nach oben

Erschienen in:

15.05.2021 | Contrast-enhanced ultrasound (CEUS) in children

Translational research in pediatric contrast-enhanced ultrasound

verfasst von: Anush Sridharan, Misun Hwang, Shelby Kutty, M. Beth McCarville, Harriet J. Paltiel, Maciej Piskunowicz, Sphoorti Shellikeri, Elizabeth Silvestro, George A. Taylor, Ryne A. Didier

Erschienen in: Pediatric Radiology | Ausgabe 12/2021

Einloggen, um Zugang zu erhalten

Abstract

The role of contrast-enhanced ultrasound (CEUS) imaging is being widely explored by various groups for its use in the pediatric population. Clinical implementation of new diagnostic or therapeutic techniques requires extensive and meticulous preclinical testing and evaluation. The impact of CEUS will be determined in part by the extent to which studies are oriented specifically toward a pediatric population. Rather than simply applying principles and techniques used in the adult population, these studies are expected to advance and augment preexisting knowledge with pediatric-specific information. To further develop this imaging modality for use in children, pediatric-focused preclinical research is essential. In this paper we describe the development and implementation of the pediatric-specific preclinical animal and phantom models that are being used to evaluate CEUS with the goal of clinical translation to children.

Darge K (2010) Voiding urosonography with US contrast agent for the diagnosis of vesicoureteric reflux in children: an update. Pediatr Radiol 40:956–962PubMedCrossRef

Darge K, Moeller RT, Trusen A et al (2005) Diagnosis of vesicoureteric reflux with low-dose contrast-enhanced harmonic ultrasound imaging. Pediatr Radiol 35:73–78PubMedCrossRef

Piskunowicz M, Kosiak W, Batko T et al (2015) Safety of intravenous application of second-generation ultrasound contrast agent in children: prospective analysis. Ultrasound Med Biol 41:1095–1099PubMedCrossRef

Stenzel M (2013) Intravenous contrast-enhanced sonography in children and adolescents — a single center experience. J Ultrason 13:133–144PubMedPubMedCentralCrossRef

Jacob J, Deganello A, Sellars ME et al (2013) Contrast enhanced ultrasound (CEUS) characterization of grey-scale sonographic indeterminate focal liver lesions in pediatric practice. Ultraschall Med 34:529–540PubMedCrossRef

Bonini G, Pezzotta G, Morzenti C et al (2007) Contrast-enhanced ultrasound with SonoVue in the evaluation of postoperative complications in pediatric liver transplant recipients. J Ultrasound 10:99–106PubMedPubMedCentralCrossRef

Ntoulia A, Anupindi SA, Darge K, Back SJ (2018) Applications of contrast-enhanced ultrasound in the pediatric abdomen. Abdom Radiol 43:948–959CrossRef

Armstrong LB, Mooney DP, Paltiel H et al (2018) Contrast enhanced ultrasound for the evaluation of blunt pediatric abdominal trauma. J Pediatr Surg 53:548–552PubMedCrossRef

Menichini G, Sessa B, Trinci M et al (2015) Accuracy of contrast-enhanced ultrasound (CEUS) in the identification and characterization of traumatic solid organ lesions in children: a retrospective comparison with baseline US and CE-MDCT. Radiol Med 120:989–1001PubMedCrossRef

10.

Kljucevsek D, Vidmar D, Urlep D, Dezman R (2016) Dynamic contrast-enhanced ultrasound of the bowel wall with quantitative assessment of Crohn’s disease activity in childhood. Radiol Oncol 50:347–354PubMedPubMedCentralCrossRef

11.

Hwang M, De Jong RM, Herman S et al (2017) Novel contrast-enhanced ultrasound evaluation in neonatal hypoxic ischemic injury: clinical application and future directions. J Ultrasound Med 36:2379–2386PubMedCrossRef

12.

Hwang M, Sridharan A, Darge K et al (2019) Novel quantitative contrast-enhanced ultrasound detection of hypoxic ischemic injury in neonates and infants: pilot study 1. J Ultrasound Med 38:2025–2038PubMedCrossRef

13.

Maj E, Papiernik D, Wietrzyk J (2016) Antiangiogenic cancer treatment: the great discovery and greater complexity. Int J Oncol 49:1773–1784PubMedPubMedCentralCrossRef

14.

Hendry SA, Farnsworth RH, Solomon B et al (2016) The role of the tumor vasculature in the host immune response: implications for therapeutic strategies targeting the tumor microenvironment. Front Immunol 7:621PubMedPubMedCentralCrossRef

15.

Hlatky L, Hahnfeldt P, Folkman J (2002) Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn’t tell us. J Natl Cancer Inst 94:883–893

16.

McCarville MB, Streck CJ, Dickson PV et al (2006) Angiogenesis inhibitors in a murine neuroblastoma model: quantitative assessment of intratumoral blood flow with contrast-enhanced gray-scale US. Radiology 240:73–81PubMedCrossRef

17.

Sims TL, McGee M, Williams RF et al (2010) IFN-β restricts tumor growth and sensitizes alveolar rhabdomyosarcoma to ionizing radiation. Mol Cancer Ther 9:761–771PubMedCrossRef

18.

Carson P (2012) MO-D-218-01: overview of methodology and standards (QIBA, IEC, AIUM and AAPM). Med Phys 39:3869–3870PubMedCrossRef

19.

Graham EM, Ruis KA, Hartman AL et al (2008) A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy. Am J Obstet Gynecol 199:587–595PubMedCrossRef

20.

Radlowski EC, Conrad MS, Lezmi S et al (2014) A neonatal piglet model for investigating brain and cognitive development in small for gestational age human infants. PLoS One 9:e91951PubMedPubMedCentralCrossRef

21.

Thibault KL, Margulies SS (1998) Age-dependent material properties of the porcine cerebrum: effect on pediatric inertial head injury criteria. J Biomech 31:1119–1126PubMedCrossRef

22.

Dickerson JW, Dobbing J (1967) Prenatal and postnatal growth and development of the central nervous system of the pig. Proc R Soc Lond B Biol Sci 166:384–395PubMedCrossRef

23.

Dobbing J, Sands J (1979) Comparative aspects of the brain growth spurt. Early Hum Dev 3:79–83PubMedCrossRef

24.

Eiby YA, Wright LL, Kalanjati VP et al (2013) A pig model of the preterm neonate: anthropometric and physiological characteristics. PLoS One 8:e68763PubMedPubMedCentralCrossRef

25.

Taylor GA, Barnewolt CE, Dunning PS (1998) Neonatal pig brain: lack of heating during Doppler US. Radiology 207:525–528PubMedCrossRef

26.

Sridharan A, Poznick L, Roberts AL et al (2019) Contrast-enhanced ultrasound (CEUS) in pediatric swine as a pediatric preclinical model for brain imaging. In: Radiological Society of North America 2019 scientific assembly and annual meeting, pp SSQ17-01

27.

Taylor GA, Soul JS, Dunning PS (1998) Sonographic ventriculography: a new potential use for sonographic contrast agents in neonatal hydrocephalus. AJNR Am J Neuroradiol 19:1931–1934PubMedPubMedCentral

28.

Morrison JL, Berry MJ, Botting KJ et al (2018) Improving pregnancy outcomes in humans through studies in sheep. Am J Physiol Regul Integr Comp Physiol 315:R1123–R1153PubMedCrossRef

29.

Back SA, Riddle A, Hohimer AR (2006) Role of instrumented fetal sheep preparations in defining the pathogenesis of human periventricular white-matter injury. J Child Neurol 21:582–589PubMedCrossRef

30.

Pringle KC (1986) Human fetal lung development and related animal models. Clin Obstet Gynecol 29:502–513PubMedCrossRef

31.

Partridge EA, Davey MG, Hornick MA et al (2017) An extra-uterine system to physiologically support the extreme premature lamb. Nat Commun 8:15112PubMedPubMedCentralCrossRef

32.

Bryner BS, Mychaliska GB (2014) ECLS for preemies: the artificial placenta. Semin Perinatol 38:122–129PubMedCrossRef

33.

Bryner B, Gray B, Perkins E et al (2015) An extracorporeal artificial placenta supports extremely premature lambs for 1 week. J Pediatr Surg 50:44–49PubMedCrossRef

34.

Didier RA, Sridharan A, Lawrence K et al (2019) Contrast-enhanced ultrasound in extracorporeal support: in vitro studies and initial experience and safety data in the extreme premature fetal lamb maintained by the extrauterine environment for neonatal development. J Ultrasound Med 38:1971–1978PubMedCrossRef

35.

Williamson RC (1976) Torsion of the testis and allied conditions. Br J Surg 63:465–476PubMedCrossRef

36.

Osumah TS, Jimbo M, Granberg CF, Gargollo PC (2018) Frontiers in pediatric testicular torsion: an integrated review of prevailing trends and management outcomes. J Pediatr Urol 14:394–401PubMedCrossRef

37.

Nason GJ, Tareen F, McLoughlin D et al (2013) Scrotal exploration for acute scrotal pain: a 10-year experience in two tertiary referral paediatric units. Scand J Urol 47:418–422PubMedCrossRef

38.

Rebik K, Wagner JM, Middleton W (2019) Scrotal ultrasound. Radiol Clin N Am 57:635–648PubMedCrossRef

39.

Pepe P, Panella P, Pennisi M, Aragona F (2006) Does color Doppler sonography improve the clinical assessment of patients with acute scrotum? Eur J Radiol 60:120–124PubMedCrossRef

40.

Burks DD, Markey BJ, Burkhard TK et al (1990) Suspected testicular torsion and ischemia: evaluation with color Doppler sonography. Radiology 175:815–821PubMedCrossRef

41.

Lerner RM, Mevorach RA, Hulbert WC, Rabinowitz R (1990) Color Doppler US in the evaluation of acute scrotal disease. Radiology 176:355–358PubMedCrossRef

42.

Sung EK, Setty BN, Castro-Aragon I (2012) Sonography of the pediatric scrotum: emphasis on the Ts — torsion, trauma, and tumors. AJR Am J Roentgenol 198:996–1003PubMedCrossRef

43.

Kalfa N, Veyrac C, Baud C et al (2004) Ultrasonography of the spermatic cord in children with testicular torsion: impact on the surgical strategy. J Urol 172:1692–1695PubMedCrossRef

44.

Blask ARN, Bulas D, Shalaby-Rana E et al (2002) Color Doppler sonography and scintigraphy of the testis: a prospective, comparative analysis in children with acute scrotal pain. Pediatr Emerg Care 18:67–71CrossRef

45.

Paltiel HJ, Connolly LP, Atala A et al (1998) Acute scrotal symptoms in boys with an indeterminate clinical presentation: comparison of color Doppler sonography and scintigraphy. Radiology 207:223–232PubMedCrossRef

46.

Paltiel HJ, Rupich RC, Babcock DS (1994) Maturational changes in arterial impedance of the normal testis in boys: Doppler sonographic study. AJR Am J Roentgenol 163:1189–1193PubMedCrossRef

47.

Wilson SR, Burns PN (2010) Microbubble-enhanced US in body imaging: what role? Radiology 257:24–39PubMedCrossRef

48.

Sidhu PS, Cantisani V, Dietrich CF et al (2018) The EFSUMB guidelines and recommendations for the clinical practice of contrast-enhanced ultrasound (CEUS) in non-hepatic applications: update 2017 (long version). Ultraschall Med 39:e2–e44PubMedCrossRef

49.

Claudon M, Dietrich CF, Choi BI et al (2013) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver — update 2012. Ultraschall Med 34:11–29PubMedCrossRef

50.

Liu X, Jang HJ, Khalili K et al (2018) Successful integration of contrast-enhanced US into routine abdominal imaging. Radiographics 38:1454–1477PubMedCrossRef

51.

Huang DY, Yusuf GT, Daneshi M et al (2017) Contrast-enhanced US-guided interventions: improving success rate and avoiding complications using US contrast agents. Radiographics 37:652–664PubMedCrossRef

52.

Lu C, Merrill C, Medellin A et al (2019) Bowel ultrasound state of the art: grayscale and Doppler ultrasound, contrast enhancement, and elastography in Crohn disease. J Ultrasound Med 38:271–288PubMedCrossRef

53.

Valentino M, Bertolotto M, Derchi L et al (2011) Role of contrast enhanced ultrasound in acute scrotal diseases. Eur Radiol 21:1831–1840PubMedCrossRef

54.

Catalano O, Lobianco R, Sandomenico F et al (2004) Real-time, contrast-enhanced sonographic imaging in emergency radiology. Radiol Med 108:454–469PubMed

55.

Paltiel HJ, Kalish LA, Susaeta RA et al (2006) Pulse-inversion US imaging of testicular ischemia: quantitative and qualitative analyses in a rabbit model. Radiology 239:718–729PubMedCrossRef

56.

Paltiel HJ, Estrada CR, Alomari AI et al (2014) Multi-planar dynamic contrast-enhanced ultrasound assessment of blood flow in a rabbit model of testicular torsion. Ultrasound Med Biol 40:361–370PubMedCrossRef

57.

Paltiel HJ, Padua HM, Gargollo PC et al (2011) Contrast-enhanced, real-time volumetric ultrasound imaging of tissue perfusion: preliminary results in a rabbit model of testicular torsion. Phys Med Biol 56:2183–2197PubMedPubMedCentralCrossRef

58.

Tse KS, Wong LS, Lau HY et al (2014) Paediatric vesicoureteric reflux imaging: where are we? Novel ultrasound-based voiding urosonography. Hong Kong Med J 20:437–443PubMedCrossRef

59.

Wong LS, Tse KS, Fan TW et al (2014) Voiding urosonography with second-generation ultrasound contrast versus micturating cystourethrography in the diagnosis of vesicoureteric reflux. Eur J Pediatr 173:1095–1101PubMedCrossRef

60.

Lebowitz RL, Olbing H, Parkkulainen KV et al (1985) International system of radiographic grading of vesicoureteric reflux. Pediatr Radiol 15:105–109PubMedCrossRef

61.

Darge K (2008) Voiding urosonography with ultrasound contrast agents for the diagnosis of vesicoureteric reflux in children: I. procedure. Pediatr Radiol 38:40–53PubMedCrossRef

62.

Darge K (2008) Voiding urosonography with US contrast agents for the diagnosis of vesicoureteric reflux in children: II. Comparison with radiological examinations. Pediatr Radiol 38:54–63PubMedCrossRef

63.

Ntoulia A, Back SJ, Shellikeri S et al (2018) Contrast-enhanced voiding urosonography (ceVUS) with the intravesical administration of the ultrasound contrast agent Optison™ for vesicoureteral reflux detection in children: a prospective clinical trial. Pediatr Radiol 48:216–226PubMedCrossRef

64.

Shellikeri S, Silvestro E, Poznick L et al (2019) 3D printed anatomic contrast enhanced voiding urosonography (ceVUS) teaching phantoms: bringing pediatric vesicoureteral reflux (VUR) to life. Pediatr Radiol 49:S81

65.

Gong Y, Cabodi M, Porter TM (2014) Acoustic investigation of pressure-dependent resonance and shell elasticity of lipid-coated monodisperse microbubbles. Appl Phys Lett 104:074103CrossRef

66.

Helfield BL, Leung BYC, Huo X, Goertz DE (2014) Scaling of the viscoelastic shell properties of phospholipid encapsulated microbubbles with ultrasound frequency. Ultrasonics 54:1419–1424PubMedCrossRef

67.

Gessner R, Lukacs M, Lee M et al (2010) High-resolution, high-contrast ultrasound imaging using a prototype dual-frequency transducer: in vitro and in vivo studies. IEEE Trans Ultrason Ferroelectr Freq Control 57:1772–1781PubMedPubMedCentralCrossRef

68.

Bouakaz A, Frigstad S, Ten Cate FJ, de Jong N (2002) Super harmonic imaging: a new imaging technique for improved contrast detection. Ultrasound Med Biol 28:59–68PubMedCrossRef

69.

Wang S, Hossack JA, Klibanov AL (2018) Targeting of microbubbles: contrast agents for ultrasound molecular imaging. J Drug Target 26:420–434PubMedPubMedCentralCrossRef

70.

Pochon S, Tardy I, Bussat P et al (2010) BR55: a lipopeptide-based VEGFR2-targeted ultrasound contrast agent for molecular imaging of angiogenesis. Investig Radiol 45:89–95CrossRef

71.

Abou-Elkacem L, Bachawal SV, Willmann JK (2015) Ultrasound molecular imaging: moving toward clinical translation. Eur J Radiol 84:1685–1693PubMedPubMedCentralCrossRef

72.

Willmann JK, Bonomo L, Testa AC et al (2017) Ultrasound molecular imaging with BR55 in patients with breast & ovarian lesions: first-in-human results. J Clin Oncol 35:2133–2140PubMedPubMedCentralCrossRef

73.

Hernot S, Klibanov AL (2008) Microbubbles in ultrasound-triggered drug and gene delivery. Adv Drug Deliv Rev 60:1153–1166PubMedPubMedCentralCrossRef

74.

Stride E (2015) Physical principles of microbubbles for ultrasound imaging and therapy. Front Neurol Neurosci 36:11–22PubMedCrossRef

75.

Kinoshita M, Hynynen K (2007) Key factors that affect sonoporation efficiency in in vitro settings: the importance of standing wave in sonoporation. Biochem Biophys Res Commun 359:860–865PubMedPubMedCentralCrossRef

76.

Phenix CP, Togtema M, Pichardo S et al (2014) High intensity focused ultrasound technology, its scope and applications in therapy and drug delivery. J Pharm Pharm Sci 17:136–153PubMedCrossRef

77.

Yan F, Li L, Deng Z et al (2013) Paclitaxel-liposome-microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers. J Control Release 166:246–255PubMedCrossRef

78.

Nittayacharn P, Nasongkla N (2017) Development of self-forming doxorubicin-loaded polymeric depots as an injectable drug delivery system for liver cancer chemotherapy. J Mater Sci Mater Med 28:101PubMedCrossRef

79.

Nesbitt H, Sheng Y, Kamila S et al (2018) Gemcitabine loaded microbubbles for targeted chemo-sonodynamic therapy of pancreatic cancer. J Control Release 279:8–16PubMedCrossRef

80.

Li F, Jin L, Wang H et al (2014) The dual effect of ultrasound-targeted microbubble destruction in mediating recombinant adeno-associated virus delivery in renal cell carcinoma: transfection enhancement and tumor inhibition. J Gene Med 16:28–39PubMedCrossRef

81.

Liu H, Chang S, Sun J et al (2014) Ultrasound-mediated destruction of LHRHa-targeted and paclitaxel-loaded lipid microbubbles induces proliferation inhibition and apoptosis in ovarian cancer cells. Mol Pharm 11:40–48PubMedCrossRef

Titel: Translational research in pediatric contrast-enhanced ultrasound
verfasst von: Anush Sridharan
Misun Hwang
Shelby Kutty
M. Beth McCarville
Harriet J. Paltiel
Maciej Piskunowicz
Sphoorti Shellikeri
Elizabeth Silvestro
George A. Taylor
Ryne A. Didier
Publikationsdatum: 15.05.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Radiology / Ausgabe 12/2021
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-021-05095-8

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Translational research in pediatric contrast-enhanced ultrasound

Abstract

Neu im Fachgebiet Radiologie

Akuter Schwindel: Wann lohnt sich eine MRT?

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Radiologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 12/2021

Contrast-enhanced ultrasound: a comprehensive review of safety in children

Ultrasound contrast agents: microbubbles made simple for the pediatric radiologist

Emerging contrast-enhanced ultrasound applications in children

Contrast-enhanced ultrasound of the pediatric bowel

Starting a pediatric contrast ultrasound service: made simple!

Contrast-enhanced ultrasound of blunt abdominal trauma in children

Neu im Fachgebiet Radiologie

Akuter Schwindel: Wann lohnt sich eine MRT?

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Radiologie