Erschienen in:
01.08.2010 | Perspective
Perspective: the bone-fat connection
verfasst von:
Miriam A. Bredella
Erschienen in:
Skeletal Radiology
|
Ausgabe 8/2010
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Excerpt
Bone strength depends on bone mineral density (BMD) and bone quality [
1]. While BMD is typically the single best predictor of trabecular bone strength, other factors, such as bone microarchitecture or composition of bone marrow, play important roles in the determination of ultimate bone strength. In this regard attention has been focused on bone marrow fat and its role in bone strength and fracture risk. Bone marrow fat negatively affects the biomechanical strength of bone as fatty marrow is a weaker biomechanical support medium than hematopoietic marrow. Higher vertebral marrow fat content has been found in subjects with morphologic evidence of bone weakness, such as endplate depression, or compression fractures, and age-related bone loss is associated with progressive infiltration of bone marrow by fat [
2,
3]. …