nach oben

European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

01.04.2009 | Concise Article

Unexpected substitution of dominant rotavirus G genotypes in French hospitalized children over five consecutive seasons

verfasst von: A. de Rougemont, J. Kaplon, P. Lebon, F. Huet, F. Denis, S. Alain, L. Fourcade, J. Grosjean, M.-J. El-Hajje, D. Gendrel, P. Pothier

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 4/2009

Einloggen, um Zugang zu erhalten

Abstract

The study was designed to evaluate the circulation of group A rotaviruses in French hospitalized children, and to detect unusual strains. This prospective study was conducted from 2001 to 2006 in children consulting for acute diarrhea at the pediatric emergency department in three French University Hospitals. The rotaviruses were detected by rapid test and genotyped by RT-PCR on the basis of their outer capsid proteins VP4 (P-type) and VP7 (G-type). The stools from 757 children were analyzed. G1P[8] strains were predominant (44.0%), followed by G9P[8] (17.7%), G3P[8] 13.1%, G4P[8] (9.5%), and G2P[4] (1.8%); mixed rotavirus infections occurred in 2.3%. G9 rotaviruses emerged during the 2004–2005 season (73.4%) and remained the second most prevalent strains. Few unusual strains, G6, G8, G12 and P[6]-types, were detected. The monitoring of rotavirus infections should be maintained to document strain distribution and to assess the emergence of new reassortants that may not respond to current rotavirus vaccines.

Bishop RF (1994) Natural history of human rotavirus infections. In: Kapikian AZ (ed) Viral infections of the gastrointestinal tract. Dekker, New York, pp 131–168

Jiang B, Gentsch JR, Glass RI (2002) The role of serum antibodies in the protection against rotavirus disease: an overview. Clin Infect Dis 34(10):1351–1361, doi:10.1086/340103 PubMedCrossRef

Estes MK, Kapikian AZ (2007) Rotaviruses. In: Knipe DM, Howley PM (eds) Fields virology. Lippincott Williams & Wilkins, Philadelphia, pp 1917–1974

Gentsch JR, Laird AR, Bielfelt B, Griffin DD, Banyai K, Ramachandran M et al (2005) Serotype diversity and reassortment between human and animal rotavirus strains: implications for rotavirus vaccine programs. J Infect Dis 192(Suppl 1):S146–S159, doi:10.1086/431499 PubMedCrossRef

Santos N, Hoshino Y (2005) Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine. Rev Med Virol 15(1):29–56, doi:10.1002/rmv.448 PubMedCrossRef

Arista S, Giammanco GM, De Grazia S, Migliore MC, Martella V, Cascio A (2004) Molecular characterization of the genotype G9 human rotavirus strains recovered in Palermo, Italy, during the winter of 1999–2000. Epidemiol Infect 132(2):343–349, doi:10.1017/S0950268803001602 PubMedCrossRef

Iturriza-Gómara M, Isherwood B, Desselberger U, Gray J (2001) Reassortment in vivo: driving force for diversity of human rotavirus strains isolated in the United Kingdom between 1995 and 1999. J Virol 75(8):3696–3705, doi:10.1128/JVI.75.8.3696-3705.2001 PubMedCrossRef

Bon F, Fromantin C, Aho S, Pothier P, Kohli E (2000) G and P genotyping of rotavirus strains circulating in France over a three-year period: detection of G9 and P[6] strains at low frequencies. The AZAY Group. J Clin Microbiol 38(4):1681–1683PubMed

Steyer A, Poljsak-Prijatelj M, Barlic-Maganja D, Bufon T, Marin J (2005) The emergence of rotavirus genotype G9 in hospitalised children in Slovenia. J Clin Virol 33(1):7–11, doi:10.1016/j.jcv.2004.09.021 PubMedCrossRef

10.

Rubilar-Abreu E, Hedlund KO, Svensson L, Mittelholzer C (2005) Serotype G9 rotavirus infections in adults in Sweden. J Clin Microbiol 43(3):1374–1376, doi:10.1128/JCM.43.3.1374-1376.2005 PubMedCrossRef

11.

Banyai K, Gentsch JR, Schipp R, Jakab F, Meleg E, Mihaly I et al (2005) Dominating prevalence of P[8],G1 and P[8],G9 rotavirus strains among children admitted to hospital between 2000 and 2003 in Budapest, Hungary. J Med Virol 76(3):414–423, doi:10.1002/jmv.20372 PubMedCrossRef

12.

Rahman M, Matthijnssens J, Goegebuer T, De Leener K, Vanderwegen L, van der Donck I et al (2005) Predominance of rotavirus G9 genotype in children hospitalized for rotavirus gastroenteritis in Belgium during 1999–2003. J Clin Virol 33(1):1–6, doi:10.1016/j.jcv.2004.09.020 PubMedCrossRef

13.

Rodrigues F, Iturriza M, Gray J, Januario L, Lemos L (2007) Epidemiology of rotavirus in Portugal: G9 as a major cause of diarrhoea in non-hospitalised children. J Clin Virol 40(3):214–217, doi:10.1016/j.jcv.2007.08.006 PubMedCrossRef

14.

Sanchez-Fauquier A, Montero V, Moreno S, Sole M, Colomina J, Iturriza-Gómara M et al (2006) Human rotavirus G9 and G3 as major cause of diarrhea in hospitalized children, Spain. Emerg Infect Dis 12(10):1536–1541PubMed

15.

Van Damme P, Giaquinto C, Maxwell M, Todd P, Van der Wielen M (2007) Distribution of rotavirus genotypes in Europe, 2004–2005: the REVEAL Study. J Infect Dis 195(Suppl 1):S17–S25, doi:10.1086/516715 PubMedCrossRef

16.

Chikhi-Brachet R, Bon F, Toubiana L, Pothier P, Nicolas JC, Flahault A et al (2002) Virus diversity in a winter epidemic of acute diarrhea in France. J Clin Microbiol 40(11):4266–4272, doi:10.1128/JCM.40.11.4266-4272.2002 PubMedCrossRef

17.

de Rougemont A, Kaplon J, Billaud G, Lina B, Pinchinat S, Derrough T, Caulin E, Pothier P, Floret D (2008) Sensitivity and specificity of the VIKIA® Rota-Adeno immuno-chromatographic test (bioMérieux) and the IDEIA™ Rotavirus ELISA kit (Dako) compared to genotyping. Pathol Biol, doi:10.1016/j.patbio.2008.08. 004

18.

Gouvea V, Glass RI, Woods P, Taniguchi K, Clark HF, Forrester B et al (1990) Polymerase chain reaction amplification and typing of rotavirus nucleic acid from stool specimens. J Clin Microbiol 28(2):276–282PubMed

19.

Gentsch JR, Glass RI, Woods P, Gouvea V, Gorziglia M, Flores J et al (1992) Identification of group A rotavirus gene 4 types by polymerase chain reaction. J Clin Microbiol 30(6):1365–1373PubMed

20.

Iturriza-Gómara M, Green J, Brown DW, Desselberger U, Gray JJ (1999) Comparison of specific and random priming in the reverse transcriptase polymerase chain reaction for genotyping group A rotaviruses. J Virol Methods 78(1–2):93–103, doi:10.1016/S0166-0934(98)00168-2 PubMedCrossRef

21.

Gomara MI, Cubitt D, Desselberger U, Gray J (2001) Amino acid substitution within the VP7 protein of G2 rotavirus strains associated with failure to serotype. J Clin Microbiol 39(10):3796–3798, doi:10.1128/JCM.39.10.3796-3798.2001 PubMedCrossRef

22.

Iturriza-Gómara M, Green J, Brown DW, Desselberger U, Gray JJ (2000) Diversity within the VP4 gene of rotavirus P[8] strains: implications for reverse transcription-PCR genotyping. J Clin Microbiol 38(2):898–901PubMed

23.

Iturriza-Gómara M, Kang G, Gray J (2004) Rotavirus genotyping: keeping up with an evolving population of human rotaviruses. J Clin Virol 31(4):259–265, doi:10.1016/j.jcv.2004.04.009 PubMedCrossRef

24.

Laird AR, Gentsch JR, Nakagomi T, Nakagomi O, Glass RI (2003) Characterization of serotype G9 rotavirus strains isolated in the United States and India from 1993 to 2001. J Clin Microbiol 41(7):3100–3111, doi:10.1128/JCM.41.7.3100-3111.2003 PubMedCrossRef

25.

Stupka JA, Parra GI, Gomez J, Arbiza J (2007) Detection of human rotavirus G9P[8] strains circulating in Argentina: phylogenetic analysis of VP7 and NSP4 genes. J Med Virol 79(6):838–842, doi:10.1002/jmv.20841 PubMedCrossRef

26.

Diwakarla CS, Palombo EA (1999) Genetic and antigenic variation of capsid protein VP7 of serotype G1 human rotavirus isolates. J Gen Virol 80(Pt 2):341–344PubMed

27.

Arista S, Giammanco GM, De Grazia S, Ramirez S, Lo Biundo C, Colomba C et al (2006) Heterogeneity and temporal dynamics of evolution of G1 human rotaviruses in a settled population. J Virol 80(21):10724–10733, doi:10.1128/JVI.00340-06 PubMedCrossRef

28.

Phan TG, Okitsu S, Maneekarn N, Ushijima H (2007) Evidence of intragenic recombination in G1 rotavirus VP7 genes. J Virol 81(18):10188–10194, doi:10.1128/JVI.00337-07 PubMedCrossRef

29.

Snodgrass DR, Fitzgerald T, Campbell I, Scott FM, Browning GF, Miller DL et al (1990) Rotavirus serotypes 6 and 10 predominate in cattle. J Clin Microbiol 28(3):504–507PubMed

30.

Rahman M, De Leener K, Goegebuer T, Wollants E, Van der Donck I, Van Hoovels L et al (2003) Genetic characterization of a novel, naturally occurring recombinant human G6P[6] rotavirus. J Clin Microbiol 41(5):2088–2095, doi:10.1128/JCM.41.5.2088-2095.2003 PubMedCrossRef

31.

O’Halloran F, Lynch M, Cryan B, O’Shea H, Fanning S (2000) Molecular characterization of rotavirus in Ireland: detection of novel strains circulating in the population. J Clin Microbiol 38(9):3370–3374PubMed

32.

Buesa J, de Souza CO, Asensi M, Martinez C, Prat J, Gil MT (2000) VP7 and VP4 genotypes among rotavirus strains recovered from children with gastroenteritis over a 3-year period in Valencia, Spain. Eur J Epidemiol 16(6):501–506, doi:10.1023/A:1007618215377 PubMedCrossRef

33.

Cunliffe NA, Gentsch JR, Kirkwood CD, Gondwe JS, Dove W, Nakagomi O et al (2000) Molecular and serologic characterization of novel serotype G8 human rotavirus strains detected in Blantyre, Malawi. Virology 274(2):309–320, doi:10.1006/viro.2000.0456 PubMedCrossRef

34.

Taniguchi K, Urasawa T, Kobayashi N, Gorziglia M, Urasawa S (1990) Nucleotide sequence of VP4 and VP7 genes of human rotaviruses with subgroup I specificity and long RNA pattern: implication for new G serotype specificity. J Virol 64(11):5640–5644PubMed

35.

Pun SB, Nakagomi T, Sherchand JB, Pandey BD, Cuevas LE, Cunliffe NA et al (2007) Detection of G12 human rotaviruses in Nepal. Emerg Infect Dis 13(3):482–484PubMedCrossRef

36.

Kheyami AM, Nakagomi T, Nakagomi O, Dove W, Hart CA, Cunliffe NA (2008) Molecular epidemiology of rotavirus diarrhea among children in Saudi Arabia: first detection of G9 and G12 strains. J Clin Microbiol 46(4):1185–1191, doi:10.1128/JCM.02244-07 PubMedCrossRef

Titel: Unexpected substitution of dominant rotavirus G genotypes in French hospitalized children over five consecutive seasons
verfasst von: A. de Rougemont
J. Kaplon
P. Lebon
F. Huet
F. Denis
S. Alain
L. Fourcade
J. Grosjean
M.-J. El-Hajje
D. Gendrel
P. Pothier
Publikationsdatum: 01.04.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 4/2009
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-008-0640-1

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

RAS-Blocker bei Hyperkaliämie möglichst nicht sofort absetzen

14.05.2024 Hyperkaliämie Nachrichten

Bei ausgeprägter Nierenfunktionsstörung steigen unter der Einnahme von Renin-Angiotensin-System(RAS)-Hemmstoffen nicht selten die Serumkaliumspiegel. Was in diesem Fall zu tun ist, erklärte Prof. Jürgen Floege beim diesjährigen Allgemeinmedizin-Update-Seminar.

Gestationsdiabetes: In der zweiten Schwangerschaft folgenreicher als in der ersten

13.05.2024 Gestationsdiabetes Nachrichten

Das Risiko, nach einem Gestationsdiabetes einen Typ-2-Diabetes zu entwickeln, hängt nicht nur von der Zahl, sondern auch von der Reihenfolge der betroffenen Schwangerschaften ab.

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

13.05.2024 Pankreaskarzinom Nachrichten

Gerade bei aggressiven Malignomen wie dem duktalen Adenokarzinom des Pankreas könnte Früherkennung die Therapiechancen verbessern. Noch jedoch klafft hier eine Lücke. Ein Studienteam hat einen Weg gesucht, sie zu schließen.

Battle of Experts: Sport vs. Spritze bei Adipositas und Typ-2-Diabetes

11.05.2024 DDG-Jahrestagung 2024 Kongressbericht

Im Battle of Experts traten zwei Experten auf dem Diabeteskongress gegeneinander an: Die eine vertrat die Auffassung „Sport statt Spritze“ bei Adipositas und Typ-2-Diabetes, der andere forderte „Spritze statt Sport!“ Am Ende waren sie sich aber einig: Die Kombination aus beidem erzielt die besten Ergebnisse.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Bildnachweise

Die Leitlinien für Ärztinnen und Ärzte, Ärztin führt eine Nierenultraschalluntersuchung durch/© Graphicroyalty / stock.adobe.com (Symbolbild mit Fotomodell), Schwangere misst Blutzucker/© MMPhotography / Getty Images / iStock (Symbolbild mit Fotomodell), Duktales Pankreaskarzinom/© Dörffel, Y., Wermke, W. / all rights reserved Springer Medizin Verlag GmbH, Füße einer adipösen Frau auf einem Laufband/© Idanupong / stock.adobe.com (Symbolbild mit Fotomodell)

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2009

The in vitro susceptibility of Campylobacter spp. to the antibacterial effect of manuka honey

In vitro activity of tigecycline against multidrug-resistant Enterobacteriaceae isolates from a Belgian hospital

Prevalence and risk factors of the whole spectrum of sexually transmitted diseases in male incoming prisoners in France

Risk factors for multidrug-resistant tuberculosis in a tuberculosis unit in Madrid, Spain

Legionella pneumophila DNA in serum samples during Legionnaires’ disease in relation to C-reactive protein levels