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Neuropsychology Review

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01.06.2009 | Review

Neuropsychological Functioning and Antiretroviral Treatment in HIV/AIDS: A Review

verfasst von: Lucette A. Cysique, Bruce J. Brew

Erschienen in: Neuropsychology Review | Ausgabe 2/2009

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Abstract

This article presents a review of studies that have investigated the neuropsychological effects of antiretroviral treatment (ART) for HIV-1 infection. It provides a brief overview of the era of monotherapy, dual-therapy, and an extended overview of the current era of combination antiretroviral therapy (CART). This review highlights that while CART has had a dramatic effect on the incidence and the severity of HIV-associated neurocognitive disorders (HAND), HAND, in its mild form, still remains prevalent. New causes of this sustained prevalence are poor CNS penetration of some antiretroviral agents, drug resistance, poor adherence, potential neurotoxicity, co-morbidities such as the long-term CART side effects in relation to cardio-vascular disease, and chronic HIV brain infection that may facilitate the expression of new forms of neurodegenerative processes. The review emphasizes the need to address methodological limitations of published studies and the need for large and representative cross-disciplinary longitudinal investigations across the HIV illness span.

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Titel: Neuropsychological Functioning and Antiretroviral Treatment in HIV/AIDS: A Review
verfasst von: Lucette A. Cysique
Bruce J. Brew
Publikationsdatum: 01.06.2009
Verlag: Springer US
Erschienen in: Neuropsychology Review / Ausgabe 2/2009
Print ISSN: 1040-7308
Elektronische ISSN: 1573-6660
DOI: https://doi.org/10.1007/s11065-009-9092-3

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