Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
European Archives of Psychiatry and Clinical Neuroscience
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience 3/2013

01.04.2013 | Original Paper

The role of a mineralocorticoid receptor gene functional polymorphism in the symptom dimensions of persistent ADHD

verfasst von: Gustavo Lucena Kortmann, Verônica Contini, Guilherme Pinto Bertuzzi, Nina Roth Mota, Diego Luiz Rovaris, Vanessa Rodrigues Paixão-Côrtes, Leandro Leal de Lima, Eugenio Horacio Grevet, Carlos Alberto Iglesias Salgado, Eduardo Schneider Vitola, Luis Augusto Rohde, Paulo Belmonte-de-Abreu, Claiton Henrique Dotto Bau

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 3/2013

Einloggen, um Zugang zu erhalten

Abstract

Attention-deficit/hyperactivity disorder (ADHD) affects approximately 5 % of school-aged children and 2.5 % of adults. Genetic studies in ADHD have pointed to genes in different neurobiological systems, with relatively small individual effects. The mineralocorticoid receptor is the main receptor involved in the initial triggering of stress response. Therefore, its encoding gene (NR3C2) is a candidate for psychiatric disorder studies, including ADHD, and behavioral phenotypes. There is evidence that the Val allele of the MRI180V polymorphism (rs5522) increases the risk of depression, attention and cognitive deficits. We investigated the possible role of the mineralocorticoid receptor gene in the symptom dimensions and susceptibility to persistent ADHD. We compared genotype and allele frequencies in 478 adult patients with ADHD and 597 controls and symptom dimensions in 449 patients and 132 controls. Diagnoses were based on the DSM-IV criteria. ADHD symptom dimensions were investigated with SNAP-IV for ADHD severity and Barkley scales for severity and impairment. Carriers of the Val allele presented higher inattention, hyperactivity/impulsivity and impairment scores, while genotype and allele frequencies did not differ between patients and controls. These results are consistent with a possible link between genetic variations in the HPA axis and inattention and hyperactivity measures.
Literatur
1.
Faraone SV, Biederman J, Mick E (2006) The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med 36:159–165PubMedCrossRef
2.
Fayyad J, De Graaf R, Kessler R, Alonso J, Angermeyer M, Demyttenaere K, De Girolamo G, Haro JM, Karam EG, Lara C, Lépine JP, Ormel J, Posada-Villa J, Zaslavsky AM, Jin R (2007) Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder. Br J Psychiatry 190:402–409PubMedCrossRef
3.
Polanczyk G, Lima MS, Horta BL, Biederman J, Rohde LA (2007) The Worldwide Prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 164:942–948PubMedCrossRef
4.
Simon V, Czobor P, Bálint S, Mészáros A, Bitter I (2009) Prevalence and correlates of adult attention deficit/hyperactivity disorder: meta-analysis. Br J Psychiatry 194:204–211PubMedCrossRef
5.
Gizer IR, Ficks C, Waldman ID (2009) Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 126:51–90PubMedCrossRef
6.
Franke B, Neale BM, Faraone SV (2009) Genome-wide association studies in ADHD. Hum Genet 126:13–50PubMedCrossRef
7.
Alleva E, Francia N (2009) Psychiatric vulnerability: suggestions from animal models and role of neurotrophins. Neurosci Biobehav Rev 33:525–536PubMedCrossRef
8.
Maccari S, Darnaudery M, Morley-Fletcher S, Zuena AR, Cinque C, Van Reeth O (2003) Prenatal stress and long-term consequences: implications of glucocorticoid hormones. Neurosci Biobehav Rev 27:119–127PubMedCrossRef
9.
Meier A (1985) Child psychiatric sequelae of maternal war stress. Acta Psychiatr Scand 72:505–511CrossRef
10.
Schell LM (1981) Environmental noise and human prenatal growth. Am J Physiol Anthropol 56:63–70CrossRef
11.
Weinstock M (1997) Does prenatal stress impair coping and regulation of hypothalamic–pituitary–adrenal axis? Neurosci Biobehav Rev 21:1–10PubMedCrossRef
12.
Weinstock M (2005) The potential influence of maternal stress hormones on development and mental health of the offspring. Brain Behav Immun 19:296–308PubMedCrossRef
13.
King JA, Barkley RA, Barrett S (1998) Attention-deficit hyperactivity disorder and the stress response. Biol Psychiatry 44:72–74PubMedCrossRef
14.
Hong HJ, Shin DW, Lee EH, Oh YH, Noh KS (2003) Hypothalamic-pituitary-adrenal reactivity in boys with attention deficit hyperactivity disorder. Yonsei Med J 44:608–614PubMed
15.
Yang SJ, Shin DW, Noh KS, Stein MA (2007) Cortisol is inversely correlated with aggression for those boys with attention deficit hyperactivity disorder who retain their reactivity to stress. Psychiatry Res 153:55–60PubMedCrossRef
16.
Lackschewitz H, Huther G, Kroner-Herwig B (2008) Physiological and psychological stress responses in adults with attention-deficit/hyperactivity disorder (ADHD). Psychoneuroendocrinology 33:612–624PubMedCrossRef
17.
van West D, Claes S, Deboutte D (2009) Differences in hypothalamic-pituitary-adrenal axis functioning among children with ADHD predominantly inattentive and combined types. Eur Child Adolesc Psychiatry 9:543–553CrossRef
18.
Kariyawasam SH, Zaw F, Handley SL (2002) Reduced salivary cortisol in children with comorbid Attention deficit hyperactivity disorder and oppositional defiant disorder. Neuro Endocrinol Lett 1:45–48
19.
Ma L, Chen YH, Chen H, Liu YY, Wang YX (2011) The function of hypothalamus-pituitary-adrenal axis in children with ADHD. Brain Res 1368:159–162PubMedCrossRef
20.
Sondeijker FE, Ferdinand RF, Oldehinkel AJ, Veenstra R, Tiemeier H, Ormel J, Verhulst FC (2007) Disruptive behaviors and HPA-axis activity in young adolescent boys and girls from the general population. J Psychiatr Res 41:570–578PubMedCrossRef
21.
de Kloet ER, Vreugdenhil E, Oitzl MS, Joëls M (1998) Brain corticosteroid receptor balance in health and disease. Endocr Rev 19:269–301PubMedCrossRef
22.
de Kloet ER, Van Acker SA, Sibug RM, Oitzl MS, Meijer OC, Rahmouni K, de Jong W (2000) Brain mineralocorticoid receptors and centrally regulated functions. Kidney Int 57:1329–1336PubMedCrossRef
23.
de Rijk RH, Wust S, Meijer OC, Zennaro MC, Federenko IS, Hellhammer DH, Giacchetti G, Vreugdenhil E, Zitman FG, de Kloet ER (2006) A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness. J Clin Endocrinol Metab 91:5083–5089CrossRef
24.
Reul JM, de Kloet ER (1985) Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 117:2505–2511PubMedCrossRef
25.
Funder JW (2004) Aldosterone, mineralocorticoid receptors and vascular inflammation. Mol Cell Endocrinol 217:263–269PubMedCrossRef
26.
de Kloet ER (2003) Hormones, brain and stress. Endocr Regul 37:51–68PubMed
27.
Otte C, Moritz S, Yassouridis A, Koop M, Madrischewski AM, Wiedemann K, Kellner M (2007) Blockade of the mineralocorticoid receptor in healthy men: effects on experimentally induced panic symptoms, stress hormones, and cognition. Neuropsychopharmacology 32:232–238PubMedCrossRef
28.
de Rijk RH, van Leeuwen N, Klok MD, Zitman FG (2008) Corticosteroid receptor-gene variants: modulators of the stress-response and implications for mental health. Eur J Pharmacol 585:492–501CrossRef
29.
de Rijk RH (2009) Single nucleotide polymorphisms related to HPA axis reactivity. NeuroImmunoModulation 16:340–352CrossRef
30.
Kuningas M, de Rijk RH, Westendorp RG, Jolles J, Slagboom PE, van Heemst D (2007) Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors. Neuropsychopharmacology 32:1295–1301PubMedCrossRef
31.
Bogdan R, Perlis RH, Fagerness J, Pizzagalli DA (2010) The impact of mineralocorticoid receptor ISO/VAL genotype (rs5522) and stress on reward learning. Genes Brain Behav 9:658–667PubMed
32.
Arai K, Nakagomi Y, Iketani M, Shimura Y, Amemiya S, Ohyama K, Shibasaki T (2003) Functional polymorphisms in the mineralocorticoid receptor and amirolide-sensitive sodium channel genes in a patient with sporadic pseudohypoaldosteronism. Hum Genet 112:91–97PubMedCrossRef
33.
de Rijk RH, de Kloet ER, Zitman FG, van Leeuwen N (2011) Mineralocorticoid receptor gene variants as determinants of HPA axis regulation and behavior. Endocr Dev 20:137–148
34.
Luijk MP, Tharner A, Bakermans-Kranenburg MJ, van Ijzendoorn MH, Jaddoe VW, Hofman A, Verhulst FC, Tiemeier H (2011) The association between parenting and attachment security is moderated by a polymorphism in the mineralocorticoid receptor gene: evidence for differential susceptibility. Biol Psychol 88:37–40PubMedCrossRef
35.
American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Press, Washington, DC
36.
Kaplan E, Fein D, Morris R, Delis DC (1991) WAIS-R: manual. Psychological corporation, San Antonio
37.
Salzano FM, Bortolini MC (2002) The evolution and genetics of Latin American populations. Cambridge University Press, Cambridge
38.
Zembrzuski VM, Callegari-Jacques SM, Hutz MH (2006) Application of an African Ancestry Index as a genomic control approach in a Brazilian population. Ann Hum Genet 70:822–828PubMedCrossRef
39.
Santos NP, Ribeiro-Rodrigues EM, Ribeiro-Dos-Santos AK, Pereira R, Gusmão L, Amorim A, Guerreiro JF, Zago MA, Matte C, Hutz MH, Santos SE (2010) Assessing individual interethnic admixture and population substructure using a 48-insertion-deletion (insel) ancestry-informative marker (aim) panel. Hum Mutat 31:184–190PubMedCrossRef
40.
Hutchison KE, Stallings M, McGeary J, Bryan A (2004) Population stratification in the candidate gene study: fatal threat or red herring? Psychol Bull 130:66–79PubMedCrossRef
41.
Mercadante MT, Asbahar F, Rosário MC, Ayres AM, Karman L, Ferrari MC, Assumpcão FB, Miguel EC (1995) K-SADS, entrevista semi-estruturada para diagnóstico em psiquiatria da infância, versão epidemiológica. FMUSP, São Paulo
42.
Grevet EH, Bau CH (2005) Interrater reliability for diagnosis in adults of attention deficit hyperactivity disorder and oppositional defiant disorder using K-SADS-E. Arq Neuropsiquiatr 63:307–310PubMedCrossRef
43.
First MB, Spitzer RL, Gibbon M, Williams JB (1998) Structured clinical interview for DSMIV (SCID-I). Biomedics Research Department, New York
44.
Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl 20):22–33; quiz 34–57
45.
Wechsler D (1981) WAIS-R—Manual for the Wechsler Adult Intelligence Scale—Revised. The Psychological Corporation, San Antonio
46.
Swanson JM (1992) School-based assessments and interventions for ADD students. KC Publishing, Irvine
47.
Barkley RA, Murphy KR (1998) Attention deficit hyperactivity disorder: a clinical workbook, vol 2. The Guilford Press, New York
48.
Grevet EH, Bau CH, Salgado CA, Ficher A, Kalil K, Victor MM, Garcia C, Sousa NO, Belmonte-de-Abreu P (2006) Lack of gender effects on subtype outcomes in adults with attention-deficit/hyperactivity disorder: support for the validity of subtypes. Eur Arch Psychiatry Clin Neurosci 256:311–319PubMedCrossRef
49.
Fischer AG, Bau CH, Grevet EH, Salgado CA, Victor MM, Kalil KL, Sousa NO, Garcia CR, Belmonte-de-Abreu P (2007) The role of comorbid major depressive disorder in the clinical presentation of adult ADHD. J Psychiatr Res 41:991–996PubMedCrossRef
50.
Contini V, Victor MM, Cerqueira CC, Polina ER, Grevet EH, Salgado CA, Karam RG, Vitola ES, Belmonte-de-Abreu P, Bau CH (2011) Adrenergic α2A receptor gene is not associated with methylphenidate response in adults with ADHD. Eur Arch Psychiatry Clin Neurosci 261:205–211PubMedCrossRef
51.
Karam RG, Bau CH, Salgado CA, Kalil KL, Victor MM, Sousa NO, Vitola ES, Picon FA, Zeni GD, Rohde LA, Belmonte-de-Abreu P, Grevet EH (2009) Late-onset ADHD in adults: milder, but still dysfunctional. J Psychiatr Res 43:697–701PubMedCrossRef
52.
Lahiri DK, Nurnberger JI Jr (1991) A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 19:5444PubMedCrossRef
53.
Sousa NO, Grevet EH, Salgado CA, Silva KL, Victor MM, Karam RG, Vitola ES, Picon FA, Zeni GD, Rohde LA, Belmonte-de-Abreu P, Bau CH (2011) Smoking and ADHD: an evaluation of self medication and behavioral disinhibition models based on comorbidity and personality patterns. J Psychiatr Res 6:829–834CrossRef
54.
Cole J, Ball HA, Martin NC, Scourfield J, McGuffin P (2009) Genetic overlap between measures of hyperactivity/inattention and mood in children and adolescents. J Am Acad Child Adolesc Psychiatry 11:1094–1101CrossRef
55.
Blase SL, Gilbert AN, Anastopoulos AD, Costello EJ, Hoyle RH, Swartzwelder HS, Rabiner DL (2009) Self-reported ADHD and adjustment in college: cross-sectional and longitudinal findings. J Attend Disord 3:297–309CrossRef
56.
Purper-Ouakil D, Franc N (2011) Emotional dysfunctions in attention deficit hyperactivity disorder. Arch Pediatr 6:679–685CrossRef
57.
Le Menuet D, Viengchareun S, Muffat-Joly M, Zennaro MC, Lombès M (2004) Expression and function of the human mineralocorticoid receptor: lessons from transgenic mouse models. Mol Cell Endocrinol 217:127–136PubMedCrossRef
58.
Neale BM, Medland SE, Ripke S, Asherson P, Franke B, Lesch KP, Faraone SV, Nguyen TT, Schäfer H, Holmans P, Daly M, Steinhausen HC, Freitag C, Reif A, Renner TJ, Romanos M, Romanos J, Walitza S, Warnke A, Meyer J, Palmason H, Buitelaar J, Vasquez AA, Lambregts-Rommelse N, Gill M, Anney RJ, Langely K, O’Donovan M, Williams N, Owen M, Thapar A, Kent L, Sergeant J, Roeyers H, Mick E, Biederman J, Doyle A, Smalley S, Loo S, Hakonarson H, Elia J, Todorov A, Miranda A, Mulas F, Ebstein RP, Rothenberger A, Banaschewski T, Oades RD, Sonuga-Barke E, McGough J, Nisenbaum L, Middleton F, Hu X, Nelson S; Psychiatric GWAS Consortium: ADHD Subgroup (2010) Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49:884–897
59.
Pan Y, Wang KS, Aragam N (2011) Ntm and nr3c2 polymorphisms influencing intelligence: Family-based association studies. Prog Neuropsychopharmacol Biol Psychiatry 35:154–160PubMedCrossRef
60.
Berrettini W, Yuan X, Tozzi F, Song K, Francks C, Chilcoat H, Waterworth D, Muglia P, Mooser V (2008) Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Mol Psychiatry 13:368–373PubMedCrossRef
61.
Shaw P, Gilliam M, Liverpool M, Weddle C, Malek M, Sharp W, Greenstein D, Evans A, Rapoport J, Giedd J (2011) Cortical development in typically developing children with symptoms of hyperactivity and impulsivity: support for a dimensional view of attention deficit hyperactivity disorder. Am J Psychiatry 168:143–151PubMedCrossRef
62.
Lubke GH, Hudziak JJ, Derks EM, van Bijsterveldt TC, Boomsma DI (2009) Maternal ratings of attention problems in ADHD: evidence for the existence of a continuum. J Am Acad Child Adolesc Psychiatry 48:1085–1093PubMedCrossRef
63.
Polderman TJ, Derks EM, Hudziak JJ, Verhulst FC, Posthuma D, Boomsma DI (2007) Across the continuum of attention skills: a twin study of the SWAN ADHD rating scale. J Child Psychol Psychiatry 48:1080–1087PubMedCrossRef
64.
El Hage W, Powell JF, Surguladze SA (2009) Vulnerability to depression: what is the role of stress genes in gene x environment interaction? Psychol Med 39:1407–1411PubMedCrossRef
65.
Gillespie CF, Phifer J, Bradley B, Ressler KJ (2009) Risk and resilience: genetic and environmental influences on development of the stress response. Depress Anxiety 26:984–992PubMedCrossRef
66.
van Leeuwen N, Bellingrath S, de Kloet ER, Zitman FG, DeRijk RH, Kudielka BM, Wüst S (2011) Human mineralocorticoid receptor (MR) gene haplotypes modulate MR expression and transactivation: implication for the stress response. Psychoneuroendocrinology 5:699–709CrossRef
67.
van Leeuwen N, Kumsta R, Entringer S, de Kloet ER, Zitman FG, DeRijk RH, Wüst S (2010) Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasone. Psychoneuroendocrinology 35:339–349PubMedCrossRef
68.
Kebir O, Joober R (2011) Neuropsychological endophenotypes in attention-deficit/hyperactivity disorder: a review of genetic association studies. Eur Arch Psychiatry Clin Neurosci 261:583–594PubMedCrossRef
Metadaten
Titel
The role of a mineralocorticoid receptor gene functional polymorphism in the symptom dimensions of persistent ADHD
verfasst von
Gustavo Lucena Kortmann
Verônica Contini
Guilherme Pinto Bertuzzi
Nina Roth Mota
Diego Luiz Rovaris
Vanessa Rodrigues Paixão-Côrtes
Leandro Leal de Lima
Eugenio Horacio Grevet
Carlos Alberto Iglesias Salgado
Eduardo Schneider Vitola
Luis Augusto Rohde
Paulo Belmonte-de-Abreu
Claiton Henrique Dotto Bau
Publikationsdatum
01.04.2013
Verlag
Springer-Verlag
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 3/2013
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-012-0321-z

Weitere Artikel der Ausgabe 3/2013

European Archives of Psychiatry and Clinical Neuroscience 3/2013 Zur Ausgabe

Original Paper

Perceived patient–parent relationships and neural representation of parents in schizophrenia

Original Paper

Single-subject classification of schizophrenia using event-related potentials obtained during auditory and visual oddball paradigms

Original Paper

Prevalence of the metabolic syndrome in patients with borderline personality disorder: results from a cross-sectional study

Original Paper

Enhanced top-down control during pursuit eye tracking in schizophrenia

Original Paper

Impaired volitional saccade control: first evidence for a new candidate endophenotype in obsessive–compulsive disorder

Original Paper

Relationship between apolipoprotein E4 genotype and white matter integrity in HIV-positive young adults in South Africa

Neu im Fachgebiet Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

23.04.2024 Depression antepartal oder postpartal Nachrichten

Bislang gibt es kein Medikament zur Prävention von Wochenbettdepressionen. Das Injektionsanästhetikum Esketamin könnte womöglich diese Lücke füllen.

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

22.04.2024 DGIM 2024 Kongressbericht

Die Kombination aus Medikamenten und Psychotherapie gilt als effektivster Ansatz bei Depressionen. Das ist bei betagten Menschen nicht anders, trotz Besonderheiten.

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

22.04.2024 DGIM 2024 Nachrichten

Um Menschen nach der Flucht aus einem Krisengebiet bestmöglich medizinisch betreuen zu können, ist es gut zu wissen, welche Erkrankungen im jeweiligen Herkunftsland häufig sind. Dabei hilft eine Internetseite der CDC (Centers for Disease Control and Prevention).

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise