Rectal cancer is a frequently diagnosed tumor worldwide. Various studies have shown the noninferiority or even slight superiority of laparoscopic resection. However, there is no clear recommendation on whether age should influence the choice of surgical approach.
Materials and methods
This study compared outcomes of laparoscopic and open surgery in rectal cancer patients. Perioperative mortality and 5-year overall, relative, and recurrence-free survival rates were analyzed separately for three age groups. Data originate from 30 regional German cancer registries that cover approximately one quarter of the German population. All primary nonmetastatic rectal adenocarcinoma cases with surgery between 2005 and 2014 were eligible for inclusion. To compare survival rates, Kaplan–Meier analysis, a relative survival model, and multivariable Cox regression were used; a sensitivity analysis assessed bias by exclusion.
Results
Ten thousand seven hundred fifty-four patients were included in the analysis. The mean laparoscopy rate was 23.0% and increased over time. Analysis of 30-day postoperative mortality rates revealed advantages for laparoscopically treated patients, although the significance level was not reached in any age group. Regarding 5-year overall survival, laparoscopy generally seems to be the superior approach, whereas for recurrence-free survival, an age-dependent gradient in effect size was observed: with a hazard ratio (HR) of 0.703 for laparoscopy, patients under 60 years benefitted more from the minimally invasive approach than older patients (septuagenarians, HR 0.923).
Conclusion
Laparoscopy shows similar results to the open approach in terms of postoperative survival in all age groups. Concerning long-term outcomes, younger patients benefitted most from the minimally invasive approach.
Hinweise
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Introduction
Colorectal cancer ranks among the top three malignant tumor entities in Germany and worldwide [1]. According to a survey conducted by the World Health Organization (WHO), 1.4 million people worldwide were diagnosed with this type of tumor in 2012 [2]. Approximately one-third of these carcinomas are located in the rectum [1].
Curative treatment of colorectal carcinoma involves radical surgical resection of the tumor. In the past, open surgery was the first choice for rectal resections, and even today, many surgeons still prefer the conventional approach. Despite promising results in favor of the minimally invasive approach derived from the high-quality COLOR II trial published in 2015 [3], as well as those from a number of other important pro- and retrospective trials [4‐7], there is an ongoing discussion on the topic [8].
Anzeige
The trend is moving increasingly toward individualized treatment pathways. It is not uncommon for benefits of a particular treatment to be associated with certain patient characteristics. Therefore, when assessing an intervention such as the surgical approach, it is necessary to conduct separate analyses for relevant subgroups. Age can have great influence on the perception of different therapeutic modalities [9]. Based on a large pooled database of German cancer registries, this study provides a comprehensive picture of short- and long-term survival after laparoscopic and open surgery with special emphasis on the influence of age.
In Germany, rectal cancer treatment is highly standardized by evidence-based guidelines and elaborate quality management processes [10‐12], which aim to ensure a patient’s adequate treatment regardless of social or economic status. Together with the huge study population of this survey allowing for detailed subgroup analyses, this guarantees ideal conditions to objectively examine oncologic outcomes after tumor resection in daily clinical practice.
Patients and methods
Data for this publication were gathered in 30 regional cancer registries located predominantly in southern and eastern Germany. Together, they cover approximately 28% of the entire German population. Each registry employs trained documentation officers who systematically collect medical records of all tumor patients registered in their area. For this purpose, all patients must provide their formal consent. Information on life status is regularly updated by official authorities or using death certificates issued by the public health service. The anonymized unified dataset of all 30 registries was prepared by data analysts of the German Cancer Registry Association (ADT) [13] in strict accordance with the organization’s high data protection standards.
According to ICD-10-GM [14], all malignant tumors located 16 cm or less from the anocutaneous line are defined as rectal cancer (C20). For the purpose of this analysis, all patients up to the age of 79 years with a diagnosis of rectal cancer and surgery between January 1, 2005 and December 31, 2014 were eligible for inclusion. Subsequently, only patients with primary nonmetastatic adenocarcinomas and elective radical sphincter-preserving surgical treatment of their tumor were considered. Details on each patient include demographics, tumor characteristics, surgical procedure, and perioperative chemoradiotherapy (Table 1). For subgroup analyses, age at surgery was categorized into the following three groups: under 60 years, 60–69 years, and 70–79 years.
Table 1
Baseline characteristics of the study population according to surgical access. Lower third ≙ 0–5.9 cm, middle third ≙ 6–11.9 cm, upper third ≙ 12–16 cm from anal verge
Open (n = 8272)
Laparoscopic (n = 2743)
χ2
Sex
Male
5848
66.3%
1508
61.0%
< 0.001
Female
2788
33.7%
965
39.0%
Age (years)
< 60
2137
25.8%
819
33.1%
< 0.001
60–69
2837
34.3%
839
33.9%
70–79
3298
39.9%
815
33.0%
Location
Lower rectum
1907
23.1%
481
19.5%
< 0.001
Middle rectum
3566
43.1%
996
40.3%
Upper rectum
2799
33.8%
996
40.3%
UICC stage
I
2728
33.0%
930
37.6%
< 0.001
II
2471
29.9%
631
25.5%
III
3073
37.1%
912
36.9%
Grading
G1/2
7055
85.3%
2135
86.3%
0.195
G3/4
1217
14.7%
338
13.7%
Perioperative chemoradiotherapy
Yes
3427
41.4%
922
37.3%
No
4845
58.6%
1551
62.7%
< 0.001
Anzeige
To compare 30-day postoperative mortality rates, uni- and multivariable logistic regression models were used. To determine the necessity of including each covariable in the multivariable model, an extensive literature search was first conducted. Thus, it was explored whether a variable has an independent influence on the outcome. Consequently, sex, tumor location, Union for International Cancer Control (UICC) stage, grading, and perioperative chemoradiotherapy were identified as potential confounders [15‐21]. Second, a χ-square distribution test was performed for the whole study population. All potential confounders with a probability of less than p = 0.5 of being equally distributed in the open and laparoscopic surgery groups were included in the final model for the regression analyses.
Median follow-up was 6.2 years. Therefore, a 5-year observation period after surgery could be used to compare survival rates in patients with laparoscopic vs. open resections. To focus on the long-term perspective, the effect of perioperative mortality was eliminated by applying a 30-day cutoff time and t = 31 days after surgery was set as the starting point for the observation period. Correspondingly, patients with a survival or observation time of less than 31 days were excluded from these analyses. In addition to Kaplan–Meier analysis, a multivariable Cox regression model was formulated [22]. Again, it was adjusted for all potential confounders that were unequally distributed in the open and laparoscopic surgery groups. To adjust for regional life expectancy, a relative survival model was computed [23]. Data on general mortality of the German population were obtained from the Human Mortality Database of the Max Planck Institutes [24].
To account for bias due to missing data, a sensitivity analysis was performed. This was based on univariable logistic regression and Kaplan–Meier analysis with inclusion of initially excluded patients. All significance tests were two sided with a significance level of 0.05; results are displayed as p values or 95% confidence intervals (CI). The findings of this survey are presented in strict compliance with the Strengthening the Reporting of Observational studies in Epidemiology (STROBE) statement [25]. During this study, IBM SPSS 25 (IBM Corp., SPSS for Windows, Armonk, NY, USA), as well as R version 3.3.2 (R Foundation for Statistical Computing, Vienna, Austria; http://www.R-project.org/), and the R package “relsurv” (Maja Pohar-Perme) were used [23].
Results
From January 1, 2005 to December 31, 2014, 29,877 patients between 18 and 79 years of age underwent radical sphincter-preserving resection of a rectal carcinoma (ICD-10-GM: C20). At the time of surgery, 29.0% of these patients had already developed distant metastases, suffered from syn- or metachronous colorectal malignancies, had a tumor with uncommon histologic subtype, or underwent an emergency procedure. A further 18.2% of the patients lacked information on UICC TNM stage, grading, or tumor location, and in 16.9% of cases, the surgical approach was unknown. These patients were excluded from further analyses (Fig. 1).
Fig. 1
Flowchart of study patient selection
×
The final dataset included 10,745 patients. The observed laparoscopy rate was 23.0% on average, with the rate increasing over time from 13.7% in 2005 to 34.1% in 2014. Laparoscopy patients were more often female (39.0 vs. 33.7%) and younger (mean age 64.2 vs. 65.8 years; median age 65.5 vs. 67.5 years). Laparoscopically resected tumors were more frequently located in the upper third of the rectum (12–16 cm from anal verge) and were more often diagnosed as UICC stage I. UICC stage III was distributed almost equally between the open and laparoscopic treatment groups (laparoscopy 36.9 vs. open surgery 37.1%; Table 1).
The overall mortality rate 30 days after surgery was 1.4%. Among patients aged 59 years or younger, 0.4% had died, compared to 2.3% among the septuagenarians. Uni- and multivariable regression analysis of 30-day postoperative mortality revealed advantages for laparoscopically treated patients, although the significance level was not reached (in the highest age group, it was missed only slightly: odds ratio, OR 0.559; 95% confidence interval, 95% CI 0.296–1.058; Fig. 2a–f).
Fig. 2
Postoperative mortality (30 days). OR odds ratio, CI two-sided 95% confidence interval. Logistic regression analysis comparing 30-day postoperative mortality rates open vs. laparoscopic surgery; reference: open approach. a Univariable logistic regression analysis on patients < 60 years. b Multivariable logistic regression analysis on patients < 60 years; adjustment for sex, location, TNM stage, grading, and perioperative therapy; reference: open approach. c Univariable logistic regression analysis on patients 60–69 years. d Multivariable logistic regression analysis on patients 60–69 years; adjustment for sex, location, TNM stage, grading, and perioperative therapy; reference: open approach. e Univariable logistic regression analysis on patients 70–79 years. f Multivariable logistic regression analysis on patients 70–79 years; adjustment for sex, location, TNM stage, grading, and perioperative therapy; reference: open approach
×
In the subsequent analyses of long-term survival, the effect of perioperative mortality has been nullified by exclusion of patients with a survival or observation time of less than 31 days.
In Kaplan–Meier analysis, patients treated with minimally invasive surgery had a significant survival advantage, regardless of age. Among septuagenarians, 74.9% of laparoscopic and 69.5% of open surgery patients survived the first 5 postoperative years (p = 0.009). A comparable advantage for laparoscopy can be seen in the middle and youngest age groups. After adjustment for sex, tumor location, UICC stage, grading, and perioperative therapy, the superiority of laparoscopy remains significant in all age groups (Fig. 3a–f).
Fig. 3
Overall survival after perioperative period (31 days–5 years). HR hazard ratio, CI two-sided 95% confidence interval. a Kaplan–Meier analysis on patients < 60 years: 5-year cumulative overall survival rate open vs. laparoscopic surgery: 87.2 vs. 91.0%, p = 0.011. b Multivariable Cox regression analysis on patients < 60 years, adjustment for sex, location, TNM stage, grading, and perioperative therapy; reference: open approach. c Kaplan–Meier analysis on patients 60–69 years: 5-year cumulative overall survival rate open vs. laparoscopic: 81.9 vs. 86.8%, p = 0.001. d Multivariable Cox regression analysis on patients 60–69 years, adjustment for sex, location, TNM stage, grading, and perioperative therapy; reference: open approach. e Kaplan–Meier analysis on patients 70–79 years: 5-year cumulative overall survival rate open vs. laparoscopic: 69.5 vs. 74.9%, p = 0.009. f Multivariable Cox regression analysis on patients 70–79 years, adjustment for sex, location, TNM stage, grading, and perioperative therapy; reference: open approach
×
Anzeige
Taking into account the baseline mortality of the German population, the 5-year relative survival rate of laparoscopic patients aged younger than 50 years was 93.2%, compared to 89.0% in the open resection group (p = 0.024). Laparoscopy also turned out to be superior in the other age groups (60–69 years 92.4 vs. 87.2%, p < 0.001; 70–79 years 87.5 vs. 80.7%, p = 0.012).
A similar situation can be observed for 5-year recurrence-free survival. While recurrence-free survival rates are generally indirectly proportional to age, laparoscopy turned out to be the significantly superior approach in all analyzed strata. For example, among patients aged 60 to 69 years, 5 years after surgery, 78.5% of laparoscopic compared to 72.4% of open surgery patients were still alive and had not yet suffered from a recurrence (p = 0.001). Upon performing a multivariable Cox regression analysis, the situation changes slightly: an age-dependent gradient can now be seen. With a HR of 0.703 (95% CI 0.578–0.855), the greatest advantage for the minimally invasive approach was achieved in the youngest age group. Among septuagenarians, no significant advantage could be observed (HR 0.923, 95% CI 0.798–1.066; Fig. 4a–f).
Fig. 4
Recurrence-free survival after perioperative period (31 days–5 years). HR hazard ratio, CI two-sided 95% confidence interval. a Kaplan–Meier analysis on patients < 60 years: 5-year cumulative recurrence-free survival rate open vs. laparoscopic: 75.1 vs. 82.9%, p < 0.001. b Multivariable Cox regression analysis on patients < 60 years, adjustment for sex, location, TNM stage, grading, and perioperative therapy; reference: open approach. c Kaplan–Meier analysis on patients 60–69 years: 5-year cumulative recurrence-free survival rate open vs. laparoscopic: 72.4 vs. 78.5%, p = 0.001. d Multivariable Cox regression analysis on patients 60–69 years, adjustment for sex, location, TNM stage, grading, and perioperative therapy; reference: open approach. e Kaplan–Meier analysis on patients 70–79 years: 5-year cumulative recurrence-free survival rate open vs. laparoscopic: 64.4 vs. 67.6%, p = 0.089. f Multivariable Cox regression analysis on patients 70–79 years, adjustment for sex, location, TNM stage, grading, and perioperative therapy; reference: open approach
×
Finally, a sensitivity analysis was conducted to quantify bias due to exclusion of patients with missing data. In terms of 30-day postoperative mortality, included patients did not have a significant advantage over excluded patients (< 60 years OR 0.96, p = 0.401; 60–69 years OR 0.95, p = 0.069; 70–79 years OR 0.98, p = 0.214). Looking at 5-year overall survival rates, included patients did have a significantly superior survival rate compared to patients excluded due to missing data (79.5 vs. 78.1%, p = 0.017). However, the absolute difference in survival rates was only 0.6%.
Discussion
The present study investigates the question of whether laparoscopy and laparotomy are equally suitable in all age groups. The analyses on 10,745 patients from a German cancer registry grid showed nonsignificant advantages for laparoscopically treated patients concerning the 30-day postoperative mortality with similar results in all age groups. In terms of 5-year overall survival, the superiority of laparoscopy remains significant in all age-stratified subgroups even after adjustment for relevant covariables. The minimally invasive approach is also followed by lower recurrence rates. Concerning 5-year recurrence-free survival, younger patients seem to benefit more from laparoscopy.
Anzeige
These results give valuable insight into the daily clinical practice of rectal cancer surgery, since data comparing long-term results after laparoscopic vs. open approaches are scarce. It is only 3 years ago, that one of the first high-quality randomized controlled trials (RCTs) on the topic, the international COLOR II trial, was published [3]. These authors demonstrated the general oncologic safety of the minimally invasive approach. The validity of these positive results in daily clinical practice was confirmed by analyzing a representative cohort of approximately 1500 patients from southern Germany [4]. However, no two patients are exactly alike, and only individualized treatment will result in optimal outcomes, hence the need for more detailed analyses.
When selecting the appropriate therapeutic pathway to treat cancer, many aspects must be considered. Age is inevitably one of these aspects. Several studies have shown that there is a strong association between age and the prevalence of comorbidities [26, 27]. Therefore, there is a consensus that studies comparing treatment options such as different surgical approaches must regard age as a potential confounder, at least if the age distribution differs between treatment groups.
In most observational studies on the topic, laparoscopically treated patients have tended to be younger. For example, Nussbaum et al. used a large cancer registry from the USA and examined approximately 19,000 patients with low anterior rectum resection due to carcinoma [28]. Patients receiving minimally invasive surgery were significantly younger by 1 year. In 2015, Yeo et al. performed a large multicenter trial and found laparoscopic surgery patients to be, on average, 2.5 years younger [29]. In the publication of Draeger et al., laparoscopy patients were younger by 2.9 years on average, with age groups significantly differently distributed among the comparison groups (p < 0.001) [4]. Kolfschoten et al. also identified lower age as a relevant predictor for the laparoscopic approach [30]. Even in the randomized COLOR II trial, an age difference of 1 year between groups could be observed, while in this case, laparoscopic patients had the higher mean age, with 66.8 years [7]. Age obviously plays an important role in the selection of surgical approach.
This raises the question of whether laparoscopy and laparotomy are equally suitable in all age groups. A large study population is crucial for representative and statistically stable results at the subgroup level. Unfortunately, the problem of enrolling a sufficiently large number of participants is a common issue in RCTs. COLOR II, for instance, although currently the largest clinical trial on rectal cancer surgery, included only 1044 patients [3]. More substantial caseloads are reached in some registry-based studies, such as that of Nussbaum et al. [28]. However, most of these investigations suffer from a different limitation: in the absence of data on long-term survival, analyses have to be restricted to perioperative outcomes. To the best of our knowledge, the present study is the first with both a substantial caseload and true long-term follow-up. The age-stratified comparison of laparoscopic and open surgery for colorectal cancer resection performed herein permits assessment of potential effect modification of survival outcomes for the first time.
Anzeige
Some limitations must be considered when interpreting the results presented in this study. Unfortunately, information on nononcologic comorbidities is lacking, since there is no consensus between the participating cancer registries on the issue and, therefore, systematic documentation of American Society of Anesthesiologists (ASA) or a comorbidity score does not take place. However, there is evidence that stratifying by age, as it was done in this study, may partly account for this shortage: older patients tend to suffer from more potentially life-threatening illnesses than younger patients [26]. According to a survey by the Dutch cancer registry on colorectal cancer patients, there is a significant association between age and the number of comorbidities [27]. Notwithstanding, a future systematic documentation of ASA or a different comorbidity score is desirable to enable more accurate risk adjustment.
As stated above, this survey aims to paint a holistic picture of national rectal cancer care. Therefore, many regional cancer registries were encouraged to provide their data. However, some of these institutions are better established than others, leading to a somewhat inhomogeneous data quality level. If information gaps could not be filled, patients had to be excluded to match mandatory statistical standards. Therefore, a sensitivity analysis was conducted and could show that the necessary exclusion process only introduced a small amount of bias into the analysis of long-term survival, while results on short-term survival were not influenced significantly at all. Thus, all presented findings can be regarded as stable.
Concerning short-term outcomes, laparoscopic surgery patients in this study had a lower postoperative mortality rate in all age groups. However, the effect size was only moderate and the significance level was not reached in any age group. Extensive literature research revealed that Landi et al. also analyzed death within 30 days after surgery and found a significantly lower mortality rate in the laparoscopic than the open surgery group for patients under 80 years (0 vs. 4.6%, p = 0.049) [31]. A possible reason for the advantage of the minimally invasive surgical approach could be the lower postoperative complication rate. For example, Kolfschoten et al. and Mroczkowski et al. observed a higher number of complications after the conventional approach [6, 30]. McKay et al. divided their collective into patients under and over 70 years and analyzed the postoperative complication rate. In both age groups, more complications occurred after open surgery. Additionally, the complication rate was higher among patients aged over 70 years, both in the open and in the laparoscopic group [32]. Taking all these studies into account, laparoscopy indeed seems to be the superior surgical approach in terms of short-term outcomes, but age is not an effect modifier.
A significant advantage of laparoscopy could again be observed for overall survival in all age groups 5 years after surgery. Regarding recurrence-free survival, rates were higher in the laparoscopic group, although the significance level was no longer reached in the oldest group. Taking a closer look at the actual effect sizes after adjustment for confounders, an age-dependent gradient can be seen: With 0.703, the HR for laparoscopy is lowest in the youngest age group, grows to 0.787 in patients between 60 and 69 years, and is highest among septuagenarians (HR = 0.923). In the long term, young people obviously benefit most from minimally invasive surgery, while survival and recurrence patterns in older patients seem to depend less on the surgical approach. Future research is indispensable to further investigate the reasons for this observation.
All results of this study are based on 10,745 patients from 30 regional cancer registries covering approximately one quarter of the German population and can be regarded as representative. Even considering all limitations, the presented findings are statistically stable over all investigated age groups. Moreover, the application of multivariable analyses and relative survival models generated adjusted results going beyond mere observation. These can be used for direct comparison with patient samples from other regions. Thus, future research on this topic shall be encouraged.
Conclusion
In terms of postoperative survival, laparoscopy is at least equivalent to open surgery, with similar results in all age groups. Laparoscopy is also followed by better long-term survival and lower recurrence rates. Particularly, younger patients seem to benefit more from the minimally invasive approach. Increased use of laparoscopy for rectal cancer should be considered in this group.
Acknowledgments
The authors thank all participating registries (Augsburg, Berlin, Dresden, Stuttgart OSP, Zwickau, Chemnitz, Dessau, Koblenz, Halle, Leipzig, Bayreuth, Göppingen OSP, Erfurt, Westfalen-Lippe, Magdeburg, Erlangen-Nürnberg, Gera, Nordhausen, Jena, Brandenburg, Suhl, Regensburg, Ulm-CCC, Reutlingen, Ravensburg, Wiesbaden, Hamburg, Hanau Klinikum, Hannover, and Mecklenburg-Vorpommern) for their cooperation. We also would like to thank Dr. Hagen Barlag (†) for preparing the dataset.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Research involving human and animal participants
This article does not contain any studies with human participants or animals performed by any of the authors.
OpenAccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Mit der Zeitschrift Die Chirurgie erhalten Sie zusätzlich Online-Zugriff auf weitere 43 chirurgische Fachzeitschriften, CME-Fortbildungen, Webinare, Vorbereitungskursen zur Facharztprüfung und die digitale Enzyklopädie e.Medpedia.
Bis 30. April 2024 bestellen und im ersten Jahr nur 199 € zahlen!
Mit e.Med Innere Medizin erhalten Sie Zugang zu CME-Fortbildungen des Fachgebietes Innere Medizin, den Premium-Inhalten der internistischen Fachzeitschriften, inklusive einer gedruckten internistischen Zeitschrift Ihrer Wahl.
Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.
Zur Behandlung schwerer Formen der chronischen Rhinosinusitis mit Nasenpolypen (CRSwNP) stehen seit Kurzem verschiedene Behandlungsmethoden zur Verfügung, darunter Biologika, wie Dupilumab, und die endoskopische Sinuschirurgie (ESS). Beim Vergleich der beiden Therapieoptionen war Dupilumab leicht im Vorteil.
Nach PCI besteht ein erhöhtes Blutungsrisiko, wenn die Behandelten eine verminderte linksventrikuläre Ejektionsfraktion aufweisen. Das Risiko ist umso höher, je stärker die Pumpfunktion eingeschränkt ist.
In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.
Update Chirurgie
Bestellen Sie unseren Fach-Newsletterund bleiben Sie gut informiert.
Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.
Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?
Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.
