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22.08.2019 | Original Article

Nailfold videocapillaroscopy alterations in dermatomyositis, antisynthetase syndrome, overlap myositis, and immune-mediated necrotizing myopathy

verfasst von: Caroline Soubrier, Julie Seguier, Marie-Pierre Di Costanzo, Mikael Ebbo, Emmanuelle Bernit, Estelle Jean, Véronique Veit, Laure Swiader, Emmanuelle Salort-Campana, Shahram Attarian, André Maues De Paula, Gilles Kaplanski, Jean-Marc Durand, Jean-Robert Harlé, Nicolas Schleinitz

Erschienen in: Clinical Rheumatology | Ausgabe 12/2019

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Abstract

Introduction/objectives

The aim of our study was to investigate possible differences in nailfold videocapillaroscopy (NVC) features between patients with dermatomyositis (DM), overlap myositis (OM), antisynthetase syndrome (ASS), and immune-mediated necrotizing myopathy (IMNM).

Methods

We performed a cross-sectional monocentric study. All patients with inflammatory myopathies (IMs) over a 6-month period were analyzed by NVC for giant and ramified capillaries, tortuosities, capillary density, disorganization, and scleroderma pattern. Clinical, biological, and pathological characteristics were retrospectively recorded. Patients were classified as having DM, OM, ASS, or IMNM for comparison. Patients were also compared with a group of patients with systemic sclerosis (SSc).

Results

NVC was analyzed in DM (n = 17), OM (n = 8), ASS (n = 12), and IMNM (n = 6). Vascular disorganization and avascular zones were observed only in DM (11.8%) and OM (62.5%). The percentage of patients with giant capillaries was higher in OM (n = 4/8) than in DM (n = 3/17) and absent in ASS and IMNM. Frequency of ramified capillaries, tortuosities, hemorrhages, or thrombosis was not different between subgroups. A scleroderma pattern was only observed in OM patients.

Conclusion

In this limited series of patients, we observed that DM and OM NVC abnormalities are different from ASS and IMNM. We could not determine NVC specific patterns associated with myositis-specific antibody subtypes of DM because of the small number of patients.

Key Points

• Nailfold videocapillaroscopy abnormalities are different in subgroups of inflammatory myopathies.

• Giant capillaries, disorganization, and major capillary loss are observed in overlap myositis and dermatomyositis but not in antisynthetase syndrome (ASS) or immune-mediated necrotizing myopathy.

• Nailfold videocapillaroscopy abnormalities in overlap myositis (with the exclusion of ASS) are close to systemic sclerosis.

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Titel: Nailfold videocapillaroscopy alterations in dermatomyositis, antisynthetase syndrome, overlap myositis, and immune-mediated necrotizing myopathy
verfasst von: Caroline Soubrier
Julie Seguier
Marie-Pierre Di Costanzo
Mikael Ebbo
Emmanuelle Bernit
Estelle Jean
Véronique Veit
Laure Swiader
Emmanuelle Salort-Campana
Shahram Attarian
André Maues De Paula
Gilles Kaplanski
Jean-Marc Durand
Jean-Robert Harlé
Nicolas Schleinitz
Publikationsdatum: 22.08.2019
Verlag: Springer London
Erschienen in: Clinical Rheumatology / Ausgabe 12/2019
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-019-04710-2

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