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Virchows Archiv

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01.01.2010 | Review and Perspective

Genome-scale approaches to the epigenetics of common human disease

verfasst von: Andrew P. Feinberg

Erschienen in: Virchows Archiv | Ausgabe 1/2010

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Abstract

Traditionally, the pathology of human disease has been focused on microscopic examination of affected tissues, chemical and biochemical analysis of biopsy samples, other available samples of convenience, such as blood, and noninvasive or invasive imaging of varying complexity, in order to classify disease and illuminate its mechanistic basis. The molecular age has complemented this armamentarium with gene expression arrays and selective analysis of individual genes. However, we are entering a new era of epigenomic profiling, i.e., genome-scale analysis of cell-heritable nonsequence genetic change, such as DNA methylation. The epigenome offers access to stable measurements of cellular state and to biobanked material for large-scale epidemiological studies. Some of these genome-scale technologies are beginning to be applied to create the new field of epigenetic epidemiology.

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Titel: Genome-scale approaches to the epigenetics of common human disease
verfasst von: Andrew P. Feinberg
Publikationsdatum: 01.01.2010
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 1/2010
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-009-0847-2

Springer Medizin

Genome-scale approaches to the epigenetics of common human disease

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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