Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
European Radiology
Erschienen in: European Radiology 2/2012

01.02.2012 | Oncology

Discrimination of paediatric brain tumours using apparent diffusion coefficient histograms

verfasst von: Jonathan G. Bull, Dawn E. Saunders, Christopher A. Clark

Erschienen in: European Radiology | Ausgabe 2/2012

Einloggen, um Zugang zu erhalten

Abstract

Objective

To determine if histograms of apparent diffusion coefficients (ADC) can be used to differentiate paediatric brain tumours.

Methods

Imaging of histologically confirmed tumours with pre-operative ADC maps were reviewed (54 cases, 32 male, mean age 6.1 years; range 0.1–15.8 years) comprising 6 groups. Whole tumour ADC histograms were calculated; normalised for volume. Stepwise logistic regression analysis was used to differentiate tumour types using histogram metrics, initially for all groups and then for specific subsets.

Results

All 6 groups (5 dysembryoplastic neuroectodermal tumours, 22 primitive neuroectodermal tumours (PNET), 5 ependymomas, 7 choroid plexus papillomas, 4 atypical teratoid rhabdoid tumours (ATRT) and 9 juvenile pilocytic astrocytomas (JPA)) were compared. 74% (40/54) were correctly classified using logistic regression of ADC histogram parameters. In the analysis of posterior fossa tumours, 80% of ependymomas, 100% of astrocytomas and 94% of PNET-medulloblastoma were classified correctly. All PNETs were discriminated from ATRTs (22 PNET and 4 supratentorial ATRTs) (100%).

Conclusions

ADC histograms are useful in differentiating paediatric brain tumours, in particular, the common posterior fossa tumours of childhood. PNETs were differentiated from supratentorial ATRTs, in all cases, which has important implications in terms of clinical management.
Key Points
• MR based apparent diffusion coefficient histograms can help differentiate paediatric brain tumours
• ADC histogram parameters correctly classified the great majority of posterior fossa tumours
Literatur
1.
Jenkinson MD, Du Plessis DG, Walker C, Smith TS (2007) Advanced MRI in the management of adult gliomas. Br J Neurosurg 21:550–561PubMedCrossRef
2.
Romano A, Bozzao A, Bonamini M, Fasoli F, Ferrante M, Floris R, Colonnese C, Fantozzi LM (2003) Diffusion-weighted MR Imaging: clinical applications in neuroradiology. Radiol Med 106:521–548PubMed
3.
Schaefer PW (2001) Applications of DWI in clinical neurology. J Neurol Sci 186(Suppl 1):S25–S35PubMedCrossRef
4.
Le Bihan D, Douek P, Argyropoulou M, Turner R, Patronas N, Fulham M (1993) Diffusion and perfusion magnetic resonance imaging in brain tumors. Top Magn Reson Imaging 5:25–31PubMedCrossRef
5.
Le Bihan D, Turner R, Douek P, Patronas N (1992) Diffusion MR imaging: clinical applications. AJR Am J Roentgenol 159:591–599PubMed
6.
Tozer DJ, Jager HR, Danchaivijitr N, Benton CE, Tofts PS, Rees JH, Waldman AD (2007) Apparent diffusion coefficient histograms may predict low-grade glioma subtype. NMR Biomed 20:49–57PubMedCrossRef
7.
Grant PE, Matsuda KM (2003) Application of new MR techniques in pediatric patients. Magn Reson Imaging Clin N Am 11:493–522PubMedCrossRef
8.
Warren KE (2009) Noninvasive assessment of pediatric brain tumors. Cancer Biol Ther 8:1881–1888PubMedCrossRef
9.
Shastri-Hurst N, Tsegaye M, Robson DK, Lowe JS, Macarthur DC (2006) Stereotactic brain biopsy: an audit of sampling reliability in a clinical case series. Br J Neurosurg 20:222–226PubMedCrossRef
10.
Winkler D, Lindner D, Richter A, Meixensberger J, Schober J (2006) The value of intraoperative smear examination of stereotaxic brain specimens. Minim Invasive Neurosurg 49:353–356PubMedCrossRef
11.
Lunsford LD, Martinez AJ (1984) Stereotactic exploration of the brain in the era of computed tomography. Surg Neurol 22:222–230PubMedCrossRef
12.
Hall WA, Liu H, Martin AJ, Truwit CL (1999) Comparison of stereotactic brain biopsy to interventional magnetic-resonance-imaging-guided brain biopsy. Stereotact Funct Neurosurg 73:148–153PubMedCrossRef
13.
Field M, Witham TF, Flickinger JC, Kondziolka D, Lunsford LD (2001) Comprehensive assessment of hemorrhage risks and outcomes after stereotactic brain biopsy. J Neurosurg 94:545–551PubMedCrossRef
14.
Bernstein M, Parrent AG (1994) Complications of CT-guided stereotactic biopsy of intra-axial brain lesions. J Neurosurg 81:165–168PubMedCrossRef
15.
Sugahara T, Korogi Y, Kochi M, Ikushima I, Shigematu Y, Hirai T, Okuda T, Liang L, Ge Y, Komohara Y, Ushio Y, Takahashi M (1999) Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging 9:53–60PubMedCrossRef
16.
17.
Meyers SP, Khademian ZP, Biegel JA, Chuang SH, Korones DN, Zimmerman RA (2006) Primary intracranial atypical teratoid/rhabdoid tumors of infancy and childhood: MRI features and patient outcomes. Am J Neuroradiol 27:962–971PubMed
18.
Krabbe K, Gideon P, Wagn P, Hansen U, Thomsen C, Madsen F (1997) MR diffusion imaging of human intracranial tumours. Neuroradiology 39:483–489PubMedCrossRef
19.
Jenkinson MD, Du Plessis DG, Smith TS, Brodbelt AR, Joyce KA, Walker C (2010) Cellularity and apparent diffusion coefficient in oligodendroglial tumours characterized by genotype. J Neurooncol 96:385–392PubMedCrossRef
20.
Humphries PD, Sebire NJ, Siegel MJ, Olsen OE (2007) Tumors in pediatric patients at diffusion-weighted MR imaging: apparent diffusion coefficient and tumor cellularity. Radiology 245:848–854PubMedCrossRef
21.
Gauvain KM, McKinstry RC, Mukherjee P, Perry A, Neil JJ, Kaufman BA, Hayashi RJ (2001) Evaluating pediatric brain tumor cellularity with diffusion-tensor imaging. Am J Roentgenol 177:449–454
22.
Erdem E, Zimmerman RA, Haselgrove JC, Bilaniuk LT, Hunter JV (2001) Diffusion-weighted imaging and fluid attenuated inversion recovery imaging in the evaluation of primitive neuroectodermal tumors. Neuroradiology 43:927–933PubMedCrossRef
23.
Schneider JF, Confort-Gouny S, Viola A, Le FY, Viout P, Bennathan M, Chapon F, Figarella-Branger D, Cozzone P, Girard N (2007) Multiparametric differentiation of posterior fossa tumors in children using diffusion-weighted imaging and short echo-time (1)H-MR spectroscopy. J Magn Reson Imaging 26:1390–1398PubMedCrossRef
24.
Rumboldt Z, Camacho DL, Lake D, Welsh CT, Castillo M (2006) Apparent diffusion coefficients for differentiation of cerebellar tumors in children. Am J Neuroradiol 27:1362–1369PubMed
25.
Yamasaki F, Kurisu K, Satoh K, Arita K, Sugiyama K, Ohtaki M, Takaba J, Tominaga A, Hanaya R, Yoshioka H, Hama S, Ito Y, Kajiwara Y, Yahara K, Saito T, Thohar MA (2005) Apparent diffusion coefficient of human brain tumors at MR imaging. Radiology 235:985–991PubMedCrossRef
26.
Gupta RK, Cloughesy TF, Sinha U, Garakian J, Lazareff J, Rubino G, Rubino L, Becker DP, Vinters HV, Alger JR (2000) Relationships between choline magnetic resonance spectroscopy, apparent diffusion coefficient and quantitative histopathology in human glioma. J Neurooncol 50:215–226PubMedCrossRef
27.
Fenton LZ, Foreman NK (2003) Atypical teratoid/rhabdoid tumor of the central nervous system in children: an atypical series and review. Pediatr Radiol 33:554–558PubMedCrossRef
28.
Chen ML, McComb JG, Krieger MD (2005) Atypical teratoid/rhabdoid tumors of the central nervous system: management and outcomes. Neurosurg Focus 18(6A):E8PubMed
29.
Rorke LB, Packer RJ, Biegel JA (1996) Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood: definition of an entity. J Neurosurg 85:56–65PubMedCrossRef
30.
Koral K, Gargan L, Bowers DC, Gimi B, Timmons CF, Weprin B, Rollins NK (2008) Imaging characteristics of atypical teratoid-rhabdoid tumor in children compared with medulloblastoma. Am J Roentgenol 190:809–814CrossRef
31.
Arslanoglu A, Aygun N, Tekhtani D, Aronson L, Cohen K, Burger PC, Yousem DM (2004) Imaging findings of CNS atypical teratoid/rhabdoid tumors. Am J Neuroradiol 25:476–480PubMed
32.
Chen YW, Wong TT, Ho DM, Huang PI, Chang KP, Shiau CY, Yen SH (2006) Impact of radiotherapy for pediatric CNS atypical teratoid/rhabdoid tumor (single institute experience). Int J Radiat Oncol Biol Phys 64:1038–1043PubMedCrossRef
33.
Plummer D (1992) DispImage a display and analysis tool for medical images. Proceedings of study group on artificial intelligence in radiology. Riv Neuroradiol 5:489–495
34.
Tofts PS (2003) Histograms: measuring subtle diffuse disease. In: Tofts PS (ed) Quantitative MRI of the brain. Wiley, Chichester, pp 581–610CrossRef
35.
Athale UH, Duckworth J, Odame I, Barr R (2009) Childhood atypical teratoid rhabdoid tumor of the central nervous system: a meta-analysis of observational studies. J Pediatr Hematol Oncol 31:651–663PubMedCrossRef
36.
Hilden JM, Meerbaum S, Burger P, Finlay J, Janss A, Scheithauer BW, Walter AW, Rorke LB, Biegel JA (2004) Central nervous system atypical teratoid/rhabdoid tumor: results of therapy in children enrolled in a registry. J Clin Oncol 22:2877–2884PubMedCrossRef
37.
Lefkowitz IB, Rorke LB, Packer RJ (1987) Atypical teratoid rhabdoid tumor of infancy: definition of an entity [abstract]. Ann Neurol 22:448–449
38.
Bruch LA, Hill DA, Cai DX, Levy BK, Dehner LP, Perry A (2001) A role for fluorescence in situ hybridization detection of chromosome 22q dosage in distinguishing atypical teratoid/rhabdoid tumors from medulloblastoma/central primitive neuroectodermal tumors. Hum Pathol 32:156–162PubMedCrossRef
39.
Lopez-Gines C, Cerda-Nicolas M, Kepes J, Donat J, Gil-Benso R, Llombart-Bosch A (2000) Complex rearrangement of chromosomes 6 and 11 as the sole anomaly in atypical teratoid/rhabdoid tumors of the central nervous system. Cancer Genet Cytogenet 122:141–152CrossRef
40.
Biegel JA, Fogelgren B, Zhou JY, James CD, Janss AJ, Allen JC, Zagzag D, Raffel C, Rorke LB (2000) Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system. Clin Cancer Res 6:2759–2763PubMed
41.
Judkins AR, Mauger J, Ht A, Rorke LB, Biegel JA (2004) Immunohistochemical analysis of hSNF5/INI1 in pediatric CNS neoplasms. Am J Surg Pathol 28:644–650PubMedCrossRef
42.
Burger PC, Yu IT, Tihan T, Friedman HS, Strother DR, Kepner JL, Duffner PK, Kun LE, Perlman EJ (1998) Atypical teratoid/rhabdoid tumor of the central nervous system: a highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: a Pediatric Oncology Group study. Am J Surg Pathol 22:1083–1092PubMedCrossRef
43.
Zuccoli G, Izzi G, Bacchini E, Tondelli MT, Ferrozzi F, Bellomi M (1999) Central nervous system atypical teratoid/rhabdoid tumour of infancy. CT and MR findings. Clin Imaging 23:356–360PubMedCrossRef
44.
Niwa T, Aida N, Tanaka M, Okubo J, Sasano M, Shishikura A, Fujita K, Ito S, Tanaka Y, Kigasawa H (2009) Diffusion-weighted imaging of an atypical teratoid/rhabdoid tumor of the cervical spine. Magn Reson Med Sci 8:135–138PubMedCrossRef
45.
Smith MA, Freidlin B, Ries LA, Simon R (1998) Trends in reported incidence of primary malignant brain tumors in children in the United States. J Natl Cancer Inst 90:1269–1277PubMedCrossRef
46.
Arora RS, Alston RD, Eden TO, Estlin EJ, Moran A, Birch JM (2009) Age-incidence patterns of primary CNS tumors in children, adolescents, and adults in England. Neuro Oncol 11:403–413PubMedCrossRef
47.
Wang S, Kim S, Chawla S, Wolf RL, Zhang WG, O’Rourke DM, Judy KD, Melhem ER, Poptani H (2009) Differentiation between glioblastomas and solitary brain metastases using diffusion tensor imaging. Neuroimage 44:653–660PubMedCrossRef
Metadaten
Titel
Discrimination of paediatric brain tumours using apparent diffusion coefficient histograms
verfasst von
Jonathan G. Bull
Dawn E. Saunders
Christopher A. Clark
Publikationsdatum
01.02.2012
Verlag
Springer-Verlag
Erschienen in
European Radiology / Ausgabe 2/2012
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-011-2255-7

Weitere Artikel der Ausgabe 2/2012

European Radiology 2/2012 Zur Ausgabe

Breast

High resolution MRI of the breast at 3 T: which BI-RADS® descriptors are most strongly associated with the diagnosis of breast cancer?

Computed Tomography

Reproducibility of volume and densitometric measures of emphysema on repeat computed tomography with an interval of 1 week

Experimental

Diagnostic performance of a near-infrared breast imaging system as adjunct to mammography versus X-ray mammography alone

Vascular-Interventional

Radiology of advanced EVAR techniques in complex abdominal aortic aneurysms

Head and Neck

Near-real time oculodynamic MRI: a feasibility study for evaluation of diplopia in comparison with clinical testing

Computed Tomography

CT image quality improvement using adaptive iterative dose reduction with wide-volume acquisition on 320-detector CT

Neu im Fachgebiet Radiologie

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

S3-Leitlinie zu Pankreaskrebs aktualisiert

23.04.2024 Pankreaskarzinom Nachrichten

Die Empfehlungen zur Therapie des Pankreaskarzinoms wurden um zwei Off-Label-Anwendungen erweitert. Und auch im Bereich der Früherkennung gibt es Aktualisierungen.

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

18.04.2024 Pädiatrische Notfallmedizin Nachrichten

Im Choosing-Wisely-Programm, das für die deutsche Initiative „Klug entscheiden“ Pate gestanden hat, sind erstmals Empfehlungen zum Umgang mit Notfällen von Kindern erschienen. Fünf Dinge gilt es demnach zu vermeiden.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise