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Graefe's Archive for Clinical and Experimental Ophthalmology
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 11/2008

01.11.2008 | Review Article

A review of in vivo animal studies in retinal prosthesis research

verfasst von: Dimiter R. Bertschinger, Evgueny Beknazar, Manuel Simonutti, Avinoam B. Safran, José A. Sahel, Serge G. Rosolen, Serge Picaud, Joel Salzmann

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 11/2008

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Abstract

Background

The development of a functional retinal prosthesis for acquired blindness is a great challenge. Rapid progress in the field over the last 15 years would not have been possible without extensive animal experimentation pertaining to device design and fabrication, biocompatibility, stimulation parameters and functional responses. This paper presents an overview of in vivo animal research related to retinal prosthetics, and aims to summarize the relevant studies.

Methods

A Pubmed search of the English language literature was performed. The key search terms were: retinal implant, retinal prosthesis, artificial vision, rat, rabbit, cat, dog, sheep, pig, minipig. In addition a manual search was performed based on references quoted in the articles retrieved through Pubmed.

Results

We identified 50 articles relevant to in vivo animal experimentation directly related to the development of a retinal implant. The highest number of publications related to the cat (n = 18).

Conclusion

The contribution of animal models to the development of retinal prosthetic devices has been enormous, and has led to human feasibility studies. Grey areas remain regarding long-term tissue-implant interactions, biomaterials, prosthesis design and neural adaptation. Animals will continue to play a key role in this rapidly evolving field.
Literatur
1.
Acland GM, Aguirre GD, Ray J, Zhang Q, Aleman TS, Cideciyan AV, Pearce-Kelling SE, Anand V, Zeng Y, Maguire AM, Jacobson SG, Hauswirth WW, Bennett J (2001) Gene therapy restores vision in a canine model of childhood blindness. Nat Genet 28:92–95PubMed
2.
Acosta AC, Espana EM, Yamamoto H, Davis S, Pinchuk L, Weber BA, Orozco M, Dubovy S, Fantes F, Parel JM (2006) A newly designed glaucoma drainage implant made of poly(styrene-b-isobutylene-b-styrene): biocompatibility and function in normal rabbit eyes. Arch Ophthalmol 124:1742–1749PubMedCrossRef
3.
Aguirre G (1978) Retinal degenerations in the dog. I. Rod dysplasia. Exp Eye Res 26:233–253PubMedCrossRef
4.
Aguirre G, Farber D, Lolley R, O’Brien P, Alligood J, Fletcher RT, Chader G (1982) Retinal degeneration in the dog. III. Abnormal cyclic nucleotide metabolism in rod-cone dysplasia. Exp Eye Res 35:625–642PubMedCrossRef
5.
Aguirre GD, Rubin LF (1975) Rod-cone dysplasia (progressive retinal atrophy) in Irish setters. J Am Vet Med Assoc 166:157–164PubMed
6.
Aguirre GD, Baldwin V, Pearce-Kelling S, Narfstrom K, Ray K, Acland GM (1998) Congenital stationary night blindness in the dog: common mutation in the RPE65 gene indicates founder effect. Mol Vis 4:23PubMed
7.
Albini TA, Rao NA, Li A, Craft CM, Fujii GY, de Juan E Jr (2004) Limited macular translocation: a clinicopathologic case report. Ophthalmology 111:1209–1214PubMedCrossRef
8.
Ali RR, Sarra GM, Stephens C, Alwis MD, Bainbridge JW, Munro PM, Fauser S, Reichel MB, Kinnon C, Hunt DM, Bhattacharya SS, Thrasher AJ (2000) Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy. Nat Genet 25:306–310PubMedCrossRef
9.
Baig-Silva MS, Hathcock CD, Hetling JR (2005) A preparation for studying electrical stimulation of the retina in vivo in rat. J Neural Eng 2:S29–S38PubMedCrossRef
10.
Binder S, Stanzel BV, Krebs I, Glittenberg C (2007) Transplantation of the RPE in AMD. Prog Retin Eye Res 26:516–554PubMedCrossRef
11.
Bradley DC, Troyk PR, Berg JA, Bak M, Cogan S, Erickson R, Kufta C, Mascaro M, McCreery D, Schmidt EM, Towle VL, Xu H (2005) Visuotopic mapping through a multichannel stimulating implant in primate V1. J Neurophysiol 93:1659–1670PubMedCrossRef
12.
Buyukmihci N, Aguirre G, Marshall J (1980) Retinal degenerations in the dog. II. Development of the retina in rod-cone dysplasia. Exp Eye Res 30:575–591PubMedCrossRef
13.
Campochiaro PA, Gaskin HC, Vinores SA (1987) Retinal cryopexy stimulates traction retinal detachment formation in the presence of an ocular wound. Arch Ophthalmol 105:1567–1570PubMedCrossRef
14.
Canola K, Angenieux B, Tekaya M, Quiambao A, Naash MI, Munier FL, Schorderet DF, Arsenijevic Y (2007) Retinal stem cells transplanted into models of late stages of retinitis pigmentosa preferentially adopt a glial or a retinal ganglion cell fate. Invest Ophthalmol Vis Sci 48:446–454PubMedCrossRef
15.
Chan F, Bradley A, Wensel TG, Wilson JH (2004) Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapy. Proc Natl Acad Sci U S A 101:9109–9114PubMedCrossRef
16.
Chen SJ, Mahadevappa M, Roizenblatt R, Weiland J, Humayun M (2006) Neural responses elicited by electrical stimulation of the retina. Trans Am Ophthalmol Soc 104:252–259PubMed
17.
Chow AY, Chow VY (1997) Subretinal electrical stimulation of the rabbit retina. Neurosci Lett 225:13–16PubMedCrossRef
18.
Chow AY, Pardue MT, Chow VY, Peyman GA, Liang C, Perlman JI, Peachey NS (2001) Implantation of silicon chip microphotodiode arrays into the cat subretinal space. IEEE Trans Neural Syst Rehabil Eng 9:86–95PubMedCrossRef
19.
Chow AY, Pardue MT, Perlman JI, Ball SL, Chow VY, Hetling JR, Peyman GA, Liang C, Stubbs EB Jr., Peachey NS (2002) Subretinal implantation of semiconductor-based photodiodes: durability of novel implant designs. J Rehabil Res Dev 39:313–321PubMed
20.
Chow AY, Chow VY, Packo KH, Pollack JS, Peyman GA, Schuchard R (2004) The artificial silicon retina microchip for the treatment of vision loss from retinitis pigmentosa. Arch Ophthalmol 122:460–469PubMedCrossRef
21.
Chowdhury V, Morley JW, Coroneo MT (2005) Feasibility of extraocular stimulation for a retinal prosthesis. Can J Ophthalmol 40:563–572PubMed
22.
Chowdhury V, Morley JW, Coroneo MT (2005) Evaluation of extraocular electrodes for a retinal prosthesis using evoked potentials in cat visual cortex. J Clin Neurosci 12:574–579PubMedCrossRef
23.
Chowdhury V, Morley JW, Coroneo MT (2005) Stimulation of the retina with a multielectrode extraocular visual prosthesis. ANZ J Surg 75:697–704PubMedCrossRef
24.
Cleary PE, Ryan SJ (1979) Experimental posterior penetrating eye injury in the rabbit. II. Histology of wound, vitreous, and retina. Br J Ophthalmol 63:312–321PubMedCrossRef
25.
Cleary PE, Ryan SJ (1979) Experimental posterior penetrating eye injury in the rabbit. I. Method of production and natural history. Br J Ophthalmol 63:306–311PubMedCrossRef
26.
Colodetti L, Weiland JD, Colodetti S, Ray A, Seiler MJ, Hinton DR, Humayun MS (2007) Pathology of damaging electrical stimulation in the retina. Exp Eye Res 85:23–33PubMedCrossRef
27.
Cordeiro MF, Constable PH, Alexander RA, Bhattacharya SS, Khaw PT (1997) Effect of varying the mitomycin-C treatment area in glaucoma filtration surgery in the rabbit. Invest Ophthalmol Vis Sci 38:1639–1646PubMed
28.
D’Cruz PM, Yasumura D, Weir J, Matthes MT, Abderrahim H, LaVail MM, Vollrath D (2000) Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet 9:645–651PubMedCrossRef
29.
DeMarco PJ Jr., Yarbrough GL, Yee CW, McLean GY, Sagdullaev BT, Ball SL, McCall MA (2007) Stimulation via a subretinally placed prosthetic elicits central activity and induces a trophic effect on visual responses. Invest Ophthalmol Vis Sci 48:916–926PubMedCrossRef
30.
Eckhorn R, Wilms M, Schanze T, Eger M, Hesse L, Eysel UT, Kisvarday ZF, Zrenner E, Gekeler F, Schwahn H, Shinoda K, Sachs H, Walter P (2006) Visual resolution with retinal implants estimated from recordings in cat visual cortex. Vision Res 46:2675–2690PubMedCrossRef
31.
Eckmiller R (1997) Learning retina implants with epiretinal contacts. Ophthalmic Res 29:281–289PubMedCrossRef
32.
Eger M, Wilms M, Eckhorn R, Schanze T, Hesse L (2005) Retino-cortical information transmission achievable with a retina implant. Biosystems 79:133–142PubMedCrossRef
33.
Gekeler F, Kobuch K, Schwahn HN, Stett A, Shinoda K, Zrenner E (2004) Subretinal electrical stimulation of the rabbit retina with acutely implanted electrode arrays. Graefes Arch Clin Exp Ophthalmol 242:587–596PubMedCrossRef
34.
Gekeler F, Szurman P, Grisanti S, Weiler U, Claus R, Greiner TO, Volker M, Kohler K, Zrenner E, Bartz-Schmidt KU (2007) Compound subretinal prostheses with extra-ocular parts designed for human trials: successful long-term implantation in pigs. Graefes Arch Clin Exp Ophthalmol 245:230–241PubMedCrossRef
35.
Gerding H (2007) A new approach towards a minimal invasive retina implant. J Neural Eng 4:S30–37PubMedCrossRef
36.
Gerding H, Benner FP, Taneri S (2007) Experimental implantation of epiretinal retina implants (EPI-RET) with an IOL-type receiver unit. J Neural Eng 4:S38–S49PubMedCrossRef
37.
Ghosh F, Engelsberg K, English RV, Petters RM (2007) Long-term neuroretinal full-thickness transplants in a large animal model of severe retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol 245:835–846PubMedCrossRef
38.
Gouws P, Moss EB, Trope GE, Ethier CR (2007) Continuous intraocular pressure (IOP) measurement during glaucoma drainage device implantation. J Glaucoma 16:329–333PubMedCrossRef
39.
Guven D, Weiland JD, Fujii G, Mech BV, Mahadevappa M, Greenberg R, Roizenblatt R, Qiu G, Labree L, Wang X, Hinton D, Humayun MS (2005) Long-term stimulation by active epiretinal implants in normal and RCD1 dogs. J Neural Eng 2:S65–S73PubMedCrossRef
40.
Guven D, Weiland JD, Maghribi M, Davidson JC, Mahadevappa M, Roizenblatt R, Qiu G, Krulevitz P, Wang X, Labree L, Humayun MS (2006) Implantation of an inactive epiretinal poly(dimethyl siloxane) electrode array in dogs. Exp Eye Res 82:81–90PubMedCrossRef
41.
Hafezi F, Grimm C, Simmen BC, Wenzel A, Reme CE (2000) Molecular ophthalmology: an update on animal models for retinal degenerations and dystrophies. Br J Ophthalmol 84:922–927PubMedCrossRef
42.
Hämmerle H, Kobuch K, Kohler K, Nisch W, Sachs H, Stelzle M (2002) Biostability of micro-photodiode arrays for subretinal implantation. Biomaterials 23:797–804PubMedCrossRef
43.
Hesse L, Schanze T, Wilms M, Eger M (2000) Implantation of retina stimulation electrodes and recording of electrical stimulation responses in the visual cortex of the cat. Graefes Arch Clin Exp Ophthalmol 238:840–845PubMedCrossRef
44.
Humayun MS, Prince M, de Juan E Jr, Barron Y, Moskowitz M, Klock IB, Milam AH (1999) Morphometric analysis of the extramacular retina from postmortem eyes with retinitis pigmentosa. Invest Ophthalmol Vis Sci 40:143–148PubMed
45.
Humayun MS (2001) Intraocular retinal prosthesis. Trans Am Ophthalmol Soc 99:271–300PubMed
46.
Humayun MS, Weiland JD, Fujii GY, Greenberg R, Williamson R, Little J, Mech B, Cimmarusti V, Van Boemel G, Dagnelie G, de Juan E Jr (2003) Visual perception in a blind subject with a chronic microelectronic retinal prosthesis. Vision Res 43:2573–2581PubMedCrossRef
47.
Jacobson SG, Aleman TS, Cideciyan AV, Sumaroka A, Schwartz SB, Windsor EA, Traboulsi EI, Heon E, Pittler SJ, Milam AH, Maguire AM, Palczewski K, Stone EM, Bennett J (2005) Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proc Natl Acad Sci U S A 102:6177–6182PubMedCrossRef
48.
Jin M, Chen Y, He S, Ryan SJ, Hinton DR (2004) Hepatocyte growth factor and its role in the pathogenesis of retinal detachment. Invest Ophthalmol Vis Sci 45:323–329PubMedCrossRef
49.
Johnson L, Scribner D, Skeath P, Klein R, Ilg D, Perkins K, Helfgott M, Sanders R, Panigrahi D (2007) Impedance-based retinal contact imaging as an aid for the placement of high resolution epiretinal prostheses. J Neural Eng 4:S17–S23PubMedCrossRef
50.
Kaluzny JJ, Jozwicki W, Wisniewska H (2007) Histological biocompatibility of new, non-absorbable glaucoma deep sclerectomy implant. J Biomed Mater Res B Appl Biomater 81:403–409PubMed
51.
Kerdraon YA, Downie JA, Suaning GJ, Capon MR, Coroneo MT, Lovell NH (2002) Development and surgical implantation of a vision prosthesis model into the ovine eye. Clin Experiment Ophthalmol 30:36–40PubMedCrossRef
52.
Khaw PT, Sherwood MB, Doyle JW, Smith MF, Grierson I, McGorray S, Schultz GS (1992) Intraoperative and post operative treatment with 5-fluorouracil and mitomycin-c: long term effects in vivo on subconjunctival and scleral fibroblasts. Int Ophthalmol 16:381–385PubMedCrossRef
53.
Khaw PT, Doyle JW, Sherwood MB, Grierson I, Schultz G, McGorray S (1993) Prolonged localized tissue effects from 5-minute exposures to fluorouracil and mitomycin C. Arch Ophthalmol 111:263–267PubMedCrossRef
54.
Kim SY, Sadda S, Humayun MS, de Juan E Jr, Melia BM, Green WR (2002) Morphometric analysis of the macula in eyes with geographic atrophy due to age-related macular degeneration. Retina 22:464–470PubMedCrossRef
55.
Kim SY, Sadda S, Pearlman J, Humayun MS, de Juan E Jr, Melia BM, Green WR (2002) Morphometric analysis of the macula in eyes with disciform age-related macular degeneration. Retina 22:471–477PubMedCrossRef
56.
Komar G, Szutter L (1968) Tierärztliche Augenheilkunde. Verlag Paul Parey, Berlin
57.
Konno T, Uchibori T, Nagai A, Kogi K, Nakahata N (2007) Effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on ocular blood flow in rabbits. Life Sci 80:1115–1122PubMedCrossRef
58.
Kuffler SW (1953) Discharge patterns and functional organization of mammalian retina. J Neurophysiol 16:37–68PubMed
59.
Laube T, Schanze T, Brockmann C, Bolle I, Stieglitz T, Bornfeld N (2003) Chronically implanted epidural electrodes in Gottinger minipigs allow function tests of epiretinal implants. Graefes Arch Clin Exp Ophthalmol 241:1013–1019PubMedCrossRef
60.
Lee D, Geller S, Walsh N, Valter K, Yasumura D, Matthes M, LaVail M, Stone J (2003) Photoreceptor degeneration in Pro23His and S334ter transgenic rats. Adv Exp Med Biol 533:297–302PubMedCrossRef
61.
Li ZY, Wong F, Chang JH, Possin DE, Hao Y, Petters RM, Milam AH (1998) Rhodopsin transgenic pigs as a model for human retinitis pigmentosa. Invest Ophthalmol Vis Sci 39:808–819PubMed
62.
Liou GI, Pakalnis VA, Matragoon S, Samuel S, Behzadian MA, Baker J, Khalil IE, Roon P, Caldwell RB, Hunt RC, Marcus DM (2002) HGF regulation of RPE proliferation in an IL-1beta/retinal hole-induced rabbit model of PVR. Mol Vis 8:494–501PubMed
63.
Little CW, Castillo B, DiLoreto DA, Cox C, Wyatt J, del Cerro C, del Cerro M (1996) Transplantation of human fetal retinal pigment epithelium rescues photoreceptor cells from degeneration in the Royal College of Surgeons rat retina. Invest Ophthalmol Vis Sci 37:204–211PubMed
64.
Lopez R, Gouras P, Kjeldbye H, Sullivan B, Reppucci V, Brittis M, Wapner F, Goluboff E (1989) Transplanted retinal pigment epithelium modifies the retinal degeneration in the RCS rat. Invest Ophthalmol Vis Sci 30:586–588PubMed
65.
Luke C, Alteheld N, Aisenbrey S, Luke M, Bartz-Schmidt KU, Walter P, Kirchhof B (2003) Electro-oculographic findings after 360 degrees retinotomy and macular translocation for subfoveal choroidal neovascularisation in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 241:710–715PubMedCrossRef
66.
Majji AB, Humayun MS, Weiland JD, Suzuki S, D’Anna SA, de Juan E Jr (1999) Long-term histological and electrophysiological results of an inactive epiretinal electrode array implantation in dogs. Invest Ophthalmol Vis Sci 40:2073–2081PubMed
67.
Marc RE, Jones BW, Watt CB, Strettoi E (2003) Neural remodeling in retinal degeneration. Prog Retin Eye Res 22:607–655PubMedCrossRef
68.
Menotti-Raymond M, David VA, Schaffer AA, Stephens R, Wells D, Kumar-Singh R, O’Brien SJ, Narfstrom K (2007) Mutation in CEP290 discovered for cat model of human retinal degeneration. J Hered 98:211–220PubMedCrossRef
69.
Montezuma SR, Loewenstein J, Scholz C, Rizzo JF 3rd (2006) Biocompatibility of materials implanted into the subretinal space of Yucatan pigs. Invest Ophthalmol Vis Sci 47:3514–3522PubMedCrossRef
70.
Morales M, Gomez-Cabrero A, Peral A, Gasull X, Pintor J (2007) Hypotensive effect of profilin on rabbit intraocular pressure. Eur J Pharmacol 567:145–148PubMedCrossRef
71.
Nadig MN (1999) Development of a silicon retinal implant: cortical evoked potentials following focal stimulation of the rabbit retina with light and electricity. Clin Neurophysiol 110:1545–1553PubMedCrossRef
72.
Nakauchi K, Fujikado T, Kanda H, Morimoto T, Choi JS, Ikuno Y, Sakaguchi H, Kamei M, Ohji M, Yagi T, Nishimura S, Sawai H, Fukuda Y, Tano Y (2005) Transretinal electrical stimulation by an intrascleral multichannel electrode array in rabbit eyes. Graefes Arch Clin Exp Ophthalmol 243:169–174PubMedCrossRef
73.
Nakauchi K, Fujikado T, Kanda H, Kusaka S, Ozawa M, Sakaguchi H, Ikuno Y, Kamei M, Tano Y (2007) Threshold suprachoroidal-transretinal stimulation current resulting in retinal damage in rabbits. J Neural Eng 4:S50–S57PubMedCrossRef
74.
Ogden TE, Brown KT (1964) Intraretinal responses of the cynamolgus monkey to electrical stimulation of the optic nerve and retina. J Neurophysiol 27:682–705PubMed
75.
76.
Palanker D, Huie P, Vankov A, Aramant R, Seiler M, Fishman H, Marmor M, Blumenkranz M (2004) Migration of retinal cells through a perforated membrane: implications for a high-resolution prosthesis. Invest Ophthalmol Vis Sci 45:3266–3270PubMedCrossRef
77.
Pang J, Cheng M, Stevenson D, Trousdale MD, Dorey CK, Blanks JC (2004) Adenoviral-mediated gene transfer to retinal explants during development and degeneration. Exp Eye Res 79:189–201PubMedCrossRef
78.
Pardue MT, Ball SL, Hetling JR, Chow VY, Chow AY, Peachey NS (2001) Visual evoked potentials to infrared stimulation in normal cats and rats. Doc Ophthalmol 103:155–162PubMedCrossRef
79.
Pardue MT, Stubbs EB Jr, Perlman JI, Narfstrom K, Chow AY, Peachey NS (2001) Immunohistochemical studies of the retina following long-term implantation with subretinal microphotodiode arrays. Exp Eye Res 73:333–343PubMedCrossRef
80.
Pardue MT, Phillips MJ, Yin H, Fernandes A, Cheng Y, Chow AY, Ball SL (2005) Possible sources of neuroprotection following subretinal silicon chip implantation in RCS rats. J Neural Eng 2:S39–S47PubMedCrossRef
81.
Pardue MT, Phillips MJ, Yin H, Sippy BD, Webb-Wood S, Chow AY, Ball SL (2005) Neuroprotective effect of subretinal implants in the RCS rat. Invest Ophthalmol Vis Sci 46:674–682PubMedCrossRef
82.
Pardue MT, Ball SL, Phillips MJ, Faulkner AE, Walker TA, Chow AY, Peachey NS (2006) Status of the feline retina 5 years after subretinal implantation. J Rehabil Res Dev 43:723–732PubMedCrossRef
83.
Pawlyk BS, Smith AJ, Buch PK, Adamian M, Hong DH, Sandberg MA, Ali RR, Li T (2005) Gene replacement therapy rescues photoreceptor degeneration in a murine model of Leber congenital amaurosis lacking RPGRIP. Invest Ophthalmol Vis Sci 46:3039–3045PubMedCrossRef
84.
Petters RM, Alexander CA, Wells KD, Collins EB, Sommer JR, Blanton MR, Rojas G, Hao Y, Flowers WL, Banin E, Cideciyan AV, Jacobson SG, Wong F (1997) Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa. Nat Biotechnol 15:965–970PubMedCrossRef
85.
Pinilla I, Cuenca N, Sauve Y, Wang S, Lund RD (2007) Preservation of outer retina and its synaptic connectivity following subretinal injections of human RPE cells in the Royal College of Surgeons rat. Exp Eye Res 85:381–392PubMedCrossRef
86.
Planck SR, Andresevic J, Chen JC, Holmes DL, Rodden W, Westra I, Wu SC, Huang XN, Kay G, Wilson DJ et al (1992) Expression of growth factor mRNA in rabbit PVR model systems. Curr Eye Res 11:1031–1039PubMedCrossRef
87.
Ray K, Baldwin VJ, Acland GM, Aguirre GD (1995) Molecular diagnostic tests for ascertainment of genotype at the rod cone dysplasia 1 (rcd1) locus in Irish setters. Curr Eye Res 14:243–247PubMedCrossRef
88.
Rizzo JF 3rd, Wyatt J, Loewenstein J, Kelly S, Shire D (2003) Methods and perceptual thresholds for short-term electrical stimulation of human retina with microelectrode arrays. Invest Ophthalmol Vis Sci 44:5355–5361PubMedCrossRef
89.
Rizzo JF 3rd, Wyatt J, Loewenstein J, Kelly S, Shire D (2003) Perceptual efficacy of electrical stimulation of human retina with a microelectrode array during short-term surgical trials. Invest Ophthalmol Vis Sci 44:5362–5369PubMedCrossRef
90.
Rizzo JF 3rd, Goldbaum S, Shahin M, Denison TJ, Wyatt J (2004) In vivo electrical stimulation of rabbit retina with a microfabricated array: strategies to maximize responses for prospective assessment of stimulus efficacy and biocompatibility. Restor Neurol Neurosci 22:429–443PubMed
91.
Sachs HG, Gekeler F, Schwahn H, Jakob W, Kohler M, Schulmeyer F, Marienhagen J, Brunner U, Framme C (2005) Implantation of stimulation electrodes in the subretinal space to demonstrate cortical responses in Yucatan minipig in the course of visual prosthesis development. Eur J Ophthalmol 15:493–499PubMed
92.
Sachs HG, Schanze T, Brunner U, Sailer H, Wiesenack C (2005) Transscleral implantation and neurophysiological testing of subretinal polyimide film electrodes in the domestic pig in visual prosthesis development. J Neural Eng 2:S57–S64PubMedCrossRef
93.
Sachs HG, Schanze T, Wilms M, Rentzos A, Brunner U, Gekeler F, Hesse L (2005) Subretinal implantation and testing of polyimide film electrodes in cats. Graefes Arch Clin Exp Ophthalmol 243:464–468PubMedCrossRef
94.
Sailer H, Shinoda K, Blatsios G, Kohler K, Bondzio L, Zrenner E, Gekeler F (2007) Investigation of thermal effects of infrared lasers on the rabbit retina: a study in the course of development of an active subretinal prosthesis. Graefes Arch Clin Exp Ophthalmol 245:1169–1178PubMedCrossRef
95.
Sakaguchi H, Fujikado T, Fang X, Kanda H, Osanai M, Nakauchi K, Ikuno Y, Kamei M, Yagi T, Nishimura S, Ohji M, Yagi T, Tano Y (2004) Transretinal electrical stimulation with a suprachoroidal multichannel electrode in rabbit eyes. Jpn J Ophthalmol 48:256–261PubMedCrossRef
96.
Salzmann J, Linderholm OP, Guyomard JL, Paques M, Simonutti M, Lecchi M, Sommerhalder J, Dubus E, Pelizzone M, Bertrand D, Sahel J, Renaud P, Safran AB, Picaud S (2006) Subretinal electrode implantation in the P23H rat for chronic stimulations. Br J Ophthalmol 90:1183–1187PubMedCrossRef
97.
Santos A, Humayun MS, de Juan E Jr, Greenburg RJ, Marsh MJ, Klock IB, Milam AH (1997) Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis. Arch Ophthalmol 115:511–515PubMedCrossRef
98.
Schanze T, Wilms M, Eger M, Hesse L, Eckhorn R (2002) Activation zones in cat visual cortex evoked by electrical retina stimulation. Graefes Arch Clin Exp Ophthalmol 240:947–954PubMedCrossRef
99.
Schanze T, Greve N, Hesse L (2003) Towards the cortical representation of form and motion stimuli generated by a retina implant. Graefes Arch Clin Exp Ophthalmol 241:685–693PubMedCrossRef
100.
Schanze T, Sachs HG, Wiesenack C, Brunner U, Sailer H (2006) Implantation and testing of subretinal film electrodes in domestic pigs. Exp Eye Res 82:332–340PubMedCrossRef
101.
Schanze T, Hesse L, Lau C, Greve N, Haberer W, Kammer S, Doerge T, Rentzos A, Stieglitz T (2007) An optically powered single-channel stimulation implant as test system for chronic biocompatibility and biostability of miniaturized retinal vision prostheses. IEEE Trans Biomed Eng 54:983–992PubMedCrossRef
102.
Schwahn HN, Gekeler F, Kohler K, Kobuch K, Sachs HG, Schulmeyer F, Jakob W, Gabel VP, Zrenner E (2001) Studies on the feasibility of a subretinal visual prosthesis: data from Yucatan micropig and rabbit. Graefes Arch Clin Exp Ophthalmol 239:961–967PubMedCrossRef
103.
Shah HA, Montezuma SR, Rizzo JF 3rd (2006) In vivo electrical stimulation of rabbit retina: effect of stimulus duration and electrical field orientation. Exp Eye Res 83:247–254PubMedCrossRef
104.
Sheedlo HJ, Li L, Turner JE (1993) Effects of RPE age and culture conditions on support of photoreceptor cell survival in transplanted RCS dystrophic rats. Exp Eye Res 57:753–761PubMedCrossRef
105.
Siu T, Morley J (2008) Implantation of episcleral electrodes via anterior orbitotomy for stimulation of the retina with induced photoreceptor degeneration: an in vivo feasibility study on a conceptual visual prosthesis. Acta Neurochir (Wien) 150:477–485CrossRef
106.
Siu TL, Morley JW (2008) In vivo evaluation of an episcleral multielectrode array for stimulation of the retina with reduced retinal ganglion cell mass. J Clin Neurosci 15:552–558PubMedCrossRef
107.
Stasi K, Paccione J, Bianchi G, Friedman A, Danias J (2006) Photodynamic treatment in a rabbit model of glaucoma surgery. Acta Ophthalmol Scand 84:661–666PubMedCrossRef
108.
Stone JL, Barlow WE, Humayun MS, de Juan E Jr, Milam AH (1992) Morphometric analysis of macular photoreceptors and ganglion cells in retinas with retinitis pigmentosa. Arch Ophthalmol 110:1634–1639PubMedCrossRef
109.
Sugie Y, Yoshikawa M, Ouji Y, Saito K, Moriya K, Ishizaka S, Matsuura T, Maruoka S, Nawa Y, Hara Y (2005) Photoreceptor cells from mouse ES cells by co-culture with chick embryonic retina. Biochem Biophys Res Commun 332:241–247PubMedCrossRef
110.
Takahashi M, Miyoshi H, Verma IM, Gage FH (1999) Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol 73:7812–7816PubMed
111.
Tschernutter M, Schlichtenbrede FC, Howe S, Balaggan KS, Munro PM, Bainbridge JW, Thrasher AJ, Smith AJ, Ali RR (2005) Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy. Gene Ther 12:694–701PubMedCrossRef
112.
Vergara O, Ogden T, Ryan S (1989) Posterior penetrating injury in the rabbit eye: effect of blood and ferrous ions. Exp Eye Res 49:1115–1126PubMedCrossRef
113.
Veske A, Nilsson SE, Narfstrom K, Gal A (1999) Retinal dystrophy of Swedish briard/briard-beagle dogs is due to a 4-bp deletion in RPE65. Genomics 57:57–61PubMedCrossRef
114.
Volker M, Shinoda K, Sachs H, Gmeiner H, Schwarz T, Kohler K, Inhoffen W, Bartz-Schmidt KU, Zrenner E, Gekeler F (2004) In vivo assessment of subretinally implanted microphotodiode arrays in cats by optical coherence tomography and fluorescein angiography. Graefes Arch Clin Exp Ophthalmol 242:792–799PubMedCrossRef
115.
Vollrath D, Feng W, Duncan JL, Yasumura D, D’Cruz PM, Chappelow A, Matthes MT, Kay MA, LaVail MM (2001) Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk. Proc Natl Acad Sci U S A 98:12584–12589PubMedCrossRef
116.
Walter P, Szurman P, Vobig M, Berk H, Ludtke-Handjery HC, Richter H, Mittermayer C, Heimann K, Sellhaus B (1999) Successful long-term implantation of electrically inactive epiretinal microelectrode arrays in rabbits. Retina 19:546–552PubMedCrossRef
117.
Walter P, Kisvarday ZF, Gortz M, Alteheld N, Rossler G, Stieglitz T, Eysel UT (2005) Cortical activation via an implanted wireless retinal prosthesis. Invest Ophthalmol Vis Sci 46:1780–1785PubMedCrossRef
118.
Weber M, Rabinowitz J, Provost N, Conrath H, Folliot S, Briot D, Cherel Y, Chenuaud P, Samulski J, Moullier P, Rolling F (2003) Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subretinal delivery. Mol Ther 7:774–781PubMedCrossRef
119.
Weiland JD, Yanai D, Mahadevappa M, Williamson R, Mech BV, Fujii GY, Little J, Greenberg RJ, de Juan E Jr, Humayun MS (2004) Visual task performance in blind humans with retinal prosthetic implants. Conf Proc IEEE Eng Med Biol Soc 6:4172–4173PubMed
120.
Wilms M, Eckhorn R (2005) Spatiotemporal receptive field properties of epiretinally recorded spikes and local electroretinograms in cats. BMC Neurosci 6:50PubMedCrossRef
121.
Yamauchi Y, Franco LM, Jackson DJ, Naber JF, Ziv RO, Rizzo JF, Kaplan HJ, Enzmann V (2005) Comparison of electrically evoked cortical potential thresholds generated with subretinal or suprachoroidal placement of a microelectrode array in the rabbit. J Neural Eng 2:S48–S56PubMedCrossRef
122.
Yanai D, Weiland JD, Mahadevappa M, Greenberg RJ, Fine I, Humayun MS (2007) Visual performance using a retinal prosthesis in three subjects with retinitis pigmentosa. Am J Ophthalmol 143:820–827PubMedCrossRef
123.
Zeng Y, Takada Y, Kjellstrom S, Hiriyanna K, Tanikawa A, Wawrousek E, Smaoui N, Caruso R, Bush RA, Sieving PA (2004) RS-1 Gene Delivery to an Adult Rs1h Knockout Mouse Model Restores ERG b-Wave with Reversal of the Electronegative Waveform of X-Linked Retinoschisis. Invest Ophthalmol Vis Sci 45:3279–3285PubMedCrossRef
124.
Zrenner E, Miliczek KD, Gabel VP, Graf HG, Guenther E, Haemmerle H, Hoefflinger B, Kohler K, Nisch W, Schubert M, Stett A, Weiss S (1997) The development of subretinal microphotodiodes for replacement of degenerated photoreceptors. Ophthalmic Res 29:269–280PubMedCrossRef
Metadaten
Titel
A review of in vivo animal studies in retinal prosthesis research
verfasst von
Dimiter R. Bertschinger
Evgueny Beknazar
Manuel Simonutti
Avinoam B. Safran
José A. Sahel
Serge G. Rosolen
Serge Picaud
Joel Salzmann
Publikationsdatum
01.11.2008
Verlag
Springer-Verlag
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 11/2008
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-008-0891-7

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