nach oben

Virchows Archiv

Erschienen in:

01.08.2004 | Case Report

Primary testicular osteosarcoma with hydrocele

verfasst von: Ji Shin Lee, Yoo Duk Choi, Chan Choi

Erschienen in: Virchows Archiv | Ausgabe 2/2004

Einloggen, um Zugang zu erhalten

Abstract

Primary testicular osteosarcoma is an extremely rare malignancy. To date, only two cases have been reported. Here, we report a third case of primary testicular osteosarcoma complicated with hydrocele. A 78-year-old man presented with right scrotal swelling. Ultrasonography revealed hydrocele and a testicular heterogeneous solid mass with focal calcification in the right testis. Right inguinal orchiectomy revealed a pure intratesticular osteosarcoma. Retroperitoneal lymph-node dissection revealed no metastasis. Thorough sampling of the tumor failed to show any additional histological components. It is unlikely that our case arose from teratoma or mixed sex-cord/stromal tumor, because no other neoplastic elements were identified in whole sampling of the tumor. He remained well without evidence of disease 44 months after operation. This case illustrates that primary pure testicular osteosarcoma may be associated with a favorable prognosis.

Ali Y, Kehinde EO, Makar R, Al-Awadi KA, Anim JT (2002) Leiomyosarcoma complicating chronic inflammation of the testis. Med Princ Pract 11:157–160CrossRefPubMed

Allan CJ, Soule EH (1971) Osteogenic sarcoma of the somatic soft tissues. Clinicopathologic study of 26 cases and review of literature. Cancer 27:1121–1133PubMed

Benassi MS, Molendini L, Gamberi G, Sollazzo MR, Ragazzini P, Merli M, Magagnoli G, Sangiorgi L, Bacchini P, Bertoni F, Picci P (1997) Altered G1 phase regulation in osteosarcoma. Int J Cancer 74:518–522CrossRefPubMed

Eble JN, Sauter G, Epstein JI, Sesterhenn IA (eds) (2004) (2004) Word Health Organization Classification of tumors. Pathology and genetics of tumors of the urinary system and male genital organs. IARC Press, Lyon

Goorin AM, Abelson HT, Frei E (1985) Osteosarcoma: fifteen years later. N Engl J Med 313:1637–1643PubMed

Lioe TF, Biggart JD (1993) Tumours of the spermatic cord and paratesticular tissue. A clinicopathological study. Br J Urol 71:600–606PubMed

Lonardo F, Ueda T, Huvos AG, Healey J, Ladanyi M (1997) p53 and MDM 2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate. Cancer 79:1541–1547CrossRefPubMed

Mathew T, Prabhakaran K (1981) Osteosarcoma of the testis. Arch Pathol Lab Med 105:38–39PubMed

Micallef M, Torreggiani WC, Hurley M, Dinsmore WW, Hogan B (2000) The ultrasound investigation of scrotal swelling. Int J STD AIDS 11:297–302CrossRefPubMed

10.

Motzer RJ, Amsterdam A, Prieto V, Sheinfeld J, Murty VV, Mazumdar M, Bosl GJ, Chaganti RS, Reuter VE (1998) Teratoma with malignant transformation: diverse malignant histologies arising in men with germ cell tumors. J Urol 159:133–138PubMed

11.

Oosterhuis JW, Castedo SM, de Jong B, Seruca R, Dam A, Vos A, de Koning J, Schraffordt Koops H, Sleijfer DT (1989) A malignant mixed gonadal stromal tumor of the testis with heterologous components and i(12p) in one of its metastases. Cancer Genet Cytogenet 41:105–114CrossRefPubMed

12.

Reuvekamp PT, Stulp RP, Schraffordt Koops H, Oosterhuis JW, Scheffer H, Buys CH (1992) Analysis of a metastasizing testicular mixed gonadal stromal tumor with osteosarcoma components suggests that a malignant tumor with the histology of osteosarcoma may develop without primary involvement of RB1 and TP53. Cancer Res 52:6705–6707PubMed

13.

Suzuki K, Shioji Y, Morita T, Tokue A (2001) Primary testicular plasmacytoma with hydrocele of the testis. Int J Urol 8:139–140CrossRefPubMed

14.

Terrier-Lacombe MJ, Martinez-Madrigal F, Porta W, Rahal J, Droz JP (1990) Embryonal rhabdomyosarcoma arising in a mature teratoma of the testis: a case report. J Urol 143:1232–1234PubMed

15.

Ueda Y, Dockhorn-Dworniczak B, Blasius S, Mellin W, Wuisman P, Bocker W, Roessner A (1993) Analysis of mutant P53 protein in osteosarcomas and other malignant and benign lesions of bone. J Cancer Res Clin Oncol 119:172–178PubMed

16.

Ulbright TM, Srigley JR, Hatzianastassiou DK, Young RH (2002) Leydig cell tumors of the testis with unusual features; adipose differentiation, calcification with ossification, and spindle-shaped tumor cells. Am J Surg Pathol 26:1424–1433CrossRefPubMed

17.

Wadayama B, Toguchida J, Shimizu T, Ishizaki K, Sasaki MS, Kotoura Y, Yamamuro T (1994) Mutation spectrum of the retinoblastoma gene in osteosarcomas. Cancer Res 54:3042–3048PubMed

18.

Washecka RM, Mariani AJ, Zuna RE, Honda SA, Chong CD (1996) Primary intratesticular sarcoma. Immunohistochemical ultrastructural and DNA flow cytometric study of three cases with a review of the literature. Cancer 77:1524–1528CrossRefPubMed

19.

Zukerberg LR, Young RH (1990) Primary testicular sarcoma: a report of two cases. Hum Pathol 21:932–935CrossRefPubMed

Titel: Primary testicular osteosarcoma with hydrocele
verfasst von: Ji Shin Lee
Yoo Duk Choi
Chan Choi
Publikationsdatum: 01.08.2004
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 2/2004
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-004-1073-6

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Primary testicular osteosarcoma with hydrocele

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2004

Galectin-3 and HBME-1 expression in oncocytic cell tumors of the thyroid

INK4a-ARF alterations in Barrett’s epithelium, intraepithelial neoplasia and Barrett’s adenocarcinoma

Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal

Wilson disease

Three-dimensional reconstruction of vessel distribution in benign and malignant lesions of thyroid

Pigmented pleomorphic adenoma, a novel melanin-pigmented benign salivary gland tumor

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie