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International Journal of Legal Medicine

Erschienen in:

01.01.2007 | Original Article

Population differences of two coding SNPs in pigmentation-related genes SLC24A5 and SLC45A2

verfasst von: Mikiko Soejima, Yoshiro Koda

Erschienen in: International Journal of Legal Medicine | Ausgabe 1/2007

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Abstract

The two genes SLC24A5 and SLC45A2 were recently identified as major determinants of pigmentation in humans and in other vertebrates. The allele p.A111T in the former gene and the allele p.L374F in the latter gene are both nearly fixed in light-skinned Europeans, and can therefore be considered ancestry informative marker (AIMs). AIMs are becoming useful for forensic identification of the phenotype from a DNA profile sampled, for example, from a crime scene. Here, we generate new allelic data for these two genes from samples of Chinese, Uygurs, Ghanaians, South African Xhosa, South African Europeans, and Sri Lankans (Tamils and Sinhalese). Our data confirm the earlier results and furthermore demonstrate that the SLC45A2 allele is a more specific AIM than the SLC24A5 allele because the former clearly distinguishes the Sri Lankans from the Europeans.

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Titel: Population differences of two coding SNPs in pigmentation-related genes SLC24A5 and SLC45A2
verfasst von: Mikiko Soejima
Yoshiro Koda
Publikationsdatum: 01.01.2007
Verlag: Springer-Verlag
Erschienen in: International Journal of Legal Medicine / Ausgabe 1/2007
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-006-0112-z

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Population differences of two coding SNPs in pigmentation-related genes SLC24A5 and SLC45A2

Abstract

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

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