „Klug entscheiden“ Pate gestanden hat, sind erstmals Empfehlungen zum Umgang mit Notfällen von Kindern erschienen. Fünf Dinge gilt es demnach zu vermeiden.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise