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01.07.2012 | Original Article

Hepatocyte transporter expression in FNH and FNH-like nodule: correlation with signal intensity on gadoxetic acid enhanced magnetic resonance images

verfasst von: Norihide Yoneda, Osamu Matsui, Azusa Kitao, Ryuuichi Kita, Kazuto Kozaka, Wataru Koda, Satoshi Kobayashi, Toshifumi Gabata, Hiroko Ikeda, Yasunori Sato, Yasuni Nakanuma

Erschienen in: Japanese Journal of Radiology | Ausgabe 6/2012

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Abstract

Purpose

Our aim was to evaluate the hepatocyte transporters in focal nodular hyperplasia (FNH) and FNH-like lesions and to correlate the grade of its expression with signal intensity on the hepatobiliary phase (HB phase) of gadoxetic-acid-enhanced magnetic resonance imaging (EOB-MRI).

Materials and methods

Thirteen histopathological confirmed cases including eight with EOB-MRI were studied. Immunohistochemical staining for transporter was performed and its grade semiquantitatively analyzed.

Results

Histopathologically, ten cases showed almost equal organic anion transporter polypeptide (OATP) 8 expression relative to the surrounding liver; the remaining three showed stronger OATP8 expression. In eight cases with EOB-MRI, two demonstrated more hyperintensity on the HB phase, and their OATP8 expression was stronger compared with the surrounding liver. The remaining six cases showed isointensity on the HB phase and revealed almost equal OATP8 expression. The expression of export transporter multi-drug-resistant proteins (MRP) 1 and 2 were almost equal relative to the surrounding liver in most cases (11/12, 92 %; 11/12, 92 %, respectively), whereas MRP3 focally overexpressed in 75 % (9/12) of cases.

Conclusion

FNH and FNH-like nodules revealed equal or stronger OATP8 expression than background liver. OATP8 expression showed significant correlation with signal intensity on the HB phase.

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Titel: Hepatocyte transporter expression in FNH and FNH-like nodule: correlation with signal intensity on gadoxetic acid enhanced magnetic resonance images
verfasst von: Norihide Yoneda
Osamu Matsui
Azusa Kitao
Ryuuichi Kita
Kazuto Kozaka
Wataru Koda
Satoshi Kobayashi
Toshifumi Gabata
Hiroko Ikeda
Yasunori Sato
Yasuni Nakanuma
Publikationsdatum: 01.07.2012
Verlag: Springer Japan
Erschienen in: Japanese Journal of Radiology / Ausgabe 6/2012
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-012-0085-4

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Hepatocyte transporter expression in FNH and FNH-like nodule: correlation with signal intensity on gadoxetic acid enhanced magnetic resonance images