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Erschienen in: Skeletal Radiology 8/2010

01.08.2010 | Perspective

Perspective: the bone-fat connection

verfasst von: Miriam A. Bredella

Erschienen in: Skeletal Radiology | Ausgabe 8/2010

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Excerpt

Bone strength depends on bone mineral density (BMD) and bone quality [1]. While BMD is typically the single best predictor of trabecular bone strength, other factors, such as bone microarchitecture or composition of bone marrow, play important roles in the determination of ultimate bone strength. In this regard attention has been focused on bone marrow fat and its role in bone strength and fracture risk. Bone marrow fat negatively affects the biomechanical strength of bone as fatty marrow is a weaker biomechanical support medium than hematopoietic marrow. Higher vertebral marrow fat content has been found in subjects with morphologic evidence of bone weakness, such as endplate depression, or compression fractures, and age-related bone loss is associated with progressive infiltration of bone marrow by fat [2, 3]. …
Literatur
1.
Zurück zum Zitat Osteoporosis prevention, diagnosis, and therapy. NIH Consens Statement. 2000;17:1–36. Osteoporosis prevention, diagnosis, and therapy. NIH Consens Statement. 2000;17:1–36.
2.
Zurück zum Zitat Schellinger D, Lin CS, Fertikh D, et al. Normal lumbar vertebrae: anatomic, age, and sex variance in subjects at proton MR spectroscopy–initial experience. Radiology. 2000;215:910–6.PubMed Schellinger D, Lin CS, Fertikh D, et al. Normal lumbar vertebrae: anatomic, age, and sex variance in subjects at proton MR spectroscopy–initial experience. Radiology. 2000;215:910–6.PubMed
3.
Zurück zum Zitat Schellinger D, Lin CS, Lim J, Hatipoglu HG, Pezzullo JC, Singer AJ. Bone marrow fat and bone mineral density on proton MR spectroscopy and dual-energy X-ray absorptiometry: their ratio as a new indicator of bone weakening. AJR Am J Roentgenol. 2004;183:1761–5.PubMed Schellinger D, Lin CS, Lim J, Hatipoglu HG, Pezzullo JC, Singer AJ. Bone marrow fat and bone mineral density on proton MR spectroscopy and dual-energy X-ray absorptiometry: their ratio as a new indicator of bone weakening. AJR Am J Roentgenol. 2004;183:1761–5.PubMed
4.
Zurück zum Zitat Gimble JM, Zvonic S, Floyd ZE, Kassem M, Nuttall ME. Playing with bone and fat. J Cell Biochem. 2006;98:251–66.CrossRefPubMed Gimble JM, Zvonic S, Floyd ZE, Kassem M, Nuttall ME. Playing with bone and fat. J Cell Biochem. 2006;98:251–66.CrossRefPubMed
5.
Zurück zum Zitat Rosen CJ, Ackert-Bicknell C, Rodriguez JP, Pino AM. Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Crit Rev Eukaryot Gene Expr. 2009;19:109–24.PubMed Rosen CJ, Ackert-Bicknell C, Rodriguez JP, Pino AM. Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Crit Rev Eukaryot Gene Expr. 2009;19:109–24.PubMed
6.
Zurück zum Zitat Rozman C, Feliu E, Berga L, Reverter JC, Climent C, Ferran MJ. Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereological study. Exp Hematol. 1989;17:34–7.PubMed Rozman C, Feliu E, Berga L, Reverter JC, Climent C, Ferran MJ. Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereological study. Exp Hematol. 1989;17:34–7.PubMed
7.
Zurück zum Zitat Post S, Abdallah BM, Bentzon JF, Kassem M. Demonstration of the presence of independent pre-osteoblastic and pre-adipocytic cell populations in bone marrow-derived mesenchymal stem cells. Bone. 2008;43:32–9.CrossRefPubMed Post S, Abdallah BM, Bentzon JF, Kassem M. Demonstration of the presence of independent pre-osteoblastic and pre-adipocytic cell populations in bone marrow-derived mesenchymal stem cells. Bone. 2008;43:32–9.CrossRefPubMed
8.
Zurück zum Zitat Dang ZC, van Bezooijen RL, Karperien M, Papapoulos SE, Lowik CW. Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis. J Bone Miner Res. 2002;17:394–405.CrossRefPubMed Dang ZC, van Bezooijen RL, Karperien M, Papapoulos SE, Lowik CW. Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis. J Bone Miner Res. 2002;17:394–405.CrossRefPubMed
9.
Zurück zum Zitat Rzonca SO, Suva LJ, Gaddy D, Montague DC, Lecka-Czernik B. Bone is a target for the antidiabetic compound rosiglitazone. Endocrinology. 2004;145:401–6.CrossRefPubMed Rzonca SO, Suva LJ, Gaddy D, Montague DC, Lecka-Czernik B. Bone is a target for the antidiabetic compound rosiglitazone. Endocrinology. 2004;145:401–6.CrossRefPubMed
10.
Zurück zum Zitat Akune T, Ohba S, Kamekura S, et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest. 2004;113:846–55.PubMed Akune T, Ohba S, Kamekura S, et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest. 2004;113:846–55.PubMed
11.
Zurück zum Zitat Mazziotti G, Angeli A, Bilezikian JP, Canalis E, Giustina A. Glucocorticoid-induced osteoporosis: an update. Trends Endocrinol Metab. 2006;17:144–9.CrossRefPubMed Mazziotti G, Angeli A, Bilezikian JP, Canalis E, Giustina A. Glucocorticoid-induced osteoporosis: an update. Trends Endocrinol Metab. 2006;17:144–9.CrossRefPubMed
12.
Zurück zum Zitat Kuiper JW, van Kuijk C, Grashuis JL, Ederveen AG, Schutte HE. Accuracy and the influence of marrow fat on quantitative CT and dual-energy X-ray absorptiometry measurements of the femoral neck in vitro. Osteoporos Int. 1996;6:25–30.CrossRefPubMed Kuiper JW, van Kuijk C, Grashuis JL, Ederveen AG, Schutte HE. Accuracy and the influence of marrow fat on quantitative CT and dual-energy X-ray absorptiometry measurements of the femoral neck in vitro. Osteoporos Int. 1996;6:25–30.CrossRefPubMed
13.
Zurück zum Zitat Schellinger D, Lin CS, Hatipoglu HG, Fertikh D. Potential value of vertebral proton MR spectroscopy in determining bone weakness. AJNR Am J Neuroradiol. 2001;22:1620–7.PubMed Schellinger D, Lin CS, Hatipoglu HG, Fertikh D. Potential value of vertebral proton MR spectroscopy in determining bone weakness. AJNR Am J Neuroradiol. 2001;22:1620–7.PubMed
14.
Zurück zum Zitat Bredella MA, Fazeli PK, Miller KK, et al. Increased bone marrow fat in anorexia nervosa. J Clin Endocrinol Metab. 2009;94:2129–36.CrossRefPubMed Bredella MA, Fazeli PK, Miller KK, et al. Increased bone marrow fat in anorexia nervosa. J Clin Endocrinol Metab. 2009;94:2129–36.CrossRefPubMed
15.
Zurück zum Zitat Gilsanz V, Chalfant J, Mo AO, Lee DC, Dorey FJ, Mittelman SD. Reciprocal relations of subcutaneous and visceral fat to bone structure and strength. J Clin Endocrinol Metab. 2009;94:3387–93. Gilsanz V, Chalfant J, Mo AO, Lee DC, Dorey FJ, Mittelman SD. Reciprocal relations of subcutaneous and visceral fat to bone structure and strength. J Clin Endocrinol Metab. 2009;94:3387–93.
16.
Zurück zum Zitat von Muhlen D, Safii S, Jassal SK, Svartberg J, Barrett-Connor E. Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study. Osteoporos Int. 2007;18:1337–44.CrossRef von Muhlen D, Safii S, Jassal SK, Svartberg J, Barrett-Connor E. Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study. Osteoporos Int. 2007;18:1337–44.CrossRef
17.
Zurück zum Zitat Papakitsou EF, Margioris AN, Dretakis KE, et al. Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women. Maturitas. 2004;47:185–93.CrossRefPubMed Papakitsou EF, Margioris AN, Dretakis KE, et al. Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women. Maturitas. 2004;47:185–93.CrossRefPubMed
18.
Zurück zum Zitat Bredella MA, Torriani M, Hosseini Ghomi R, et al. Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women. Obesity. 2010 (in press). Bredella MA, Torriani M, Hosseini Ghomi R, et al. Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women. Obesity. 2010 (in press).
Metadaten
Titel
Perspective: the bone-fat connection
verfasst von
Miriam A. Bredella
Publikationsdatum
01.08.2010
Verlag
Springer-Verlag
Erschienen in
Skeletal Radiology / Ausgabe 8/2010
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-010-0936-y

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