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12.12.2018 | Review

Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition

verfasst von: Salvatore Giovanni Vitale, Stella Capriglione, Gabriella Zito, Salvatore Lopez, Ferdinando Antonio Gulino, Federica Di Guardo, Amerigo Vitagliano, Marco Noventa, Valentina Lucia La Rosa, Fabrizio Sapia, Gaetano Valenti, Agnese Maria Chiara Rapisarda, Isabel Peterlunger, Diego Rossetti, Antonio Simone Laganà

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 2/2019

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Abstract

Purpose

Gynaecological cancer management in older people represents a current challenge. Therefore, in the present paper, we aimed to gather all the evidence reported in the literature concerning gynecological cancers in the elderly, illustrating the state of art and the future perspectives.

Methods

We searched MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS and Grey literature (Google Scholar; British Library) from January 1952 to May 2017, using the terms “ovarian cancer”, “endometrial cancer”, “cervical cancer”, “gynecological cancers” combined with ‘elderly’, ‘cancer’, ‘clinical trial’ and ‘geriatric assessment’.

Results

The search identified 81 citations, of which 65 were potentially relevant after initial evaluation and met the criteria for inclusion and were analyzed. We divided all included studies into three different issue: “Endometrial cancer”, “Ovarian cancer” and “Cervical cancer”.

Conclusions

The present literature review shows that, in spite of the higher burden of comorbidities, elderly patients can also benefit from standard treatment to manage their gynecological cancers. It is important to overcome the common habit of undertreating the elderly patients because they are more fragile and with a lower life expectancy than their younger counterpart. Further trials with elderly women are warranted.

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Titel: Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition
verfasst von: Salvatore Giovanni Vitale
Stella Capriglione
Gabriella Zito
Salvatore Lopez
Ferdinando Antonio Gulino
Federica Di Guardo
Amerigo Vitagliano
Marco Noventa
Valentina Lucia La Rosa
Fabrizio Sapia
Gaetano Valenti
Agnese Maria Chiara Rapisarda
Isabel Peterlunger
Diego Rossetti
Antonio Simone Laganà
Publikationsdatum: 12.12.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 2/2019
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-5006-z

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Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition