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Erschienen in:

01.10.2019 | Original

Randomised evaluation of active control of temperature versus ordinary temperature management (REACTOR) trial

verfasst von: Paul J. Young, Michael J. Bailey, Frances Bass, Richard W. Beasley, Ross C. Freebairn, Naomi E. Hammond, Frank M. P. van Haren, Meg L. Harward, Seton J. Henderson, Diane M. Mackle, Colin J. McArthur, Shay P. McGuinness, John A. Myburgh, Manoj K. Saxena, Anne M. Turner, Steve A. R. Webb, Rinaldo Bellomo, the REACTOR investigators, ANZICS Clinical Trials Group

Erschienen in: Intensive Care Medicine | Ausgabe 10/2019

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Abstract

Purpose

It is unknown whether protocols targeting systematic prevention and treatment of fever achieve lower mean body temperature than usual care in intensive care unit (ICU) patients. The objective of the Randomised Evaluation of Active Control of temperature vs. ORdinary temperature management trial was to confirm the feasibility of such a protocol with a view to conducting a larger trial.

Methods

We randomly assigned 184 adults without acute brain pathologies who had a fever in the previous 12 h, and were expected to be ventilated beyond the calendar day after recruitment, to systematic prevention and treatment of fever or usual care. The primary outcome was mean body temperature in the ICU within 7 days of randomisation. Secondary outcomes included in-hospital mortality, ICU-free days and survival time censored at hospital discharge.

Results

Compared with usual temperature management, active management significantly reduced mean temperature. In both groups, fever generally abated within 72 h. The mean temperature difference between groups was greatest in the first 48 h, when it was generally in the order of 0.5 °C. Overall, 23 of 89 patients assigned to active management (25.8%) and 23 of 89 patients assigned to usual management (25.8%) died in hospital (odds ratio 1.0, 95% CI 0.51–1.96, P = 1.0). There were no statistically significant differences between groups in ICU-free days or survival to day 90.

Conclusions

Active temperature management reduced body temperature compared with usual care; however, fever abated rapidly, even in patients assigned to usual care, and the magnitude of temperature separation was small.

Trial registration

Australian and New Zealand Clinical Trials Registry Number, ACTRN12616001285448

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Titel: Randomised evaluation of active control of temperature versus ordinary temperature management (REACTOR) trial
verfasst von: Paul J. Young
Michael J. Bailey
Frances Bass
Richard W. Beasley
Ross C. Freebairn
Naomi E. Hammond
Frank M. P. van Haren
Meg L. Harward
Seton J. Henderson
Diane M. Mackle
Colin J. McArthur
Shay P. McGuinness
John A. Myburgh
Manoj K. Saxena
Anne M. Turner
Steve A. R. Webb
Rinaldo Bellomo
the REACTOR investigators
ANZICS Clinical Trials Group
Publikationsdatum: 01.10.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 10/2019
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-019-05729-4

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Randomised evaluation of active control of temperature versus ordinary temperature management (REACTOR) trial