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24.09.2018 | Original Contribution

Bifidobacterium pseudocatenulatum CECT 7765 supplementation improves inflammatory status in insulin-resistant obese children

verfasst von: Jesús Sanchis-Chordà, Eva M. Gómez del Pulgar, Joaquín Carrasco-Luna, Alfonso Benítez-Páez, Yolanda Sanz, Pilar Codoñer-Franch

Erschienen in: European Journal of Nutrition | Ausgabe 7/2019

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Abstract

Purpose

The relationships between gut microbiota and obesity-related co-morbidities have been increasingly recognized. Low-grade inflammation may be the main factor in the pathogenesis of such disorders. We investigated the effect of the potential probiotic Bifidobacterium pseudocatenulatum CECT 7765 on cardiometabolic risk factors, inflammatory cytokines and gut microbiota composition in obese children with insulin resistance.

Methods

The study included 48 obese children (10–15 years old) with insulin resistance. They received dietary advice and were assigned to take the capsules with or without probiotic (10⁹⁻¹⁰ CFU) daily for 13 weeks. Clinical, biochemical and gut microbiome measurements were made at baseline and at the end of the intervention.

Results

There was a significant improvement in body mass index in all children after the intervention, suggesting that weight changes are related to the dietary advice. A significant decrease in circulating high-sensitive C-reactive protein (P = 0.026) and monocyte chemoattractant protein-1 (P = 0.032) and an increase in high-density lipoprotein cholesterol (P = 0.035) and omentin-1 (P = 0.023) in children receiving probiotic supplementation were observed compared to the control group. Regarding gut microbiota, probiotic administration significantly increased the proportion of the Rikenellaceae family members, particularly of the Alistipes genus.

Conclusions

The beneficial effects of the intervention on inflammatory markers and lipid profile suggest that B. pseudocatenulatum CECT 7765 intake together with dietary recommendations can improve inflammatory status in children with obesity and insulin resistance. These effects are parallel to increases in bacterial groups associated with a lean phenotype. The modulation of gut microbiota with probiotic supplementation can be considered an effective tool to ameliorate some obesity-related disorders in children.

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Titel: Bifidobacterium pseudocatenulatum CECT 7765 supplementation improves inflammatory status in insulin-resistant obese children
verfasst von: Jesús Sanchis-Chordà
Eva M. Gómez del Pulgar
Joaquín Carrasco-Luna
Alfonso Benítez-Páez
Yolanda Sanz
Pilar Codoñer-Franch
Publikationsdatum: 24.09.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 7/2019
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-018-1828-5

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Bifidobacterium pseudocatenulatum CECT 7765 supplementation improves inflammatory status in insulin-resistant obese children

Abstract

Purpose

Methods

Results

Conclusions

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