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CardioVascular and Interventional Radiology

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01.08.2011 | Laboratory Investigation

Adrenal Radiofrequency Ablation in Swine: Change in Blood Pressure and Histopathologic Analysis

verfasst von: Koichiro Yamakado, Haruyuki Takaki, Katsunori Uchida, Atsuhiro Nakatsuka, Taizo Shiraishi, Kan Takeda

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 4/2011

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Abstract

Purpose

To evaluate changes in blood pressure during adrenal radiofrequency ablation (RFA) and analyze histopathologic outcomes in swine adrenal glands.

Materials and Methods

Animal Care Committee approval was obtained for this study. After laparotomy, a single adrenal gland was ablated from each of six animals (six RF sessions total). An internally cooled-tip RF electrode was placed along the long axis of the adrenal gland, and RF energy was applied for 10 min in each adrenal gland. Blood pressure and heart rate were monitored, and serum epinephrine, norepinephrine, and cortisol levels were measured before, during, and after RFA. Histological study was performed using hematoxylin-eosin staining.

Results

RFA was completed according to a planned protocol in all adrenal glands. Blood pressure increased to >200 mm Hg after an increase in heart rate during all six RF sessions. Mean serum epinephrine and norepinephrine levels increased significantly during RFA. However, mean cortisol levels showed no significant increase during or after RFA. Histological studies showed adrenal cell necrosis throughout the adrenal glands in all but one pig, with the mean necrosis rate being 99.1 ± 2.3% (range 94.3–100%).

Conclusion

Adrenal RFA causes extensive adrenal cell damage and causes catecholamine-induced hypertension.

Livraghi T, Goldberg SN, Lazzaroni S et al (2000) Hepatocellular carcinoma: radio-frequency ablation of medium and large lesions. Radiology 214(3):761–768PubMed

Yamakado K, Hase S, Matsuoka T et al (2007) Radiofrequency ablation for the treatment of unrespectable lung metastases in patients with colorectal cancer: a multicenter study in Japan. J Vasc Interv Radiol 18(3):393–398PubMedCrossRef

Gervais DA, McGovern FJ, Arellano RS, McDougal WS, Mueller PR (2003) Renal cell carcinoma: clinical experience and technical success with radio-frequency ablation of 42 tumors. Radiology 226(2):417–424PubMedCrossRef

Nakatsuka A, Yamakado K, Maeda M et al (2004) Radiofrequency ablation combined with bone cement injection for the treatment of bone malignancies. J Vasc Interv Radiol 15(7):707–712PubMed

Wood BJ, Abraham J, Hvizda JL, Alexander HR, Fojo T (2003) Radiofrequency ablation of adrenal tumors and adrenocortical carcinoma metastases. Cancer 97(3):554–560PubMedCrossRef

Mayo-Smith WW, Dupuy DE (2004) Adrenal neoplasms: CT-guided radiofrequency ablation―Preliminary results. Radiology 231(1):225–230PubMedCrossRef

Yamakado K, Anai H, Takaki H et al (2009) Adrenal metastasis from hepatocellular carcinoma: radiofrequency ablation combined with adrenal arterial chemoembolization in six patients. AJR Am J Roentgenol 192(6):300–305CrossRef

Lo WK, van Sonnenberg E, Shankar S et al (2006) Percutaneous CT-guided radiofrequency ablation of symptomatic bilateral adrenal metastases in a single session. J Vasc Interv Radiol 17(1):175–179PubMedCrossRef

Chini EN, Brown MJ, Farrell MA, Charboneau JW (2004) Hypertensive crisis in a patient undergoing percutaneous radiofrequency ablation of an adrenal mass under general anesthesia. Anesth Analg 99(6):1867–1869PubMedCrossRef

10.

Arima K, Yamakado K, Suzuki R et al (2007) Image-guided radiofrequency ablation for adrenocortical adenoma with cushing syndrome: outcomes after mean follow-up of 33 months. Urology 70(3):407–411PubMedCrossRef

11.

Al-Shaikh AA, Al-Rawas MM, Al-Asnag MA (2004) Primary hyperaldosteronism treated by radiofrequency ablation. Saudi Med J 25(11):1711–1714PubMed

12.

Johnson SP, Bagrosky BM, Mitchell EL, McIntyre RC Jr, Grant NG (2008) CT-guided radiofrequency ablation of an aldosterone-secreting primary adrenal tumor in a surgically unfit patient. J Vasc Interv Radiol 19(7):1115–1117PubMedCrossRef

13.

Onik G, Onik C, Medary I et al (2003) Life-threatening hypertensive crises in two patients undergoing hepatic radiofrequency ablation. AJR Am J Roentgenol 181(2):495–497PubMed

14.

Keeling AN, Sabharwal T, Allen MJ, Hegarty NJ, Adam A (2009) Hypertensive crisis during radiofrequency ablation of the adrenal gland. J Vasc Interv Radiol 20(7):990–991PubMedCrossRef

15.

Itoh T, Orba Y, Takei H et al (2002) Immunohistochemical detection of hepatocellular carcinoma in the setting of ongoing necrosis after radiofrequency ablation. Mod Pathol 15(2):110–115PubMedCrossRef

16.

Holzbauer M, Newport HM (1969) Adrenal secretion rates and adrenal tissue concentrations of pregnenolone, progesterone, 11 beta OH-androstenedione and some other steroids in young pigs and dogs. J Physiol 200(3):821–848PubMed

17.

Sillence MN, Etherton TD (1989) Chronic effects of recombinant porcine growth hormone on adrenal weight and activity in pigs. J Anim Sci 67(7):1740–1743PubMed

18.

Barrett KE, Barman SM, Boitano S, Brooks HL (2010) The adrenal medulla and adrenal cortex. In: Weitz M, Brown M (eds) Ganong’s review of medical physiology, 23rd edn. McGraw-Hill, New York, NY, pp 337–361

19.

Atwell TD, Wass CT, Charboneau JW, Callstrom MR, Farrell MA, Sengupta S (2006) Malignant hypertension during cryoablation of an adrenal gland tumor. J Vasc Interv Radiol 17(3):573–575PubMedCrossRef

20.

Sudheendra D, Wood BJ (2006) Appropriate premedication risk reduction during adrenal ablation. J Vasc Interv Radiol 17(8):1367–1368PubMedCrossRef

21.

Fransson BA, Keegan RD, Ragle CA, Haldorson GJ, Greene SA (2009) Hemodynamic changes during laparoscopic radiofrequency ablation of normal adrenal tissue in dogs. Vet Surg 38(4):490–497PubMedCrossRef

22.

Funder JW, Carey RM, Fardella C et al (2008) Endocrine society. Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 93(9):3266–3281PubMedCrossRef

23.

Stowasser M (2009) Update in primary aldosteronism. J Clin Endocrinol Metab 94(10):3623–3630PubMedCrossRef

24.

Rossi GP, Seccia TM, Pessina AC (2008) Primary aldosteronism―part I: prevalence, screening, and selection of cases for adrenal vein sampling. J Nephrol 21(4):447–454PubMed

25.

Noguchi M, Earashi M, Fujii H, Yokoyama K, Harada K, Tsuneyama K (2006) Radiofrequency ablation of small breast cancer followed by surgical resection. J Surg Oncol 93(2):120–128PubMedCrossRef

26.

Kurosumi M, Akashi-Tanaka S, Akiyama F et al (2008) Committee for production of histopathological criteria for assessment of therapeutic response of Japanese Breast Cancer Society. Histopathological criteria for assessment of therapeutic response in breast cancer (2007 version). Breast Cancer 15(1):5–7PubMedCrossRef

Titel: Adrenal Radiofrequency Ablation in Swine: Change in Blood Pressure and Histopathologic Analysis
verfasst von: Koichiro Yamakado
Haruyuki Takaki
Katsunori Uchida
Atsuhiro Nakatsuka
Taizo Shiraishi
Kan Takeda
Publikationsdatum: 01.08.2011
Verlag: Springer-Verlag
Erschienen in: CardioVascular and Interventional Radiology / Ausgabe 4/2011
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-010-0078-6

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Adrenal Radiofrequency Ablation in Swine: Change in Blood Pressure and Histopathologic Analysis