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03.04.2020 | Original Article

Ex vivo diffusion-weighted MRI tractography of the Göttingen minipig limbic system

verfasst von: Johannes Bech, Dariusz Orlowski, Andreas N. Glud, Tim B. Dyrby, Jens Christian H. Sørensen, Carsten R. Bjarkam

Erschienen in: Brain Structure and Function | Ausgabe 3/2020

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Abstract

The limbic system encompasses a collection of brain areas primarily involved in higher cognitive and emotional processing. Altered function in the limbic circuitry may play a major role in various psychiatric disorders. This study aims to provide a high-quality ex vivo diffusion-weighted MRI (DWI) tractographic overview of the Göttingen minipig limbic system pathways, which are currently not well described. This may facilitate future translational large animal studies. The study used previously obtained post-mortem DWI scans in 3 female Göttingen minipigs aging 11–15 months. The tractography performed on the DWI data set was made using a probabilistic algorithm, and regions of interest (ROIs) were defined in accordance with a histological atlas. The investigated pathways included the fornix, mammillothalamic tract, stria terminalis, stria medullaris, habenulo-interpeduncular tract, and cingulum. All the investigated limbic connections could be visualized with a high detail yielding a comprehensive three-dimensional overview, which was emphasized by the inclusion of video material. The minipig limbic system pathways displayed using tractography closely resembled what was previously described in both human studies and neuronal tracing studies from other mammalian species. We encountered well-known inherent methodological challenges of tractography, e.g., partial volume effects and complex white matter regions, which may have contributed to derouted false-positive streamlines and the failure to visualize some of the minor limbic pathway ramifications. This underlines the importance of preexisting anatomical knowledge. Conclusively, we have, for the first time, provided an overview and substantial insight of the Göttingen minipig limbic system.

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Aggleton JP, Brown MW (1999) Episodic memory, amnesia, and the hippocampal-anterior thalamic axis. Behav Brain Sci 22(3):425–444CrossRefPubMed

Aggleton JP, Desimone R, Mishkin M (1986) The origin, course, and termination of the hippocampothalamic projections in the macaque. J Comp Neurol 243(3):409–421. https://doi.org/10.1002/cne.902430310 CrossRefPubMed

Antolin-Fontes B, Ables JL, Gorlich A, Ibanez-Tallon I (2015) The habenula–interpeduncular pathway in nicotine aversion and withdrawal. Neuropharmacology 96(Pt B):213–222. https://doi.org/10.1016/j.neuropharm.2014.11.019 CrossRefPubMed

Basser PJ, Mattiello J, LeBihan D (1994) MR diffusion tensor spectroscopy and imaging. Biophys J 66(1):259–267. https://doi.org/10.1016/s0006-3495(94)80775-1 CrossRefPubMedPubMedCentral

Bech J, Glud AN, Sangill R, Petersen M, Frandsen J, Orlowski D, West MJ, Pedersen M, Sorensen JCH, Dyrby TB, Bjarkam CR (2018) The porcine corticospinal decussation: a combined neuronal tracing and tractography study. Brain Res Bull 142:253–262. https://doi.org/10.1016/j.brainresbull.2018.08.004 CrossRefPubMed

Behrens TE, Berg HJ, Jbabdi S, Rushworth MF, Woolrich MW (2007) Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? NeuroImage 34(1):144–155. https://doi.org/10.1016/j.neuroimage.2006.09.018 CrossRefPubMed

Bjarkam CR, Cancian G, Glud AN, Ettrup KS, Jorgensen RL, Sorensen JC (2009) MRI-guided stereotaxic targeting in pigs based on a stereotaxic localizer box fitted with an isocentric frame and use of SurgiPlan computer-planning software. J Neurosci Methods 183(2):119–126. https://doi.org/10.1016/j.jneumeth.2009.06.019 CrossRefPubMed

Bjarkam CR, Glud AN, Orlowski D, Sorensen JC, Palomero-Gallagher N (2017a) The telencephalon of the Gottingen minipig, cytoarchitecture and cortical surface anatomy. Brain Struct Funct. https://doi.org/10.1007/s00429-016-1327-5 CrossRefPubMed

Bjarkam CR, Nielsen MS, Glud AN, Rosendal F, Mogensen P, Bender D, Doudet D, Moller A, Sorensen JC (2008) Neuromodulation in a minipig MPTP model of Parkinson disease. Br J Neurosurg 22(Suppl 1):S9–12. https://doi.org/10.1080/02688690802448285 CrossRefPubMed

Bjarkam CR, Orlowski D, Tvilling L, Bech J, Glud AN, Sorensen JH (2017b) Exposure of the pig CNS for histological analysis: a manual for decapitation, skull opening, and brain removal. J Vis Exp JoVE 122:45–48. https://doi.org/10.3791/55511 CrossRef

Broca P (1877) Sur la circonvolution limbique et la scissure limbique. Bulletins et Mémoires de la Société d'Anthropologie de Paris 646–657

Brodal A (1969) Neurological anatomy, 2nd edn. Oxford University Press, Oxford

Catani M, Dell'acqua F, Thiebaut de Schotten M (2013) A revised limbic system model for memory, emotion and behaviour. Neurosci Biobehav Rev 37(8):1724–1737. https://doi.org/10.1016/j.neubiorev.2013.07.001 CrossRefPubMed

Christensen AB, Sorensen JCH, Ettrup KS, Orlowski D, Bjarkam CR (2018) Pirouetting pigs: a large non-primate animal model based on unilateral 6-hydroxydopamine lesioning of the nigrostriatal pathway. Brain Res Bull 139:167–173. https://doi.org/10.1016/j.brainresbull.2018.02.010 CrossRefPubMed

Coenen VA, Allert N, Madler B (2011) A role of diffusion tensor imaging fiber tracking in deep-brain stimulation surgery: DBS of the dentato–rubro–thalamic tract (drt) for the treatment of therapy-refractory tremor. Acta Neurochir 153(8):1579–1585. https://doi.org/10.1007/s00701-011-1036-z CrossRefPubMed

Concha L, Gross DW, Beaulieu C (2005) Diffusion tensor tractography of the limbic system. AJNR Am J Neuroradiol 26(9):2267–2274PubMedPubMedCentral

De Olmos JS, Ingram WR (1972) The projection field of the stria terminalis in the rat brain. An experimental study. J Comp Neurol 146(3):303–334. https://doi.org/10.1002/cne.901460303 CrossRefPubMed

Dolezalova D, Hruska-Plochan M, Bjarkam CR, Sorensen JC, Cunningham M, Weingarten D, Ciacci JD, Juhas S, Juhasova J, Motlik J, Hefferan MP, Hazel T, Johe K, Carromeu C, Muotri A, Bui J, Strnadel J, Marsala M (2014) Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies. J Comp Neurol 522(12):2784–2801. https://doi.org/10.1002/cne.23575 CrossRefPubMed

Donahue CJ, Sotiropoulos SN, Jbabdi S, Hernandez-Fernandez M, Behrens TE, Dyrby TB, Coalson T, Kennedy H, Knoblauch K, Van Essen DC, Glasser MF (2016) Using diffusion tractography to predict cortical connection strength and distance: a quantitative comparison with tracers in the monkey. J Neurosci 36(25):6758–6770. https://doi.org/10.1523/jneurosci.0493-16.2016 CrossRefPubMedPubMedCentral

Dyrby TB, Baare WF, Alexander DC, Jelsing J, Garde E, Sogaard LV (2011) An ex vivo imaging pipeline for producing high-quality and high-resolution diffusion-weighted imaging datasets. Hum Brain Mapp 32(4):544–563. https://doi.org/10.1002/hbm.21043 CrossRefPubMed

Dyrby TB, Innocenti GM, Bech M, Lundell H (2018) Validation strategies for the interpretation of microstructure imaging using diffusion MRI. NeuroImage 182:62–79. https://doi.org/10.1016/j.neuroimage.2018.06.049 CrossRefPubMed

Dyrby TB, Sogaard LV, Parker GJ, Alexander DC, Lind NM, Baare WF, Hay-Schmidt A, Eriksen N, Pakkenberg B, Paulson OB, Jelsing J (2007) Validation of in vitro probabilistic tractography. NeuroImage 37(4):1267–1277. https://doi.org/10.1016/j.neuroimage.2007.06.022 CrossRefPubMed

Ettrup KS, Glud AN, Orlowski D, Fitting LM, Meier K, Soerensen JC, Bjarkam CR, Alstrup AK (2011) Basic surgical techniques in the Gottingen minipig: intubation, bladder catheterization, femoral vessel catheterization, and transcardial perfusion. J Vis Exp JoVE 52(52):2652. https://doi.org/10.3791/2652 CrossRef

Ettrup KS, Sorensen JC, Bjarkam CR (2010) The anatomy of the Gottingen minipig hypothalamus. J Chem Neuroanat 39(3):151–165. https://doi.org/10.1016/j.jchemneu.2009.12.004 CrossRefPubMed

Fang X, Mou Y, Huang Z, Li Y, Han L, Zhang Y, Feng Y, Chen Y, Jiang X, Zhao W, Sun X, Xiong Z, Yang L, Liu H, Fan D, Mao L, Ren L, Liu C, Wang J, Li K, Wang G, Yang S, Lai L, Zhang G, Li Y, Wang J, Bolund L, Yang H, Wang J, Feng S, Li S, Du Y (2012) The sequence and analysis of a Chinese pig genome. GigaScience 1(1):16. https://doi.org/10.1186/2047-217x-1-16 CrossRefPubMedPubMedCentral

Glud AN, Hedegaard C, Nielsen MS, Sorensen JC, Bendixen C, Jensen PH, Larsen K, Bjarkam CR (2010) Direct gene transfer in the Gottingen minipig CNS using stereotaxic lentiviral microinjections. Acta Neurobiol Exp 70(3):308–315

Glud AN, Hedegaard C, Nielsen MS, Sorensen JC, Bendixen C, Jensen PH, Mogensen PH, Larsen K, Bjarkam CR (2011) Direct MRI-guided stereotaxic viral mediated gene transfer of alpha-synuclein in the Gottingen minipig CNS. Acta Neurobiol Exp 71(4):508–518

Gomes N, Soares SC, Silva S, Silva CF (2018) Mind the snake: fear detection relies on low spatial frequencies. Emotion (Washington, DC) 18(6):886–895. https://doi.org/10.1037/emo0000391 CrossRef

Groenewegen HJ, Ahlenius S, Haber SN, Kowall NW, Nauta WJ (1986) Cytoarchitecture, fiber connections, and some histochemical aspects of the interpeduncular nucleus in the rat. J Comp Neurol 249(1):65–102. https://doi.org/10.1002/cne.902490107 CrossRefPubMed

Herkenham M, Nauta WJ (1977) Afferent connections of the habenular nuclei in the rat. A horseradish peroxidase study, with a note on the fiber-of-passage problem. J Comp Neurol 173(1):123–146. https://doi.org/10.1002/cne.901730107 CrossRefPubMed

Hikosaka O, Sesack SR, Lecourtier L, Shepard PD (2008) Habenula: crossroad between the basal ganglia and the limbic system. J Neurosci 28(46):11825–11829. https://doi.org/10.1523/jneurosci.3463-08.2008 CrossRefPubMedPubMedCentral

Huff W, Lenartz D, Schormann M, Lee SH, Kuhn J, Koulousakis A, Mai J, Daumann J, Maarouf M, Klosterkotter J, Sturm V (2010) Unilateral deep brain stimulation of the nucleus accumbens in patients with treatment-resistant obsessive-compulsive disorder: outcomes after one year. Clin Neurol Neurosurg 112(2):137–143. https://doi.org/10.1016/j.clineuro.2009.11.006 CrossRefPubMed

Janak PH, Tye KM (2015) From circuits to behaviour in the amygdala. Nature 517(7534):284–292. https://doi.org/10.1038/nature14188 CrossRefPubMedPubMedCentral

Jelsing J, Hay-Schmidt A, Dyrby T, Hemmingsen R, Uylings HB, Pakkenberg B (2006) The prefrontal cortex in the Gottingen minipig brain defined by neural projection criteria and cytoarchitecture. Brain Res Bull 70(4–6):322–336. https://doi.org/10.1016/j.brainresbull.2006.06.009 CrossRefPubMed

Jenkinson M, Beckmann CF, Behrens TE, Woolrich MW, Smith SM (2012) FSL NeuroImage 62(2):782–790. https://doi.org/10.1016/j.neuroimage.2011.09.015 CrossRefPubMed

Jones DK (2004) The effect of gradient sampling schemes on measures derived from diffusion tensor MRI: a Monte Carlo study. Magn Reson Med 51(4):807–815. https://doi.org/10.1002/mrm.20033 CrossRefPubMed

Jones DK, Christiansen KF, Chapman RJ, Aggleton JP (2013) Distinct subdivisions of the cingulum bundle revealed by diffusion MRI fibre tracking: implications for neuropsychological investigations. Neuropsychologia 51(1):67–78. https://doi.org/10.1016/j.neuropsychologia.2012.11.018 CrossRefPubMedPubMedCentral

Kamali A, Sair HI, Blitz AM, Riascos RF, Mirbagheri S, Keser Z, Hasan KM (2016) Revealing the ventral amygdalofugal pathway of the human limbic system using high spatial resolution diffusion tensor tractography. Brain Struct Funct 221(7):3561–3569. https://doi.org/10.1007/s00429-015-1119-3 CrossRefPubMed

Kamali A, Yousem DM, Lin DD, Sair HI, Jasti SP, Keser Z, Riascos RF, Hasan KM (2015) Mapping the trajectory of the stria terminalis of the human limbic system using high spatial resolution diffusion tensor tractography. Neurosci Lett 608:45–50. https://doi.org/10.1016/j.neulet.2015.09.035 CrossRefPubMed

Kotter R, Stephan KE (1997) Useless or helpful? The "limbic system" concept. Rev Neurosci 8(2):139–145CrossRefPubMed

Kwon HG, Hong JH, Jang SH (2010) Mammillothalamic tract in human brain: diffusion tensor tractography study. Neurosci Lett 481(1):51–53. https://doi.org/10.1016/j.neulet.2010.06.052 CrossRefPubMed

LeDoux JE (2000) Emotion circuits in the brain. Annu Rev Neurosci 23:155–184. https://doi.org/10.1146/annurev.neuro.23.1.155 CrossRefPubMed

Lillethorup TP, Glud AN, Alstrup AKO, Mikkelsen TW, Nielsen EH, Zaer H, Doudet DJ, Brooks DJ, Sorensen JCH, Orlowski D, Landau AM (2018) Nigrostriatal proteasome inhibition impairs dopamine neurotransmission and motor function in minipigs. Exp Neurol 303:142–152. https://doi.org/10.1016/j.expneurol.2018.02.005 CrossRefPubMed

Lima LB, Bueno D, Leite F, Souza S, Goncalves L, Furigo IC, Donato J Jr, Metzger M (2017) Afferent and efferent connections of the interpeduncular nucleus with special reference to circuits involving the habenula and raphe nuclei. J Comp Neurol 525(10):2411–2442. https://doi.org/10.1002/cne.24217 CrossRefPubMed

Lind NM, Moustgaard A, Jelsing J, Vajta G, Cumming P, Hansen AK (2007) The use of pigs in neuroscience: modeling brain disorders. Neurosci Biobehav Rev 31(5):728–751. https://doi.org/10.1016/j.neubiorev.2007.02.003 CrossRefPubMed

Liptrot MG, Sidaros K, Dyrby TB (2014) Addressing the path-length-dependency confound in white matter tract segmentation. PLoS ONE 9(5):e96247. https://doi.org/10.1371/journal.pone.0096247 CrossRefPubMedPubMedCentral

Maclean PD (1949) Psychosomatic disease and the visceral brain; recent developments bearing on the Papez theory of emotion. Psychosom Med 11(6):338–353CrossRefPubMed

Maclean PD (1952) Some psychiatric implications of physiological studies on frontotemporal portion of limbic system (visceral brain). Electroencephalogr Clin Neurophysiol 4(4):407–418CrossRefPubMed

Mahady LJ, Perez SE, Emerich DF, Wahlberg LU, Mufson EJ (2017) Cholinergic profiles in the Goettingen miniature pig (Sus scrofa domesticus) brain. J Comp Neurol 525(3):553–573. https://doi.org/10.1002/cne.24087 CrossRefPubMed

Maier-Hein KH, Neher PF, Houde JC, Cote MA, Garyfallidis E, Zhong J, Chamberland M, Yeh FC, Lin YC, Ji Q, Reddick WE, Glass JO, Chen DQ, Feng Y, Gao C, Wu Y, Ma J, Renjie H, Li Q, Westin CF, Deslauriers-Gauthier S, Gonzalez JOO, Paquette M, St-Jean S, Girard G, Rheault F, Sidhu J, Tax CMW, Guo F, Mesri HY, David S, Froeling M, Heemskerk AM, Leemans A, Bore A, Pinsard B, Bedetti C, Desrosiers M, Brambati S, Doyon J, Sarica A, Vasta R, Cerasa A, Quattrone A, Yeatman J, Khan AR, Hodges W, Alexander S, Romascano D, Barakovic M, Auria A, Esteban O, Lemkaddem A, Thiran JP, Cetingul HE, Odry BL, Mailhe B, Nadar MS, Pizzagalli F, Prasad G, Villalon-Reina JE, Galvis J, Thompson PM, Requejo FS, Laguna PL, Lacerda LM, Barrett R, Dell'Acqua F, Catani M, Petit L, Caruyer E, Daducci A, Dyrby TB, Holland-Letz T, Hilgetag CC, Stieltjes B, Descoteaux M (2017) The challenge of mapping the human connectome based on diffusion tractography. Nat Commun 8(1):1349. https://doi.org/10.1038/s41467-017-01285-x CrossRefPubMedPubMedCentral

Mayberg HS (1997) Limbic-cortical dysregulation: a proposed model of depression. J Neuropsychiatry Clin Neurosci 9(3):471–481. https://doi.org/10.1176/jnp.9.3.471 CrossRefPubMed

Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, Schwalb JM, Kennedy SH (2005) Deep brain stimulation for treatment-resistant depression. Neuron 45(5):651–660. https://doi.org/10.1016/j.neuron.2005.02.014 CrossRefPubMed

McIntosh AM, Munoz Maniega S, Lymer GK, McKirdy J, Hall J, Sussmann JE, Bastin ME, Clayden JD, Johnstone EC, Lawrie SM (2008) White matter tractography in bipolar disorder and schizophrenia. Biol Psychiat 64(12):1088–1092. https://doi.org/10.1016/j.biopsych.2008.07.026 CrossRefPubMed

Meidahl AC, Orlowski D, Sorensen JC, Bjarkam CR (2016) The retrograde connections and anatomical segregation of the gottingen minipig nucleus accumbens. Front Neuroanat 10:117. https://doi.org/10.3389/fnana.2016.00117 CrossRefPubMedPubMedCentral

Mufson EJ, Pandya DN (1984) Some observations on the course and composition of the cingulum bundle in the rhesus monkey. J Comp Neurol 225(1):31–43. https://doi.org/10.1002/cne.902250105 CrossRefPubMed

Murray EA (2007) The amygdala, reward and emotion. Trends Cognit Sci 11(11):489–497. https://doi.org/10.1016/j.tics.2007.08.013 CrossRef

Nelson AJD, Vann SD (2017) The importance of mammillary body efferents for recency memory: towards a better understanding of diencephalic amnesia. Brain Struct Funct 222(5):2143–2156. https://doi.org/10.1007/s00429-016-1330-x CrossRefPubMed

Orlowski D, Glud AN, Palomero-Galagher N, Sorensen JCH, Bjarkam CR (2019) Online histological atlas of the Gottingen minipig brain. Heliyon 5(3):e01363. https://doi.org/10.1016/j.heliyon.2019.e01363 CrossRefPubMedPubMedCentral

Orlowski D, Michalis A, Glud AN, Korshoj AR, Fitting LM, Mikkelsen TW, Mercanzini A, Jordan A, Dransart A, Sorensen JCH (2017) Brain tissue reaction to deep brain stimulation—a longitudinal study of DBS in the Goettingen Minipig. Neuromodulation 20(5):417–423. https://doi.org/10.1111/ner.12576 CrossRefPubMed

Papez JW (1937) A proposed mechanism of emotion. Arch Neurol Psychiatry 38(4):725–743. https://doi.org/10.1001/archneurpsyc.1937.02260220069003 CrossRef

Pascalau R, Popa Stanila R, Sfrangeu S, Szabo B (2018) Anatomy of the limbic white matter tracts as revealed by fiber dissection and tractography. World Neurosurg 113:e672–e689. https://doi.org/10.1016/j.wneu.2018.02.121 CrossRefPubMed

Petersen MV, Lund TE, Sunde N, Frandsen J, Rosendal F, Juul N, Ostergaard K (2017) Probabilistic versus deterministic tractography for delineation of the cortico-subthalamic hyperdirect pathway in patients with Parkinson disease selected for deep brain stimulation. J Neurosurg 126(5):1657–1668. https://doi.org/10.3171/2016.4.jns1624 CrossRefPubMed

Seo D, Rabinowitz AG, Douglas RJ, Sinha R (2018) Limbic response to stress linking life trauma and hypothalamus-pituitary-adrenal axis function. Psychoneuroendocrinology 99:38–46. https://doi.org/10.1016/j.psyneuen.2018.08.023 CrossRefPubMedPubMedCentral

Sorensen JC, Nielsen MS, Rosendal F, Deding D, Ettrup KS, Jensen KN, Jorgensen RL, Glud AN, Meier K, Fitting LM, Moller A, Alstrup AK, Ostergaard L, Bjarkam CR (2011) Development of neuromodulation treatments in a large animal model–do neurosurgeons dream of electric pigs? Prog Brain Res 194:97–103. https://doi.org/10.1016/b978-0-444-53815-4.00014-5 CrossRefPubMed

Sturm V, Lenartz D, Koulousakis A, Treuer H, Herholz K, Klein JC, Klosterkotter J (2003) The nucleus accumbens: a target for deep brain stimulation in obsessive-compulsive- and anxiety-disorders. J Chem Neuroanat 26(4):293–299CrossRefPubMed

Swanson LW, Petrovich GD (1998) What is the amygdala? Trends Neurosci 21(8):323–331CrossRefPubMed

Thiebaut de Schotten M, Dell'Acqua F, Valabregue R, Catani M (2012) Monkey to human comparative anatomy of the frontal lobe association tracts. Cortex 48(1):82–96. https://doi.org/10.1016/j.cortex.2011.10.001 CrossRefPubMed

Tournier JD, Calamante F, Connelly A (2007) Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution. NeuroImage 35(4):1459–1472. https://doi.org/10.1016/j.neuroimage.2007.02.016 CrossRefPubMed

Tournier JD, Calamante F, Connelly A (2010) Improved probabilistic streamlines tractography by 2nd order integration over fibre orientation distributions. Proc Int Soc Magn Reson Med 1670

Tournier JD, Calamante F, Connelly A (2012) MRtrix: diffusion tractography in crossing fiber regions. Int J Imaging Syst Technol 22(1):53–66. https://doi.org/10.1002/ima.22005 CrossRef

Tournier JD, Calamante F, Gadian DG, Connelly A (2004) Direct estimation of the fiber orientation density function from diffusion-weighted MRI data using spherical deconvolution. NeuroImage 23(3):1176–1185. https://doi.org/10.1016/j.neuroimage.2004.07.037 CrossRefPubMed

Woolf NJ (1991) Cholinergic systems in mammalian brain and spinal cord. Prog Neurobiol 37(6):475–524CrossRefPubMed

Yakovlev PI (1948) Motility, behavior and the brain; stereodynamic organization and neural coordinates of behavior. J Nerv Ment Dis 107(4):313–335CrossRefPubMed

Titel: Ex vivo diffusion-weighted MRI tractography of the Göttingen minipig limbic system
verfasst von: Johannes Bech
Dariusz Orlowski
Andreas N. Glud
Tim B. Dyrby
Jens Christian H. Sørensen
Carsten R. Bjarkam
Publikationsdatum: 03.04.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 3/2020
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-020-02058-x

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