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Erschienen in:
01.10.2007 | SHORT COMMUNICATION
C-reactive protein and n–3 fatty acids in patients with a previous myocardial infarction
A placebo-controlled randomized study
Erschienen in: European Journal of Nutrition | Ausgabe 7/2007
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Background
Dietary intake of the marine long-chain n–3 polyunsaturated fatty acids (PUFA) may reduce mortality after a myocardial infarction (MI). This may partly be attributed to their anti-inflammatory properties.
Aim of the study
To investigate the effect of n–3 PUFA on C-reactive protein (CRP) in patients with a previous MI.
Methods
In a double-blind design, forty-one patients (mean age 63 ± 7 years) were randomized to receive daily supplements with 5.2 g of n–3 PUFA or olive oil (control). Serum CRP was measured with a highly sensitive assay (hs-CRP) before and after 12 weeks supplements. Compliance was monitored by measuring the incorporation of n–3 PUFA into platelets.
Results
The content of n–3 PUFA in platelets increased significantly in the n–3 PUFA supplemented group, whereas no changes were seen in controls. There was a minor increase in hs-CRP in the n–3 PUFA group (2.46 vs. 2.70 mg/l) and a small decrease in hs-CRP in the control group (2.52 vs. 1.67 mg/l). The changes, however, were not statistically significant (P = 0.30 and 0.43, respectively).
Conclusion
Supplementation with 5.2 g of n–3 PUFA for 12 weeks had no hs-CRP lowering effect in patients with a previous MI.