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Pediatric Radiology
Erschienen in: Pediatric Radiology 3/2015

01.09.2015 | Advances in Pediatric Neuroradiology

Pediatric brain tumors

verfasst von: Tina Y. Poussaint, Ashok Panigrahy, Thierry A. G. M. Huisman

Erschienen in: Pediatric Radiology | Sonderheft 3/2015

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Abstract

Among all causes of death in children from solid tumors, pediatric brain tumors are the most common. This article includes an overview of a subset of infratentorial and supratentorial tumors with a focus on tumor imaging features and molecular advances and treatments of these tumors. Key to understanding the imaging features of brain tumors is a firm grasp of other disease processes that can mimic tumor on imaging. We also review imaging features of a common subset of tumor mimics.
Literatur
1.
Gurney J, Smith M, Bunin G (1999) CNS and miscellaneous intracranial and intraspinal neoplasms. In: Ries L, Smith M, Gurney J (eds) Cancer incidence and survival among children and adolescents: United States SEER program 1975–1995 NIH publication no. 99–4649. National Cancer Institute SEER Program, Bethesda, pp 51–63
2.
Ostrom QT, Gittleman H, Farah P et al (2013) CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2006–2010. Neuro-Oncol 15:ii1–56
3.
Dunbar SF, Barnes PD, Tarbell NJ (1993) Radiologic determination of the caudal border of the spinal field in cranial spinal irradiation. Int J Radiat Oncol Biol Phys 26:669–673CrossRefPubMed
4.
Gauvain KM, McKinstry RC, Mukherjee P et al (2001) Evaluating pediatric brain tumor cellularity with diffusion-tensor imaging. AJR Am J Roentgenol 177:449–454CrossRefPubMed
5.
Hamstra DA, Rehemtulla A, Ross BD (2007) Diffusion magnetic resonance imaging: a biomarker for treatment response in oncology. J Clin Oncol 25:4104–4109CrossRefPubMed
6.
Qiu D, Kwong DL, Chan GC et al (2007) Diffusion tensor magnetic resonance imaging finding of discrepant fractional anisotropy between the frontal and parietal lobes after whole-brain irradiation in childhood medulloblastoma survivors: reflection of regional white matter radiosensitivity? Int J Radiat Oncol Biol Phys 69:846–851CrossRefPubMed
7.
Raybaud C, Barkovich AJ (2012) Intracranial, orbital and neck masses of childhood. In: Barkovich AJ, Raybaud C (eds) Pediatric neuroimaging. Lippincott Williams & Wilkins, Philadelphia, pp 637--807
8.
Pollack IF, Jakacki RI (2011) Childhood brain tumors: epidemiology, current management and future directions. Nat Rev Neurol 7:495–506CrossRefPubMed
9.
10.
Maleci A, Cervoni L, Delfini R (1992) Medulloblastoma in children and in adults: a comparative study. Acta Neurochir 119:62–67CrossRefPubMed
11.
Koci TM, Chiang F, Mehringer CM et al (1993) Adult cerebellar medulloblastoma: imaging features with emphasis on MR findings. [see comments]. AJNR Am J Neuroradiol 14:929–939PubMed
12.
Meyers SP, Kemp SS, Tarr RW (1992) MR imaging features of medulloblastomas. AJR Am J Roentgenol 158:859–865CrossRefPubMed
13.
Hayes LL, Jones RA, Palasis S et al (2012) Drop metastases to the pediatric spine revealed with diffusion-weighted MR imaging. Pediatr Radiol 42:1009–1013CrossRefPubMed
14.
Rumboldt Z, Camacho DL, Lake D et al (2006) Apparent diffusion coefficients for differentiation of cerebellar tumors in children. AJNR Am J Neuroradiol 27:1362–1369PubMed
15.
Kovanlikaya A, Panigrahy A, Krieger MD et al (2005) Untreated pediatric primitive neuroectodermal tumor in vivo: quantitation of taurine with MR spectroscopy. Radiology 236:1020–1025CrossRefPubMed
16.
Panigrahy A, Krieger MD, Gonzalez-Gomez I et al (2006) Quantitative short echo time 1H-MR spectroscopy of untreated pediatric brain tumors: preoperative diagnosis and characterization. AJNR Am J Neuroradiol 27:560–572PubMed
17.
Tong Z, Yamaki T, Harada K et al (2004) In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. Magn Reson Imaging 22:1017–1024CrossRefPubMed
18.
Perreault S, Ramaswamy V, Achrol AS et al (2014) MRI surrogates for molecular subgroups of medulloblastoma. AJNR Am J Neuroradiol 35:1263–1269CrossRefPubMed
19.
Roujeau T, Machado G, Garnett MR et al (2007) Stereotactic biopsy of diffuse pontine lesions in children. J Neurosurg 107:1–4CrossRefPubMed
20.
Hipp SJ, Steffen-Smith E, Hammoud D et al (2011) Predicting outcome of children with diffuse intrinsic pontine gliomas using multiparametric imaging. Neuro-Oncol 13:904–909PubMedCentralCrossRefPubMed
21.
Prabhu SP, Ng S, Vajapeyam S et al (2011) DTI assessment of the brainstem white matter tracts in pediatric BSG before and after therapy: a report from the pediatric brain tumor consortium. Childs Nerv Syst 27:11–18PubMedCentralCrossRefPubMed
22.
Helton KJ, Edwards M, Steen RG et al (2005) Neuroimaging-detected late transient treatment-induced lesions in pediatric patients with brain tumors. J Neurosurg 102:ii179–186
23.
Poussaint TY, Kocak M, Vajapeyam S et al (2011) MRI as a central component of clinical trials analysis in brainstem glioma: a report from the pediatric brain tumor consortium (PBTC). Neuro-Oncol 13:417–427PubMedCentralCrossRefPubMed
24.
Chen HJ, Panigrahy A, Dhall G et al (2010) Apparent diffusion and fractional anisotropy of diffuse intrinsic brain stem gliomas. AJNR Am J Neuroradiol 31:1879–1885CrossRefPubMed
25.
Helton KJ, Phillips NS, Khan RB et al (2006) Diffusion tensor imaging of tract involvement in children with pontine tumors. AJNR Am J Neuroradiol 27:786–793PubMed
26.
Zukotynski KA, Fahey FH, Kocak M et al (2011) Evaluation of 18 F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the pediatric brain tumor consortium. J Nucl Med 52:188–195PubMedCentralCrossRefPubMed
27.
Panigrahy A, Bluml S (2009) Neuroimaging of pediatric brain tumors: from basic to advanced magnetic resonance imaging (MRI). J Child Neurol 24:1343–1365CrossRefPubMed
28.
29.
Hwang EI, Packer RJ (2012) Pediatric brain tumors (an overview), vol 2, Pediatric Cancer. Springer, Dordrecht, pp 61–73
30.
Plaza MJ, Borja MJ, Altman N et al (2013) Conventional and advanced MRI features of pediatric intracranial tumors: posterior fossa and suprasellar tumors. AJR Am J Roentgenol 200:1115–1124CrossRefPubMed
31.
Poussaint TY (2008) Diagnostic imaging of primary pediatric brain tumors. In: Hodler J, von Schulthess GK, Zollikofer CL (eds) Diseases of the Brain, Head & Neck, Spine. Springer-Verlag Italia, Milan, pp 277–287
32.
Poussaint TY, Rossi A (2012) Imaging of pediatric brain and spinal cord tumors. In: Hodler J, von Schulthess GK, Zollikofer CL (eds) Diseases of the Brain, Head & Neck, Spine 2012–2015. Springer-Verlag Italia, Milan, pp 203–214
33.
Cavalheiro S, Di Rocco C, Valenzuela S et al (2010) Craniopharyngiomas: intratumoral chemotherapy with interferon-alpha: a multicenter preliminary study with 60 cases. Neurosurg Focus 28:E12–E16
34.
Singh RK, Gutman M, Bucana CD et al (1995) Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proc Natl Acad Sci U S A 92:4562–4566PubMedCentralCrossRefPubMed
35.
Nucci ML, Shorr R, Abuchowski A (1991) The therapeutic value of poly (ethylene glycol)-modified proteins. Adv Drug Deliv Rev 6:133–151CrossRef
36.
Yeung JT, Pollack IF, Panigrahy A et al (2012) Pegylated interferon-alpha-2b for children with recurrent craniopharyngioma. J Neurosurg Pediatr 10:498–503CrossRefPubMed
37.
Jones DT, Kocialkowski S, Liu L et al (2008) Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. Cancer Res 68:8673–8677PubMedCentralCrossRefPubMed
38.
Pfister S, Janzarik WG, Remke M et al (2008) BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. J Clin Invest 118:1739–1749PubMedCentralCrossRefPubMed
39.
Raabe EH, Lim KS, Kim JM et al (2011) BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model. Clin Cancer Res 17:3590–3599PubMedCentralCrossRefPubMed
40.
41.
Sievert AJ, Lang S-S, Boucher KL et al (2013) Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas. Proc Natl Acad Sci 110:5957–5962PubMedCentralCrossRefPubMed
42.
Jones C, Perryman L, Hargrave D (2012) Paediatric and adult malignant glioma: close relatives or distant cousins? Nat Rev Clin Oncol 9:400–413CrossRefPubMed
43.
44.
45.
46.
47.
Pollack IF, Jakacki RI, Butterfield LH et al (2014) Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and nonbrainstem gliomas. J Clin Oncol 32:2050–2058PubMedCentralCrossRefPubMed
48.
Huisman TA (2009) Tumor-like lesions of the brain. Cancer Imaging 9:S10--S13
49.
Lo WD, Lee J, Rusin J et al (2008) Intracranial hemorrhage in children: an evolving spectrum. Arch Neurol 65:1629--1633
50.
McAdam LC, Blaser SI, Banwell BL (2002) Pediatric tumefactive demyelination: case series and review of the literature. Pediatr Neurol 26:18–25CrossRefPubMed
Metadaten
Titel
Pediatric brain tumors
verfasst von
Tina Y. Poussaint
Ashok Panigrahy
Thierry A. G. M. Huisman
Publikationsdatum
01.09.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Radiology / Ausgabe Sonderheft 3/2015
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-015-3326-8

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