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International Journal of Legal Medicine

Erschienen in:

01.11.2007 | Original Article

Haplotypes of 20 Y-chromosomal STRs in a population sample from southeast China (Chaoshan area)

verfasst von: Mei Sen Shi, Jian Pin Tang, Ru Feng Bai, Xiao Jun Yu, Jun Yao Lv, Bo Hu

Erschienen in: International Journal of Legal Medicine | Ausgabe 6/2007

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Abstract

In this study, 20 Y-specific short tandem repeat (STR) loci (DYS434, Y-GATA-A10, Y-GATA-H4, DYS438, DYS439, DYS443, DYS444, DYS446, DYS447, DYS448, DYS456, DYS458, DYS460, DYS520, DYS531, DYS557, DYS622, DYS630, DYS635(Y-GATA-C4), and DYS709) were analyzed in 158 unrelated healthy men from southeast China by three fluorescence-labeled multiplex polymerase chain reaction systems. The Y-STR multiplexes developed have followed the published nomenclature and International Society for Forensic Genetics (ISFG) guidelines for STR analysis. Gene diversity ranged from 0.2506 at DYS434 to 0.8034 at DYS447. A total of 157 different haplotypes were observed, and among these, 156 were unique, while 1 was found two times. The haplotype diversity value calculated from all 20 loci combined was 0.9997, which is informative. Furthermore, 80 father–son pairs, previously confirmed by autosomal STR analysis, were typed using the same 20 Y-STR loci, and four mutation events were identified at the Y-GATA-H4, DYS439, DYS456, and DYS458 loci, giving an average mutation rate of 0.25% per locus per generation (95% confidence interval 0.09–0.54). These results including the haplotype data at 20 Y-STR loci would enrich Chinese genetic informational resources and provide useful information in forensic practice.

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Titel: Haplotypes of 20 Y-chromosomal STRs in a population sample from southeast China (Chaoshan area)
verfasst von: Mei Sen Shi
Jian Pin Tang
Ru Feng Bai
Xiao Jun Yu
Jun Yao Lv
Bo Hu
Publikationsdatum: 01.11.2007
Verlag: Springer-Verlag
Erschienen in: International Journal of Legal Medicine / Ausgabe 6/2007
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-007-0186-2

Die Highlights vom Kongress des American College of Cardiology 2024

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Haplotypes of 20 Y-chromosomal STRs in a population sample from southeast China (Chaoshan area)

Abstract

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

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