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Pediatric Nephrology

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01.04.2010 | Original Article

Etiology and treatment of growth retardation in children with chronic kidney disease and end-stage renal disease: a historical perspective

verfasst von: Richard N. Fine

Erschienen in: Pediatric Nephrology | Ausgabe 4/2010

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Abstract

Dramatic changes have occurred in our understanding of the etiology of the growth retardation associated with chronic kidney disease (CKD) and end-stage renal disease (ESRD) during the past 50 years. Significant interest has been focused on preventing and/or correcting the growth retardation because of the emergence of the dual therapeutic modalities of dialysis and renal transplantation to prolong the lives of infants, children, and adolescents afflicted with CKD and ESRD. These efforts have resulted in a significant improvement in the height Z-score over the past two decades of children with CKD and ESRD. This has had a salutary impact on the final adult height of such children which should hopefully lead to an enhanced quality of life in the future. This report addresses the progress that has been made in the management of growth retardation in the pediatric population with CKD and ESRD.

Tönshoff B, Fine RN (2005) Growth and growth hormone treatment in children with chronic renal insufficiency. In: Nissenson AR (ed) Clinical dialysis. McGraw-Hill, New York, pp 611–651

Mahesh S, Kaskel F (2008) Growth hormone axis in chronic kidney disease. Pediatr Nephrol 23:41–48CrossRefPubMed

Mak RH, Cheung WW, Roberts CT Jr (2008) The growth hormone-insulin-like growth factor-I axis in chronic kidney disease. Growth Horm IGF Res 18:17–25CrossRefPubMed

Tönshoff B, Kiepe D, Ciarmatori S (2005) Growth hormone/insulin-like growth factor system in children with chronic renal failure. Pediatr Nephrol 20:279–289CrossRefPubMed

Postel-Vinay MC, Tar A, Crosnier H, Broyer M, Rappaport R, Tönshoff B, Mehls O (1991) Plasma growth hormone-binding activity is low in uraemic children. Pediatr Nephrol 5:545–547CrossRefPubMed

Rabkin R, Sun DF, Chen Y, Tan J, Schaefer F (2005) Growth hormone resistance in uremia, a role for impaired JAK/STAT signaling. Pediatr Nephrol 20:313–318CrossRefPubMed

Tönshoff B, Blum WF, Mehls O (1996) Serum insulin-like growth factors and their binding proteins in children with end-stage renal disease. Pediatr Nephrol 10:269–274PubMed

Blum WF, Ranke MB, Kietzmann K, Tönshoff B, Mehls O (1991) Growth hormone resistance and inhibition of somatomedin activity by excess of insulin-like growth factor binding protein in uraemia. Pediatr Nephrol 5:539–544CrossRefPubMed

Bereket A, Lang CH, Blethen SL, Kaskel FJ, Steward C, Wilson TA (1997) Growth hormone treatment in growth retarded children with end stage renal failure: effect on free/dissociable IGF-1 levels. J Pediatr Endocrinol Metab 10:197–202PubMed

10.

Schaefer F, Veldhuis JD, Stanhope R, Jones J, Scharer K (1994) Alterations in growth hormone secretion and clearance in peripubertal boys with chronic renal failure and after renal transplantation. Cooperative Study Group of Pubertal development in Chronic Renal Failure. J Clin Endocrinol Metab 78:1298–1306CrossRefPubMed

11.

Furth SL, Hwang W, Yang C, Neu AM, Fivosh BA, Powe NR (2002) Growth failure, risk of hospitalization and death for children with end-stage renal disease. Pediatr Nephrol 17:450–455CrossRefPubMed

12.

Rosenkranz J, Reichwald-Klugger E, Oh J, Turzer M, Mehls O, Schaefer F (2005) Psychosocial rehabilitation and satisfaction with life in adults with childhood-onset of end-stage renal disease. Pediatr Nephrol 20:1288–1294CrossRefPubMed

13.

Broyer M, Le Bihan C, Charbit M, Guest G, Tet MJ, Gagnadoux MF, Niaudet P (2004) Long-term social outcome of children after kidney transplantation. Transplantation 77:1033–1037CrossRefPubMed

14.

Betts PR, Magrath G (1974) Growth pattern and dietary intake of children with chronic renal insufficiency. Br Med J 2:189–193CrossRefPubMed

15.

Centers for Disease Control and Prevention, National Center for Health Statistics, CDC Growth Charts. Available at: http://www.cdc.gov/growthcharts/clinical_charts.htm. Accessed 8 Oct 2009

16.

North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) 2008 annual report. Available at: https://web.emmes.com/study/ped/annlrept/annlrept.html. Accessed 8 Oct 2009

17.

Van Dyck M, Bilem N, Proesmans W (1999) Conservative treatment for chronic renal failure from birth: a 3-year follow-up study. Pediatr Nephrol 13:865–869CrossRefPubMed

18.

Salusky IB, Ramirez JA, Oppenheim WL, Gales B, Segre GV, Goodman WH (1994) Biochemical markers of renal osteodystrophy in pediatric patient undergoing CAPD/CCPD. Kidney Int 45:253–258CrossRefPubMed

19.

Schaefer F, Seidel C, Binding A, Gasser T, Largo RH, Prader A, Schärer K (1990) Pubertal growth in chronic renal failure. Pediatr Res 28:5–10CrossRefPubMed

20.

North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS) 2007 annual report. Available at: https://web.emmes.com/study/ped/annlrept/annlrept.html. Accessed 8 Oct 2009

21.

Saland JM, Guisberg HN (2007) Lipoprotein metabolism in chronic renal insufficiency. Pediatr Nephrol 22:1095–1112CrossRefPubMed

22.

Kaufman DB (1998) Growth hormone and renal osteodystrophy: a case report. Pediatr Nephrol 12:157–159CrossRefPubMed

23.

Blethen SL, Rundle AC (1996) Slipped capital femoral epiphysis in children treated with growth hormone. A summary of the National Cooperative Growth Study Experience. Horm Res 46:113–116CrossRefPubMed

24.

Reeves GD, Doyle DA (2002) Growth hormone treatment and pseudotumor cerebri: coincidence or close relationship? J Pediatr Endocrinol Metab 15:723–730PubMed

25.

Radetti G, Crepaz R, Paganini C, Gentili L, Pitscheider W (1999) Medium-term cardiovascular effects of high-dose growth hormone treatment in growth hormone-deficient children. Horm Res 52:247–252CrossRefPubMed

26.

Fine RN, Kohaut EC, Brown D, Perlman AJ, the Genentech Cooperative Study Group (1994) Growth after recombinant human growth hormone treatment in children with chronic renal failure: Report of a multicenter randomized double-blind placebo-controlled study. J Pediatr 124:374–382CrossRefPubMed

27.

Vimalachandra D, Craig JC, Cowell CT, Knight JF (2001) Growth hormone treatment in children with chronic renal failure: a meta-analysis of randomized controlled trials. J Pediatr 139:560–567CrossRefPubMed

28.

Mencarelli F, Kiepe D, Leozappa G, Stringini G, Cappa M, Emma F (2009) Growth hormone treatment started in the first year of life with chronic renal failure. Pediatr Nephrol 24:1039–1046CrossRefPubMed

29.

Fine RN, Kohaut E, Brown D, Kuntze J, Attie KM (1996) Long term (5-year) Treatment of growth retarded children with Chronic Renal Insufficiency, (CRI), with Recombinant Human Growth Hormone (rhGH). Kidney Int 49:781–785CrossRefPubMed

30.

Hokken-Koelega A, Mulder P, De Jong R, Lilien M, Donckerwolcke R, Groothof J (2000) Long-term effects of growth hormone treatment on growth and puberty in patients with chronic renal insufficiency. Pediatr Nephrol 14:701–706CrossRefPubMed

31.

Haffner D, Schaefer F, Nissel R, Wühl E, Tönshoff B, Mehls O, the German study group for growth hormone treatment in chronic renal failure (2000) Effect of growth hormone treatment on the adult height of children with chronic renal failure. N Engl J Med 343:923–930CrossRefPubMed

32.

Bérard E, André JL, Guest G, Berthier F, Afanetti M, Cochat P, Broyer M, French Society for Pediatric Nephrology (2008) Long-term results of rhGH treatment in children with renal failure: experience of the French Society of Pediatric Nephrology. Pediatr Nephrol 23:2031–2038CrossRefPubMed

33.

Bérard E, Crosnier H, Six-Beneton A, Chevallier T, Cochat P, Broyer M, French Society of Pediatric Nephrology (1998) Recombinant human growth hormone treatment of children on hemodialysis. Pediatr Nephrol 12:304–310CrossRefPubMed

34.

Jabs K, Sullivan EK, Avner ED, Harmon WE (1996) Alternate-day steroid dosing improves growth without adversely affecting graft survival or long-term graft function. A report of the North American Pediatric Renal Transplant Cooperative Study. Transplantation 61:31–36CrossRefPubMed

35.

Chakrabarti P, Wong HY, Scantlebury VP, Jordan ML, Vivas C, Ellis D, Lombardozzi-Lane S, Hakala TR, Fung JJ, Simmons RL, Starzl TE, Shapiro R (2000) Outcome after steroid withdrawal in pediatric renal transplant patients receiving tacrolimus-based immunosuppression. Transplantation 70:760–764CrossRefPubMed

36.

Li L, Chang A, Naesens M, Kambham N, Waskerwitz J, Martin J, Wong C, Alexander S, Grimm P, Concepcion W, Salvatierra O, Sarwal MM (2009) Steroid-free immunosuppression since 1999: 129 pediatric renal transplants with sustained graft and patients benefits. Am J Transplant 9:1362–1372CrossRefPubMed

37.

Tejani A, Fine R, Alexander S, Harmon W, Stablein D (1993) Factors predictive of sustained growth in children after renal transplantation. J Pediatr 122:397–402CrossRefPubMed

38.

Hokken-Koelega AC, Stijnen T, de Jong RC, Donckerwolcke RA, Groothoff JW, Wolff ED, Blum WF, de Muinck Keizer-Schrama SM, Drop SL (1996) A placebo-controlled double-blind trial of growth hormone treatment in prepubertal children with renal allografts. Kidney Int Suppl 53:S128–134PubMed

39.

Maxwell H, Rees L (1998) Randomised controlled trial of recombinant human growth hormone in prepubertal renal transplant recipients. Arch Dis Child 79:481–487CrossRefPubMed

40.

Guest G, Bérard E, Crosnier H, Chevallier T, Rappaport R, Broyer M (1998) Effects of growth hormone in short children after renal transplantation. Pediatr Nephrol 12:437–446CrossRefPubMed

41.

Fine RN, Stablein D, Cohen A, Tejani A, Kohaut E (2002) Recombinant human growth hormone (rhGH) post-renal transplantation in children: Randomized one year controlled study of the North American pediatric renal transplant cooperative study (NAPRTCS). Kidney Int 62:688–696CrossRefPubMed

42.

Mehl O (2002) Does growth hormone treatment affect the risk of post-transplant renal cancer? Pediatr Nephrol 17:984–989CrossRef

Titel: Etiology and treatment of growth retardation in children with chronic kidney disease and end-stage renal disease: a historical perspective
verfasst von: Richard N. Fine
Publikationsdatum: 01.04.2010
Verlag: Springer-Verlag
Erschienen in: Pediatric Nephrology / Ausgabe 4/2010
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-009-1409-1

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