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Seminars in Immunopathology

Erschienen in:

01.12.2006 | Review

IgA and IgA-specific receptors in human disease: structural and functional insights into pathogenesis and therapeutic potential

verfasst von: Michelle M. Gomes, Andrew B. Herr

Erschienen in: Seminars in Immunopathology | Ausgabe 4/2006

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Abstract

IgA antibodies play an important role in humoral immunity. IgA is the predominant antibody in mucosal secretions and the second most prevalent in the serum. It occupies a unique position among human antibodies in that it can both trigger and suppress inflammatory responses, depending on the situation. Recent structural and functional studies have revealed details of the structure of IgA and its interaction with key cell-surface receptors. We look at the role IgA and IgA receptors (particularly FcαRI) play in the pathogenesis of diseases such as IgA nephropathy and other autoimmune conditions. Finally, we address the potential of IgA as a therapeutic tool to either trigger specific inflammatory responses to destroy target cells or suppress inflammatory responses in the case of autoimmune diseases, and the promise of mucosal vaccines for eliciting specific IgA responses to pathogens in mucosal environments.

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Titel: IgA and IgA-specific receptors in human disease: structural and functional insights into pathogenesis and therapeutic potential
verfasst von: Michelle M. Gomes
Andrew B. Herr
Publikationsdatum: 01.12.2006
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 4/2006
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-006-0048-x

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