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Erschienen in:

06.10.2017 | Musculoskeletal

Association of weight change with progression of meniscal intrasubstance degeneration over 48 months: Data from the Osteoarthritis Initiative

verfasst von: Julio Brandao Guimaraes, Michael C. Nevitt, Charles E. McCulloch, Benedikt J. Schwaiger, Alexandra S. Gersing, Luca Facchetti, Matthew D. Bucknor, Nattagan Chanchek, Felix Liu, Gabby B. Joseph, Thomas M. Link

Erschienen in: European Radiology | Ausgabe 3/2018

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Abstract

Objectives

To investigate the association of weight change over 48 months with progression of meniscal intrasubstance degeneration (MID).

Methods

We studied 487 subjects with MID at baseline and after 48 months using 3-T MRI with the same protocol (FSE sequences with and without fat suppression). These participants lost weight (≥3%, n = 141), had moderate weight gain (3–10%, n = 77), substantial weight gain (>10%, n = 15) or maintained stable weight (n = 254). Progression of MID to a meniscal tear was assessed using the WORMS grading system and compared among weight change groups using logistic regression. ANOVA and chi-square tests were used to study the differences in subjects’ characteristics.

Results

Progression of MID increased from weight loss to substantial weight gain (p < 0.001) and was significantly more likely with both moderate weight gain (odds ratio [OR], 4.9; 95% confidence interval [CI] 2.4–8.9) and substantial weight gain (OR, 9.5; 95% CI 3.2–28.5) compared to stable weight. Results were similar in both menisci for moderate weight gain (medial: OR, 6.8; 95% CI 3.5–11.3; lateral: OR, 2.6; 95% CI 1.1–6.6) and substantial weight gain (medial: OR, 21.0; 95% CI 5.1–80.7; lateral: OR, 9.7; 95% CI 0.95–100.2).

Conclusion

Weight gain is associated with an increased likelihood that meniscal intrasubstance degeneration will progress with the risk increasing with greater weight gain.

Key Points

• Subjects who gained weight were more likely to develop meniscal tears.

• Greater amount of weight gain was associated with an increasing likelihood of progression.

• Prevention of weight gain has health benefits for the meniscus.

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Titel: Association of weight change with progression of meniscal intrasubstance degeneration over 48 months: Data from the Osteoarthritis Initiative
verfasst von: Julio Brandao Guimaraes
Michael C. Nevitt
Charles E. McCulloch
Benedikt J. Schwaiger
Alexandra S. Gersing
Luca Facchetti
Matthew D. Bucknor
Nattagan Chanchek
Felix Liu
Gabby B. Joseph
Thomas M. Link
Publikationsdatum: 06.10.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 3/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-5054-y

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Association of weight change with progression of meniscal intrasubstance degeneration over 48 months: Data from the Osteoarthritis Initiative