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24.05.2018 | Gastrointestinal

Diffusion kurtosis imaging in the characterisation of rectal cancer: utilizing the most repeatable region-of-interest strategy for diffusion parameters on a 3T scanner

verfasst von: Yiqun Sun, Qin Xiao, Feixiang Hu, Caixia Fu, Huixun Jia, Xu Yan, Chao Xin, Sanjun Cai, Weijun Peng, Xiaolin Wang, Tong Tong, Yajia Gu

Erschienen in: European Radiology | Ausgabe 12/2018

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Abstract

Objectives

Our goal was to investigate the correlation between histopathology and diffusion parameters by utilising the most repeatable region-of-interest (ROI) strategy for diffusion parameters in rectal cancer on a 3T scanner.

Methods

113 patients underwent DKI-MR and 66 of these patients received surgery without neoadjuvant chemoradiotherapy. Two readers independently measured the parameters using three slice protocols including single slice, three slices and whole-tumour slice (WTS), combined with one of two ROIs, including outline and round ROI. ANOVA, Kruskal-Wallis, a paired sample t-test, interclass correlation coefficient (ICC), Bland-Altman, Student’s t-tests, receiver operating characteristic curves and z statistic were used for statistical analysis.

Results

There were no significant differences among the three slice protocols in ADC values (p = 0.822, 0.987), K values (p = 0.842, 0.859) and D values (p = 0.917, 0.988) using round and outline ROI, respectively. The ADC and D values derived from outline ROIs were higher than those from round ROIs (all p < 0.001 for ADC, all p < 0.001 for D), while K values derived from outline ROIs were lower than those from round ROIs (p < 0.001, p = 0.001, p < 0.001) using three slice protocols, respectively. The WTS-outline ROI resulted in the best intra- and inter-observer ICC. Utilising the WTS-outline ROI method, the AUC for assessment of well-differentiated tumours was 0.871 by K and 0.809 by ADC; and the AUC for T2 was 0.768 by K.

Conclusions

The most repeatable strategy was the WTS-outline ROI method. In addition to DWI, DKI also have diagnostic value for rectal cancer histopathological characteristics utilising the WTS-outline ROI on a 3T scanner.

Key Points

• DKI using a 3T scanner is feasible for assessing rectal cancer.

• ROI and slice protocol show considerable influence on DKI parameters.

• DKI parameters exhibit excellent repeatability using whole-tumour slice-outline ROI on 3T scanner.

• DKI has considerable diagnostic value for the estimation of rectal cancer characteristics.

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Titel: Diffusion kurtosis imaging in the characterisation of rectal cancer: utilizing the most repeatable region-of-interest strategy for diffusion parameters on a 3T scanner
verfasst von: Yiqun Sun
Qin Xiao
Feixiang Hu
Caixia Fu
Huixun Jia
Xu Yan
Chao Xin
Sanjun Cai
Weijun Peng
Xiaolin Wang
Tong Tong
Yajia Gu
Publikationsdatum: 24.05.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 12/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5495-y

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Diffusion kurtosis imaging in the characterisation of rectal cancer: utilizing the most repeatable region-of-interest strategy for diffusion parameters on a 3T scanner