Erschienen in:
18.02.2022 | Correspondence
Concerns about study design and suggestion of additional analysis of therapeutic drug monitoring-guided piperacillin/tazobactam therapy for patients with sepsis
verfasst von:
Shodai Yoshihiro, Shunsuke Taito
Erschienen in:
Intensive Care Medicine
|
Ausgabe 6/2022
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Excerpt
In a recent study published in Intensive Care Medicine, Hagel et al. compared therapeutic drug monitoring (TDM)-guided piperacillin/tazobactam (TAZ/PIPC) therapy with a fixed-dose therapy in patients with sepsis [
1]. It is unfortunate that individualized antibiotic therapy was found to be not beneficial for patients with sepsis. Here, we would like to point out some concerns about the study methodology. …