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Virchows Archiv

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01.03.2009 | Case Report

Turquoise to dark green organs at autopsy

verfasst von: Arne Warth, Benjamin Goeppert, Christian Bopp, Peter Schirmacher, Christa Flechtenmacher, Jürgen Burhenne

Erschienen in: Virchows Archiv | Ausgabe 3/2009

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Abstract

We report the case of a 72-year-old man who died in septic shock following pancreatectomy. At autopsy, organs were discoloured with a rapid colour change from turquoise to dark green, especially of the myocardium. The patient had received 200 mg methylene blue (MB), i.v., for treatment of septic shock 90 min prior to death. Analysis of tissue samples by liquid extraction and liquid chromatography coupled to tandem mass spectrometry demonstrated different concentrations of MB and its metabolites azure A and B in the heart, lungs, kidneys, and liver. Our findings clearly demonstrate the relation of MB administration and organ discolouration at autopsy and shed a new light on MB distribution and accumulation in septic shock.

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Titel: Turquoise to dark green organs at autopsy
verfasst von: Arne Warth
Benjamin Goeppert
Christian Bopp
Peter Schirmacher
Christa Flechtenmacher
Jürgen Burhenne
Publikationsdatum: 01.03.2009
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 3/2009
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-009-0734-x

Springer Medizin

Turquoise to dark green organs at autopsy

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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