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CardioVascular and Interventional Radiology

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01.08.2015 | Laboratory Investigation

Renal Sympathetic Denervation by CT-scan-Guided Periarterial Ethanol Injection in Sheep

verfasst von: Kavous Firouznia, Sayed jaber Hosseininasab, Saeid Amanpour, Arya Haj-Mirzaian, Roza Miri, Ahad Muhammadnejad, Samad Muhammadnejad, Amir H. Jalali, Farrokhlagha Ahmadi, Hadi Rokni-Yazdi

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 4/2015

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Abstract

Background

Renal nerves are a recent target in the treatment of hypertension. Renal sympathetic denervation (RSD) is currently performed using catheter-based radiofrequency ablation (RFA) and because this method has limitations, percutaneous magnetic resonance (MR)-guided periarterial ethanol injection is a suggested alternative. However, few studies have been conducted on the effectiveness of percutaneous ethanol injection for RSD.

Aim

To evaluate the feasibility, efficacy, and complications of computed tomography (CT)-guided periarterial ethanol injection.

Methods

Ethanol (10 ml, 99.6 %) was injected around the right renal artery in six sheep under CT guidance with the left kidney serving as a control. Before and after the intervention, the sheep underwent MR imaging studies and the serum creatinine level was measured. One month after the intervention, the sheep were euthanized and norepinephrine (NE) concentration in the renal parenchyma was measured to evaluate the efficacy of the procedure. The treated tissues were also examined histopathologically to evaluate vascular, parenchymal, and neural injury.

Results

The right kidney parenchymal NE concentration decreased significantly compared with the left kidney after intervention (average reduction: 40 %, P = 0.0016). Histologic examination revealed apparent denervation with no other vascular or parenchymal injuries observed in the histological and imaging studies.

Conclusion

Effective and feasible RSD was achieved using CT-guided periarterial ethanol injection. This technique may be a potential alternative to catheter-based RFA in the treatment of hypertension.

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Titel: Renal Sympathetic Denervation by CT-scan-Guided Periarterial Ethanol Injection in Sheep
verfasst von: Kavous Firouznia
Sayed jaber Hosseininasab
Saeid Amanpour
Arya Haj-Mirzaian
Roza Miri
Ahad Muhammadnejad
Samad Muhammadnejad
Amir H. Jalali
Farrokhlagha Ahmadi
Hadi Rokni-Yazdi
Publikationsdatum: 01.08.2015
Verlag: Springer US
Erschienen in: CardioVascular and Interventional Radiology / Ausgabe 4/2015
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-015-1109-0

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Renal Sympathetic Denervation by CT-scan-Guided Periarterial Ethanol Injection in Sheep