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Erschienen in: Pediatric Radiology 11/2015

01.10.2015 | Original Article

Imaging of childhood inflammatory myofibroblastic tumor

verfasst von: Berna Oguz, Hatice Nursun Ozcan, Burak Omay, Burce Ozgen, Mithat Haliloglu

Erschienen in: Pediatric Radiology | Ausgabe 11/2015

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Abstract

Background

Inflammatory myofibroblastic tumor is a rare benign neoplasm and most commonly involves the lung but occurs in extrapulmonary locations.

Objective

To present imaging findings in inflammatory myofibroblastic tumors in children based on a single-centre experience.

Materials and methods

We retrospectively reviewed CT and MRI findings of children diagnosed with inflammatory myofibroblastic tumor in a single institution.

Results

We identified 15 children (range: 1–17 years) with inflammatory myofibroblastic tumor. The tumor was localized to the lung (n = 5), mediastinum (n = 3), trachea (n = 1), bronchus (n = 1), abdomen (n = 2) and orbit (n = 3). All the extraorbital tumors were solid masses with homogeneous or heterogeneous enhancement. Four lung tumors and one posterior mediastinal tumor contained calcification. Local recurrence following surgical removal occurred in two children with invasion of the esophagus and of the left atrium in one. Localized masses were seen in all children with orbital tumour. Two of these had episcleritis and perineuritis; one had episcleritis, tendonitis, perineuritis, myositis and dacryoadenitis.

Conclusion

The locations and imaging features of inflammatory myofibroblastic tumors are variable.
Literatur
1.
Zurück zum Zitat Hedlund GL, Navoy JF, Galliani CA et al (1999) Aggressive manifestations of inflammatory pulmonary pseudotumor in children. Pediatr Radiol 29:112–116CrossRefPubMed Hedlund GL, Navoy JF, Galliani CA et al (1999) Aggressive manifestations of inflammatory pulmonary pseudotumor in children. Pediatr Radiol 29:112–116CrossRefPubMed
2.
Zurück zum Zitat Patankar T, Prasad S, Shenoy A et al (2000) Pulmonary inflammatory pseudotumor in children. Australas Radiol 44:318–320CrossRefPubMed Patankar T, Prasad S, Shenoy A et al (2000) Pulmonary inflammatory pseudotumor in children. Australas Radiol 44:318–320CrossRefPubMed
3.
Zurück zum Zitat Karnak I, Senocak ME, Ciftci AO et al (2001) Inflammatory myofibroblastic tumor in children: diagnosis and treatment. J Pediatr Surg 36:908–912CrossRefPubMed Karnak I, Senocak ME, Ciftci AO et al (2001) Inflammatory myofibroblastic tumor in children: diagnosis and treatment. J Pediatr Surg 36:908–912CrossRefPubMed
4.
Zurück zum Zitat Patnana M, Sevrukov AB, Elsayes KM et al (2012) Inflammatory pseudotumor: the great mimicker. AJR Am J Roentgenol 198:W217–W227CrossRefPubMed Patnana M, Sevrukov AB, Elsayes KM et al (2012) Inflammatory pseudotumor: the great mimicker. AJR Am J Roentgenol 198:W217–W227CrossRefPubMed
5.
Zurück zum Zitat Narla LD, Newman B, Spottswood SS et al (2003) Inflammatory pseudotumor. Radiographics 23:719–729CrossRefPubMed Narla LD, Newman B, Spottswood SS et al (2003) Inflammatory pseudotumor. Radiographics 23:719–729CrossRefPubMed
6.
Zurück zum Zitat Kim SJ, Kim WS, Cheon JE et al (2009) Inflammatory myofibroblastic tumors of the abdomen as mimickers of malignancy: imaging features in nine children. AJR Am J Roentgenol 193:1419–1424CrossRefPubMed Kim SJ, Kim WS, Cheon JE et al (2009) Inflammatory myofibroblastic tumors of the abdomen as mimickers of malignancy: imaging features in nine children. AJR Am J Roentgenol 193:1419–1424CrossRefPubMed
7.
Zurück zum Zitat Choi BY, Kim WS, Cheon JE et al (2003) Inflammatory myofibroblastic tumour of the liver in a child: CT and MR findings. Pediatr Radiol 33:30–33CrossRefPubMed Choi BY, Kim WS, Cheon JE et al (2003) Inflammatory myofibroblastic tumour of the liver in a child: CT and MR findings. Pediatr Radiol 33:30–33CrossRefPubMed
8.
Zurück zum Zitat Day DL, Sane S, Dehner LP (1986) Inflammatory pseudotumor of the mesentery and small intestine. Pediatr Radiol 16:210–215CrossRefPubMed Day DL, Sane S, Dehner LP (1986) Inflammatory pseudotumor of the mesentery and small intestine. Pediatr Radiol 16:210–215CrossRefPubMed
9.
Zurück zum Zitat Taratuta E, Krinsky G, Genega E et al (1996) Pediatric inflammatory pseudotumor of the stomach: contrast-enhanced CT and MR imaging findings. AJR Am J Roentgenol 167:919–920CrossRefPubMed Taratuta E, Krinsky G, Genega E et al (1996) Pediatric inflammatory pseudotumor of the stomach: contrast-enhanced CT and MR imaging findings. AJR Am J Roentgenol 167:919–920CrossRefPubMed
10.
Zurück zum Zitat Sanders BM, West KW, Gingalewski C et al (2001) Inflammatory pseudotumor of the alimentary tract: clinical and surgical experience. J Pediatr Surg 36:169–173CrossRefPubMed Sanders BM, West KW, Gingalewski C et al (2001) Inflammatory pseudotumor of the alimentary tract: clinical and surgical experience. J Pediatr Surg 36:169–173CrossRefPubMed
11.
Zurück zum Zitat Park SB, Cho KS, Kim JK et al (2008) Inflammatory pseudotumor (myoblastic tumor) of the genitourinary tract. AJR Am J Roentgenol 191:1255–1262CrossRefPubMed Park SB, Cho KS, Kim JK et al (2008) Inflammatory pseudotumor (myoblastic tumor) of the genitourinary tract. AJR Am J Roentgenol 191:1255–1262CrossRefPubMed
12.
Zurück zum Zitat Brunn H (1939) Two interesting benign lung tumours of contradictory histopathology: remarks on the necessity for maintaining the chest tumour registry. J Thorac Cardiovasc 9:119–131 Brunn H (1939) Two interesting benign lung tumours of contradictory histopathology: remarks on the necessity for maintaining the chest tumour registry. J Thorac Cardiovasc 9:119–131
13.
Zurück zum Zitat Umiker WO, Iverson LC (1954) Post inflammatory tumor of the lung: report of four cases simulating xanthoma, fibroma or plasma cell granuloma. J Thorac Surg 28:55–62PubMed Umiker WO, Iverson LC (1954) Post inflammatory tumor of the lung: report of four cases simulating xanthoma, fibroma or plasma cell granuloma. J Thorac Surg 28:55–62PubMed
14.
Zurück zum Zitat Kirkpatrick JA Jr, Harris GB, Kushner DC (1984) Thoracic complications of plasma cell granuloma of the lung. Ann Radiol 27:145–149PubMed Kirkpatrick JA Jr, Harris GB, Kushner DC (1984) Thoracic complications of plasma cell granuloma of the lung. Ann Radiol 27:145–149PubMed
15.
Zurück zum Zitat Cook JR, Dehner LP, Collins MH et al (2001) Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study. Am J Surg Pathol 25:1364–1368CrossRefPubMed Cook JR, Dehner LP, Collins MH et al (2001) Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study. Am J Surg Pathol 25:1364–1368CrossRefPubMed
16.
Zurück zum Zitat Lawrence B, Perez-Atayde A, Hibbard MK et al (2000) TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. Am J Pathol 157:377–384PubMedCentralCrossRefPubMed Lawrence B, Perez-Atayde A, Hibbard MK et al (2000) TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. Am J Pathol 157:377–384PubMedCentralCrossRefPubMed
17.
Zurück zum Zitat Priebe-Richter C, Ivanyi P, Buer J et al (2005) Inflammatory pseudotumor of the lung following invasive aspergillosis in a patient with chronic graft-vs.-host disease. Eur J Haematol 75:68–72CrossRefPubMed Priebe-Richter C, Ivanyi P, Buer J et al (2005) Inflammatory pseudotumor of the lung following invasive aspergillosis in a patient with chronic graft-vs.-host disease. Eur J Haematol 75:68–72CrossRefPubMed
18.
Zurück zum Zitat Takayama Y, Yabuuchi H, Matsuo Y et al (2008) Computed tomographic and magnetic resonance features of inflammatory myofibroblastic tumor of the lung in children. Radiat Med 26:613–617CrossRefPubMed Takayama Y, Yabuuchi H, Matsuo Y et al (2008) Computed tomographic and magnetic resonance features of inflammatory myofibroblastic tumor of the lung in children. Radiat Med 26:613–617CrossRefPubMed
19.
Zurück zum Zitat Yan FH, Zhou KR, Jiang YP et al (2001) Inflammatory pseudotumor of the liver: 13 cases of MRI findings. World J Gastroenterol 7:422–424PubMed Yan FH, Zhou KR, Jiang YP et al (2001) Inflammatory pseudotumor of the liver: 13 cases of MRI findings. World J Gastroenterol 7:422–424PubMed
20.
Zurück zum Zitat McCarville MB, Hoffer FA, Adelman S et al (2007) MRI and biological behavior of desmoid tumors in children. AJR Am J Roentgenol 189:633–640CrossRefPubMed McCarville MB, Hoffer FA, Adelman S et al (2007) MRI and biological behavior of desmoid tumors in children. AJR Am J Roentgenol 189:633–640CrossRefPubMed
21.
Zurück zum Zitat Huellner MW, Schwizer B, Burger I et al (2010) Inflammatory pseudotumor of the lung with high FDG uptake. Clin Nucl Med 35:722–723CrossRefPubMed Huellner MW, Schwizer B, Burger I et al (2010) Inflammatory pseudotumor of the lung with high FDG uptake. Clin Nucl Med 35:722–723CrossRefPubMed
22.
Zurück zum Zitat Alongi F, Bolognesi A, Gajate AM et al (2010) Inflammatory pseudotumor of mediastinum treated with tomotherapy and monitored with FDG-PET/CT: case report and literature review. Tumori 96:322–326PubMed Alongi F, Bolognesi A, Gajate AM et al (2010) Inflammatory pseudotumor of mediastinum treated with tomotherapy and monitored with FDG-PET/CT: case report and literature review. Tumori 96:322–326PubMed
23.
Zurück zum Zitat Athanassiadi K, Laenger F, Dickgreber N et al (2009) Multiple inflammatory myofibroblastic tumors involving lung and mediastinum: a rare clinical entity. Thorac Cardiov Surg 57:343–346CrossRef Athanassiadi K, Laenger F, Dickgreber N et al (2009) Multiple inflammatory myofibroblastic tumors involving lung and mediastinum: a rare clinical entity. Thorac Cardiov Surg 57:343–346CrossRef
24.
Zurück zum Zitat Corneli G, Alifano M, Forti Parri S et al (2001) Invasive inflammatory pseudotumor involving the lung and mediastinum. Thorac Cardiovasc Surg 49:124–126CrossRefPubMed Corneli G, Alifano M, Forti Parri S et al (2001) Invasive inflammatory pseudotumor involving the lung and mediastinum. Thorac Cardiovasc Surg 49:124–126CrossRefPubMed
25.
Zurück zum Zitat Li L, Burke A, He J et al (2011) Sudden unexpected death due to inflammatory myofibroblastic tumor of the heart: a case report and review of the literature. Int J Legal Med 125:81–85CrossRefPubMed Li L, Burke A, He J et al (2011) Sudden unexpected death due to inflammatory myofibroblastic tumor of the heart: a case report and review of the literature. Int J Legal Med 125:81–85CrossRefPubMed
26.
Zurück zum Zitat Sugiyama K, Nakajima Y (2008) Inflammatory myofibroblastic tumor in the mediastinum mimicking a malignant tumor. Diagn Interv Radiol 14:197–199PubMed Sugiyama K, Nakajima Y (2008) Inflammatory myofibroblastic tumor in the mediastinum mimicking a malignant tumor. Diagn Interv Radiol 14:197–199PubMed
27.
Zurück zum Zitat Guan Y, Chen G, Zhang W et al (2012) Computed tomography appearance of inflammatory myofibroblastic tumor in the mediastinum. J Comput Assist Tomogr 36:654–658CrossRefPubMed Guan Y, Chen G, Zhang W et al (2012) Computed tomography appearance of inflammatory myofibroblastic tumor in the mediastinum. J Comput Assist Tomogr 36:654–658CrossRefPubMed
28.
Zurück zum Zitat Dhouib A, Barrazzone C, Reverdin A et al (2013) Inflammatory myofibroblastic tumor of the lung: a rare cause of atelectasis in children. Pediatr Radiol 43:381–384CrossRefPubMed Dhouib A, Barrazzone C, Reverdin A et al (2013) Inflammatory myofibroblastic tumor of the lung: a rare cause of atelectasis in children. Pediatr Radiol 43:381–384CrossRefPubMed
29.
Zurück zum Zitat De Palma A, Loizzi D, Sollitto F et al (2009) Surgical treatment of a rare case of tracheal inflammatory pseudotumor in pediatric age. Interact Cardiovasc Thorac Surg 9:1035–1037CrossRefPubMed De Palma A, Loizzi D, Sollitto F et al (2009) Surgical treatment of a rare case of tracheal inflammatory pseudotumor in pediatric age. Interact Cardiovasc Thorac Surg 9:1035–1037CrossRefPubMed
30.
Zurück zum Zitat Franquet T, Montes M, Aizcorbe M et al (1989) Inflammatory pseudotumor of the spleen: ultrasound and computed tomographic findings. Gastrointest Radiol 14:181–183CrossRefPubMed Franquet T, Montes M, Aizcorbe M et al (1989) Inflammatory pseudotumor of the spleen: ultrasound and computed tomographic findings. Gastrointest Radiol 14:181–183CrossRefPubMed
31.
Zurück zum Zitat Tublin ME, Moser AJ, Marsh JW et al (2007) Biliary inflammatory pseudotumor: imaging features in seven patients. AJR Am J Roentgenol 188:W44–W48CrossRefPubMed Tublin ME, Moser AJ, Marsh JW et al (2007) Biliary inflammatory pseudotumor: imaging features in seven patients. AJR Am J Roentgenol 188:W44–W48CrossRefPubMed
32.
Zurück zum Zitat Uysal S, Tuncbilek I, Unlubay D et al (2005) Inflammatory pseudotumor of the sigmoid colon mesentery: US and CT findings. Eur Radiol 15:633–635CrossRefPubMed Uysal S, Tuncbilek I, Unlubay D et al (2005) Inflammatory pseudotumor of the sigmoid colon mesentery: US and CT findings. Eur Radiol 15:633–635CrossRefPubMed
33.
Zurück zum Zitat Slavotinek JP, Bourne AJ, Sage MR et al (2000) Inflammatory pseudotumor of the pancreas in a child. Pediatr Radiol 30:801–803CrossRefPubMed Slavotinek JP, Bourne AJ, Sage MR et al (2000) Inflammatory pseudotumor of the pancreas in a child. Pediatr Radiol 30:801–803CrossRefPubMed
34.
Zurück zum Zitat Lee HJ, Kim JS, Choi YS et al (2007) Treatment of inflammatory myofibroblastic tumor of the chest: the extent of resection. Ann Thorac Surg 84:221–224CrossRefPubMed Lee HJ, Kim JS, Choi YS et al (2007) Treatment of inflammatory myofibroblastic tumor of the chest: the extent of resection. Ann Thorac Surg 84:221–224CrossRefPubMed
35.
Zurück zum Zitat Melloni G, Caretta A, Ciriaco P et al (2005) Inflammatory pseudotumor of the lung in adults. Ann Thorac Surg 79:426–432CrossRefPubMed Melloni G, Caretta A, Ciriaco P et al (2005) Inflammatory pseudotumor of the lung in adults. Ann Thorac Surg 79:426–432CrossRefPubMed
36.
Zurück zum Zitat Belanger C, Zhang KS, Reddy AK et al (2010) Inflammatory disorders of the orbit in childhood: a case series. Am J Ophthalmol 150:460–463CrossRefPubMed Belanger C, Zhang KS, Reddy AK et al (2010) Inflammatory disorders of the orbit in childhood: a case series. Am J Ophthalmol 150:460–463CrossRefPubMed
37.
Zurück zum Zitat Weber AL, Romo LV, Sabates NR (1999) Pseudotumor of the orbit: clinical, pathologic, and radiologic evaluation. Radiol Clin North Am 37:151–168CrossRefPubMed Weber AL, Romo LV, Sabates NR (1999) Pseudotumor of the orbit: clinical, pathologic, and radiologic evaluation. Radiol Clin North Am 37:151–168CrossRefPubMed
38.
39.
Zurück zum Zitat Martin CJ (1997) Orbital pseudotumor: a case report and overview. J Am Optom Assoc 68:775–781PubMed Martin CJ (1997) Orbital pseudotumor: a case report and overview. J Am Optom Assoc 68:775–781PubMed
40.
Zurück zum Zitat Sepahdari AR, Aakalu VK, Setabutr P et al (2010) Indeterminate orbital masses: restricted diffusion at MR imaging with echo-planar diffusion-weighted imaging predicts malignancy. Radiology 256:554–564CrossRefPubMed Sepahdari AR, Aakalu VK, Setabutr P et al (2010) Indeterminate orbital masses: restricted diffusion at MR imaging with echo-planar diffusion-weighted imaging predicts malignancy. Radiology 256:554–564CrossRefPubMed
41.
Zurück zum Zitat Mombaerts J, Sachlingermann RO, Koorneef L (1996) Are systemic corticosteroids useful in the management of orbital pseudotumors. Ophthalmology 103:521–528CrossRefPubMed Mombaerts J, Sachlingermann RO, Koorneef L (1996) Are systemic corticosteroids useful in the management of orbital pseudotumors. Ophthalmology 103:521–528CrossRefPubMed
42.
Zurück zum Zitat Cherukupally SR, Mankarious LA, Fraquin W et al (2003) Pediatric non-orbital pseudotumor of the head and neck. Int J Pediatr Otorhinolaryngol 67:649–653CrossRefPubMed Cherukupally SR, Mankarious LA, Fraquin W et al (2003) Pediatric non-orbital pseudotumor of the head and neck. Int J Pediatr Otorhinolaryngol 67:649–653CrossRefPubMed
43.
Zurück zum Zitat Park SB, Lee JH, Weon YC (2009) Imaging findings of head and neck inflammatory pseudotumor. AJR Am J Roentgenol 193:1180–1186CrossRefPubMed Park SB, Lee JH, Weon YC (2009) Imaging findings of head and neck inflammatory pseudotumor. AJR Am J Roentgenol 193:1180–1186CrossRefPubMed
45.
Zurück zum Zitat Weber MA, Wiehoever A, Stieltjes B et al (2005) Intracerebral manifestation of an atypical monoclonal plasma cell hyperplasia depicted by MR perfusion and diffusion tensor imaging and MR spectroscopy. AJR Am J Roentgenol 185:784–787CrossRefPubMed Weber MA, Wiehoever A, Stieltjes B et al (2005) Intracerebral manifestation of an atypical monoclonal plasma cell hyperplasia depicted by MR perfusion and diffusion tensor imaging and MR spectroscopy. AJR Am J Roentgenol 185:784–787CrossRefPubMed
Metadaten
Titel
Imaging of childhood inflammatory myofibroblastic tumor
verfasst von
Berna Oguz
Hatice Nursun Ozcan
Burak Omay
Burce Ozgen
Mithat Haliloglu
Publikationsdatum
01.10.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Radiology / Ausgabe 11/2015
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-015-3377-x

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