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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

01.10.2005 | Review article

Neurotoxicity induced by beta-lactam antibiotics: from bench to bedside

verfasst von: K. M. Chow, A. C. Hui, C. C. Szeto

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 10/2005

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Abstract

Central nervous system toxicity following administration of beta-lactam antibiotics, of which penicillin is the prototype, is a potential cause of morbidity and mortality. In recent years, important advances have been made in the pathogenesis of antibiotic-related neurotoxicity. This review focuses on the experimental and clinical aspects of neurotoxicity caused by beta-lactam antibiotics. The purpose is to provide an update on the pathogenesis, mechanism, and clinical manifestations of the neurotoxicity, along with an overview of the relationship between antibiotic structure and convulsive action. In particular, some of the prevailing ideas about pathogenesis are highlighted, including theories of the mechanism of pathogencity. A better understanding of antibiotic-related neurotoxicity, as derived from animal models and human clinical experience, would be of value in facilitating more efficient and safer use of antimicrobial compounds.

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Titel: Neurotoxicity induced by beta-lactam antibiotics: from bench to bedside
verfasst von: K. M. Chow
A. C. Hui
C. C. Szeto
Publikationsdatum: 01.10.2005
Verlag: Springer-Verlag
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 10/2005
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-005-0021-y

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