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International Journal of Legal Medicine

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01.01.2010 | Technical Note

Validation of six closely linked STRs located in the chromosome X centromere region

verfasst von: Jeanett Edelmann, Sandra Hering, Christa Augustin, Stefan Kalis, Reinhard Szibor

Erschienen in: International Journal of Legal Medicine | Ausgabe 1/2010

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Abstract

We propose that clusters of closely linked markers, which segregate as stable haplotypes, provide a high potential to solve complex kinship cases. It is known that the X-chromosomal centromere region shows an extremely low degree of recombination. Hence, we focused our interest on the region between 56 and 64 Mb distant from the Xp telomere and considered 6 STRs which are now registered in the Genome Data Base as DXS10161, DXS10159, DXS10162, DXS10163, DXS10164, and DXS10165. All of these markers show a tetranucleotide or pentanucleotide structure and exhibit high or medium polymorphic information content. As a peculiarity, DXS10163 is a combination of a pentanucleotide STR and an 18 bp INDEL polymorphism. We report here the primer sequences, the repeat structures, the allele distributions and parameters of forensic interest for a German population sample.

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Titel: Validation of six closely linked STRs located in the chromosome X centromere region
verfasst von: Jeanett Edelmann
Sandra Hering
Christa Augustin
Stefan Kalis
Reinhard Szibor
Publikationsdatum: 01.01.2010
Verlag: Springer-Verlag
Erschienen in: International Journal of Legal Medicine / Ausgabe 1/2010
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-009-0328-9

Springer Medizin

Validation of six closely linked STRs located in the chromosome X centromere region

Abstract

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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