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European Journal of Applied Physiology
Erschienen in: European Journal of Applied Physiology 2/2018

18.12.2017 | Original Article

A mathematical model of the effects of resistance exercise-induced muscle hypertrophy on body composition

verfasst von: Marcella Torres, Eric T. Trexler, Abbie E. Smith-Ryan, Angela Reynolds

Erschienen in: European Journal of Applied Physiology | Ausgabe 2/2018

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Abstract

Purpose

Current diet and exercise methods used to maintain or improve body composition often have poor long-term outcomes. We hypothesize that resistance exercise (RE) should aid in the maintenance of a healthy body composition by preserving lean mass (LM) and metabolic rate.

Method

We extended a previously developed energy balance model of human metabolism to include muscle hypertrophy in response to RE. We first fit model parameters to a hypothetical individual to simulate an RE program and then compared the effects of a hypocaloric diet only to the diet with either cardiovascular exercise (CE) or RE. We then simulated a cohort of individuals with different responses to RE by varying the parameters controlling it using Latin Hypercube Sampling (LHS). Finally, we fit the model to mean data from an elderly population on an RE program.

Conclusion

The model is able to reproduce the time course of change in LM in response to RE and can be used to generate a simulated cohort for in silico clinical studies. Simulations suggest that the additional LM generated by RE may shift the body composition to a healthier state.
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Metadaten
Titel
A mathematical model of the effects of resistance exercise-induced muscle hypertrophy on body composition
verfasst von
Marcella Torres
Eric T. Trexler
Abbie E. Smith-Ryan
Angela Reynolds
Publikationsdatum
18.12.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Applied Physiology / Ausgabe 2/2018
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-017-3787-6

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