nach oben

Journal of Neural Transmission

Erschienen in:

22.05.2017 | Neurology and Preclinical Neurological Studies - Review Article

The IL-1β phenomena in neuroinflammatory diseases

verfasst von: Andrew S. Mendiola, Astrid E. Cardona

Erschienen in: Journal of Neural Transmission | Ausgabe 5/2018

Einloggen, um Zugang zu erhalten

Abstract

It is becoming increasingly clear that neuroinflammation has a causal role in the pathogenesis of central nervous system (CNS)-related diseases, and therefore therapeutic strategies targeting the regulation or availability of inflammatory mediators can be used to prevent or mitigate pathology. Interestingly, the proinflammatory cytokine, interleukin-1 beta (IL-1β), has been implicated in perpetuating immune responses and contributing to disease severity in a variety of CNS diseases ranging from multiple sclerosis, neurodegenerative diseases, traumatic brain injury, and diabetic retinopathy. Moreover, pharmacological blockade of IL-1 signaling has shown to be beneficial in some autoimmune and autoinflammatory diseases, making IL-1β a promising therapeutic target in neuroinflammatory conditions. This review highlights recent advances of our understanding on the multifaceted roles of IL-1β in neuroinflammatory diseases.

Ando DG, Clayton J, Kono D, Urban JL, Sercarz EE (1989) Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell Immunol 124(1):132–143. doi:10.1016/0008-8749(89)90117-2 PubMedCrossRef

Antonetti DA, Klein R, Gardner TW (2012) Diabetic retinopathy. N Engl J Med 366(13):1227–1239. doi:10.1056/NEJMra1005073 PubMedCrossRef

Aubé B, Lévesque SA, Paré A, Chamma É, Kébir H, Gorina R, Lécuyer M-A, Alvarez JI, De Koninck Y, Engelhardt B, Prat A, Côté D, Lacroix S (2014) Neutrophils mediate blood–spinal cord barrier disruption in demyelinating neuroinflammatory diseases. J Immunol 193(5):2438–2454. doi:10.4049/jimmunol.1400401 PubMedCrossRef

Auron PE, Webb AC, Rosenwasser LJ, Mucci SF, Rich A, Wolff SM, Dinarello CA (1984) Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc Natl Acad Sci USA 81(24):7907–7911PubMedPubMedCentralCrossRef

Babcock AA, Ilkjær L, Clausen BH, Villadsen B, Dissing-Olesen L, Bendixen AT, Lyck L, Lambertsen KL, Finsen B (2015) Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice. Brain Behav Immun 48:86–101PubMedCrossRef

Bading H (2017) Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations. J Exp Med 214(3):569PubMedPubMedCentral

Barber AJ, Antonetti DA, Kern TS, Reiter CEN, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK (2005) The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci 46(6):2210–2218. doi:10.1167/iovs.04-1340 PubMedCrossRef

Becher B, Spath S, Goverman J (2017) Cytokine networks in neuroinflammation. Nat Rev Immunol 17(1):49–59. doi:10.1038/nri.2016.123 PubMedCrossRef

Block ML, Hong J-S (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76(2):77–98. doi:10.1016/j.pneurobio.2005.06.004 PubMedCrossRef

Blum-Degena D, Müller T, Kuhn W, Gerlach M, Przuntek H, Riederer P (1995) Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer’s and de novo Parkinson’s disease patients. Neurosci Lett 202(1):17–20CrossRef

Burger D, Molnarfi N, Weber MS, Brandt KJ, Benkhoucha M, Gruaz L, Chofflon M, Zamvil SS, Lalive PH (2009) Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1β in human monocytes and multiple sclerosis. Proc Natl Acad Sci USA 106(11):4355–4359. doi:10.1073/pnas.0812183106 PubMedPubMedCentralCrossRef

Burm SM, Peferoen LA, Zuiderwijk-Sick EA, Haanstra KG, t Hart BA, van der Valk P, Amor S, Bauer J, Bajramovic JJ (2016) Expression of IL-1beta in rhesus EAE and MS lesions is mainly induced in the CNS itself. J Neuroinflammation 13(1):138. doi:10.1186/s12974-016-0605-8 PubMedPubMedCentralCrossRef

Cacabelos R, Alvarez X, Fernandez-Novoa L, Franco A, Mangues R, Pellicer A, Nishimura T (1994) Brain interleukin-1 beta in Alzheimer’s disease and vascular dementia. Methods Find Exp Clin Pharmacol 16(2):141–151PubMed

Cannella B, Raine CS (1995) The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol 37(4):424–435. doi:10.1002/ana.410370404 PubMedCrossRef

Cardona SM, Mendiola AS, Yang Y-C, Adkins SL, Torres V, Cardona AE (2015) Disruption of fractalkine signaling leads to microglial activation and neuronal damage in the diabetic retina. ASN Neuro 7(5). doi:10.1177/1759091415608204

Carmo A, Cunha-Vaz JG, Carvalho AP, Lopes MC (2000) Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes. Mediat Inflamm 9(5):243–248. doi:10.1080/09629350020025764 CrossRef

Carson MJ (2002) Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis. Glia 40(2):218–231. doi:10.1002/glia.10145 PubMedPubMedCentralCrossRef

Cavelti-Weder C, Babians-Brunner A, Keller C, Stahel MA, Kurz-Levin M, Zayed H, Solinger AM, Mandrup-Poulsen T, Dinarello CA, Donath MY (2012) Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes. Diabetes Care 35(8):1654–1662. doi:10.2337/dc11-2219 PubMedPubMedCentralCrossRef

Cerani A, Tetreault N, Menard C, Lapalme E, Patel C, Sitaras N, Beaudoin F, Leboeuf D, De Guire V, Binet F, Dejda A, Rezende Flavio A, Miloudi K, Sapieha P (2013) Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1. Cell Metab 18(4):505–518. doi:10.1016/j.cmet.2013.09.003 PubMedCrossRef

Cherry JD, Olschowka JA, O’Banion MK (2015) Arginase 1⁺ microglia reduce Abeta plaque deposition during IL-1beta-dependent neuroinflammation. J Neuroinflammation 12:203. doi:10.1186/s12974-015-0411-8 PubMedPubMedCentralCrossRef

Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS, Ma L, Watowich SS, Jetten AM, Tian Q, Dong C (2009) Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30(4):576–587. doi:10.1016/j.immuni.2009.02.007 PubMedPubMedCentralCrossRef

Codarri L, Gyulveszi G, Tosevski V, Hesske L, Fontana A, Magnenat L, Suter T, Becher B (2011) ROR[gamma]t drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol 12(6):560–567. doi:10.1038/ni.2027 PubMedCrossRef

Condello C, Yuan P, Schain A, Grutzendler J (2015) Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nat Commun 6:6176. doi:10.1038/ncomms7176 PubMedPubMedCentralCrossRef

Croxford AL, Lanzinger M, Hartmann FJ, Schreiner B, Mair F, Pelczar P, Clausen BE, Jung S, Greter M, Becher B (2015) The cytokine GM-CSF drives the inflammatory signature of CCR2⁺ monocytes and licenses autoimmunity. Immunity 43(3):502–514. doi:10.1016/j.immuni.2015.08.010 PubMedCrossRef

Cunningham C (2013) Microglia and neurodegeneration: the role of systemic inflammation. Glia 61(1):71–90. doi:10.1002/glia.22350 PubMedCrossRef

Daria A, Colombo A, Llovera G, Hampel H, Willem M, Liesz A, Haass C, Tahirovic S (2016) Young microglia restore amyloid plaque clearance of aged microglia. EMBO J. doi:10.15252/embj.201694591 PubMedPubMedCentralCrossRef

Davalos D, Akassoglou K (2012) Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol 34(1):43–62. doi:10.1007/s00281-011-0290-8 PubMedCrossRef

Davis BK, Wen H, Ting JP (2011) The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol 29:707PubMedPubMedCentralCrossRef

de Jong BA, Huizinga TWJ, Bollen ELEM, Uitdehaag BMJ, Bosma GPT, van Buchem MA, Remarque EJ, Burgmans ACS, Kalkers NF, Polman CH, Westendorp RGJ (2002) Production of IL-1β and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis. J Neuroimmunol 126(1–2):172–179. doi:10.1016/S0165-5728(02)00056-5 PubMedCrossRef

Demircan N, Safran BG, Soylu M, Ozcan AA, Sizmaz S (2005) Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy. Eye 20(12):1366–1369. doi:10.1038/sj.eye.6702138 PubMedCrossRef

Dendrou CA, Fugger L, Friese MA (2015) Immunopathology of multiple sclerosis. Nat Rev Immunol 15(9):545–558. doi:10.1038/nri3871 PubMedCrossRef

Dinarello CA (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27(1):519–550. doi:10.1146/annurev.immunol.021908.132612 PubMedCrossRef

Dinarello CA (2011) Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117(14):3720–3732. doi:10.1182/blood-2010-07-273417 PubMedPubMedCentralCrossRef

Dinarello CA, Simon A, van der Meer JWM (2012) Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev Drug Discov 11(8):633–652. doi:10.1038/nrd3800 PubMedPubMedCentralCrossRef

Dror E, Dalmas E, Meier DT, Wueest S, Thevenet J, Thienel C, Timper K, Nordmann TM, Traub S, Schulze F, Item F, Vallois D, Pattou F, Kerr-Conte J, Lavallard V, Berney T, Thorens B, Konrad D, Boni-Schnetzler M, Donath MY (2017) Postprandial macrophage-derived IL-1[beta] stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat Immunol 18(3):283–292. doi:10.1038/ni.3659 PubMedCrossRef

Du Y, Veenstra A, Palczewski K, Kern TS (2013) Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci USA 110(41):16586–16591. doi:10.1073/pnas.1314575110 PubMedPubMedCentralCrossRef

Eandi CM, Messance HC, Augustin S, Dominguez E, Lavalette S, Forster V, Hu SJ, Siquieros L, Craft CM, Sahel J-A (2016) Subretinal mononuclear phagocytes induce cone segment loss via IL-1β. eLife 5:e16490. doi:10.7554/eLife.16490 PubMedPubMedCentralCrossRef

El-Behi M, Ciric B, Dai H, Yan Y, Cullimore M, Safavi F, Zhang G-X, Dittel BN, Rostami A (2011) The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol 12(6):568–575. doi:10.1038/ni.2031 PubMedPubMedCentralCrossRef

Freeman LC, Ting JP (2016) The pathogenic role of the inflammasome in neurodegenerative diseases. J Neurochem 136(Suppl 1):29–38. doi:10.1111/jnc.13217 PubMedCrossRef

Fu AKY, Hung K-W, Yuen MYF, Zhou X, Mak DSY, Chan ICW, Cheung TH, Zhang B, Fu W-Y, Liew FY, Ip NY (2016) IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline. Proc Natl Acad Sci USA 113(19):E2705–E2713. doi:10.1073/pnas.1604032113 PubMedPubMedCentralCrossRef

Furlan R, Martino G, Galbiati F, Poliani PL, Smiroldo S, Bergami A, Desina G, Comi G, Flavell R, Su MS, Adorini L (1999) Caspase-1 regulates the inflammatory process leading to autoimmune demyelination. J Immunol 163(5):2403–2409PubMed

Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, Mehler MF, Conway SJ, Ng LG, Stanley ER, Samokhvalov IM, Merad M (2010) Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330(6005):841. doi:10.1126/science.1194637 PubMedPubMedCentralCrossRef

Grathwohl SA, Kalin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, Jucker M (2009) Formation and maintenance of Alzheimer’s disease [beta]-amyloid plaques in the absence of microglia. Nat Neurosci 12(11):1361–1363. doi:10.1038/nn.2432 PubMedPubMedCentralCrossRef

Gray EJ, Gardner TW (2015) Retinal failure in diabetes: a feature of retinal sensory neuropathy. Curr Diabetes Rep 15(12):107. doi:10.1007/s11892-015-0683-5 CrossRef

Grebing M, Nielsen HH, Fenger CD, Jensen K, von Linstow CU, Clausen BH, Söderman M, Lambertsen KL, Thomassen M, Kruse TA (2016) Myelin-specific T cells induce interleukin-1beta expression in lesion-reactive microglial-like cells in zones of axonal degeneration. Glia 64(3):407–424. doi:10.1002/glia.22937 PubMedCrossRef

Griffin W, Stanley L, Ling C, White L, MacLeod V, Perrot L, White C, Araoz C (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci USA 86(19):7611–7615PubMedPubMedCentralCrossRef

Grigsby JG, Cardona SM, Pouw CE, Muniz A, Mendiola AS, Tsin AT, Allen DM, Cardona AE (2014) The role of microglia in diabetic retinopathy. J Ophthalmol 2014:705783. doi:10.1155/2014/705783 PubMedPubMedCentralCrossRef

Guarda G, Braun M, Staehli F, Tardivel A, Mattmann C, Förster I, Farlik M, Decker T, Du Pasquier Renaud A, Romero P, Tschopp J (2011) Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2):213–223. doi:10.1016/j.immuni.2011.02.006 PubMedCrossRef

Gulen MF, Kang Z, Bulek K, Youzhong W, Kim TW, Chen Y, Altuntas CZ, Sass Bak-Jensen K, McGeachy MJ, Do J-S, Xiao H, Delgoffe GM, Min B, Powell JD, Tuohy VK, Cua DJ, Li X (2010) The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity 32(1):54–66. doi:10.1016/j.immuni.2009.12.003 PubMedPubMedCentralCrossRef

Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT (2008) The NALP3 inflammasome is involved in the innate immune response to amyloid-[beta]. Nat Immunol 9(8):857–865. doi:10.1038/ni.1636 PubMedPubMedCentralCrossRef

Hanamsagar R, Hanke ML, Kielian T (2012) Toll-like receptor (TLR) and inflammasome actions in the central nervous system. Trends Immunol 33(7):333–342PubMedPubMedCentralCrossRef

Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng T-C, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT (2013) NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice. Nature 493(7434):674–678. doi:10.1038/nature11729 PubMedCrossRef

Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP (2015) Neuroinflammation in Alzheimer’s disease. Lancet Neurol 14(4):388–405. doi:10.1016/s1474-4422(15)70016-5 PubMedCrossRefPubMedCentral

Heppner FL, Ransohoff RM, Becher B (2015) Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci 16(6):358–372. doi:10.1038/nrn3880 PubMedCrossRef

Holmes C, Cunningham C, Zotova E, Woolford J, Dean C, Kerr S, Culliford D, Perry VH (2009) Systemic inflammation and disease progression in Alzheimer disease. Neurology 73(10):768–774. doi:10.1212/WNL.0b013e3181b6bb95 PubMedPubMedCentralCrossRef

Hu SJ, Calippe B, Lavalette S, Roubeix C, Montassar F, Housset M, Levy O, Delarasse C, Paques M, Sahel J-A, Sennlaub F, Guillonneau X (2015) Upregulation of P2RX7 in Cx3cr1-deficient mononuclear phagocytes leads to increased interleukin-1β secretion and photoreceptor neurodegeneration. J Neurosci 35(18):6987–6996. doi:10.1523/jneurosci.3955-14.2015 PubMedCrossRef

Inoue M, Williams KL, Gunn MD, Shinohara ML (2012) NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 109(26):10480–10485. doi:10.1073/pnas.1201836109 PubMedPubMedCentralCrossRef

Jacobs CA, Baker PE, Roux ER, Picha KS, Toivola B, Waugh S, Kennedy MK (1991) Experimental autoimmune encephalomyelitis is exacerbated by IL-1 alpha and suppressed by soluble IL-1 receptor. J Immunol 146(9):2983–2989PubMed

Jäger A, Dardalhon V, Sobel RA, Bettelli E, Kuchroo VK (2009) Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol 183(11):7169–7177. doi:10.4049/jimmunol.0901906 PubMedPubMedCentralCrossRef

Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT (2015) TREM2 deficiency eliminates TREM2⁺ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models. J Exp Med 212(3):287–295. doi:10.1084/jem.20142322 PubMedPubMedCentralCrossRef

Jiang Y, Liu L, Curtiss E, Steinle JJ (2017) Epac1 blocks NLRP3 inflammasome to reduce IL-1β in retinal endothelial cells and mouse retinal vasculature. Mediat Inflamm. doi:10.1155/2017/2860956 CrossRef

Kanwar M, Chan P-S, Kern TS, Kowluru RA (2007) Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Invest Ophthalmol Vis Sci 48(8):3805–3811. doi:10.1167/iovs.06-1280 PubMedCrossRef

Kara EE, McKenzie DR, Bastow CR, Gregor CE, Fenix KA, Ogunniyi AD, Paton JC, Mack M, Pombal DR, Seillet C, Dubois B, Liston A, MacDonald KPA, Belz GT, Smyth MJ, Hill GR, Comerford I, McColl SR (2015) CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells. Nat Commun 6:8644. doi:10.1038/ncomms9644 PubMedPubMedCentralCrossRef

Kawana N, Yamamoto Y, Ishida T, Saito Y, Konno H, Arima K, Ji Satoh (2013) Reactive astrocytes and perivascular macrophages express NLRP3 inflammasome in active demyelinating lesions of multiple sclerosis and necrotic lesions of neuromyelitis optica and cerebral infarction. Clin Exp Neuroimmunol 4(3):296–304. doi:10.1111/cen3.12068 CrossRef

Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, Holscher C, Muller DN, Luckow B, Brocker T, Debowski K, Fritz G, Opdenakker G, Diefenbach A, Biber K, Heikenwalder M, Geissmann F, Rosenbauer F, Prinz M (2013) Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci 16(3):273–280. doi:10.1038/nn.3318 PubMedCrossRef

Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM (2011) Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer’s disease model. J Immunol 187(12):6539–6549. doi:10.4049/jimmunol.1100620 PubMedPubMedCentralCrossRef

Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A (2013) Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J Biol Chem 288(21):15326–15341. doi:10.1074/jbc.M112.448712 PubMedPubMedCentralCrossRef

Kowluru RA, Odenbach S (2004) Role of interleukin-1β in the development of retinopathy in rats: effect of antioxidants. Invest Ophthalmol Vis Sci 45(11):4161–4166. doi:10.1167/iovs.04-0633 PubMedCrossRef

Krady JK, Basu A, Allen CM, Xu Y, LaNoue KF, Gardner TW, Levison SW (2005) Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes 54(5):1559–1565. doi:10.2337/diabetes.54.5.1559 PubMedCrossRef

Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, McClanahan T, Kastelein RA, Cua DJ (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201(2):233–240. doi:10.1084/jem.20041257 PubMedPubMedCentralCrossRef

LaRock CN, Todd J, LaRock DL, Olson J, O’Donoghue AJ, Robertson AAB, Cooper MA, Hoffman HM, Nizet V (2016) IL-1β is an innate immune sensor of microbial proteolysis. Sci Immunol 1(2):eaah3539. doi:10.1126/sciimmunol.aah3539 PubMedCentralCrossRefPubMed

Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses JA, Seifert B, Mandrup-Poulsen T, Donath MY (2007) Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 356(15):1517–1526. doi:10.1056/NEJMoa065213 PubMedCrossRef

Larsen CM, Faulenbach M, Vaag A, Ehses JA, Donath MY, Mandrup-Poulsen T (2009) Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes. Diabetes Care 32(9):1663–1668. doi:10.2337/dc09-0533 PubMedPubMedCentralCrossRef

Lee SC, Liu W, Brosnan CF, Dickson DW (1994) GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures. Glia 12(4):309–318PubMedCrossRef

Lévesque SA, Paré A, Mailhot B, Bellver-Landete V, Kébir H, Lécuyer M-A, Alvarez JI, Prat A, Vaccari JPdR, Keane RW, Lacroix S (2016) Myeloid cell transmigration across the CNS vasculature triggers IL-1β-driven neuroinflammation during autoimmune encephalomyelitis in mice. J Exp Med 213(6):929–949. doi:10.1084/jem.20151437 PubMedPubMedCentralCrossRef

Liu Y, Biarnés Costa M, Gerhardinger C (2012) IL-1β is upregulated in the diabetic retina and retinal vessels: cell-specific effect of high glucose and IL-1β autostimulation. PLoS One 7(5):e36949. doi:10.1371/journal.pone.0036949 PubMedPubMedCentralCrossRef

Loukovaara S, Piippo N, Kinnunen K, Hytti M, Kaarniranta K, Kauppinen A (2017) NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy. Acta Ophthalmol (Copenh). doi:10.1111/aos.13427 CrossRef

Lu P, Li L, Liu G, Zhang X, Mukaida N (2009) Enhanced experimental corneal neovascularization along with aberrant angiogenic factor expression in the absence of IL-1 receptor antagonist. Invest Ophthalmol Vis Sci 50(10):4761–4768. doi:10.1167/iovs.08-2732 PubMedCrossRef

Macrez R, Stys PK, Vivien D, Lipton SA, Docagne F (2016) Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities. Lancet Neurol 15(10):1089–1102. doi:10.1016/S1474-4422(16)30165-X PubMedCrossRef

Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY (2002) Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110(6):851–860. doi:10.1172/jci15318 PubMedPubMedCentralCrossRef

Mandolesi G, Musella A, Gentile A, Grasselli G, Haji N, Sepman H, Fresegna D, Bullitta S, De Vito F, Musumeci G, Di Sanza C, Strata P, Centonze D (2013) Interleukin-1β alters glutamate transmission at purkinje cell synapses in a mouse model of multiple sclerosis. J Neurosci 33(29):12105. doi:10.1523/JNEUROSCI.5369-12.2013 PubMedCrossRef

Mao Z, Liu C, Ji S, Yang Q, Ye H, Han H, Xue Z (2017) The NLRP3 inflammasome is involved in the pathogenesis of Parkinson’s disease in rats. Neurochem Res 42(4):1104–1115. doi:10.1007/s11064-017-2185-0 PubMedCrossRef

Mariathasan S, Monack DM (2007) Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7(1):31–40PubMedCrossRef

Martin D, Near SL (1995) Protective effect of the interleukin-1 receptor antagonist (IL-1ra) on experimental allergic encephalomyelitis in rats. J Neuroimmunol 61(2):241–245. doi:10.1016/0165-5728(95)00108-E PubMedCrossRef

Martin BN, Wang C, C-j Zhang, Kang Z, Gulen MF, Zepp JA, Zhao J, Bian G, J-s Do, Min B, Pavicic PG Jr, El-Sanadi C, Fox PL, Akitsu A, Iwakura Y, Sarkar A, Wewers MD, Kaiser WJ, Mocarski ES, Rothenberg ME, Hise AG, Dubyak GR, Ransohoff RM, Li X (2016) T cell-intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis. Nat Immunol 17(5):583–592. doi:10.1038/ni.3389 PubMedPubMedCentralCrossRef

Martin E, Boucher C, Fontaine B, Delarasse C (2017) Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer’s disease models: effects of aging and amyloid pathology. Aging Cell 16(1):27–38. doi:10.1111/acel.12522 PubMedCrossRef

Mason JL, Suzuki K, Chaplin DD, Matsushima GK (2001) Interleukin-1β promotes repair of the CNS. J Neurosci 21(18):7046–7052PubMedCrossRef

Matousek SB, Ghosh S, Shaftel SS, Kyrkanides S, Olschowka JA, O’Banion MK (2012) Chronic IL-1β-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer’s disease without inducing overt neurodegeneration. J Neuroimmune Pharmacol 7(1):156–164PubMedCrossRef

Mellergård J, Edström M, Vrethem M, Ernerudh J, Dahle C (2010) Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid. Mult Scler 16(2):208–217. doi:10.1177/1352458509355068 PubMedCrossRef

Mendiola AS, Garza R, Cardona SM, Mythen SA, Lira SA, Akassoglou K, Cardona AE (2017) Fractalkine signaling attenuates perivascular clustering of microglia and fibrinogen leakage during systemic inflammation in mouse models of diabetic retinopathy. Front Cell Neurosci 10:303. doi:10.3389/fncel.2016.00303 PubMedPubMedCentralCrossRef

Mohr S, Xi X, Tang J, Kern TS (2002) Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients. Diabetes 51(4):1172–1179. doi:10.2337/diabetes.51.4.1172 PubMedCrossRef

Mufazalov IA, Schelmbauer C, Regen T, Kuschmann J, Wanke F, Gabriel LA, Hauptmann J, Muller W, Pinteaux E, Kurschus FC, Waisman A (2016) IL-1 signaling is critical for expansion but not generation of autoreactive GM-CSF⁺ Th17 cells. EMBO J. doi:10.15252/embj.201694615 PubMedPubMedCentralCrossRef

Netea MG, van de Veerdonk FL, van der Meer JWM, Dinarello CA, Joosten LAB (2015) Inflammasome-independent regulation of IL-1-family cytokines. Annu Rev Immunol 33(1):49–77. doi:10.1146/annurev-immunol-032414-112306 PubMedCrossRef

Neumann H, Kotter MR, Franklin RJM (2009) Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132(2):288–295. doi:10.1093/brain/awn109 PubMedCrossRef

Patel NS, Paris D, Mathura V, Quadros AN, Crawford FC, Mullan MJ (2005) Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer’s disease. J Neuroinflammation 2(1):1CrossRef

Patel JI, Saleh GM, Hykin PG, Gregor ZJ, Cree IA (2006) Concentration of haemodynamic and inflammatory related cytokines in diabetic retinopathy. Eye 22(2):223–228. doi:10.1038/sj.eye.6702584 PubMedCrossRef

Paul J, Strickland S, Melchor JP (2007) Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer’s disease. J Exp Med 204(8):1999. doi:10.1084/jem.20070304 PubMedPubMedCentralCrossRef

Peelen E, Damoiseaux J, Muris AH, Knippenberg S, Smolders J, Hupperts R, Thewissen M (2015) Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis. Mol Immunol 63(2):521–529. doi:10.1016/j.molimm.2014.10.008 PubMedCrossRef

Prinz M, Priller J, Sisodia SS, Ransohoff RM (2011) Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci 14(10):1227–1235. doi:10.1038/nn.2923 PubMedCrossRef

Prokop S, Miller KR, Heppner FL (2013) Microglia actions in Alzheimer’s disease. Acta Neuropathol 126(4):461–477. doi:10.1007/s00401-013-1182-x PubMedCrossRef

Rangachari M, Kuchroo VK (2013) Using EAE to better understand principles of immune function and autoimmune pathology. J Autoimmun 45:31–39. doi:10.1016/j.jaut.2013.06.008 PubMedPubMedCentralCrossRef

Raphael I, Nalawade S, Eagar TN, Forsthuber TG (2015) T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Cytokine 74(1):5–17. doi:10.1016/j.cyto.2014.09.011 PubMedCrossRef

Rivera JC, Sitaras N, Noueihed B, Hamel D, Madaan A, Zhou T, Honoré J-C, Quiniou C, Joyal J-S, Hardy P, Sennlaub F, Lubell W, Chemtob S (2013) Microglia and interleukin-1beta in ischemic retinopathy elicit microvascular degeneration through neuronal semaphorin-3A. Arterioscler Thromb Vasc Biol 33(8):1881–1891. doi:10.1161/atvbaha.113.301331 PubMedCrossRef

Rossi S, Motta C, Studer V, Macchiarulo G, Volpe E, Barbieri F, Ruocco G, Buttari F, Finardi A, Mancino R, Weiss S, Battistini L, Martino G, Furlan R, Drulovic J, Centonze D (2014) Interleukin-1beta causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53. Mol Neurodegener 9:56. doi:10.1186/1750-1326-9-56 PubMedPubMedCentralCrossRef

Ryu JK, McLarnon JG (2009) A leaky blood–brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain. J Cell Mol Med 13(9a):2911–2925. doi:10.1111/j.1582-4934.2008.00434.x PubMedCrossRef

Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S, Bonventre JV, Woolf CJ (2001) Interleukin-1[beta]-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 410(6827):471–475. doi:10.1038/35068566 PubMedCrossRef

Saresella M, La Rosa F, Piancone F, Zoppis M, Marventano I, Calabrese E, Rainone V, Nemni R, Mancuso R, Clerici M (2016) The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease. Mol Neurodegener 11:23. doi:10.1186/s13024-016-0088-1 PubMedPubMedCentralCrossRef

Schiffenbauer J, Streit WJ, Butfiloski E, LaBow M, Edwards C, Moldawer LL (2000) The induction of EAE is only partially dependent on TNF receptor signaling but requires the IL-1 type I receptor. Clin Immunol 95(2):117–123. doi:10.10006/clim.2000.4851 PubMedCrossRef

Scuderi S, D’amico AG, Federico C, Saccone S, Magro G, Bucolo C, Drago F, D’Agata V (2015) Different retinal expression patterns of IL-1α, IL-1β, and their receptors in a rat model of type 1 STZ-induced diabetes. J Mol Neurosci 56(2):431–439. doi:10.1007/s12031-015-0505-x PubMedCrossRef

Seppi D, Puthenparampil M, Federle L, Ruggero S, Toffanin E, Rinaldi F, Perini P, Gallo P (2014) Cerebrospinal fluid IL-1β correlates with cortical pathology load in multiple sclerosis at clinical onset. J Neuroimmunol 270(1–2):56–60. doi:10.1016/j.jneuroim.2014.02.014 PubMedCrossRef

Shaftel SS, Carlson TJ, Olschowka JA, Kyrkanides S, Matousek SB, O’Banion MK (2007a) Chronic interleukin-1β expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood–brain barrier permeability without overt neurodegeneration. J Neurosci 27(35):9301–9309. doi:10.1523/jneurosci.1418-07.2007 PubMedCrossRef

Shaftel SS, Kyrkanides S, Olschowka JA, Jen-nie HM, Johnson RE, O’Banion MK (2007b) Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest 117(6):1595–1604PubMedPubMedCentralCrossRef

Shaftel SS, Griffin WST, O’Banion MK (2008) The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. J Neuroinflammation 5(1):1CrossRef

Sheng JG, Mrak RE, Griffin WST (1997) Neuritic plaque evolution in Alzheimer’s disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94(1):1–5PubMedCrossRef

Simard AR, Soulet D, Gowing G, Julien J-P, Rivest S (2006) Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer’s disease. Neuron 49(4):489–502PubMedCrossRef

Sivakumar V, Foulds WS, Luu CD, Ling E-A, Kaur C (2011) Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina. J Pathol 224(2):245–260. doi:10.1002/path.2858 PubMedCrossRef

Sohn EH, van Dijk HW, Jiao C, Kok PHB, Jeong W, Demirkaya N, Garmager A, Wit F, Kucukevcilioglu M, van Velthoven MEJ, DeVries JH, Mullins RF, Kuehn MH, Schlingemann RO, Sonka M, Verbraak FD, Abràmoff MD (2016) Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus. Proc Natl Acad Sci USA 113(19):E2655–E2664. doi:10.1073/pnas.1522014113 PubMedPubMedCentralCrossRef

Stahel M, Becker M, Graf N, Michels S (2016) SYSTEMIC INTERLEUKIN 1β INHIBITION IN PROLIFERATIVE DIABETIC RETINOPATHY: a prospective open-label study using canakinumab. Retina 36(2):385–391. doi:10.1097/IAE.0000000000000701 PubMedPubMedCentralCrossRef

Sutton C, Brereton C, Keogh B, Mills KHG, Lavelle EC (2006) A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 203(7):1685–1691. doi:10.1084/jem.20060285 PubMedPubMedCentralCrossRef

Takahashi JL, Giuliani F, Power C, Imai Y, Yong VW (2003) Interleukin-1β promotes oligodendrocyte death through glutamate excitotoxicity. Ann Neurol 53(5):588–595. doi:10.1002/ana.10519 PubMedCrossRef

Tang J, Kern TS (2011) Inflammation in diabetic retinopathy. Prog Retin Eye Res 30(5):343–358. doi:10.1016/j.preteyeres.2011.05.002 PubMedPubMedCentralCrossRef

Tonade D, Liu H, Kern TS (2016) Photoreceptor cells produce inflammatory mediators that contribute to endothelial cell death in diabetes-induced inflammation in photoreceptors. Invest Ophthalmol Vis Sci 57(10):4264–4271. doi:10.1167/iovs.16-19859 PubMedPubMedCentralCrossRef

Trapp BD, Nave K-A (2008) Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 31(1):247–269. doi:10.1146/annurev.neuro.30.051606.094313 PubMedCrossRef

Vallejo S, Palacios E, Romacho T, Villalobos L, Peiró C, Sánchez-Ferrer CF (2014) The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats. Cardiovasc Diabetol 13(1):1. doi:10.1186/s12933-014-0158-z CrossRef

Vandanmagsar B, Youm Y-H, Ravussin A, Galgani JE, Stadler K, Mynatt RL, Ravussin E, Stephens JM, Dixit VD (2011) The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 17(2):179–188. doi:10.1038/nm.2279 PubMedPubMedCentralCrossRef

Vela JM, Molina-Holgado E, Arévalo-Martín Á, Almazán G, Guaza C (2002) Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells. Mol Cell Neurosci 20(3):489–502. doi:10.1006/mcne.2002.1127 PubMedCrossRef

Vincent JA, Mohr S (2007) Inhibition of caspase-1/interleukin-1β signaling prevents degeneration of retinal capillaries in diabetes and galactosemia. Diabetes 56(1):224–230. doi:10.2337/db06-0427 PubMedCrossRef

Vogel DY, Vereyken EJ, Glim JE, Heijnen PD, Moeton M, van der Valk P, Amor S, Teunissen CE, van Horssen J, Dijkstra CD (2013) Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status. J Neuroinflammation 10:35. doi:10.1186/1742-2094-10-35 PubMedPubMedCentralCrossRef

Vom Berg J, Prokop S, Miller KR, Obst J, Kälin RE, Lopategui-Cabezas I, Wegner A, Mair F, Schipke CG, Peters O (2012) Inhibition of IL-12/IL-23 signaling reduces Alzheimer’s disease-like pathology and cognitive decline. Nat Med 18(12):1812–1819PubMedCrossRef

Wang Y, Ulland TK, Ulrich JD, Song W, Tzaferis JA, Hole JT, Yuan P, Mahan TE, Shi Y, Gilfillan S, Cella M, Grutzendler J, DeMattos RB, Cirrito JR, Holtzman DM, Colonna M (2016) TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. J Exp Med 213(5):667–675. doi:10.1084/jem.20151948 PubMedPubMedCentralCrossRef

Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT-H, Brickey WJ, Ting JPY (2011) Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 12(5):408–415. doi:10.1038/ni.2022 PubMedPubMedCentralCrossRef

Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z, Zhou R (2015) Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell 160(1–2):62–73. doi:10.1016/j.cell.2014.11.047 PubMedCrossRef

Yang F, Wang Z, Wei X, Han H, Meng X, Zhang Y, Shi W, Li F, Xin T, Pang Q, Yi F (2014) NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke. J Cereb Blood Flow Metab 34(4):660–667. doi:10.1038/jcbfm.2013.242 PubMedPubMedCentralCrossRef

Ye L, Huang Y, Zhao L, Li Y, Sun L, Zhou Y, Qian G, Zheng JC (2013) IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase. J Neurochem 125(6):897–908. doi:10.1111/jnc.12263 PubMedPubMedCentralCrossRef

Yin J, Zhao F, Chojnacki JE, Fulp J, Klein WL, Zhang S, Zhu X (2017) NLRP3 inflammasome inhibitor ameliorates amyloid pathology in a mouse model of Alzheimer’s disease. Mol Neurobiol. doi:10.1007/s12035-017-0467-9 PubMedCentralCrossRefPubMed

Zhang B, Gaiteri C, Bodea L-G, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, Fluder E, Clurman B, Melquist S, Narayanan M, Suver C, Shah H, Mahajan M, Gillis T, Mysore J, MacDonald ME, Lamb JR, Bennett DA, Molony C, Stone DJ, Gudnason V, Myers AJ, Schadt EE, Neumann H, Zhu J, Emilsson V (2013) Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease. Cell 153(3):707–720. doi:10.1016/j.cell.2013.03.030 PubMedPubMedCentralCrossRef

Zhao L, Zabel MK, Wang X, Ma W, Shah P, Fariss RN, Qian H, Parkhurst CN, Gan WB, Wong WT (2015) Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration. EMBO Mol Med 7(9):1179–1197. doi:10.15252/emmm.201505298 PubMedPubMedCentralCrossRef

Titel: The IL-1β phenomena in neuroinflammatory diseases
verfasst von: Andrew S. Mendiola
Astrid E. Cardona
Publikationsdatum: 22.05.2017
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 5/2018
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-017-1732-9

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2018

In vivo PET imaging of neuroinflammation in Alzheimer’s disease

Interleukin 6 and complement serum level study in Parkinson’s disease

Neuroinflammatory responses in Alzheimer’s disease

Neuroinflammation in neurodegeneration: role in pathophysiology, therapeutic opportunities and clinical perspectives

Let’s make microglia great again in neurodegenerative disorders