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01.06.2010 | Musculoskeletal

Does joint alignment affect the T2 values of cartilage in patients with knee osteoarthritis?

verfasst von: Klaus M. Friedrich, Timothy Shepard, Gregory Chang, Ligong Wang, James S. Babb, Mark Schweitzer, Ravinder Regatte

Erschienen in: European Radiology | Ausgabe 6/2010

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Abstract

Objective

To assess the relationship between T2 values of femorotibial cartilage and knee alignment in patients with clinical symptoms of medial osteoarthritis (OA).

Methods

Twenty-four patients (mean age ± standard deviation, 62.5 ± 9.9 years) with clinical symptoms of medial knee OA, 12 with varus and 12 with valgus alignment of the femorotibial joint, were investigated on 3T MR using a 2D multi-echo spin echo (MESE) sequence for T2 mapping. Analysis of covariance, Spearman correlation coefficients, exact Mann-Whitney tests, and Fisher’s exact tests were used for statistical analysis.

Results

Overall the T2 values of cartilage in the medial compartment (median ± interquartile-range, 49.44 ± 6.58) were significantly higher (P = 0.0043) than those in the lateral compartment (47.15 ± 6.87). Patients with varus alignment (50.83 ± 6.30 ms) had significantly higher T2 values of cartilage (P < 0.0001) than patients with valgus alignment (46.20 ± 6.00 ms). No statistically significant association between the T2 values of cartilage (in either location) and the Kellgren Lawrence score was found in the varus or in the valgus group.

Conclusion

T2 measurements were increased in medial knee OA patients with varus alignment, adding support to the theory of an association of OA and joint alignment.

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Titel: Does joint alignment affect the T2 values of cartilage in patients with knee osteoarthritis?
verfasst von: Klaus M. Friedrich
Timothy Shepard
Gregory Chang
Ligong Wang
James S. Babb
Mark Schweitzer
Ravinder Regatte
Publikationsdatum: 01.06.2010
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 6/2010
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-009-1689-7

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Does joint alignment affect the T2 values of cartilage in patients with knee osteoarthritis?