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01.03.2018 | ABDOMINAL RADIOLOGY

Haralick’s texture features for the prediction of response to therapy in colorectal cancer: a preliminary study

verfasst von: Damiano Caruso, Marta Zerunian, Maria Ciolina, Domenico de Santis, Marco Rengo, Mumtaz H. Soomro, Gaetano Giunta, Silvia Conforto, Maurizio Schmid, Emanuele Neri, Andrea Laghi

Erschienen in: La radiologia medica | Ausgabe 3/2018

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Abstract

Purpose

Haralick features Texture analysis is a recent oncologic imaging biomarker used to assess quantitatively the heterogeneity within a tumor. The aim of this study is to evaluate which Haralick’s features are the most feasible in predicting tumor response to neoadjuvant chemoradiotherapy (CRT) in colorectal cancer.

Materials and Methods

After MRI and histological assessment, eight patients were enrolled and divided into two groups based on response to neoadjuvant CRT in complete responders (CR) and non-responders (NR). Oblique Axial T2-weighted MRI sequences before CRT were analyzed by two radiologists in consensus drawing a ROI around the tumor. 14 over 192 Haralick’s features were extrapolated from normalized gray-level co-occurrence matrix in four different directions. A dedicated statistical analysis was performed to evaluate distribution of the extracted Haralick’s features computing mean and standard deviation.

Results

Pretreatment MRI examination showed significant value (p < 0.05) of 5 over 14 computed Haralick texture. In particular, the significant features are the following: concerning energy, contrast, correlation, entropy and inverse difference moment.

Conclusions

Five Haralick’s features showed significant relevance in the prediction of response to therapy in colorectal cancer and might be used as additional imaging biomarker in the oncologic management of colorectal patients.

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Titel: Haralick’s texture features for the prediction of response to therapy in colorectal cancer: a preliminary study
verfasst von: Damiano Caruso
Marta Zerunian
Maria Ciolina
Domenico de Santis
Marco Rengo
Mumtaz H. Soomro
Gaetano Giunta
Silvia Conforto
Maurizio Schmid
Emanuele Neri
Andrea Laghi
Publikationsdatum: 01.03.2018
Verlag: Springer Milan
Erschienen in: La radiologia medica / Ausgabe 3/2018
Print ISSN: 0033-8362
Elektronische ISSN: 1826-6983
DOI: https://doi.org/10.1007/s11547-017-0833-8

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Haralick’s texture features for the prediction of response to therapy in colorectal cancer: a preliminary study