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22.10.2019 | Letter to the Editor

Letter to the Editor re: Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [¹⁸F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter

verfasst von: Paolo Zanotti-Fregonara, Mattia Veronese, Gaia Rizzo, Belen Pascual, Joseph C. Masdeu, Federico E. Turkheimer

Erschienen in: Molecular Imaging and Biology | Ausgabe 1/2020

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We read with great interest the recent article of Sridharan et al., in which they investigated the specific binding of [¹⁸F]GE-180 in a population of subjects with multiple sclerosis [1]. By using pharmacological blockade with XBD173, they were able to confirm in vivo for the first time the presence of specific binding of [¹⁸F]GE-180 in the living human brain. …

Sridharan S, Raffel J, Nandoskar A et al (2019) Confirmation of specific binding of the 18-kDa translocator protein (TSPO) radioligand [¹⁸F]GE-180: a blocking study using XBD173 in multiple sclerosis normal appearing white and grey matter. Mol Imaging Biol 21(5):935–944CrossRef

Unterrainer M, Fleischmann DF, Diekmann C et al (2018) Comparison of (18)F-GE-180 and dynamic ¹⁸F-FET PET in high grade glioma: a double-tracer pilot study. Eur J Nucl Med Mol Imaging 21:935–944

Unterrainer M, Mahler C, Vomacka L et al (2018) TSPO PET with [¹⁸F]GE-180 sensitively detects focal neuroinflammation in patients with relapsing-remitting multiple sclerosis. Eur J Nucl Med Mol Imaging 45:1423–1431CrossRef

Vomacka L, Albert NL, Lindner S et al (2017) TSPO imaging using the novel PET ligand [¹⁸F]GE-180: quantification approaches in patients with multiple sclerosis. EJNMMI Res 7:89CrossRef

Albert NL, Unterrainer M, Brendel M et al (2019) In response to: the validity of ¹⁸F-GE180 as a TSPO imaging agent. Eur J Nucl Med Mol Imaging 46:1208–1211CrossRef

Zanotti-Fregonara P, Veronese M, Pascual B et al (2019) The validity of ¹⁸F-GE180 as a TSPO imaging agent. Eur J Nucl Med Mol Imaging 46:1205–1207CrossRef

Zanotti-Fregonara P, Pascual B, Rizzo G et al (2018) Head-to-head comparison of ¹¹C-PBR28 and ¹⁸F-GE180 for quantification of the translocator protein in the human brain. J Nucl Med 59:1260–1266CrossRef

Richards EM, Zanotti-Fregonara P, Fujita M et al (2018) PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects. EJNMMI Res 8:57CrossRef

Boutin H, Murray K, Pradillo J et al (2015) ¹⁸F-GE-180: a novel TSPO radiotracer compared to ¹¹C-R-PK11195 in a preclinical model of stroke. Eur J Nucl Med Mol Imaging 42:503–511CrossRef

10.

Chaney A, Cropper HC, Johnson EM et al (2019) ¹¹C-DPA-713 versus ¹⁸F-GE-180: A preclinical comparison of TSPO-PET tracers to visualize acute and chronic neuroinflammation in a mouse model of ischemic stroke. J Nucl Med 60:122–128CrossRef

11.

Wadsworth H, Jones PA, Chau WF et al (2012) [¹⁸F]GE-180: a novel fluorine-18 labelled PET tracer for imaging translocator protein 18 kDa (TSPO). Bioorg Med Chem Lett 22:1308–1313CrossRef

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Owen DR, Guo Q, Kalk NJ et al (2014) Determination of [¹¹C]PBR28 binding potential in vivo: a first human TSPO blocking study. J Cereb Blood Flow Metab 34:989–994CrossRef

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Feeney C, Scott G, Raffel J et al (2016) Kinetic analysis of the translocator protein positron emission tomography ligand [¹⁸F]GE-180 in the human brain. Eur J Nucl Med Mol Imaging 43:2201–2210CrossRef

Titel: Letter to the Editor re: Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [18F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter
verfasst von: Paolo Zanotti-Fregonara
Mattia Veronese
Gaia Rizzo
Belen Pascual
Joseph C. Masdeu
Federico E. Turkheimer
Publikationsdatum: 22.10.2019
Verlag: Springer International Publishing
Erschienen in: Molecular Imaging and Biology / Ausgabe 1/2020
Print ISSN: 1536-1632
Elektronische ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-019-01433-3

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Letter to the Editor re: Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [¹⁸F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter

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