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Digestive Diseases and Sciences

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01.12.2009 | Original Article

A 10-Year Follow-up of a Longitudinal Study of Gallstone Prevalence at Necropsy in South East England

verfasst von: Hamed N. Khan, Margaret Harrison, Eryl E. Bassett, Tom Bates

Erschienen in: Digestive Diseases and Sciences | Ausgabe 12/2009

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Abstract

The purpose of this study was to examine a previous increase in male gallstone disease and to consider the burden of gallstones in a necropsy study with matched controls over a decade. Gallstone prevalence in 5,050 males fell from 20.2% to 19.1% (P = 0.022) and in 4,125 females fell from 30.4% to 29.0% (P = 0.03). Female gallstone subjects had a higher BMI than controls 24.5 vs. 23.3 (P < 0.01), but males did not. Gallstones were twice as common in diabetics, but not with coronary heart disease (CHD). A third of elderly patients of both sexes had gallstones, but cholecystectomy was more common in females, 17:10%. Gallstone-related mortality was 0.7%. The prevalence of gallstones fell slightly. The association between gallstones and diabetes was confirmed, but not for CHD, and for BMI this was confined to females. Gallstones are very common in the elderly, but most are unoperated and seldom cause death.

Included those cases resident outside the Trust.

Misciagna G, Centonze S, Leoci C, et al. Diet, physical activity, and gallstones - a population-based, case–control study in southern Italy. Am J Clin Nutr. 1999;69:120–126.PubMed

Nakeeb A, Comuzzie AG, Martin L, et al. Gallstones: genetics versus environment. Ann Surg. 2002;235:842–849. doi:10.1097/00000658-200206000-00012.CrossRefPubMed

Vitetta L, Sali A, Little P, Mrazek L. Gallstones and gall bladder carcinoma. Aust NZ J Surg. 2000;70:667–673. doi:10.1046/j.1440-1622.2000.01926.x.CrossRef

Freedman J, Ye W, Naslund E, Lagergren J. Association between cholecystectomy and adenocarcinoma of the esophagus. Gastroenterology. 2001;121:548–553. doi:10.1053/gast.2001.27217.CrossRefPubMed

Lagergren J, Ye W, Ekbom A. Intestinal cancer after cholecystectomy: is bile involved in carcinogenesis? Gastroenterology. 2001;121:542–547. doi:10.1053/gast.2001.27083.CrossRefPubMed

Reid FDA, Mercer PM, Harrison M, Bates T. Cholecystectomy as a risk factor for colorectal cancer: a meta-analysis. Scand J Gastroenterol. 1996;31:160–169. doi:10.3109/00365529609031981.CrossRefPubMed

Mercer PM, Reid FDA, Harrison M, Bates T. The relationship between cholecystectomy, unoperated gallstone disease and colorectal cancer. Scand J Gastroenterol. 1995;30:1017–1020. doi:10.3109/00365529509096347.CrossRefPubMed

Reshetnikov OV, Ryabikov AN, Shakhmatov SG, Malyutina SK. Gallstone disease prevalence in Western Siberia: cross-sectional ultrasound study versus autopsy. J Gastroenterol Hepatol. 2002;17:702–707. doi:10.1046/j.1440-1746.2002.02758.x.CrossRefPubMed

Massarrat S. Prevalence of gallstone disease in Iran. J Gastroenterol Hepatol. 2001;16:564–567. doi:10.1046/j.1440-1746.2001.02478.x.CrossRefPubMed

10.

Bateson MC. Gallstones and cholecystectomy in modern Britain. Postgrad Med J. 2000;76:700–703. doi:10.1136/pmj.76.901.700.CrossRefPubMed

11.

Everhart JE, Khare M, Hill M, Maurer KR. Prevalence and ethnic differences in gallbladder disease in the United States. Gastroenterology. 1999;117:632–639. doi:10.1016/S0016-5085(99)70456-7.CrossRefPubMed

12.

McFarlane MJ. Supportive evidence for the validity of the epidemiologic necropsy for gallstones. J Gen Intern Med. 1990;5:495–500. doi:10.1007/BF02600878.CrossRefPubMed

13.

Jorgensen T, Rossen K, Thorvaldsen P. Are autopsy studies reliable in assessing gallstone prevalence in the community? Int J Epidemiol. 1994;23:566–569. doi:10.1093/ije/23.3.566.CrossRefPubMed

14.

Godfrey PJ, Bates T, Harrison M, King MB, Padley NR. Gallstones and mortality: a study of all gallstone related deaths in a single health district. Gut. 1984;25:1029–1033. doi:10.1136/gut.25.10.1029.CrossRef

15.

Bates T, Harrison M, Lowe D, Lawson C, Padley N. Longitudinal study of gall stone prevalence at necropsy. Gut. 1992;33:103–107. doi:10.1136/gut.33.1.103.CrossRefPubMed

16.

Diehl AK, Haffner AK, Hazuda HP, Stern MP. Coronary risk factors and clinical gallbladder disease: an approach to the prevention of gallstones? Am J Public Health. 1987;77:841–845. doi:10.2105/AJPH.77.7.841.CrossRefPubMed

17.

Mendez-Sanchez N, Bahena-Aponte J, Chavez-Tapia NC, et al. Strong association between gallstones and cardiovascular disease. Am J Gastroenterol. 2005;100:827–830. doi:10.1111/j.1572-0241.2005.41214.x.CrossRefPubMed

18.

Acalovschi M, Pascu M, Iobagiu S, et al. Increasing gallstone prevalence and cholecystectomy rate in a large Romanian town. A necropsy study. Dig Dis Sci. 1995;40:2582–2586. doi:10.1007/BF02220445.CrossRefPubMed

19.

Mendez-Sanchez N, Jessurun J, Ponciano-Rodriguez G, Alonso-de-Ruiz P, Uribe M, Hernandez-Avila M. Prevalence of gallstone disease in Mexico. A necropsy study. Dig Dis Sci. 1993;38:680–683. doi:10.1007/BF01316800.CrossRefPubMed

20.

Avgerinos DV, Bjornsson J. Malignant neoplasms: discordance between clinical diagnoses and autopsy findings in 3, 118 cases. APMIS. 2001;109:774–780. doi:10.1034/j.1600-0463.2001.d01-145.x.CrossRefPubMed

21.

Kratzer W, Mason RA, Kachele V. Prevalence of gallstones in sonographic surveys worldwide. J Clin Ultrasound. 1999;27:1–7. doi:10.1002/(SICI)1097-0096(199901)27:1<1::AID-JCU1>3.0.CO;2-H.CrossRefPubMed

22.

Dhar SC, Ansari S, Saha M, et al. Gallstone disease in a rural Bangladeshi community. Indian J Gastroenterol. 2001;20:223–226.PubMed

23.

Everhart JE, Yeh F, Lee ET, et al. Prevalence of gallbladder disease in American Indian populations: findings from the Strong Heart Study. Hepatology. 2002;35:1507–1512. doi:10.1053/jhep.2002.33336.CrossRefPubMed

24.

Rosmorduc O, Hermelin B, Poupon R. MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. Gastroenterology. 2001;120:1459–1467. doi:10.1053/gast.2001.23947.CrossRefPubMed

25.

Katsika D, Tuvblad C, Einarsson C, Lichtestein P, Marschall HU. Body mass index, alcohol, tobacco and symptomatic gallstone disease: a Swedish twin study. J Intern Med. 2007;262:581–587. doi:10.1111/j.1365-2796.2007.01860.x.CrossRefPubMed

26.

Volzke H, Baumeister SE, Alte D, et al. Independent risk factors for gallstone formation in a region with a high cholelithiasis prevalence. Digestion. 2005;71:97–105. doi:10.1159/000084525.CrossRefPubMed

27.

Tung TH, Ho HM, Shih HC, et al. A population-based follow-up study of gallstone disease among type 2 diabetics in Kinmen, Taiwan. World J Gastroenterol. 2006;12:4536–4540.PubMed

28.

Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Central adiposity, regional fat distribution, and the risk of cholecystectomy. Gut. 2006;55:708–714. doi:10.1136/gut.2005.076133.CrossRefPubMed

29.

Caroli-Bosc FX, Pugliese P, Peten EP, et al. Gallbladder volume in adults and its relationship to age, sex, body mass index, body surface area and gallstones. An epidemiologic study in a nonselected population in France. Digestion. 1999;60:344–348.CrossRefPubMed

30.

Chapman BA, Frampton CM, Wilson IR, Chisholm RJ, Allan RB, Burt MJ. Gallstone prevalence in Christchurch: risk factors and clinical significance. N Z Med J. 2000;113:46–48.PubMed

31.

Borch K, Jonsson KA, Zdolsek JM, Halldestam I, Kullman E. Prevalence of gallstone disease in a Swedish population sample. Relations to occupation, childbirth, health status, life style, medications, and blood lipids. Scand J Gastroenterol. 1998;33:1219–1225. doi:10.1080/00365529850172601.CrossRefPubMed

32.

Mendez-Sanchez N, Zamora-Valdes D, Chaves-Tapia NC, Uribe M. Role of diet in cholesterol gallstone formation. Clin Chim Acta. 2007;376:1–8. doi:10.1016/j.cca.2006.08.036.CrossRefPubMed

33.

Shaffer EA. Gallstone disease: Epidemiology of gallbladder stone disease. Best Pract Res Clin Gastroenterol. 2006;20:981–986. doi:10.1016/j.bpg.2006.05.004.CrossRefPubMed

34.

Social trends 19, London: HMSO; 1989:118–22.

35.

Kono S, Shinchi K, Ikeda N, Yanai F, Imanishi K. Prevalence of gallstone disease in relation to smoking, alcohol use, obesity, and glucose tolerance: a study of self-defense officials in Japan. Am J Epidemiol. 1992;136:787–794.CrossRefPubMed

36.

Chapman BA, Chapman TM, Frampton CM, et al. Gallbladder volume: comparison of diabetics and controls. Dig Dis Sci. 1998;43:344–348. doi:10.1023/A:1018810523399.CrossRefPubMed

37.

Shinchi K, Kono S, Honjo S, Imanishi K, Hirohata T. Serum lipids and gallstone disease. A study of self-defense officials in Japan. Ann Epidemiol. 1993;3:614–618.PubMedCrossRef

38.

Bateson MC. Gallbladder disease and cholecystectomy rate are independently variable. Lancet. 1984;2:621–624. doi:10.1016/S0140-6736(84)90605-6.CrossRefPubMed

39.

Plant JCT, Percy I, Bates T, Gastard J, DeNercy YH. Incidence of gallbladder disease in Canada, England and France. Lancet. 1973;2:249–251. doi:10.1016/S0140-6736(73)93148-6.CrossRefPubMed

40.

Shaper NL, Harrison M, Bates T. Impact of laparoscopic cholecystectomy on surgical training. Ann R Coll Surg Engl. 1996;78:39–42.PubMed

Titel: A 10-Year Follow-up of a Longitudinal Study of Gallstone Prevalence at Necropsy in South East England
verfasst von: Hamed N. Khan
Margaret Harrison
Eryl E. Bassett
Tom Bates
Publikationsdatum: 01.12.2009
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 12/2009
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-008-0682-3

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