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European Radiology
Erschienen in: European Radiology 1/2014

01.01.2014 | Computer Applications

Fractal analysis in radiological and nuclear medicine perfusion imaging: a systematic review

verfasst von: Florian Michallek, Marc Dewey

Erschienen in: European Radiology | Ausgabe 1/2014

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Abstract

Objectives

To provide an overview of recent research in fractal analysis of tissue perfusion imaging, using standard radiological and nuclear medicine imaging techniques including computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) and to discuss implications for different fields of application.

Methods

A systematic review of fractal analysis for tissue perfusion imaging was performed by searching the databases MEDLINE (via PubMed), EMBASE (via Ovid) and ISI Web of Science.

Results

Thirty-seven eligible studies were identified. Fractal analysis was performed on perfusion imaging of tumours, lung, myocardium, kidney, skeletal muscle and cerebral diseases. Clinically, different aspects of tumour perfusion and cerebral diseases were successfully evaluated including detection and classification. In physiological settings, it was shown that perfusion under different conditions and in various organs can be properly described using fractal analysis.

Conclusions

Fractal analysis is a suitable method for quantifying heterogeneity from radiological and nuclear medicine perfusion images under a variety of conditions and in different organs. Further research is required to exploit physiologically proven fractal behaviour in the clinical setting.

Key Points

• Fractal analysis of perfusion images can be successfully performed.
• Tumour, pulmonary, myocardial, renal, skeletal muscle and cerebral perfusion have already been examined.
• Clinical applications of fractal analysis include tumour and brain perfusion assessment.
• Fractal analysis is a suitable method for quantifying perfusion heterogeneity.
• Fractal analysis requires further research concerning the development of clinical applications.
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Metadaten
Titel
Fractal analysis in radiological and nuclear medicine perfusion imaging: a systematic review
verfasst von
Florian Michallek
Marc Dewey
Publikationsdatum
01.01.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 1/2014
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-013-2977-9

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