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19.11.2016 | Review

Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review

verfasst von: H. Cao Dinh, I. Beyer, T. Mets, O. O. Onyema, R. Njemini, W. Renmans, M. De Waele, K. Jochmans, S. Vander Meeren, I. Bautmans

Erschienen in: Calcified Tissue International | Ausgabe 2/2017

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Abstract

Aging affects negatively the immune system, defined as immunosenescence, which increases the susceptibility of elderly persons to infection, autoimmune disease, and cancer. There are strong indications that physical exercise in elderly persons may prevent the age-related decline in immune response without significant side effects. Consequently, exercise is being considered as a safe mode of intervention to reduce immunosenescence. The aim of this review was to appraise the existing evidence regarding the impact of exercise on surface markers of cellular immunosenescence in either young and old humans or animals. PubMed and Web of Science were systematically screened, and 28 relevant articles in humans or animals were retrieved. Most of the intervention studies demonstrated that an acute bout of exercise induced increases in senescent, naïve, memory CD4⁺ and CD8⁺ T-lymphocytes and significantly elevated apoptotic lymphocytes in peripheral blood. As regards long-term effects, exercise induced increased levels of T-lymphocytes expressing CD28⁺ in both young and elderly subjects. Few studies found an increase in natural killer cell activity following a period of training. We can conclude that exercise has considerable effects on markers of cellular aspects of the immune system. However, very few studies have been conducted so far to investigate the effects of exercise on markers of cellular immunosenescence in elderly persons. Implications for immunosenescence need further investigation.

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Titel: Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review
verfasst von: H. Cao Dinh
I. Beyer
T. Mets
O. O. Onyema
R. Njemini
W. Renmans
M. De Waele
K. Jochmans
S. Vander Meeren
I. Bautmans
Publikationsdatum: 19.11.2016
Verlag: Springer US
Erschienen in: Calcified Tissue International / Ausgabe 2/2017
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-016-0212-9

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Blutdrucksenkung könnte Uterusmyome verhindern

„Jeder Fall von plötzlichem Tod muss obduziert werden!“

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

Schlechtere Vorhofflimmern-Prognose bei kleinem linken Ventrikel

Update Innere Medizin

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

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Weitere Artikel der Ausgabe 2/2017

DXA-Based Measurements in Diabetes: Can They Predict Fracture Risk?

Efficacy of Osteoporosis Therapies in Diabetic Patients

Bone-Derived Factors: A New Gateway to Regulate Glycemia

Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism

Diabetes Drug Effects on the Skeleton

Epidemiology of Fractures in Diabetes

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Blutdrucksenkung könnte Uterusmyome verhindern

„Jeder Fall von plötzlichem Tod muss obduziert werden!“

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

Schlechtere Vorhofflimmern-Prognose bei kleinem linken Ventrikel

Update Innere Medizin