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Comparative Clinical Pathology

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01.10.2012 | Original Article

The impact of allicin on lead-induced oxidative damage in selected organs of the common carp (Cyprinus carpio)

verfasst von: Davar Shahsavani, Hasan Baghshani, Mohammad Reza Aslani, Fatemeh Sadat Fatemi

Erschienen in: Comparative Clinical Pathology | Ausgabe 5/2012

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Abstract

Lead-induced oxidative stress contributes to the pathogenesis of lead poisoning. Considering the antioxidant properties of allicin, the objective of this study was to evaluate the efficacy of allicin in preventing lead-induced oxidative damage in the liver, kidney, brain, and gill of the common carp. Fish were divided randomly into five groups, depending on the combination of lead acetate and allicin treatments. The oxidative stress was measured by the malondialdehyde (MDA) level, reduced glutathione (GSH) content, and by enzymatic activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in tissue homogenates. Lead acetate exposure (7.0 mgL⁻¹, 10 days) caused a significant decrease in GSH concentration in the liver, kidney, and brain; SOD activity in the liver, kidney, and gill; and GPx activity in the liver and brain. MDA content in the liver, kidney, brain, and gill showed a significant increase following lead acetate treatment compared with the normal control group. Administration of allicin was markedly effective in decreasing lead-induced lipid peroxidation and increasing the cellular antioxidant enzyme activities and GSH levels. These results suggest that allicin can modulate lead-induced oxidative stress and might have some therapeutic and prophylactic effects on lead poisoning.

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Titel: The impact of allicin on lead-induced oxidative damage in selected organs of the common carp (Cyprinus carpio)
verfasst von: Davar Shahsavani
Hasan Baghshani
Mohammad Reza Aslani
Fatemeh Sadat Fatemi
Publikationsdatum: 01.10.2012
Verlag: Springer-Verlag
Erschienen in: Comparative Clinical Pathology / Ausgabe 5/2012
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-010-1172-5

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Springer Medizin

The impact of allicin on lead-induced oxidative damage in selected organs of the common carp (Cyprinus carpio)

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Springer Medizin

Abstract

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