Multicontrast-weighted magnetic resonance imaging of atherosclerotic plaques at 3.0 and 1.5 Tesla: ex-vivo comparison with histopathologic correlation | springermedizin.de

Springer Medizin

nach oben

European Radiology

Erschienen in:

01.01.2007 | Experimental

Multicontrast-weighted magnetic resonance imaging of atherosclerotic plaques at 3.0 and 1.5 Tesla: ex-vivo comparison with histopathologic correlation

verfasst von: Andreas Koops, Harald Ittrich, Susan Petri, Andrew Priest, Alexander Stork, Ute Lockemann, Gerhard Adam, Christoph Weber

Erschienen in: European Radiology | Ausgabe 1/2007

Einloggen, um Zugang zu erhalten

Abstract

The purpose was to analyze magnetic resonance (MR) plaque imaging at 3.0 Tesla and 1.5 Tesla in correlation with histopathology. MR imaging (MRI) of the abdominal aorta and femoral artery was performed on seven corpses using T1-weighted, T2-weighted, and PD-weighted sequences at 3.0 and 1.5 Tesla. Cross-sectional images at the branching of the inferior mesenteric artery and the profunda femoris were rated with respect to image quality. Corresponding cross sections of the imaged vessels were obtained at autopsy. The atherosclerotic plaques in the histological slides and MR images were classified according to the American Heart Association (AHA) and analyzed for differences. MRI at 3.0 Tesla offered superior depiction of arterial wall composition in all contrast weightings, rated best for T2-weighted images. Comparing for field strength, the highest differences were observed in T1-weighted and T2-weighted techniques (both P≤0.001), with still significant differences in PD-weighted sequence (P≤0.005). The majority of plaques were histologically classified as calcified plaques. In up to 21% of the cases, MRI at both field strengths detected signal loss characteristic of calcification although calcified plaque was absent in histology. MRI at 3.0 Tesla offers superior plaque imaging quality compared with 1.5 Tesla, but further work is necessary to determine whether this translates in superior diagnostic accuracy.

Anzeige

1.

Falk E, Shah PK, Fuster V (1995) Coronary plaque disruption. Circulation 92:657–671PubMed

2.

Rodriguez-Granillo GA, Garcia-Garcia HM, McFadden EP, Valgimigli M, Aoki J, de Feyter P, Serruys PW (2005) In vivo intravascular ultrasound-derived thin-cap fibroatheroma detection using ultrasound radiofrequency data analysis. J Am Coll Cardiol 46:2038–2042PubMedCrossRef

3.

de Weert TT, Ouhlous M, Zondervan PE, Hendriks JM, Dippel DWJ, van Sambeek MRHM, van der Lugt A (2005) In vitro characterization of atherosclerotic carotid plaque with multidetector computed tomography and histopathological correlation. Eur Radiol 15:1906–1914PubMedCrossRef

4.

Martin AJ, Gotlieb AI, Henkelman RM (1995) High-resolution MR imaging of human arteries. J Magn Reson Imaging 5:93–100PubMedCrossRef

5.

Toussaint JF, Southern JF, Fuster V, Kantor HL (1995) T2-weighted contrast for NMR characterization of human atherosclerosis. Arterioscler Thromb Vasc Biol 15:1533–1542PubMed

6.

Yuan C, Perry C, O’Brien KD, Hatsukami TS, Eary JF, Brown BG (1997) In vitro and in situ magnetic resonance imaging signal features of atherosclerotic plaque-associated lipids. Arterioscler Thromb Vasc Biol 17:1496–1503PubMed

7.

Correia LC, Atalar E, KelemenMD, Ocali O, Hutchins GM, Fleg JL, Gerstenblith G, Zerhouni EA, Lima JA (1997) Intravascular magnetic resonance imaging of aortic atherosclerotic plaque composition. Arterioscler Thromb Vasc Biol 17:3626–3632PubMed

8.

Shinnar M, Fallon JT, Wehrli S, Levin M, Dalmacy D, Fayad ZA, Badimon JJ, Harrington M, Harrington E, Fuster V (1999) The diagnostic accuracy of ex vivo MRI for human atherosclerotic plaque characterization. Arterioscler Thromb Vasc Biol 19:2756–2761PubMed

9.

Skinner MP, Yuan C, Mitsumori L, Hayes CE, Raines EW, Nelson JA, Ross R (1995) Serial magnetic resonance imaging of experimental atherosclerosis detects lesion fine structure, progression and complication in vivo. Nat Med 1:69–73PubMedCrossRef

10.

Toussaint JF, LaMuraglia GR, Southern JF, Fuster V, Kantor HL (1996) Magnetic resonance images lipid, fibrous, calcified, hemorrhagic and thrombotic components of human atherosclerosis in vivo. Circulation 94:932–938PubMed

11.

von Ingersleben G, Schmiedl UP, Hatsukami TS, Nelson JA, Subramaniam DS, Ferguson MS, Yuan C (1997) Characterization of atherosclerotic plaques at the carotid bifurcation: correlation of high-resolution MR imaging with histologic analysis - preliminary study. Radiographics 17:1417–1423

12.

Fayad ZA, Fuster V (2000) Characterization of atherosclerotic plaques by magnetic resonance imaging. Ann N Y Acad Sci 902:173–186PubMedCrossRef

13.

Hatsukami TS, Ross R, Polissar NL, Yuan C (2000) Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in-vivo with high-resolution magnetic resonance imaging. Circulation 102:959–964PubMed

14.

Serfaty JM, Chaabane L, Tabib A, Chevallier JM, Briguet A, Douek PC (2001) Atherosclerotic plaques: classification and characterization with T2-weighted high-spatial-resolution MR imaging - an in vitro study. Radiology 219:403–410PubMed

15.

Yuan C, Mitsumori LM, Ferguson MS, Nayak L, Polissar NL, Echelard D, Ortiz G, Small R, Davies JW, Kerwin WS, Hatsukami TS (2001) In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrage in advanced human carotid plaques. Circulation 104:2051–2056PubMedCrossRef

16.

Coombs BD, Rapp JH, Ursell PC, Reilly LM, Saloner D (2001) Structure of plaque at carotid bifurcation: high-resolution MRI with histological correlation. Stroke 32:2516–2521PubMed

17.

Cai JM, Hatsukami TS, Ferguson MS, Small R, Polissar NL, Yuan C (2002) Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. Circulation 106:1368–1373PubMedCrossRef

18.

Fuster V, Badimon L, Badimon JJ, Cheseboro JH (1992) The pathogenesis of coronary artery disease and the acute coronary syndrome. N Engl J Med 326:310–318PubMedCrossRef

19.

Leiner T, Gerretsen S, Botnar R, Lutgens E, Cappendijk V, Kooi E, van Engelshoven J (2005) Magnetic resonance imaging of atherosclerosis. Eur Radiol 15:1087–1099PubMedCrossRef

20.

Stary HC, Chandler AB, Dismore RE, Fuster V, Glagov SG, Insull W, Rosenfeld ME, Schwarzt CJ, Wagner WD, Wissler RW (1995) A definition of advanced types of atherosclerosis: a report from the Committee on Vasular Lesions of the Council on Atherosclerosis. Circulation 92:1355–1374PubMed

21.

Cheng GC, Loree HM, Kamm RD, Fishbein MC, Lee RT (1993) Distribution of circumferential stress in ruptured and stable atherosclerotic lesions: a structural analysis with histopathological correlation. Circulation 87:1179–1187PubMed

22.

Wen H, Denison TJ, Singerman RW, Balaban RS (1997) The intrinsic signal-to-noise ratio in human cardiac imaging at 1.5, 3, and 4 T. J Magn Reson 125:65–71PubMedCrossRef

23.

Maynor CH, Charles HC, Herfkens RJ, Suddarth SA (1989) Chemical shift imaging of atherosclerosis at 7.0 T. Invest Radiol 24:52–60PubMedCrossRef

24.

Choudhury RP, Aguinaldo JG, Rong JX, Fallon JT, Fuster V, Fisher EA, Fayad ZA (2001) Serial non-invasive high-resolution magnetic resonance imaging measures the progression of atherosclerosis in apolipoprotein E-deficient mice. J Am Coll Cardiol 37:1A–648A

25.

MacLennon RN (1993) Interrater reliability with SPSS for Windows 5.0. The American Stastistician 47:292–296CrossRef

26.

Yuan C, Kerwin WS (2004) MRI and atherosclerosis. J Magn Reson Imaging 19:710–719PubMedCrossRef

27.

Mitsumori LM, Hatsukami TS, Ferguson MS, Kerwin WS, Cai J, Yuan C (2003) In vivo accuracy of multisequence MR imaging for identifying unstable fibrous caps in advanced human carotid plaques. J Magn Reson Imaging 17:410–420PubMedCrossRef

28.

Trivedi RA, U-Kim-Im JM, Graves MJ, Horsley J, Goddard M, Kirkpatrick PJ, Gillard JH (2004) MRI-derived measurements of fibrous-cap and lipid-core thickness: the potential for identifying vulnerable carotid plaques in vivo. Neuroradiology 46:738–743PubMedCrossRef

29.

Abdomaali N, Langenfeld M, Krahforst R, Schick C, Thalhammer A, Schmitt J, Schulze T, Schmächinger V, Vogl TJ (2002) Vessel wall MRI of the thoracic aorta: correlation to histology and transesophageal ultrasound. preliminary results. Fortschr Röntgenstr 174:568–572CrossRef

30.

Chan SK, Jaffer FA, Botnar RM (2001) Scan reproducibility of magnetic resonance imaging assessment of aortic atherosclerosis. J Cardiovasc Magn Reson 3:331–338PubMedCrossRef

31.

Corti R, Fayad ZA, Fuster V, Worthley SG, Helft G, Chesebro J, Mercuri M, Badimon JJ (2001) Effects of lipid-lowering by simvastatin on human atherosclerotic lesion: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging. Circulation 104:249–252PubMedCrossRef

32.

Corti R, Fuster V, Fayad ZA, Worthley SG, Helft G, Smith D, Weinberger J, Wentzel J, Mizsei G, Mercuri M, Badimon JJ (2002) Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two year’s follow-up by high-resolution noninvasive magnetic resonance imaging. Circulation 106:2884–2887PubMedCrossRef

33.

Jaffer FA, O’Donnell CJ, Larson MG, Chan SK, Kissinger KV, Kupka MJ, Salton C, Botnar RM, Levy D, Manning WJ (2002) Age and sex distribution of subclinical aortic atherosclerosis. Arterioscler Thromb Vasc Biol 22:849–854PubMedCrossRef

Titel: Multicontrast-weighted magnetic resonance imaging of atherosclerotic plaques at 3.0 and 1.5 Tesla: ex-vivo comparison with histopathologic correlation
verfasst von: Andreas Koops
Harald Ittrich
Susan Petri
Andrew Priest
Alexander Stork
Ute Lockemann
Gerhard Adam
Christoph Weber
Publikationsdatum: 01.01.2007
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 1/2007
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-006-0265-7

Anzeige

Neu im Fachgebiet Radiologie

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

S3-Leitlinie zu Pankreaskrebs aktualisiert

23.04.2024 Pankreaskarzinom Nachrichten

Die Empfehlungen zur Therapie des Pankreaskarzinoms wurden um zwei Off-Label-Anwendungen erweitert. Und auch im Bereich der Früherkennung gibt es Aktualisierungen.

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

18.04.2024 Pädiatrische Notfallmedizin Nachrichten

Im Choosing-Wisely-Programm, das für die deutsche Initiative „Klug entscheiden“ Pate gestanden hat, sind erstmals Empfehlungen zum Umgang mit Notfällen von Kindern erschienen. Fünf Dinge gilt es demnach zu vermeiden.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen