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01.06.2015 | Molecular Imaging

Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results

verfasst von: Hao Hu, Xin Cao, Fei Kang, Min Wang, Yenan Lin, Muhan Liu, Shujun Li, Liping Yao, Jie Liang, Jimin Liang, Yongzhan Nie, Xueli Chen, Jing Wang, Kaichun Wu

Erschienen in: European Radiology | Ausgabe 6/2015

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Abstract

Objectives

Cerenkov luminescence imaging (CLI) provides potential to use clinical radiotracers for optical imaging. The goal of this study was to present a newly developed endoscopic CLI (ECLI) system and illustrate its feasibility and potential in distinguishing and quantifying cancerous lesions of the GI tract.

Methods

The ECLI system was established by integrating an electron-multiplying charge-coupled device camera with a flexible fibre endoscope. Phantom experiments and animal studies were conducted to test and illustrate the system in detecting and quantifying the presence of radionuclide in vitro and in vivo. A pilot clinical study was performed to evaluate our system in clinical settings.

Results

Phantom and mice experiments demonstrated its ability to acquire both the luminescent and photographic images with high accuracy. Linear quantitative relationships were also obtained when comparing the ECLI radiance with the radiotracer activity (r ² = 0.9779) and traditional CLI values (r ² = 0.9025). Imaging of patients revealed the potential of ECLI in the identification and quantification of cancerous tissue from normal, which showed good consistence with the clinical PET examination.

Conclusions

The new ECLI system shows good consistence with the clinical PET examination and has great potential for clinical translation and in aiding detection of the GI tract disease.

Key Points

• CLI preserves the characteristics of both optical and radionuclide imaging.

• CLI provides great potential for clinical translation of optical imaging.

• The newly developed endoscopic CLI (ECLI) has quantification and imaging capacities.

• GI tract has accessible open surfaces, making ECLI a potentially suitable technique.

• Cerenkov endoscopy has great clinical potential in detecting GI disease.

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Titel: Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results
verfasst von: Hao Hu
Xin Cao
Fei Kang
Min Wang
Yenan Lin
Muhan Liu
Shujun Li
Liping Yao
Jie Liang
Jimin Liang
Yongzhan Nie
Xueli Chen
Jing Wang
Kaichun Wu
Publikationsdatum: 01.06.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 6/2015
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3574-2

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Feasibility study of novel endoscopic Cerenkov luminescence imaging system in detecting and quantifying gastrointestinal disease: first human results