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01.04.2006 | Original Article

Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy

verfasst von: Andrea Ambrosini-Spaltro, Fabrizio Salvi, Christine M. Betts, Giovanni P. Frezza, Antonio Piemontese, Pietro Del Prete, Cristina Baldoni, Maria P. Foschini, Giuseppe Viale

Erschienen in: Virchows Archiv | Ausgabe 4/2006

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Abstract

The purpose of the study is to highlight oncocytic modifications in rectal adenocarcinomas and evaluate a possible correlation with preoperative radiochemotherapy (RCT). Twenty-eight cases of advanced rectal carcinoma, treated preoperatively by 5-fluorouracil (200–225 mg/m²) and 44–46 Gy in 22–23 fractions, were studied. All patients underwent biopsy before RCT. Surgery was performed within 6 weeks after RCT. In all cases oncocytic modifications were searched for on hematoxylin and eosin (H&E) and at immunohistochemistry using an antimitochondrial antibody. In addition, in two cases, both pre- and post-RCT tissues were examined at electron microscopy. All tumors were adenocarcinomas. In pre-RCT biopsies, oncocytic changes were difficult to find on H&E, while the antimitochondrial antibody strongly stained numerous neoplastic cells (mean 48.4%). In post-RCT surgical specimens, oncocytic changes were detected in 24 out of 28 cases on H&E and the antimitochondrial antibody stained most of the residual neoplastic cells (mean 76.7%). Ultrastructural examination revealed large and bizarre mitochondria inside tumor cells both in pre- and post-RCT tissues. In conclusion, the present data suggest that rectal adenocarcinomas are “mitochondrion-rich” tumors. After preoperative RCT, residual neoplastic cells acquire a definite oncocytic phenotype.

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Titel: Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy
verfasst von: Andrea Ambrosini-Spaltro
Fabrizio Salvi
Christine M. Betts
Giovanni P. Frezza
Antonio Piemontese
Pietro Del Prete
Cristina Baldoni
Maria P. Foschini
Giuseppe Viale
Publikationsdatum: 01.04.2006
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 4/2006
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-005-0137-6

Springer Medizin

Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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