nach oben

Virchows Archiv

Erschienen in:

01.04.2006 | Case Report

α-fetoprotein expression in a dedifferentiated liposarcoma

verfasst von: Martino Bosco, Elena Allia, Jean-Michel Coindre, Chiara Odasso, Alberto Pagani, Donatella Pacchioni

Erschienen in: Virchows Archiv | Ausgabe 4/2006

Einloggen, um Zugang zu erhalten

Abstract

Extremely rare cases of paraneoplastic syndromes or ectopic production of proteins associated with liposarcoma are reported in literature. We describe a unique case of relapsing retroperitoneal dedifferentiated liposarcoma with biochemical, immunohistochemical, and molecular evidence of alpha-fetoprotein (AFP) ectopic production. The lesion was associated to elevated AFP plasma levels that subsided after tumor removal. Immunohistochemical studies showed AFP production by a minority of tumor cells and reverse transcriptase polymerase chain reaction confirmed AFP mRNA expression. Finding of MDM2 and CDK4 iperexpression by immunohistochemistry confirmed the diagnosis of dedifferentiated liposarcoma.

Abelev GI (1971) α-fetoprotein in association with malignant tumors. Adv Cancer Res 14:295–357PubMedCrossRef

Badve SS, Saxena R, Soman CS, Kiri VM, Raghuvanshi SR, Patoria NK (1992) α-fetoprotein production by rhabdomyosarcoma of the urinary bladder. Indian J Cancer 29:177–180PubMed

Binh MB, Sastre-Garau X, Guillou L, de Pinieux G, Terrier P, Lagace R, Aurias A, Hostein I, Coindre JM (2005) MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol 29:1340–1347CrossRefPubMed

Coindre JM, Terrier P, Bui NB, Bonichon F, Collin F, Le Doussal V, Mandard AM, Vilain MO, Jacquemier J, Duplay H, Sastre X, Barlier C, Henry-Amar M, Mace-Lesech J, Contesso G (1996) Prognostic factors in adult patients with locally controlled soft tissue sarcoma. A study of 546 patients from the French Federation of Cancer Centers Sarcoma Group. J Clin Oncol 14:869–877PubMed

Cui R, Nguyen TT, Taube JH, Stratton SA, Feuerman MH, Barton MC (2005) Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcript ion. J Biol Chem 280:39152–39160CrossRefPubMed

Dei Tos AP, Pedeutour F (2002) Dedifferentiated liposarcoma. In: Fletcher CDM, Unni KK, Mertens F (eds) Tumours of Soft Tissue and Bone: Pathology and Genetics. World Health Organization Classification of Tumours, IARC, Lyon, pp 38–39

des Guetz G, Mariani P, Freneaux P, Pouillart P (2004) Paraneoplastic syndromes in cancer: Case 2. Leucocytosis associated with liposarcoma recurrence: original presentation of liposarcoma recurrence. J Clin Oncol 22:2242–2243CrossRefPubMed

Hocking GR, Shembrey M, Hay D, Ostor AG (1995) α-fetoprotein-producing adenocarcinoma of the sigmoid colon with possible hepatoid differentiation. Pathology 27:277–279CrossRefPubMed

Kaplan I, Hodak E, Ackerman L, Mimouni D, Anhalt GJ, Calderon S (2004) Neoplasms associated with paraneoplastic pemphigus: a review with emphasis on non-hematologic malignancy and oral mucosal manifestations. Oral Oncol 40:553–562CrossRefPubMed

10.

Kono K, Amemiya H, Sekikawa T, Iizuka H, Takahashi A, Fujii H, Matsumoto Y (2002) Clinicopathologic features of gastric cancers producing α-fetoprotein. Dig Surg 19:359–365CrossRefPubMed

11.

Maida Y, Kyo S, Takakura M, Kanaya T, Inoue M (1998) Ovarian endometrioid adenocarcinoma with ectopic production of alpha-fetoprotein. Gynecol Oncol 71:133–136CrossRefPubMed

12.

Mizejewski GJ (1985) New insights into AFP structure and function: potential biomedical applications. In: Mizejewski GJ and Porter IH (eds) α-fetoprotein and Congenital Disorders. Academic, Orlando, pp 5–34

13.

Nakamura A, Tanaka S, Takayama H, Sakamoto M, Ishii H, Kusano M, Onizuka Y, Ota S, Mitamura K (1998) A mesenteric liposarcoma with production of granulocyte colony-stimulating factor. Intern Med 37:884–890PubMedCrossRef

14.

Wang XW and Xie H (1998) Stimulation of tumor cell growth by α-fetoprotein. Int J Cancer 75:596–599CrossRef

15.

Yano T, Kishimoto T, Tomaru U, Kawarada Y, Kato H, Yoshiki T, Ishikura H (2003) Further evidence of hepatic transdifferentiation in hepatoid adenocarcinomas of the stomach: quantitative analysis of mRNA for albumin and hepatocyte nuclear factor-4alpha. Pathology 35:75–78CrossRefPubMed

Titel: α-fetoprotein expression in a dedifferentiated liposarcoma
verfasst von: Martino Bosco
Elena Allia
Jean-Michel Coindre
Chiara Odasso
Alberto Pagani
Donatella Pacchioni
Publikationsdatum: 01.04.2006
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 4/2006
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-006-0151-3

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

α-fetoprotein expression in a dedifferentiated liposarcoma

Abstract

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2006

Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury

How to define follicular thyroid carcinoma?

Chromogranin A in gastric neuroendocrine tumours: an immunohistochemical and biochemical study with region-specific antibodies

The significance of the P504S expression pattern of high-grade prostatic intraepithelial neoplasia (HGPIN) with and without adenocarcinoma of the prostate in biopsy and radical prostatectomy specimens

Announcements

Multihormonality and entrapment of islets in pancreatic endocrine tumors

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren