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Erschienen in: Skeletal Radiology 3/2007

01.03.2007 | Case Report

Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor

verfasst von: Michael Kyriakos, Georges Y. El-Khoury, Douglas J. McDonald, Joseph A. Buckwalter, Murali Sundaram, Barry DeYoung, Michael P. O’Brien

Erschienen in: Skeletal Radiology | Ausgabe 3/2007

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Abstract

Two adult patients are described with multifocal osteolytic lesions radiologically simulating a vascular tumor. One patient had multiple bones involved. Histologically, the individual lesions had the features of the nidus of osteoid osteoma/osteoblastoma. A review of the English language medical literature yielded only one other reported case with similar features. The process is designated as osteoblastomatosis to indicate its bone-forming character, prominent osteoblast proliferation, and multiplicity. The cases are distinguished from multifocal/multicentric osteoid osteoma and osteoblastoma, and from benign and malignant vascular tumors.
Literatur
1.
Zurück zum Zitat Dorfman HD, Czerniak B. Bone tumors. St. Louis: CV Mosby; 1998. p. 441–481 Dorfman HD, Czerniak B. Bone tumors. St. Louis: CV Mosby; 1998. p. 441–481
2.
Zurück zum Zitat Mirra JM. Bone tumors. Clinical, radiologic, and pathologic correlations. Philadephia:Lea & Febiger; 1989 Mirra JM. Bone tumors. Clinical, radiologic, and pathologic correlations. Philadephia:Lea & Febiger; 1989
3.
Zurück zum Zitat Mulder JD, Kroon HM, Schütte HE, Taconis WK. Radiologic atlas of bone tumors. Amsterdam: Elsevier; 1993 Mulder JD, Kroon HM, Schütte HE, Taconis WK. Radiologic atlas of bone tumors. Amsterdam: Elsevier; 1993
4.
Zurück zum Zitat Schajowicz F. Tumors and tumorlike lesions of bone. Pathology, radiology, and treatment. 2nd edition. Berlin:Springer; 1994 Schajowicz F. Tumors and tumorlike lesions of bone. Pathology, radiology, and treatment. 2nd edition. Berlin:Springer; 1994
5.
Zurück zum Zitat Unni KK. Dahlin’s bone tumors. General aspects and data on 11,087 cases. 5th ed. Philadelphia:Lippincott-Raven; 1996 Unni KK. Dahlin’s bone tumors. General aspects and data on 11,087 cases. 5th ed. Philadelphia:Lippincott-Raven; 1996
6.
Zurück zum Zitat Jaffe HL. Benign osteoblastoma. Bull Hosp JT Dis 1956;17:141–151 Jaffe HL. Benign osteoblastoma. Bull Hosp JT Dis 1956;17:141–151
7.
Zurück zum Zitat Lichtenstein L. Benign osteoblastoma. A category of osteoid- and bone-forming tumors other than classical osteoid osteoma, which may be mistaken for giant-cell tumor or osteogenic sarcoma. Cancer 1956;9:1044–1052PubMedCrossRef Lichtenstein L. Benign osteoblastoma. A category of osteoid- and bone-forming tumors other than classical osteoid osteoma, which may be mistaken for giant-cell tumor or osteogenic sarcoma. Cancer 1956;9:1044–1052PubMedCrossRef
8.
Zurück zum Zitat Resnick D, Kyriakos M, Greenway GD. Tumors and tumor-like lesions of bone: imaging and pathology of specific lesions. In: Resnick D, editor. Diagnosis of bone and joint disorders. 4th ed. Philadelphia:WB Saunders; 2002 Resnick D, Kyriakos M, Greenway GD. Tumors and tumor-like lesions of bone: imaging and pathology of specific lesions. In: Resnick D, editor. Diagnosis of bone and joint disorders. 4th ed. Philadelphia:WB Saunders; 2002
9.
Zurück zum Zitat Dahlin DC, Johnson EW Jr. Giant osteoid osteoma. J Bone Joint Surg Am 1954;36:559–572PubMed Dahlin DC, Johnson EW Jr. Giant osteoid osteoma. J Bone Joint Surg Am 1954;36:559–572PubMed
10.
Zurück zum Zitat Jaffe HL. “Osteoid-osteoma” A benign osteoblastic tumor composed of osteoid and atypical bone. Arch Surg 1935;31:709–728 Jaffe HL. “Osteoid-osteoma” A benign osteoblastic tumor composed of osteoid and atypical bone. Arch Surg 1935;31:709–728
11.
Zurück zum Zitat McLeod RA, Dahlin DC, Beabout JW. The spectrum of osteoblastoma. Am J Roentgenol 1976;126:321–335 McLeod RA, Dahlin DC, Beabout JW. The spectrum of osteoblastoma. Am J Roentgenol 1976;126:321–335
12.
Zurück zum Zitat Lucas DR, Unni KK, McLeod RA, O’Connor MI, Sim FH. Osteoblastoma: clinicopathologic study of 306 cases. Hum Pathol 1994;25:117–134PubMedCrossRef Lucas DR, Unni KK, McLeod RA, O’Connor MI, Sim FH. Osteoblastoma: clinicopathologic study of 306 cases. Hum Pathol 1994;25:117–134PubMedCrossRef
13.
Zurück zum Zitat Lichtenstein L, Sawyer WR. Benign osteoblastoma. Further observations and report of twenty additional cases. J Bone Joint Surg Am 1964;46:755–765PubMed Lichtenstein L, Sawyer WR. Benign osteoblastoma. Further observations and report of twenty additional cases. J Bone Joint Surg Am 1964;46:755–765PubMed
14.
Zurück zum Zitat O’Connell JX, Rosenthal DI, Mankin HJ, Gudger GK, Dickersin GR, Schiller AL, Rosenberg AE. A unique multifocal osteoblastoma-like tumor of the bones of a single lower extremity. Report of a case. J Bone Joint Surg Am 1993;75:597–602PubMed O’Connell JX, Rosenthal DI, Mankin HJ, Gudger GK, Dickersin GR, Schiller AL, Rosenberg AE. A unique multifocal osteoblastoma-like tumor of the bones of a single lower extremity. Report of a case. J Bone Joint Surg Am 1993;75:597–602PubMed
15.
Zurück zum Zitat Dorfman HD, Weiss SW. Borderline osteoblastic tumors: problems in the differential diagnosis of aggressive osteoblastoma and low-grade osteosarcoma. Semin Diagn Pathol 1984;1:215–234PubMed Dorfman HD, Weiss SW. Borderline osteoblastic tumors: problems in the differential diagnosis of aggressive osteoblastoma and low-grade osteosarcoma. Semin Diagn Pathol 1984;1:215–234PubMed
16.
Zurück zum Zitat Greenspan A. Benign bone-forming lesions: osteoma, osteoid osteoma, and osteoblastoma. Clinical, imaging, pathologic, and differential considerations. Skeletal Radiol 1993;22:485–500PubMed Greenspan A. Benign bone-forming lesions: osteoma, osteoid osteoma, and osteoblastoma. Clinical, imaging, pathologic, and differential considerations. Skeletal Radiol 1993;22:485–500PubMed
17.
Zurück zum Zitat Schajowicz F, Lemos C. Osteoid osteoma and osteoblastoma. Closely related entities of osteoblastic derivation. Acta Orthop Scand 1970;41:272–291PubMedCrossRef Schajowicz F, Lemos C. Osteoid osteoma and osteoblastoma. Closely related entities of osteoblastic derivation. Acta Orthop Scand 1970;41:272–291PubMedCrossRef
18.
Zurück zum Zitat Glynn JJ, Lichtenstein L. Osteoid-osteoma with multicentric nidus. A report of two cases. J Bone Joint Surg Am 1973;55:855–858PubMed Glynn JJ, Lichtenstein L. Osteoid-osteoma with multicentric nidus. A report of two cases. J Bone Joint Surg Am 1973;55:855–858PubMed
19.
Zurück zum Zitat Alcalay M, Clarac J-P, Bontoux D. Double osteoid-osteoma in adjacent carpal bones. A case report. J Bone Joint Surg Am 1982;64:779–780PubMed Alcalay M, Clarac J-P, Bontoux D. Double osteoid-osteoma in adjacent carpal bones. A case report. J Bone Joint Surg Am 1982;64:779–780PubMed
20.
Zurück zum Zitat Keim HA, Reina EG. Osteoid-osteoma as a cause of scoliosis. J Bone Joint Surg Am 1975;57:159–163PubMed Keim HA, Reina EG. Osteoid-osteoma as a cause of scoliosis. J Bone Joint Surg Am 1975;57:159–163PubMed
21.
Zurück zum Zitat Sherman MS. Osteoid osteoma. Review of the literature and report of thirty cases. J Bone Joint Surg 1947;29:918–930PubMed Sherman MS. Osteoid osteoma. Review of the literature and report of thirty cases. J Bone Joint Surg 1947;29:918–930PubMed
22.
Zurück zum Zitat Lapidus PW, Salem EP. Osteoid osteoma. Report of a case with probable double lesion. Arch Surg 1949;58:318–327PubMed Lapidus PW, Salem EP. Osteoid osteoma. Report of a case with probable double lesion. Arch Surg 1949;58:318–327PubMed
23.
Zurück zum Zitat Greenspan A, Elguezabel A, Bryk D. Multifocal osteoid osteoma. A case report and review of the literature. Am J Roentgenol 1974;121:103–106 Greenspan A, Elguezabel A, Bryk D. Multifocal osteoid osteoma. A case report and review of the literature. Am J Roentgenol 1974;121:103–106
24.
Zurück zum Zitat O’Dell CW Jr, Resnick D, Niwayama G, Goergen TG, Linovitz RJ. Osteoid osteomas arising in adjacent bones: Report of a case. J Can Assoc Radiol 1976;27:298–300PubMed O’Dell CW Jr, Resnick D, Niwayama G, Goergen TG, Linovitz RJ. Osteoid osteomas arising in adjacent bones: Report of a case. J Can Assoc Radiol 1976;27:298–300PubMed
25.
Zurück zum Zitat Ghiam GF, Bora FW Jr. Osteoid osteoma of the carpal bones. J Hand Surg 1978;3:280–283 Ghiam GF, Bora FW Jr. Osteoid osteoma of the carpal bones. J Hand Surg 1978;3:280–283
26.
Zurück zum Zitat Rand JA, Sim FH, Unni KK. Two osteoid-osteomas in one patient. A case report. J Bone Joint Surg Am 1982;64:1243PubMed Rand JA, Sim FH, Unni KK. Two osteoid-osteomas in one patient. A case report. J Bone Joint Surg Am 1982;64:1243PubMed
27.
Zurück zum Zitat Calderoni P, Gusella A, Martucci E. Multiple osteoid osteoma in the 7th dorsal vertebra. Ital J Orthop Traumatol 1984;10:257–260PubMed Calderoni P, Gusella A, Martucci E. Multiple osteoid osteoma in the 7th dorsal vertebra. Ital J Orthop Traumatol 1984;10:257–260PubMed
28.
29.
Zurück zum Zitat Keret D, Harcke HT, MacEwen GD, Bowen JR. Multiple osteoid osteomas of the fifth lumbar vertebra. A case report. Clin Orthop 1989;248:163–168PubMed Keret D, Harcke HT, MacEwen GD, Bowen JR. Multiple osteoid osteomas of the fifth lumbar vertebra. A case report. Clin Orthop 1989;248:163–168PubMed
30.
Zurück zum Zitat Allieu Y, Lussiez B, Benichou M, Cenac P. A double nidus osteoid osteoma in a finger. J Hand Surg [Am] 1989;14:538–541 Allieu Y, Lussiez B, Benichou M, Cenac P. A double nidus osteoid osteoma in a finger. J Hand Surg [Am] 1989;14:538–541
31.
Zurück zum Zitat Asada Y, Suzuki I, Suzuki M, Fukushima M. Atypical multiple benign osteoblastomas accompanied by simple bone cysts. A case report. J Craniomaxillofac Surg 1991;19:166–171, 1991PubMed Asada Y, Suzuki I, Suzuki M, Fukushima M. Atypical multiple benign osteoblastomas accompanied by simple bone cysts. A case report. J Craniomaxillofac Surg 1991;19:166–171, 1991PubMed
32.
Zurück zum Zitat Muren C, Höglund M, Engkvist O, Juhlin L. Osteoid osteomas of the hand. Report of three cases and review of the literature. Acta Radiol 1991;32:62–66PubMedCrossRef Muren C, Höglund M, Engkvist O, Juhlin L. Osteoid osteomas of the hand. Report of three cases and review of the literature. Acta Radiol 1991;32:62–66PubMedCrossRef
33.
Zurück zum Zitat Nelson MC, Lack EE, Freedman MT. Case report 856. Multifocal osteoid osteoma in a 2.5-year-old child. Skeletal Radiol 1994;23:465–467PubMedCrossRef Nelson MC, Lack EE, Freedman MT. Case report 856. Multifocal osteoid osteoma in a 2.5-year-old child. Skeletal Radiol 1994;23:465–467PubMedCrossRef
34.
Zurück zum Zitat Schai P, Friederich N, Krüger A, Jundt G, Herbe E, Buess P. Discrete synchronous multifocal osteoid osteoma of the humerus. Skeletal Radiol 1996;25:667–670PubMedCrossRef Schai P, Friederich N, Krüger A, Jundt G, Herbe E, Buess P. Discrete synchronous multifocal osteoid osteoma of the humerus. Skeletal Radiol 1996;25:667–670PubMedCrossRef
35.
Zurück zum Zitat Gonzalez G, Abril JC, Mediero IG, Epeldegui T. Osteoid osteoma with a multicentric nidus. Int Orthop 1996;20:61–63PubMedCrossRef Gonzalez G, Abril JC, Mediero IG, Epeldegui T. Osteoid osteoma with a multicentric nidus. Int Orthop 1996;20:61–63PubMedCrossRef
36.
Zurück zum Zitat Zmurko MG, Mott MP, Lucas DR, Hamre MR, Miller PR. Multicentric osteoid osteoma. Orthopedics 2004;27:1294–1296PubMed Zmurko MG, Mott MP, Lucas DR, Hamre MR, Miller PR. Multicentric osteoid osteoma. Orthopedics 2004;27:1294–1296PubMed
37.
Zurück zum Zitat Jaffe HL, Mayer L. An osteoblastic osteoid tissue-forming tumor of a metacarpal bone. Arch Surg 1932;24:550–564 Jaffe HL, Mayer L. An osteoblastic osteoid tissue-forming tumor of a metacarpal bone. Arch Surg 1932;24:550–564
38.
Zurück zum Zitat Sinha S, Housden P. Discrete synchoronous multifocal osteoid osteoma of the femur. Pediatr Radiol 2004;34:280PubMedCrossRef Sinha S, Housden P. Discrete synchoronous multifocal osteoid osteoma of the femur. Pediatr Radiol 2004;34:280PubMedCrossRef
39.
Zurück zum Zitat Chiou Y-Y, Rosenthal DI, Rosenberg AE. “Beaded” osteoid osteoma: a possible transition between solitary and multicentric tumor. Skeletal Radiol 2003;32:412–415PubMedCrossRef Chiou Y-Y, Rosenthal DI, Rosenberg AE. “Beaded” osteoid osteoma: a possible transition between solitary and multicentric tumor. Skeletal Radiol 2003;32:412–415PubMedCrossRef
40.
Zurück zum Zitat Kenan S, Abdelwahab IF, Klein MJ, Hermann G, Lewis MM. Case report 864. Elliptical, multicentric periosteal osteoid osteoma. Skeletal Radiol 1994;23:565–568PubMed Kenan S, Abdelwahab IF, Klein MJ, Hermann G, Lewis MM. Case report 864. Elliptical, multicentric periosteal osteoid osteoma. Skeletal Radiol 1994;23:565–568PubMed
41.
Zurück zum Zitat Larsen LJ, Mall JC, Ichtertz DF. Metachronous osteoid-osteomas. Report of a case. J Bone Joint Surg Am 1991;73:612–614PubMed Larsen LJ, Mall JC, Ichtertz DF. Metachronous osteoid-osteomas. Report of a case. J Bone Joint Surg Am 1991;73:612–614PubMed
42.
Zurück zum Zitat Bullough, PG, Schneider, R. Case 12. International Skeletal Society Meeting, Singapore, 2005 Bullough, PG, Schneider, R. Case 12. International Skeletal Society Meeting, Singapore, 2005
43.
Zurück zum Zitat Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma. A vascular tumor often mistaken for a carcinoma. Cancer 1982;50:970–981PubMedCrossRef Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma. A vascular tumor often mistaken for a carcinoma. Cancer 1982;50:970–981PubMedCrossRef
44.
Zurück zum Zitat Kleer CG, Unni KK, McLeod RA. Epithelioid hemangioendothelioma of bone. Am J Surg Pathol 1996;20:1301–1311PubMedCrossRef Kleer CG, Unni KK, McLeod RA. Epithelioid hemangioendothelioma of bone. Am J Surg Pathol 1996;20:1301–1311PubMedCrossRef
45.
Zurück zum Zitat Tsuneyoshi M, Dorfman HD, Bauer TW. Epithelioid hemangioendothelioma of bone. A clinicopathologic, ultrastructural, and immonohistochemical study. Am J Surg Pathol 1986;10:754–764PubMedCrossRef Tsuneyoshi M, Dorfman HD, Bauer TW. Epithelioid hemangioendothelioma of bone. A clinicopathologic, ultrastructural, and immonohistochemical study. Am J Surg Pathol 1986;10:754–764PubMedCrossRef
46.
Zurück zum Zitat O’Connell JX, Kattapuram SV, Mankin HJ, Bhan AK, Rosenberg AE. Epithelioid hemangioma of bone. A tumor often mistaken for low-grade angiosarcoma or malignant hemangioendothelioma. Am J Surg Pathol 1993;17:610–617PubMedCrossRef O’Connell JX, Kattapuram SV, Mankin HJ, Bhan AK, Rosenberg AE. Epithelioid hemangioma of bone. A tumor often mistaken for low-grade angiosarcoma or malignant hemangioendothelioma. Am J Surg Pathol 1993;17:610–617PubMedCrossRef
47.
Zurück zum Zitat Wenger DE, Wold LE. Benign vascular lesions of bone: radiologic and pathologic features. Skeletal Radiol 2000;29:63–74PubMedCrossRef Wenger DE, Wold LE. Benign vascular lesions of bone: radiologic and pathologic features. Skeletal Radiol 2000;29:63–74PubMedCrossRef
48.
Zurück zum Zitat Levey DS, MacCormack LM, Sartoris DJ, Haghighi P, Resnick D, Thorne R. Cystic angiomatosis: case report and review of the literature. Skeletal Radiol 1996;25:287–293PubMedCrossRef Levey DS, MacCormack LM, Sartoris DJ, Haghighi P, Resnick D, Thorne R. Cystic angiomatosis: case report and review of the literature. Skeletal Radiol 1996;25:287–293PubMedCrossRef
49.
Zurück zum Zitat Schajowicz F, Aiello CL, Francone MV, Giannini RE. Cystic angiomatosis (hamartous haemolymphangiomatosis) of bone. A clinicopathological study of three cases. J Bone Joint Surg Br 1978;60:100–106PubMed Schajowicz F, Aiello CL, Francone MV, Giannini RE. Cystic angiomatosis (hamartous haemolymphangiomatosis) of bone. A clinicopathological study of three cases. J Bone Joint Surg Br 1978;60:100–106PubMed
50.
Zurück zum Zitat Gutierrez RM, Spjut HJ. Skeletal angiomatosis. Report of three cases and review of the literature. Clin Orthop 1972;85:82–97PubMedCrossRef Gutierrez RM, Spjut HJ. Skeletal angiomatosis. Report of three cases and review of the literature. Clin Orthop 1972;85:82–97PubMedCrossRef
51.
Zurück zum Zitat Ishida T, Dorfman HD, Steiner CG, Norman A. Cystic angiomatosis of bone with sclerotic changes mimicking osteoblastic metastases. Skeletal Radiol 1994;23:247–252PubMedCrossRef Ishida T, Dorfman HD, Steiner CG, Norman A. Cystic angiomatosis of bone with sclerotic changes mimicking osteoblastic metastases. Skeletal Radiol 1994;23:247–252PubMedCrossRef
Metadaten
Titel
Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor
verfasst von
Michael Kyriakos
Georges Y. El-Khoury
Douglas J. McDonald
Joseph A. Buckwalter
Murali Sundaram
Barry DeYoung
Michael P. O’Brien
Publikationsdatum
01.03.2007
Verlag
Springer-Verlag
Erschienen in
Skeletal Radiology / Ausgabe 3/2007
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-006-0113-5

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